Parkinson DiseaseNCT03582670
Prospective Memory Training in Parkinson Disease
A study testing Strategy Training and Process Training in people with Parkinson Disease, run by Washington University School of Medicine at 1 site in United States.
Trial summary
The long term goal of this work is to reduce disability among people with Parkinson disease (PD) by enabling them to cope with cognitive decline so they can perform and participate in desired activities and roles. Read more about this study
- Who is it for?
- Ages 50 years and older
- Conditions the study is for
- Parkinson Disease
- What is being tested?
- Strategy Training and Process Training
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 15 participants
- Where
- 1 siteUnited States
- Study dates
- 1 Oct 2017to 1 Jul 2020
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 50 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Males and females over age 50
- Meet criteria for typical idiopathic PD
- Hoehn \& Yahr stage I-III
- Treated with levodopa/carbidopa
- Have PD with Mild Cognitive Impairment (PD-MCI) according to Movement Disorders Society (MDS) Level II diagnostic criteria.
- Medications should be stable for 4 weeks prior with no changes planned during the study (we will document any unplanned changes).
Who cannot join
- Dementia according to MDS criteria or MoCA score <21
- Other neurological disorders,
- Brain surgery
- History of psychotic disorder
- Change in medication during the study
- Treatment with medications that interfere with cognition (e.g. anticholinergics)
- Any condition that would interfere with participation (e.g., non-English speaking, significant current depression).
Trial locations and contacts
1 site in 1 country.
United States1 site
Washington University School of Medicine
St Louis, Missouri, 63110
About this study
The long term goal of this work is to reduce disability among people with Parkinson disease (PD) by enabling them to cope with cognitive decline so they can perform and participate in desired activities and roles. This project focuses on prospective memory, or the ability to remember to execute delayed intentions at the appropriate moment in the future. The current study tests the effects of two primary cognitive intervention approaches (process training \& strategy training) on prospective memory performance in PD. The investigators will conduct a single-blind randomized controlled trial in which individuals with mild cognitive impairment in PD (PD-MCI; N = 90) will complete pre-training assessment, randomization to training group (control, process training, strategy training), four training sessions (process and strategy training groups), and post-training assessment.
Read the detailed description
RANDOMIZATION
Once a participant is enrolled in the study and completes the Pre-testing session (described in detail below), they will be randomized into one of the following study groups:
- Process Training Group - the trainer teaches the participant about event- and time-based prospective memory tasks, respectively. The trainer simply tells the participant that s/he will be practicing both types of tasks in training games.
- Strategy Training Group - In training sessions 1 and 2, in addition to teaching about event- and time-based tasks, the trainer teaches the participant specific strategies for each type of task (implementation intentions for event-based and strategic clock-checking for time-based; and instructs in their use before and during the training games.
- Contro1 Group - Receives no training sessions. Only Completes the PRE, POST and 1-month \& 3-month Follow Up portions of the study.
STUDY VISITS
- On the day of their testing appointment, participants will arrive at their designated location at the WUSM Movement Disorders Clinic for their testing session. All participants will provide written informed consent before their first testing session begins, and the examiner will answer any questions before beginning testing. Scheduled participants will be mailed or emailed (depending on their preference) study information and a copy of the consent form. Participants will receive reminder calls 1-2 days before their appointments.
- Demographics will be collected on all participants. This includes age, gender, years of education, living status, race, and ethnicity after consent is obtained. This can be completed online via Redcap or on paper at the testing session.
- Investigators will collect PD clinical characteristics from the Movement Disorders Clinical Record. Clinical Characteristics includes: Hoehhn \& Yahr Stage, year of first PD symptoms, year of initial PD diagnosis, MoCA score at most recent clinic visit, Side of symptom onset, type of symptom onset (tremor vs. bradykinesia), PD medications, and most recent Unified Parkinson Disease Rating Scale Motor Score.
Participant Questionnaires:
Participants will complete the PRMQ, CAPM, IPA and BDI questionnaires.
