Speed Endurance Training Protocol 1SPENSERNCT03602248
Speed Endurance Training, Muscle Damage and Performance in Soccer Players
A study testing Speed endurance training protocol A and Speed endurance training protocol B in people with Speed Endurance Training Protocol 1 and Speed Endurance Training Protocol 2, run by University of Thessaly at 1 site in Greece.
Trial summary
Soccer is an intermittent sport in which the aerobic and anaerobic capacity of the players are both very important. Elite football players perform an average of 150-250 short and intense movements during a match, demonstrating the significant contribution of the anaerobic energy system. Read more about this study
- Who is it for?
- Ages 18 to 25 years, men onlyHealthy volunteers can take part
- Conditions the study is for
- Speed Endurance Training Protocol 1, Speed Endurance Training Protocol 2, Control
- What is being tested?
- Speed endurance training protocol A and Speed endurance training protocol B
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 10 participants
- Where
- 1 siteGreece
- Study dates
- 8 May 2018to 1 Sep 2018
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 25 years
- Men only
- Healthy volunteers accepted
- Adult
Who may be able to join
- Absence of any musculoskeletal injury for at least 6 months prior to the study
- No use of any drugs or ergogenic supplements for at least 6 months prior to the study
- Absence of regular soccer training for the last 3 years
Who cannot join
- Any recent incidence of musculoskeletal injury
- Use of any drugs or ergogenic supplements for the last 6 months
- Regular soccer training for the last 3 years
Trial locations and contacts
1 site in 1 country.
Greece1 site
Laboratory of Exercise Biochemistry, Exercise Physiology,and Sports Nutrition, School of Physical Education and Sport Science, University of Thessaly
Trikala, Thessaly, 42100
About this study
Official title: Acute Effects of Two Different Speed Endurance Protocols on Performance, Muscle Damage Markers and Neuromuscular Fatigue in Soccer Players
Soccer is an intermittent sport in which the aerobic and anaerobic capacity of the players are both very important. Elite football players perform an average of 150-250 short and intense movements during a match, demonstrating the significant contribution of the anaerobic energy system. Speed endurance training consists a tool to enhance the performance of aerobic and anaerobic system. This training includes actions such as sprinting, changes of direction, accelerations, decelerations, jumps and shooting, characterized by a strong eccentric component. Eccentric actions are associated with exercise induced muscle damage (EIMD). Nevertheless, to date, EIMD responses following a session of speed endurance training have not yet been investigated. Therefore, the aim of the present study is to examine the EIMD responses and changes on performance and neuromuscular fatigue indices after two different speed endurance training protocols.
Read the detailed description
Football is a team sport in which mean and maximum heart rate ranges from 85 to 98% of the maximum heart rate during a competitive match. Elite football players perform an average of 150-250 short and intense movements during a match while blood lactate values range from 2 to 14 mmol/L demonstrating that the anaerobic energy system contributes significantly during the game. Acceleration and deceleration ability as well as ability to perform repeated sprints and changes of direction greatly determine performance in soccer.
Soccer players' ability to perform repetitive high intensity sprints over a long period of time can be improved by speed endurance training. Speed endurance training consists of repetitive intense exercise bouts at a higher intensity than maximum aerobic speed (MAS) lasting from 10 to 40 seconds and has been proven to be an important tool for improving performance in trained soccer players. Improved performance is attributed to the muscle's increased regulatory capacity regarding intense exercise, enhanced recovery of the energy stores, increased activity and number of muscle enzymes and accelerated by-products removal, thereby contributing to the maintenance of homeostasis and delay of fatigue occurrence during intense exercise.
