Lung CancerNCT03567538
National Register Studies in Thoracic Surgery
An observational study of Lung Cancer and Pulmonary Metastasis, run by Karolinska University Hospital at 1 site in Sweden.
Trial summary
The overall project aim is to study risk and outcomes following thoracic surgery by cross-linking high-quality national Swedish health-data registers for population-based investigations of individual level clinically relevant patient data. Read more about this study
- Who is it for?
- Ages 18 to 110 years
- Conditions the study is for
- Lung Cancer, Pulmonary Metastasis, Surgery
- What is being tested?
- Thoracic surgery
- Type of treatment
- Surgery or procedure
- How many people
- 20,000 participants
- Where
- 1 siteSweden
- Study dates
- 1 Jan 2018to 1 Jan 2029
- Phase
- Observational
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 110 years
- All sexes
- Adult, Older adult
Study population: All adult patients who underwent thoracic surgery in Sweden during the study period
Who may be able to join
- All adult patients who underwent thoracic surgery in Sweden during the study period
Who cannot join
- -
Trial locations and contacts
1 site in 1 country.
About this study
The overall project aim is to study risk and outcomes following thoracic surgery by cross-linking high-quality national Swedish health-data registers for population-based investigations of individual level clinically relevant patient data.
Read the detailed description
The purpose of this research project is to study risks and outcomes in patients who underwent thoracic surgery, primarily for lung cancer. We aim to establish a fundament for the conduct of nationwide population-based studies by linking patient-level data from the Swedish quality register for thoracic surgery (ThoR) and other national health-data registers maintained by the government agencies Statistics Sweden and the National Board of Health and Welfare. Cross-linking patient-level data is possible through the Personal Identity Number assigned to every individual who has resided in Sweden on a permanent basis. The Swedish Personal Identity Number is the unique identifier in all national registers.
Specifically, we aim:
- To analyze the association between socioeconomic factors and prognosis in patients undergoing pulmonary resection for lung cancer.
- To investigate the implementation of minimally invasive surgery for lung cancer in Sweden.
- Conditions
- Lung Cancer, Pulmonary Metastasis, Surgery
- Being tested
- Thoracic surgery
- Keywords
- Thoracic surgery, Lung surgery, Epidemiologic Methods
- Medical subject headings
- Lung Neoplasms
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Thoracic surgeryProcedure or surgery
Thoracic surgery, pulmonary resection, minimally invasive thoracic surgery, video assisted thoracic surgery (VATS)
What is being measured
The primary outcome is the main question the study is designed to answer.
All-cause mortality
Death from any cause
Measured: 15 years
Secondary outcomes (1)
Postoperative complications
Complications related to surgery
Measured: 30 days
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted25 Jun 2018
- Study start1 Jan 2018
- Primary completion1 Jan 2029 (estimated)
- Study completion1 Jan 2029 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (5)Papers the sponsor has linked to this study.
- Other trials for Lung CancerStudies of the same condition, open and under way.
- More trials run by Karolinska University HospitalThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Retrospective
- Enrolment
- 20,000 participants (actual)
Sponsor and investigators
- Lead sponsor
- Karolinska University Hospital
- Sponsor type
- University, hospital or other
- Collaborators
- Karolinska Institutet
- Responsible party
- Principal investigator, Ulrik Sartipy, MD, PhD, Karolinska University Hospital
- Investigators
- Ulrik Sartipy, MD, PhD, Principal investigator, Karolinska University Hospital/Karolinska Institutet
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT03567538
- Sponsor's protocol ID
- NatRegThx
- Status last verified
- Aug 2026
- First submitted
- 13 Jun 2018
- Last updated
- 5 Aug 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No: There is no plan to make individual participant data available to other researchers.
Publications
Jackson V, Al-Ameri M, Sartipy U. Weekday and Survival After Pulmonary Resections for Lung Cancer: A Swedish Nationwide Cohort Study. Chest. 2018 May;153(5):1284-1286. doi: 10.1016/j.chest.2018.03.022. No abstract available.
PubMed 29731047Al-Ameri M, Bergman P, Franco-Cereceda A, Sartipy U. Video-assisted thoracoscopic versus open thoracotomy lobectomy: a Swedish nationwide cohort study. J Thorac Dis. 2018 Jun;10(6):3499-3506. doi: 10.21037/jtd.2018.05.177.
PubMed 30069346Al-Ameri M, Persson M, Bergman P, Franco-Cereceda A, Sartipy U. Surgery for pulmonary metastases from colorectal cancer: survival and prognostic factors. J Thorac Dis. 2018 Jun;10(6):3372-3380. doi: 10.21037/jtd.2018.05.120.
PubMed 30069332Sachs E, Jackson V, Sartipy U. Household disposable income and long-term survival after pulmonary resections for lung cancer. Thorax. 2020 Sep;75(9):764-770. doi: 10.1136/thoraxjnl-2019-214321. Epub 2020 Jun 20.