- Prospective and Retrospective Memory Questionnaire (PRMQ; attached) - Used to rate the participant's everyday retrospective and prospective memory.
- Comprehensive Assessment of Prospective Memory (CAPM; attached) - Used to rate the participant's everyday prospective memory
- Impact of Participation and Autonomy (IPA; attached)- A questionnaire about the participant's ability to take part in daily activities.
- Beck Depression Inventory (BDI, attached) - Used to characterize current depression, which is common in PD.
Informant Report Questionnaires:
Participant's will identify an informant (spouse, relative, or close friend) to fill out the PRMQ Proxy Report, a Self-Reported CAPM, and a CAPM - Proxy Report.
Demographics will be collected on all informants. This includes age, gender, years of education, living status, race, and ethnicity.
Participant and Informant questionnaires can be filled out prior to the study session via Redcap. Most participants request this method because it saves them time on the day of the study session. The online questionnaires have a consent form to look over before filling them out (see attached online consent), and the participant agrees to the consent by clicking "Next" in the online form, and completing the questionnaires; if participants elect to complete the questionnaires on paper, they can complete them at their testing session. The research team will will first go over the written consent with them at the session before the participant fills out the written questionnaires. Experimenters will check the questionnaires for completion. This procedure will also be followed if the participant elects to fill out the online questionnaire in Redcap.
Testing sessions:
Participants will perform testing while on their regular PD medications.
Pre-training Assessment: (1.5 hours) - MoCA and Virtual Week.
- The Montreal Cognitive Assessment (MoCA; attached) will be administered to assess global cognition at the time of the study visit.
- The Virtual Week test (attached) will be administered to the participant. It is a computerized board game that simulates daily life and real-world prospective memory challenges. Each circuit represents one day in which the participant completes time-appropriate activities and makes choices about them (i.e. the ongoing activity). Each day has 8 prospective memory tasks (4 event based, 4 time based). Participants complete a practice day and then three test days, with equivalent versions counterbalanced across Pre and Post testing. The main outcome variable is the proportion of correct prospective memory responses for each task type (12 event based, 12 time based).
Strategy Training Sessions (GROUPS 1-Process Training AND 2-Strategy Training ONLY): These are 4 sessions that occur over the next 2 weeks after the Pre-training Assessment. (1 HOUR EACH) GROUP 1, Process training: In sessions 1 and 2, the trainer teaches the participant about event- and time-based prospective memory tasks, respectively. In sessions 3 and 4, the trainer simply tells the participant that s/he will be practicing both types of tasks in the training games. In all sessions, the participant completes the training games with no strategy instruction from the trainer. Feedback on accuracy is provided after each training game. This is typical of a process training approach and expects that either practice of the training tasks will improve prospective memory ability per se or participants will develop effective strategies for completing prospective memory tasks on their own. At the end of each session after completing both training games, the trainer reminds the participant of his/her real-life prospective memory goals, provides a handout that lists the goals, and instructs the participant to try to complete them as intended. It should be noted that the inclusion of even this minimal level of discussion of real-life cognitive tasks is not typical of process training interventions.
GROUP 2, Strategy Training: In training sessions 1 and 2, in addition to teaching about event- and time-based tasks, the trainer teaches the participant specific strategies for each type of task (implementation intentions for event-based and strategic clock-checking for time-based) and instructs in their use before and during the training games. In sessions 3 and 4, the trainer tells the participant s/he will be practicing both types of tasks in the training games and can support the participant's strategy use if needed. Feedback on accuracy and strategy use are provided after each training game. At the end of each session after completing the training games, the trainer and participant discuss how the strategies can be applied to the participant's real-life prospective memory goals, and the trainer helps the participant develop written action plans to do so. Plans are reviewed (and modified if necessary) at each session.