Speed endurance training includes repeated high intensity actions such as sprinting, changes of direction, accelerations, decelerations, jumps and shooting. However, these movements have a strong eccentric component which has been associated with exercise induced muscle damage (EIMD) and inflammation. EIMD increases plasma creatine kinase (CK) levels and the delayed onset of muscle soreness (DOMS) and reduces power production capacity. CK increases after a soccer match, peaks at 48 hours and returns to rest values 5-7 days after the match. DOMS increases immediately after a soccer match, peaks at 24-72 hours and is normalized ~5 days post match. The reduction in power production capacity is observed immediately after the match and remains reduced for ~72 hours with the largest decrease observed at 48 hours post-match. Nevertheless, to date, EIMD responses following a session of speed endurance training have not yet been investigated. Therefore, the aim of the proposed study is to examine the EIMD responses and changes on performance and neuromuscular fatigue indices after two speed endurance training protocols.
A preliminary power analysis (effect size >0.55, probability error of 0.05, power of 0.90) revealed that a total sample of 8-10 soccer players required to detect statistically meaningful differences after a speed endurance training protocol.
A randomized, three-trial (speed endurance protocol A vs. speed endurance protocol B vs. control), cross-over, repeated measures design will be implemented. The study will be performed one week after the end of the in-season to minimize the detraining effect. Prior to the first trial participants will have their body mass, height, body composition and performance measured and will be familiarized with all the testing procedures. Each experimental trial (speed endurance training protocol A and B) will include a speed endurance training session on Monday. The second trial (between training trials) will serve as control, where only performance measurements and blood sampling will be performed. Performance assessment and blood sampling will be performed immediately after each speed endurance training session and daily for three days post training session. Each training session will be performed on natural grass surface under the same environmental conditions (i.e. temperature and humidity). A 5-day recovery period will be used between trials. During the training sessions, participants will consume only water ad libitum. Field activity during training sessions will be recorded using high time-resolution Global Positioning System (GPS) instrumentation and heart rate monitoring. Before each training session, a standard breakfast and meal will be consumed by all players as previously described.
Speed endurance training protocols Speed endurance training protocol A will consist of 1 set of 8 repetitions interspersed by 2,5 minutes of recovery with a work to rest ratio of 1:5 (25-30 seconds all out work) whereas speed endurance training protocol B will consist of 1 set of 8 repetitions interspersed by 4 minutes of recovery with a work to rest ratio of 1:8 (25-30 seconds all out work). Both training protocols will include the same exercise (drill), consisting of multiple linear sprints, changes of direction, ball contacts, passes, and shooting. Prior to the training sessions, a 15-min standard warm-up (free running, active stretching, ball contacts and sprints) will be performed.
- Being tested
- Speed endurance training protocol A, Speed endurance training protocol B
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Speed endurance training protocol AOther
1 set of 8 repetitions interspersed by 2,5 minutes of recovery with a work to rest ratio of 1:5 (25-30 seconds all out work)
Speed endurance training protocol BOther
1 set of 8 repetitions interspersed by 4 minutes of recovery with a work to rest ratio of 1:8 (25-30 seconds all out work)
| Study group | Role | What they receive |
|---|---|---|
| Speed endurance training protocol A | Experimental | Performance of two different speed endurance training protocols:
Speed endurance training protocol A will consist of 1 set of 8 repetitions interspersed by 2,5 minutes of recovery with a work to rest ratio of 1:5 (25-30 seconds all out work). Receives: Other: Speed endurance training protocol A |
| Speed endurance training protocol B | Experimental | Speed endurance training protocol B will consist of 1 set of 8 repetitions interspersed by 4 minutes of recovery with a work to rest ratio of 1:8 (25-30 seconds all out work) Receives: Other: Speed endurance training protocol B |
| Control condition | No intervention | No training protocol will be performed, the participants will perform only the measurements for performance and muscle damage and neuromuscular fatigue |
What is being measured
The primary outcome is the main question the study is designed to answer.
