StrokeNCT03579992
Myoelectric Computer Interface to Reduce Muscle Co-activation After Stroke
A study testing 60-min isometric MyCI training, 90-min isometric MyCI training and 90-min movement MyCI training in people with Stroke, run by Northwestern University at 1 site in United States.
Trial summary
This study examines whether in-lab training with a myoelectric-computer interface (MyCI) can reduce abnormal muscle co-activation after stroke. Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Stroke
- What is being tested?
- 60-min isometric MyCI training, 90-min isometric MyCI training and 90-min movement MyCI training
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 35 participants
- Where
- 1 siteUnited States
- Study dates
- Jul 2014to Nov 2017
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Stroke survivors at least 6 months after stroke onset
- Persistent moderate to severe arm impairment
- Increased arm tone
Who cannot join
- Substantial impairment of vision, memory, language or concentration
- Botulinum toxin use in the affected arm
- Concomitant participation in another research study on the arm
Trial locations and contacts
1 site in 1 country.
About this study
This study examines whether in-lab training with a myoelectric-computer interface (MyCI) can reduce abnormal muscle co-activation after stroke.
- Conditions
- Stroke
- Being tested
- 60-min isometric MyCI training, 90-min isometric MyCI training, 90-min movement MyCI training
- Medical subject headings
- Stroke
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
60-min isometric MyCI trainingBehavioural
EMG-controlled in-lab training with arm restrained for 60 minutes per session
90-min isometric MyCI trainingBehavioural
EMG-controlled in-lab training with arm restrained for 90 minutes per session
90-min movement MyCI trainingBehavioural
EMG-controlled in-lab training without restraint for 90 minutes per session
| Study group | Role | What they receive |
|---|---|---|
| 60-minute Isometric | Experimental | 60-min Isometric MyCI training: EMG-controlled game training for 60-minutes per session Receives: Behavioral: 60-min isometric MyCI training |
| 90-minute Isometric | Experimental | 90-min Isometric MyCI training: EMG-controlled game training for 90-minutes per session Receives: Behavioral: 90-min isometric MyCI training |
| 90-minute Movement | Experimental | 90-min movement MyCI training: EMG-controlled game training for 90-minutes per session Receives: Behavioral: 90-min movement MyCI training |
What is being measured
The primary outcome is the main question the study is designed to answer.
Fugl-Meyer Assessment - Upper Extremity
Scale 0-66, total score
Measured: 6 weeks
Secondary outcomes (3)
Fugl-Meyer Assessment - Upper Extremity
Scale 0-66, total score
Measured: 10 weeks
Wolf Motor Function Test
Timed test
Measured: 6 and 10 weeks
Motor Activity Log
30-question test, total score
Measured: 6 and 10 weeks
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted9 Jul 2018
- Study startJul 2014
- Primary completionNov 2017
- Study completionNov 2017
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (2)Papers the sponsor has linked to this study.
- Other trials for StrokeStudies of the same condition, open and under way.
- More trials run by Northwestern UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind
- Who is masked
- Outcomes assessor
- Enrolment
- 35 participants (actual)
Sponsor and investigators
- Lead sponsor
- Northwestern University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Marc Slutzky, Northwestern University
- Investigators
- Marc Slutzky, MD, PhD, Principal investigator, Northwestern University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT03579992
- Sponsor's protocol ID
- STU00042554
- Status last verified
- Apr 2026
- First submitted
- 28 Jun 2018
- Last updated
- 13 Apr 2026
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Publications
Mugler EM, Tomic G, Singh A, Hameed S, Lindberg EW, Gaide J, Alqadi M, Robinson E, Dalzotto K, Limoli C, Jacobson T, Lee J, Slutzky MW. Myoelectric Computer Interface Training for Reducing Co-Activation and Enhancing Arm Movement in Chronic Stroke Survivors: A Randomized Trial. Neurorehabil Neural Repair. 2019 Apr;33(4):284-295. doi: 10.1177/1545968319834903. Epub 2019 Mar 19.
PubMed 30888251Seo G, Kishta A, Mugler E, Slutzky MW, Roh J. Myoelectric interface training enables targeted reduction in abnormal muscle co-activation. J Neuroeng Rehabil. 2022 Jul 1;19(1):67. doi: 10.1186/s12984-022-01045-z.