- The Bangor Goal-Setting Interview (BGSI) - The BGSI is a structured assessment developed for use in cognitive rehabilitation research. It offers a standardized means of eliciting individual goals and rating goal attainment over time and has been successfully used in RCTs with older adults, including those with mild to moderate dementia. During the first two training sessions, after an explanation of the prospective memory task types (session 1: event, session 2: time), participants complete the BGSI with the trainer to identify and set goals for their real-life prospective memory tasks. Participants identify up to 6 prospective memory tasks they anticipate having to complete over the next 2 weeks (before Post assessment), define goals for completing each task, and describe what needs to happen for the goal to be considered partially (25%, 50%, and/or 75%) and fully achieved.
- Credibility/ Expectancy Questionnaire (CEQ; attached) - this will be completed by the participant after the second training session to rate how credible they think the strategy instruction training is, and how well they think it will work on 1) their performance on the computer task, and 2) their performance in everyday life.
Post-training Assessment (1.5 hours) - (For Groups 1 (Process) and 2 (Strategy) = One week after the last training session; For Group 3 (Control) = 3-4 weeks after the Pre-Training Assessment): Virtual Week and NIH Toolbox Cognitive Battery
- The Virtual Week Task will be administered again, but with new tasks to remember.
- The NIH Toolbox Cognitive Battery (instructions attached) will be administered to obtain an overall measure of executive function. This battery includes a Picture Vocabulary Test, Picture Sequence Memory Test, Flanker Inhibitory Control and Attention Test, Dimensional Change Card Sort Test, List Sorting Working Memory Test, Pattern Comparison, and Oral Reading Test.
- GROUPS 1 (Process) and 2 (STRATEGY) ONLY: Based on their BGSI interview during the training sessions, participants report on their performance of each task and, in collaboration with the trainer, rate each task for attainment on a 10-point scale using the previously determined descriptors as reference (higher scores indicate better goal attainment). Task attainment scores are averaged to yield a mean attainment score.
One-month Follow-up Assessment (40 minutes) (One month after the Post Training Assessment):
The PRMQ, IPA and CAPM Questionnaires will be given to participants for a second time as follow-up online in Redcap or by mail (depending on the participant's preference).
The study informant will fill out proxy-reported PRMQ and CAPM for a second time as a follow-up online in Redcap or by mail (depending on the informant's preference).
Three-month Follow-up Assessment (40 minutes) (Three months after the Post Assessment):
The PRMQ, CAPM, and IPA Questionnaire will be given to participants for a third time as follow-up online in Redcap or by mail (depending on the participant's preference).
The study informant will fill out proxy-reported PRMQ and CAPM for a third time as a follow-up online in Redcap or by mail (depending on the informant's preference).
- Conditions
- Parkinson Disease
- Being tested
- Strategy Training, Process Training, Control Group
- Keywords
- Prospective Memory, Occupational Therapy
- Medical subject headings
- Parkinson Disease
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Strategy TrainingBehavioural
Participants will attend four strategy training sessions total. In sessions 1 and 2, in addition to teaching about event- and time-based tasks, the trainer teaches the participant specific strategies for each type of task (implementation intentions for event-based and strategic clock-checking for time-based). In sessions 3 and 4, the trainer tells the participant s/he will be practicing both types of tasks in the training games and can support the participant's strategy use if needed. Feedback on accuracy and strategy use are provided after each training game. At the end of each session after completing the training games, the trainer and participant discuss how the strategies can be applied to the participant's real-life prospective memory goals, and the trainer helps the participant develop written action plans to do so. Plans are reviewed (and modified if necessary) at each session.
Process TrainingBehavioural
Participants will attend four process training sessions in this group. In sessions 1 and 2, the trainer teaches the participant about event- and time-based prospective memory tasks, respectively. In sessions 3 and 4, the trainer simply tells the participant that s/he will be practicing both types of tasks in the training games. In all sessions, the participant completes the training games with no strategy instruction from the trainer. Feedback on accuracy is provided after each training game. At the end of each session after completing both training games, the trainer reminds the participant of his/her real-life prospective memory goals, provides a handout that lists the goals, and instructs the participant to try to complete them as intended. Of note, even this minimal level of discussion of real-life cognitive tasks is not typical of process training interventions, but we include it to control for that which is occurring in the strategy training group.