Differences in changes in creatine kinase (CK) between the two training protocols
Creatine kinase (CK) is a muscle damage marker
Measured: Baseline, Day 1, Day 2, Day 3
Differences in changes in delayed onset of muscle soreness (DOMS) between the two training protocols
Delayed onset of muscle soreness (DOMS) is a muscle damage marker
Measured: Pre-protocol, Day 1, Day 2, Day 3
Differences in changes in maximal concentric strength between the two training protocols
Maximal concentric strength is used as a muscle damage marker
Measured: Baseline, Day 1, Day 2, Day 3
Differences in changes in maximal eccentric strength between the two training protocols
Maximal eccentric strength is used as a muscle damage marker
Measured: Baseline, Day 1, Day 2, Day 3
Secondary outcomes (5)
Differences in changes in countermovement jump between the two training protocols
Countermovement jump is used as a performance marker
Measured: Baseline, Day 1, Day 2, Day 3
Differences in changes in Repeated Sprint Ability (RSA) between the two training protocols
Repeated Sprint Ability (RSA) is a performance marker
Measured: Baseline, Day 1, Day 2, Day 3
Differences in changes in maximal concentric strength between the two training protocols
Maximal concentric strength is used as a performance marker
Measured: Baseline, Day 1, Day 2, Day 3
Differences in changes in maximal eccentric strength between the two training protocols
Maximal eccentric strength is used as a performance marker
Measured: Baseline, Day 1, Day 2, Day 3
Differences in changes in maximal isometric strength between the two training protocols
Maximal isometric strength is used as a neuromuscular fatigue marker
Measured: Baseline, Hour 1, Hour 2, Hour 3
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted26 Jul 2018
- Study start8 May 2018
- Primary completion31 Jul 2018
- Study completion1 Sep 2018
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (3)Papers the sponsor has linked to this study.
- Other trials for Speed Endurance Training Protocol 1Studies of the same condition, open and under way.
- More trials run by University of ThessalyThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Screening
- Allocation
- Randomised
- Intervention model
- Crossover
- Masking
- None (open label)
- Enrolment
- 10 participants (actual)
Sponsor and investigators
- Lead sponsor
- University of Thessaly
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Ioannis G. Fatouros, University of Thessaly
- Investigators
- Ioannis G Fatouros, PhD, Principal investigator, University of Thessaly
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT03602248
- Sponsor's protocol ID
- SpEndu2018
- Acronym
- SPENSER
- Status last verified
- Sep 2020
- First submitted
- 12 Jun 2018
- Last updated
- 24 Sep 2020
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Publications
Mohr M, Krustrup P, Bangsbo J. Match performance of high-standard soccer players with special reference to development of fatigue. J Sports Sci. 2003 Jul;21(7):519-28. doi: 10.1080/0264041031000071182.
PubMed 12848386Ade JD, Harley JA, Bradley PS. Physiological response, time-motion characteristics, and reproducibility of various speed-endurance drills in elite youth soccer players: small-sided games versus generic running. Int J Sports Physiol Perform. 2014 May;9(3):471-9. doi: 10.1123/ijspp.2013-0390. Epub 2014 Feb 7.
PubMed 24509482Fatouros IG, Chatzinikolaou A, Douroudos II, Nikolaidis MG, Kyparos A, Margonis K, Michailidis Y, Vantarakis A, Taxildaris K, Katrabasas I, Mandalidis D, Kouretas D, Jamurtas AZ. Time-course of changes in oxidative stress and antioxidant status responses following a soccer game. J Strength Cond Res. 2010 Dec;24(12):3278-86. doi: 10.1519/JSC.0b013e3181b60444.
