Access and Transport to Paediatric Intensive CareDEPICTNCT03520192
Differences in Access to Emergency Paediatric Intensive Care and Care During Transport
An observational study of Access and Transport to Paediatric Intensive Care, run by Great Ormond Street Hospital for Children NHS Foundation Trust at 1 site in United Kingdom.
Trial summary
There are fewer than 30 paediatric intensive care units (PICUs) in the United Kingdom (UK). This means that a critically ill child taken to their nearest hospital will need to be transferred to a PICU. Read more about this study
- Who is it for?
- Ages Up to 16 years
- Conditions the study is for
- Access and Transport to Paediatric Intensive Care
- How many people
- 2,838 participants
- Where
- 1 siteUnited Kingdom
- Study dates
- 1 Jan 2019to 31 Dec 2021
- Phase
- Observational
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages Up to 16 years
- All sexes
- No healthy volunteers
- Child
Study population: Children and young people (age <16 years) transported by a PIC retrieval team for emergency admission to a paediatric intensive care unit in England and Wales.
Who may be able to join
- Children and young people (age <16 years) transported by a PIC retrieval team for emergency admission to a paediatric intensive care unit in England and Wales.
Who cannot join
- None
Trial locations and contacts
1 site in 1 country.
United Kingdom1 site
Great Ormond Street Hospital for Children NHS Foundation Trust
London
About this study
Official title: Critically Ill Children and Young People: do National Differences in
There are fewer than 30 paediatric intensive care units (PICUs) in the United Kingdom (UK). This means that a critically ill child taken to their nearest hospital will need to be transferred to a PICU. Such transports are usually done by PICU retrieval teams (PICRTs), mobile teams who take specialist expertise to the child and safely transport them to a PICU.
There are national variations in how PICRTs are organised and deliver clinical care. There has been little research into these differences and how they might influence outcomes and experiences for sick children and families. The investigators do not know if national variation in how PICRT services are organised and delivered matters, or whether current standards help achieve the best outcomes for patients. This clinical study aims to understand how existing differences in access to paediatric intensive care and care provided by PICRTs affect clinical outcomes and experiences for transported critically ill children and families. The investigators will analyse routine national audit data to examine various aspects such as how long it takes a PICRT to reach the patient, how long it takes the child to reach the PICU, the seniority of clinicians performing the transport, medical procedures performed by the PICRT and any critical incidents during transport, and investigate whether any of these factors influence how likely a child is to survive. The investigators will also collect and analyse information about the experiences of sick children by interviewing the families involved, and staff experiences of PICU retrieval by interviewing clinicians. Alongside this work, the investigators will look at the costs of different ways of delivering PICRT services for sick children, and use mathematical techniques to study if and how alternate models of service delivery can improve clinical outcomes in a cost effective manner. The research team in this trial includes PICU and transport clinicians, parents, academic experts and an National Health Service (NHS) commissioner.
Independent committees consisting of clinicians and parents will be formed to oversee the study. The work from this study will directly inform the development of evidence-based national standards for PICU transport and help improve the patient experience for critically ill children and their families.
- Keywords
- Paediatric, Critical care, Transport
What is being measured
The primary outcome is the main question the study is designed to answer.
Mortality
Number
Measured: 30 days
Secondary outcomes (11)
Mortality
Number
Measured: up to 90 days
Mortality
Number
Measured: 90 days
Mortality
Number
Measured: One year
Length of stay
Number (days)
Measured: up to 90 days
Days on invasive ventilation
Number (days)
Measured: up to 90 days
Vasoactive agent therapy
Number (days)
Measured: up to 90 days
Renal replacement therapy
Number (days)
Measured: up to 90 days
Extra-corporeal life support
Number (days)
Measured: up to 90 days
Length of hospital stay
Number (days)
Measured: up to 90 days
Number of hospital admissions
Number
Measured: One year
Days in hospital
Number (days)
Measured: One year
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted9 May 2018
- Study start1 Jan 2019
- Primary completion31 Dec 2021
- Study completion31 Dec 2021
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (7)Papers the sponsor has linked to this study.
- Other trials for Access and Transport to Paediatric Intensive CareStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Prospective
- Enrolment
- 2,838 participants (actual)
Sponsor and investigators
- Lead sponsor
- Great Ormond Street Hospital for Children NHS Foundation Trust
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT03520192
- Sponsor's protocol ID
- 15HC47
- Acronym
- DEPICT
- Status last verified
- Oct 2022
- First submitted
- 9 Nov 2017
- Last updated
- 4 Oct 2022
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Publications
Ramnarayan P, Evans R, Draper ES, Seaton SE, Wray J, Morris S, Pagel C; DEPICT Study Investigators. Differences in access to Emergency Paediatric Intensive Care and care during Transport (DEPICT): study protocol for a mixed methods study. BMJ Open. 2019 Jul 16;9(7):e028000. doi: 10.1136/bmjopen-2018-028000.