Control GroupBehavioural
Participants in this group do not attend any sessions during the time the other groups are participating in the Strategy or Process Training
| Study group | Role | What they receive |
|---|---|---|
| Strategy Training Intervention | Experimental | Study participants receive specific memory strategy training with training games, as well as feedback on accuracy and performance. Receives: Behavioral: Strategy Training |
| Process Training | Active comparator | Study participants attend training sessions and complete training games, but receive no specific strategy training Receives: Behavioral: Process Training |
| Control Group | Other | Study participants do not attend any strategy training sessions. Receives: Behavioral: Control Group |
What is being measured
The primary outcome is the main question the study is designed to answer.
Virtual Week
A computerized board game that simulates daily life and real-world prospective memory challenges. Each circuit represents one day in which the participant completes time-appropriate activities and makes choices about them (i.e. the ongoing activity). Each day has 8 prospective memory tasks (4 event based, 4 time based). Participants complete a practice day and then three test days, with equivalent versions counterbalanced across Pre and Post testing. The main outcome variable is the proportion of correct prospective memory responses for each task type (12 event based, 12 time based). Change of performance on the Virtual Week from the Pre- and Post-session will be measured.
Measured: 4 to 6 weeks
Prospective and Retrospective Memory Questionnaire
Used to rate the participant's everyday retrospective and prospective memory. Change in scores on this questionnaire will be measured.
Measured: Through completion of the study, up to 16 weeks.
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted11 Jul 2018
- Study start1 Oct 2017
- Primary completion1 Jul 2020
- Study completion1 Jul 2020
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Parkinson DiseaseStudies of the same condition, open and under way.
- More trials run by Washington University School of MedicineThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Supportive care
- Allocation
- Randomised
- Intervention model
- Factorial
- Masking
- Single blind
- Who is masked
- Participant
- Enrolment
- 15 participants (actual)
Sponsor and investigators
- Lead sponsor
- Washington University School of Medicine
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT03582670
- Sponsor's protocol ID
- 201709182
- Status last verified
- Apr 2021
- First submitted
- 6 Jun 2018
- Last updated
- 6 Apr 2021
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 6 Apr 2021. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Prospective Memory Training in Parkinson Disease
- ClinicalTrials.gov ID
- NCT03582670
- Acronym / sponsor ID
- 201709182
- Conditions
- Parkinson Disease
- Keywords
- Prospective Memory, Occupational Therapy
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 15 participants (actual)
- Lead sponsor
- Washington University School of MedicineUniversity, hospital or other
- Study start
- 1 Oct 2017 (actual)
- Primary completion
- 1 Jul 2020 (actual)
- Study completion
- 1 Jul 2020 (actual)
- First posted
- 11 Jul 2018 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The long term goal of this work is to reduce disability among people with Parkinson disease (PD) by enabling them to cope with cognitive decline so they can perform and participate in desired activities and roles. This project focuses on prospective memory, or the ability to remember to execute delayed intentions at the appropriate moment in the future. The current study tests the effects of two primary cognitive intervention approaches (process training \& strategy training) on prospective memory performance in PD. The investigators will conduct a single-blind randomized controlled trial in which individuals with mild cognitive impairment in PD (PD-MCI; N = 90) will complete pre-training assessment, randomization to training group (control, process training, strategy training), four training sessions (process and strategy training groups), and post-training assessment.
Detailed description
RANDOMIZATION
Once a participant is enrolled in the study and completes the Pre-testing session (described in detail below), they will be randomized into one of the following study groups:
- Process Training Group - the trainer teaches the participant about event- and time-based prospective memory tasks, respectively. The trainer simply tells the participant that s/he will be practicing both types of tasks in training games.