PubMed 35778757
Study at a glance
From the registry record, last updated by the sponsor on 13 Apr 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Myoelectric Computer Interface to Reduce Muscle Co-activation After Stroke
- ClinicalTrials.gov ID
- NCT03579992
- Acronym / sponsor ID
- STU00042554
- Conditions
- Stroke
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 35 participants (actual)
- Lead sponsor
- Northwestern UniversityUniversity, hospital or other
- Study start
- Jul 2014 (actual)
- Primary completion
- Nov 2017 (actual)
- Study completion
- Nov 2017 (actual)
- First posted
- 9 Jul 2018 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study examines whether in-lab training with a myoelectric-computer interface (MyCI) can reduce abnormal muscle co-activation after stroke.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (outcomes assessor)
- Number of arms
- 3
| Arm | Type | Receives |
|---|---|---|
| 60-minute Isometric | Experimental | Behavioral: 60-min isometric MyCI training60-min Isometric MyCI training: EMG-controlled game training for 60-minutes per session |
| 90-minute Isometric | Experimental | Behavioral: 90-min isometric MyCI training90-min Isometric MyCI training: EMG-controlled game training for 90-minutes per session |
| 90-minute Movement | Experimental | Behavioral: 90-min movement MyCI training90-min movement MyCI training: EMG-controlled game training for 90-minutes per session |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (3 listed)
- Stroke survivors at least 6 months after stroke onset
- Persistent moderate to severe arm impairment
- Increased arm tone
Key exclusion criteria (3 listed)
- Substantial impairment of vision, memory, language or concentration
- Botulinum toxin use in the affected arm
- Concomitant participation in another research study on the arm
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| 60-min isometric MyCI trainingEMG-controlled in-lab training with arm restrained for 60 minutes per session | Behavioural | 60-minute Isometric |
| 90-min isometric MyCI trainingEMG-controlled in-lab training with arm restrained for 90 minutes per session | Behavioural | 90-minute Isometric |
| 90-min movement MyCI trainingEMG-controlled in-lab training without restraint for 90 minutes per session | Behavioural | 90-minute Movement |
Primary outcome
Fugl-Meyer Assessment - Upper Extremity
Time frame: 6 weeks
Scale 0-66, total score
3 secondary outcomes
Fugl-Meyer Assessment - Upper Extremity
Time frame: 10 weeks
Wolf Motor Function Test
Time frame: 6 and 10 weeks
Motor Activity Log
Time frame: 6 and 10 weeks
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 13 Apr 2026.
- Results publication: PubMed 30888251Mugler EM, Tomic G, Singh A, Hameed S, Lindberg EW, Gaide J, Alqadi M, Robinson E, Dalzotto K, Limoli C, Jacobson T, Lee J, Slutzky MW. Myoelectric Computer Interface Training for Reducing Co-Activation and Enhancing Arm Movement in Chronic Stroke Survivors: A Randomized Trial. Neurorehabil Neural Repair. 2019 Apr;33(4):284-295. doi: 10.1177/1545968319834903. Epub 2019 Mar 19.
- Derived from this study: PubMed 35778757Seo G, Kishta A, Mugler E, Slutzky MW, Roh J. Myoelectric interface training enables targeted reduction in abnormal muscle co-activation. J Neuroeng Rehabil. 2022 Jul 1;19(1):67. doi: 10.1186/s12984-022-01045-z.
Related trials for Stroke
Not yet recruiting
Foot Drop Rehabilitation and Mobility in Chronic Stroke
Stroke
Enrolling by invitation
Study on the Efficacy and Safety of Non-Invasive Brain-Computer Interface With MRI-Guided Multi-Channel Time-Domain Interference Stimulation in Treating Motor Dysfunction in Acute Cerebral Infarction Patients
Acute Ichemic Stroke
RecruitingObservational study
Development, Validation and Normative Data of the Italian Battery for the Recognition of Famous Faces (FAME)
Stroke, Alzheimer s Disease
Enrolling by invitation
Long-Term Clinical, Health Economic, and Process Evaluation of Intensive Technology-Integrated Motor Rehabilitation in Chronic Neurological Conditions (INTeRAcT-bis)
Stroke, Spinal Cord Injuries (SCI)
Not yet recruitingPhase 2
Rimonabant for Improving Walking Ability in Patients With Chronic Stroke
Chronic Stroke
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Marc Slutzky, MD, PhD principal investigator
Northwestern University
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing 60-min isometric MyCI training, 90-min isometric MyCI training and 90-min movement MyCI training in people with Stroke, run by Northwestern University at 1 site in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 3 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 13 Apr 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Fugl-Meyer Assessment - Upper Extremity (time frame: 6 weeks). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT03579992, which also lists 2 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 13 Apr 2026.