PubMed 31315865Seaton SE, Ramnarayan P, Pagel C, Davies P, Draper ES; DEPICT Study Team. Impact on 30-day survival of time taken by a critical care transport team to reach the bedside of critically ill children. Intensive Care Med. 2020 Oct;46(10):1953-1955. doi: 10.1007/s00134-020-06149-5. Epub 2020 Jun 22. No abstract available.
PubMed 32572530Seaton SE, Ramnarayan P, Davies P, Hudson E, Morris S, Pagel C, Rajah F, Wray J, Draper ES; DEPICT Study Team. Does time taken by paediatric critical care transport teams to reach the bedside of critically ill children affect survival? A retrospective cohort study from England and Wales. BMC Pediatr. 2020 Jun 19;20(1):301. doi: 10.1186/s12887-020-02195-6.
PubMed 32560633Seaton SE, Draper ES, Pagel C, Rajah F, Wray J, Ramnarayan P; DEPICT Study Team. The effect of care provided by paediatric critical care transport teams on mortality of children transported to paediatric intensive care units in England and Wales: a retrospective cohort study. BMC Pediatr. 2021 May 3;21(1):217. doi: 10.1186/s12887-021-02689-x.
PubMed 33941116Evans REC, Barber V, Seaton S, Ramnarayan P, Davies P, Wray J; DEPICT Study Group. Is Parental Presence in the Ambulance Associated With Parental Satisfaction During Emergency Pediatric Intensive Care Retrieval? A Cross-Sectional Questionnaire Study. Pediatr Crit Care Med. 2022 Sep 1;23(9):708-716. doi: 10.1097/PCC.0000000000002995. Epub 2022 May 27.
PubMed 35969657Evans REC, Barber V, Seaton S, Draper ES, Rajah F, Pagel C, Polke E, Ramnarayan P, Wray J; DEPICT Study Investigators. Development of a parent experience measure for paediatric critical care transport teams. Nurs Crit Care. 2022 May;27(3):367-374. doi: 10.1111/nicc.12648. Epub 2021 May 24.
PubMed 34028143Alexander EC, Mallick A, Seaton SE, Evans R, Barber V, Wray J, Ramnarayan P; Differences in Access to Emergency pediatric Intensive Care and care during Transport (DEPICT) study group. Child and Parent Outcomes in the 2018-2019 DEPICT (Differences in Access to Emergency Pediatric Intensive Care and Care During Transport) Study: 12-Month Follow-Up Data. Pediatr Crit Care Med. 2026 Feb 1;27(2):166-175. doi: 10.1097/PCC.0000000000003877. Epub 2025 Dec 19.
PubMed 41416858
Study at a glance
From the registry record, last updated by the sponsor on 4 Oct 2022. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Critically Ill Children and Young People: do National Differences in
- ClinicalTrials.gov ID
- NCT03520192
- Acronym / sponsor ID
- DEPICT / 15HC47
- Keywords
- Paediatric, Critical care, Transport
- Study type
- Observational
- Recruitment status
- Completed
- Enrolment
- 2,838 participants (actual)
- Lead sponsor
- Great Ormond Street Hospital for Children NHS Foundation TrustUniversity, hospital or other
- Study start
- 1 Jan 2019 (actual)
- Primary completion
- 31 Dec 2021 (actual)
- Study completion
- 31 Dec 2021 (actual)
- First posted
- 9 May 2018 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
There are fewer than 30 paediatric intensive care units (PICUs) in the United Kingdom (UK). This means that a critically ill child taken to their nearest hospital will need to be transferred to a PICU. Such transports are usually done by PICU retrieval teams (PICRTs), mobile teams who take specialist expertise to the child and safely transport them to a PICU.
There are national variations in how PICRTs are organised and deliver clinical care. There has been little research into these differences and how they might influence outcomes and experiences for sick children and families. The investigators do not know if national variation in how PICRT services are organised and delivered matters, or whether current standards help achieve the best outcomes for patients. This clinical study aims to understand how existing differences in access to paediatric intensive care and care provided by PICRTs affect clinical outcomes and experiences for transported critically ill children and families. The investigators will analyse routine national audit data to examine various aspects such as how long it takes a PICRT to reach the patient, how long it takes the child to reach the PICU, the seniority of clinicians performing the transport, medical procedures performed by the PICRT and any critical incidents during transport, and investigate whether any of these factors influence how likely a child is to survive. The investigators will also collect and analyse information about the experiences of sick children by interviewing the families involved, and staff experiences of PICU retrieval by interviewing clinicians. Alongside this work, the investigators will look at the costs of different ways of delivering PICRT services for sick children, and use mathematical techniques to study if and how alternate models of service delivery can improve clinical outcomes in a cost effective manner. The research team in this trial includes PICU and transport clinicians, parents, academic experts and an National Health Service (NHS) commissioner.