- Strategy Training Group - In training sessions 1 and 2, in addition to teaching about event- and time-based tasks, the trainer teaches the participant specific strategies for each type of task (implementation intentions for event-based and strategic clock-checking for time-based; and instructs in their use before and during the training games.
- Contro1 Group - Receives no training sessions. Only Completes the PRE, POST and 1-month \& 3-month Follow Up portions of the study.
STUDY VISITS
- On the day of their testing appointment, participants will arrive at their designated location at the WUSM Movement Disorders Clinic for their testing session. All participants will provide written informed consent before their first testing session begins, and the examiner will answer any questions before beginning testing. Scheduled participants will be mailed or emailed (depending on their preference) study information and a copy of the consent form. Participants will receive reminder calls 1-2 days before their appointments.
- Demographics will be collected on all participants. This includes age, gender, years of education, living status, race, and ethnicity after consent is obtained. This can be completed online via Redcap or on paper at the testing session.
- Investigators will collect PD clinical characteristics from the Movement Disorders Clinical Record. Clinical Characteristics includes: Hoehhn \& Yahr Stage, year of first PD symptoms, year of initial PD diagnosis, MoCA score at most recent clinic visit, Side of symptom onset, type of symptom onset (tremor vs. bradykinesia), PD medications, and most recent Unified Parkinson Disease Rating Scale Motor Score.
Participant Questionnaires:
Participants will complete the PRMQ, CAPM, IPA and BDI questionnaires.
- Prospective and Retrospective Memory Questionnaire (PRMQ; attached) - Used to rate the participant's everyday retrospective and prospective memory.
- Comprehensive Assessment of Prospective Memory (CAPM; attached) - Used to rate the participant's everyday prospective memory
- Impact of Participation and Autonomy (IPA; attached)- A questionnaire about the participant's ability to take part in daily activities.
- Beck Depression Inventory (BDI, attached) - Used to characterize current depression, which is common in PD.
Informant Report Questionnaires:
Participant's will identify an informant (spouse, relative, or close friend) to fill out the PRMQ Proxy Report, a Self-Reported CAPM, and a CAPM - Proxy Report.
Demographics will be collected on all informants. This includes age, gender, years of education, living status, race, and ethnicity.
Participant and Informant questionnaires can be filled out prior to the study session via Redcap. Most participants request this method because it saves them time on the day of the study session. The online questionnaires have a consent form to look over before filling them out (see attached online consent), and the participant agrees to the consent by clicking "Next" in the online form, and completing the questionnaires; if participants elect to complete the questionnaires on paper, they can complete them at their testing session. The research team will will first go over the written consent with them at the session before the participant fills out the written questionnaires. Experimenters will check the questionnaires for completion. This procedure will also be followed if the participant elects to fill out the online questionnaire in Redcap.
Testing sessions:
Participants will perform testing while on their regular PD medications.
Pre-training Assessment: (1.5 hours) - MoCA and Virtual Week.
- The Montreal Cognitive Assessment (MoCA; attached) will be administered to assess global cognition at the time of the study visit.
- The Virtual Week test (attached) will be administered to the participant. It is a computerized board game that simulates daily life and real-world prospective memory challenges. Each circuit represents one day in which the participant completes time-appropriate activities and makes choices about them (i.e. the ongoing activity). Each day has 8 prospective memory tasks (4 event based, 4 time based). Participants complete a practice day and then three test days, with equivalent versions counterbalanced across Pre and Post testing. The main outcome variable is the proportion of correct prospective memory responses for each task type (12 event based, 12 time based).