PubMed 32564001Sachs E, Sartipy U, Jackson V. Sex and Survival After Surgery for Lung Cancer: A Swedish Nationwide Cohort. Chest. 2021 May;159(5):2029-2039. doi: 10.1016/j.chest.2020.11.010. Epub 2020 Nov 17.
PubMed 33217414
Study at a glance
From the registry record, last updated by the sponsor on 5 Aug 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- National Register Studies in Thoracic Surgery
- ClinicalTrials.gov ID
- NCT03567538
- Acronym / sponsor ID
- NatRegThx
- Conditions
- Lung Cancer, Pulmonary Metastasis, Surgery
- Keywords
- Thoracic surgery, Lung surgery, Epidemiologic Methods
- Study type
- Observational
- Recruitment status
- Active, not recruiting
- Enrolment
- 20,000 participants (actual)
- Lead sponsor
- Karolinska University HospitalUniversity, hospital or other
- Collaborators
- Karolinska Institutet
- Study start
- 1 Jan 2018 (actual)
- Primary completion
- 1 Jan 2029 (estimated)
- Study completion
- 1 Jan 2029 (estimated)
- First posted
- 25 Jun 2018 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The overall project aim is to study risk and outcomes following thoracic surgery by cross-linking high-quality national Swedish health-data registers for population-based investigations of individual level clinically relevant patient data.
Detailed description
The purpose of this research project is to study risks and outcomes in patients who underwent thoracic surgery, primarily for lung cancer. We aim to establish a fundament for the conduct of nationwide population-based studies by linking patient-level data from the Swedish quality register for thoracic surgery (ThoR) and other national health-data registers maintained by the government agencies Statistics Sweden and the National Board of Health and Welfare. Cross-linking patient-level data is possible through the Personal Identity Number assigned to every individual who has resided in Sweden on a permanent basis. The Swedish Personal Identity Number is the unique identifier in all national registers.
Specifically, we aim:
- To analyze the association between socioeconomic factors and prognosis in patients undergoing pulmonary resection for lung cancer.
- To investigate the implementation of minimally invasive surgery for lung cancer in Sweden.
Study design
- Observational model
- Cohort
- Time perspective
- Retrospective
Who may qualify
- Ages
- 18 to 110 years
- Sex
- All
- Age groups
- Adult, Older adult
- Study population
- All adult patients who underwent thoracic surgery in Sweden during the study period
Key inclusion criteria (1 listed)
- All adult patients who underwent thoracic surgery in Sweden during the study period
Key exclusion criteria (1 listed)
- -
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Thoracic surgeryThoracic surgery, pulmonary resection, minimally invasive thoracic surgery, video assisted thoracic surgery (VATS) | Procedure or surgery | – |
Primary outcome
All-cause mortality
Time frame: 15 years
Death from any cause
1 secondary outcome
Postoperative complications
Time frame: 30 days
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 5 Aug 2026.
- Background: PubMed 29731047Jackson V, Al-Ameri M, Sartipy U. Weekday and Survival After Pulmonary Resections for Lung Cancer: A Swedish Nationwide Cohort Study. Chest. 2018 May;153(5):1284-1286. doi: 10.1016/j.chest.2018.03.022. No abstract available.
- Background: PubMed 30069346Al-Ameri M, Bergman P, Franco-Cereceda A, Sartipy U. Video-assisted thoracoscopic versus open thoracotomy lobectomy: a Swedish nationwide cohort study. J Thorac Dis. 2018 Jun;10(6):3499-3506. doi: 10.21037/jtd.2018.05.177.
- Background: PubMed 30069332Al-Ameri M, Persson M, Bergman P, Franco-Cereceda A, Sartipy U. Surgery for pulmonary metastases from colorectal cancer: survival and prognostic factors. J Thorac Dis. 2018 Jun;10(6):3372-3380. doi: 10.21037/jtd.2018.05.120.
- Results publication: PubMed 32564001Sachs E, Jackson V, Sartipy U. Household disposable income and long-term survival after pulmonary resections for lung cancer. Thorax. 2020 Sep;75(9):764-770. doi: 10.1136/thoraxjnl-2019-214321. Epub 2020 Jun 20.
- Results publication: PubMed 33217414Sachs E, Sartipy U, Jackson V. Sex and Survival After Surgery for Lung Cancer: A Swedish Nationwide Cohort. Chest. 2021 May;159(5):2029-2039. doi: 10.1016/j.chest.2020.11.010. Epub 2020 Nov 17.
- Individual participant dataSharing planned: No. There is no plan to make individual participant data available to other researchers.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Ulrik Sartipy, MD, PhD principal investigator
Karolinska University Hospital/Karolinska Institutet
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Lung Cancer and Pulmonary Metastasis, run by Karolinska University Hospital at 1 site in Sweden.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 1 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: under way, not looking for participants, as of the sponsor's last update on 5 Aug 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Sweden. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
All-cause mortality (time frame: 15 years). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT03567538, which also lists 5 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 5 Aug 2026.