Independent committees consisting of clinicians and parents will be formed to oversee the study. The work from this study will directly inform the development of evidence-based national standards for PICU transport and help improve the patient experience for critically ill children and their families.
Study design
- Observational model
- Cohort
- Time perspective
- Prospective
Who may qualify
- Ages
- Up to 16 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Child
- Study population
- Children and young people (age <16 years) transported by a PIC retrieval team for emergency admission to a paediatric intensive care unit in England and Wales.
Key inclusion criteria (1 listed)
- Children and young people (age <16 years) transported by a PIC retrieval team for emergency admission to a paediatric intensive care unit in England and Wales.
Key exclusion criteria (1 listed)
- None
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Primary outcome
Mortality
Time frame: 30 days
Number
11 secondary outcomes
Mortality
Time frame: up to 90 days
Mortality
Time frame: 90 days
Mortality
Time frame: One year
Length of stay
Time frame: up to 90 days
Days on invasive ventilation
Time frame: up to 90 days
Vasoactive agent therapy
Time frame: up to 90 days
Renal replacement therapy
Time frame: up to 90 days
Extra-corporeal life support
Time frame: up to 90 days
Length of hospital stay
Time frame: up to 90 days
Number of hospital admissions
Time frame: One year
Days in hospital
Time frame: One year
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 4 Oct 2022.
- Background: PubMed 31315865Ramnarayan P, Evans R, Draper ES, Seaton SE, Wray J, Morris S, Pagel C; DEPICT Study Investigators. Differences in access to Emergency Paediatric Intensive Care and care during Transport (DEPICT): study protocol for a mixed methods study. BMJ Open. 2019 Jul 16;9(7):e028000. doi: 10.1136/bmjopen-2018-028000.
- Results publication: PubMed 32572530Seaton SE, Ramnarayan P, Pagel C, Davies P, Draper ES; DEPICT Study Team. Impact on 30-day survival of time taken by a critical care transport team to reach the bedside of critically ill children. Intensive Care Med. 2020 Oct;46(10):1953-1955. doi: 10.1007/s00134-020-06149-5. Epub 2020 Jun 22. No abstract available.
- Results publication: PubMed 32560633Seaton SE, Ramnarayan P, Davies P, Hudson E, Morris S, Pagel C, Rajah F, Wray J, Draper ES; DEPICT Study Team. Does time taken by paediatric critical care transport teams to reach the bedside of critically ill children affect survival? A retrospective cohort study from England and Wales. BMC Pediatr. 2020 Jun 19;20(1):301. doi: 10.1186/s12887-020-02195-6.
- Results publication: PubMed 33941116Seaton SE, Draper ES, Pagel C, Rajah F, Wray J, Ramnarayan P; DEPICT Study Team. The effect of care provided by paediatric critical care transport teams on mortality of children transported to paediatric intensive care units in England and Wales: a retrospective cohort study. BMC Pediatr. 2021 May 3;21(1):217. doi: 10.1186/s12887-021-02689-x.
- Results publication: PubMed 35969657Evans REC, Barber V, Seaton S, Ramnarayan P, Davies P, Wray J; DEPICT Study Group. Is Parental Presence in the Ambulance Associated With Parental Satisfaction During Emergency Pediatric Intensive Care Retrieval? A Cross-Sectional Questionnaire Study. Pediatr Crit Care Med. 2022 Sep 1;23(9):708-716. doi: 10.1097/PCC.0000000000002995. Epub 2022 May 27.
- Results publication: PubMed 34028143Evans REC, Barber V, Seaton S, Draper ES, Rajah F, Pagel C, Polke E, Ramnarayan P, Wray J; DEPICT Study Investigators. Development of a parent experience measure for paediatric critical care transport teams. Nurs Crit Care. 2022 May;27(3):367-374. doi: 10.1111/nicc.12648. Epub 2021 May 24.
- Derived from this study: PubMed 41416858Alexander EC, Mallick A, Seaton SE, Evans R, Barber V, Wray J, Ramnarayan P; Differences in Access to Emergency pediatric Intensive Care and care during Transport (DEPICT) study group. Child and Parent Outcomes in the 2018-2019 DEPICT (Differences in Access to Emergency Pediatric Intensive Care and Care During Transport) Study: 12-Month Follow-Up Data. Pediatr Crit Care Med. 2026 Feb 1;27(2):166-175. doi: 10.1097/PCC.0000000000003877. Epub 2025 Dec 19.
- Individual participant dataSharing planned: No
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Access and Transport to Paediatric Intensive Care, run by Great Ormond Street Hospital for Children NHS Foundation Trust at 1 site in United Kingdom.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 1 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 4 Oct 2022. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United Kingdom. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Mortality (time frame: 30 days). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT03520192, which also lists 7 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 4 Oct 2022.