Strategy Training Sessions (GROUPS 1-Process Training AND 2-Strategy Training ONLY): These are 4 sessions that occur over the next 2 weeks after the Pre-training Assessment. (1 HOUR EACH) GROUP 1, Process training: In sessions 1 and 2, the trainer teaches the participant about event- and time-based prospective memory tasks, respectively. In sessions 3 and 4, the trainer simply tells the participant that s/he will be practicing both types of tasks in the training games. In all sessions, the participant completes the training games with no strategy instruction from the trainer. Feedback on accuracy is provided after each training game. This is typical of a process training approach and expects that either practice of the training tasks will improve prospective memory ability per se or participants will develop effective strategies for completing prospective memory tasks on their own. At the end of each session after completing both training games, the trainer reminds the participant of his/her real-life prospective memory goals, provides a handout that lists the goals, and instructs the participant to try to complete them as intended. It should be noted that the inclusion of even this minimal level of discussion of real-life cognitive tasks is not typical of process training interventions.
GROUP 2, Strategy Training: In training sessions 1 and 2, in addition to teaching about event- and time-based tasks, the trainer teaches the participant specific strategies for each type of task (implementation intentions for event-based and strategic clock-checking for time-based) and instructs in their use before and during the training games. In sessions 3 and 4, the trainer tells the participant s/he will be practicing both types of tasks in the training games and can support the participant's strategy use if needed. Feedback on accuracy and strategy use are provided after each training game. At the end of each session after completing the training games, the trainer and participant discuss how the strategies can be applied to the participant's real-life prospective memory goals, and the trainer helps the participant develop written action plans to do so. Plans are reviewed (and modified if necessary) at each session.
- The Bangor Goal-Setting Interview (BGSI) - The BGSI is a structured assessment developed for use in cognitive rehabilitation research. It offers a standardized means of eliciting individual goals and rating goal attainment over time and has been successfully used in RCTs with older adults, including those with mild to moderate dementia. During the first two training sessions, after an explanation of the prospective memory task types (session 1: event, session 2: time), participants complete the BGSI with the trainer to identify and set goals for their real-life prospective memory tasks. Participants identify up to 6 prospective memory tasks they anticipate having to complete over the next 2 weeks (before Post assessment), define goals for completing each task, and describe what needs to happen for the goal to be considered partially (25%, 50%, and/or 75%) and fully achieved.
- Credibility/ Expectancy Questionnaire (CEQ; attached) - this will be completed by the participant after the second training session to rate how credible they think the strategy instruction training is, and how well they think it will work on 1) their performance on the computer task, and 2) their performance in everyday life.
Post-training Assessment (1.5 hours) - (For Groups 1 (Process) and 2 (Strategy) = One week after the last training session; For Group 3 (Control) = 3-4 weeks after the Pre-Training Assessment): Virtual Week and NIH Toolbox Cognitive Battery
- The Virtual Week Task will be administered again, but with new tasks to remember.
- The NIH Toolbox Cognitive Battery (instructions attached) will be administered to obtain an overall measure of executive function. This battery includes a Picture Vocabulary Test, Picture Sequence Memory Test, Flanker Inhibitory Control and Attention Test, Dimensional Change Card Sort Test, List Sorting Working Memory Test, Pattern Comparison, and Oral Reading Test.
- GROUPS 1 (Process) and 2 (STRATEGY) ONLY: Based on their BGSI interview during the training sessions, participants report on their performance of each task and, in collaboration with the trainer, rate each task for attainment on a 10-point scale using the previously determined descriptors as reference (higher scores indicate better goal attainment). Task attainment scores are averaged to yield a mean attainment score.
One-month Follow-up Assessment (40 minutes) (One month after the Post Training Assessment):
The PRMQ, IPA and CAPM Questionnaires will be given to participants for a second time as follow-up online in Redcap or by mail (depending on the participant's preference).
The study informant will fill out proxy-reported PRMQ and CAPM for a second time as a follow-up online in Redcap or by mail (depending on the informant's preference).
Three-month Follow-up Assessment (40 minutes) (Three months after the Post Assessment):
The PRMQ, CAPM, and IPA Questionnaire will be given to participants for a third time as follow-up online in Redcap or by mail (depending on the participant's preference).
The study informant will fill out proxy-reported PRMQ and CAPM for a third time as a follow-up online in Redcap or by mail (depending on the informant's preference).
Study design
- Primary purpose
- Supportive care
- Allocation
- Randomised
- Intervention model
- Factorial
- Masking
- Single blind (participant)
- Number of arms
- 3
| Arm | Type | Receives |
|---|---|---|
| Strategy Training Intervention | Experimental | Behavioral: Strategy TrainingStudy participants receive specific memory strategy training with training games, as well as feedback on accuracy and performance. |
| Process Training | Active comparator | Behavioral: Process TrainingStudy participants attend training sessions and complete training games, but receive no specific strategy training |
| Control Group | Other | Behavioral: Control GroupStudy participants do not attend any strategy training sessions. |
Who may qualify
- Ages
- 50 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (6 listed)
- Males and females over age 50
- Meet criteria for typical idiopathic PD
- Hoehn \& Yahr stage I-III
- Treated with levodopa/carbidopa
- Have PD with Mild Cognitive Impairment (PD-MCI) according to Movement Disorders Society (MDS) Level II diagnostic criteria.
Key exclusion criteria (7 listed)
- Dementia according to MDS criteria or MoCA score <21
- Other neurological disorders,
- Brain surgery
- History of psychotic disorder
- Change in medication during the study
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Strategy TrainingParticipants will attend four strategy training sessions total. In sessions 1 and 2, in addition to teaching about event- and time-based tasks, the trainer teaches the participant specific strategies for each type of task (implementation intentions for event-based and strategic clock-checking for time-based). In sessions 3 and 4, the trainer tells the participant s/he will be practicing both types of tasks in the training games and can support the participant's strategy use if needed. Feedback on accuracy and strategy use are provided after each training game. At the end of each session after completing the training games, the trainer and participant discuss how the strategies can be applied to the participant's real-life prospective memory goals, and the trainer helps the participant develop written action plans to do so. Plans are reviewed (and modified if necessary) at each session. | Behavioural | Strategy Training Intervention |
| Process TrainingParticipants will attend four process training sessions in this group. In sessions 1 and 2, the trainer teaches the participant about event- and time-based prospective memory tasks, respectively. In sessions 3 and 4, the trainer simply tells the participant that s/he will be practicing both types of tasks in the training games. In all sessions, the participant completes the training games with no strategy instruction from the trainer. Feedback on accuracy is provided after each training game. At the end of each session after completing both training games, the trainer reminds the participant of his/her real-life prospective memory goals, provides a handout that lists the goals, and instructs the participant to try to complete them as intended. Of note, even this minimal level of discussion of real-life cognitive tasks is not typical of process training interventions, but we include it to control for that which is occurring in the strategy training group. | Behavioural | Process Training |
| Control GroupParticipants in this group do not attend any sessions during the time the other groups are participating in the Strategy or Process Training | Behavioural | Control Group |
Primary outcome
Virtual Week
Time frame: 4 to 6 weeks
A computerized board game that simulates daily life and real-world prospective memory challenges. Each circuit represents one day in which the participant completes time-appropriate activities and makes choices about them (i.e. the ongoing activity). Each day has 8 prospective memory tasks (4 event based, 4 time based). Participants complete a practice day and then three test days, with equivalent versions counterbalanced across Pre and Post testing. The main outcome variable is the proportion of correct prospective memory responses for each task type (12 event based, 12 time based). Change of performance on the Virtual Week from the Pre- and Post-session will be measured.
Prospective and Retrospective Memory Questionnaire
Time frame: Through completion of the study, up to 16 weeks.
Used to rate the participant's everyday retrospective and prospective memory. Change in scores on this questionnaire will be measured.
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 6 Apr 2021.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Strategy Training and Process Training in people with Parkinson Disease, run by Washington University School of Medicine at 1 site in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 6 inclusion and 7 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 6 Apr 2021. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Virtual Week (time frame: 4 to 6 weeks). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 6 Apr 2021.