PubMed 19996787
Study at a glance
From the registry record, last updated by the sponsor on 24 Sep 2020. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Acute Effects of Two Different Speed Endurance Protocols on Performance, Muscle Damage Markers and Neuromuscular Fatigue in Soccer Players
- ClinicalTrials.gov ID
- NCT03602248
- Acronym / sponsor ID
- SPENSER / SpEndu2018
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 10 participants (actual)
- Lead sponsor
- University of ThessalyUniversity, hospital or other
- Study start
- 8 May 2018 (actual)
- Primary completion
- 31 Jul 2018 (actual)
- Study completion
- 1 Sep 2018 (actual)
- First posted
- 26 Jul 2018 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Soccer is an intermittent sport in which the aerobic and anaerobic capacity of the players are both very important. Elite football players perform an average of 150-250 short and intense movements during a match, demonstrating the significant contribution of the anaerobic energy system. Speed endurance training consists a tool to enhance the performance of aerobic and anaerobic system. This training includes actions such as sprinting, changes of direction, accelerations, decelerations, jumps and shooting, characterized by a strong eccentric component. Eccentric actions are associated with exercise induced muscle damage (EIMD). Nevertheless, to date, EIMD responses following a session of speed endurance training have not yet been investigated. Therefore, the aim of the present study is to examine the EIMD responses and changes on performance and neuromuscular fatigue indices after two different speed endurance training protocols.
Detailed description
Football is a team sport in which mean and maximum heart rate ranges from 85 to 98% of the maximum heart rate during a competitive match. Elite football players perform an average of 150-250 short and intense movements during a match while blood lactate values range from 2 to 14 mmol/L demonstrating that the anaerobic energy system contributes significantly during the game. Acceleration and deceleration ability as well as ability to perform repeated sprints and changes of direction greatly determine performance in soccer.
Soccer players' ability to perform repetitive high intensity sprints over a long period of time can be improved by speed endurance training. Speed endurance training consists of repetitive intense exercise bouts at a higher intensity than maximum aerobic speed (MAS) lasting from 10 to 40 seconds and has been proven to be an important tool for improving performance in trained soccer players. Improved performance is attributed to the muscle's increased regulatory capacity regarding intense exercise, enhanced recovery of the energy stores, increased activity and number of muscle enzymes and accelerated by-products removal, thereby contributing to the maintenance of homeostasis and delay of fatigue occurrence during intense exercise.
Speed endurance training includes repeated high intensity actions such as sprinting, changes of direction, accelerations, decelerations, jumps and shooting. However, these movements have a strong eccentric component which has been associated with exercise induced muscle damage (EIMD) and inflammation. EIMD increases plasma creatine kinase (CK) levels and the delayed onset of muscle soreness (DOMS) and reduces power production capacity. CK increases after a soccer match, peaks at 48 hours and returns to rest values 5-7 days after the match. DOMS increases immediately after a soccer match, peaks at 24-72 hours and is normalized ~5 days post match. The reduction in power production capacity is observed immediately after the match and remains reduced for ~72 hours with the largest decrease observed at 48 hours post-match. Nevertheless, to date, EIMD responses following a session of speed endurance training have not yet been investigated. Therefore, the aim of the proposed study is to examine the EIMD responses and changes on performance and neuromuscular fatigue indices after two speed endurance training protocols.
A preliminary power analysis (effect size >0.55, probability error of 0.05, power of 0.90) revealed that a total sample of 8-10 soccer players required to detect statistically meaningful differences after a speed endurance training protocol.
A randomized, three-trial (speed endurance protocol A vs. speed endurance protocol B vs. control), cross-over, repeated measures design will be implemented. The study will be performed one week after the end of the in-season to minimize the detraining effect. Prior to the first trial participants will have their body mass, height, body composition and performance measured and will be familiarized with all the testing procedures. Each experimental trial (speed endurance training protocol A and B) will include a speed endurance training session on Monday. The second trial (between training trials) will serve as control, where only performance measurements and blood sampling will be performed. Performance assessment and blood sampling will be performed immediately after each speed endurance training session and daily for three days post training session. Each training session will be performed on natural grass surface under the same environmental conditions (i.e. temperature and humidity). A 5-day recovery period will be used between trials. During the training sessions, participants will consume only water ad libitum. Field activity during training sessions will be recorded using high time-resolution Global Positioning System (GPS) instrumentation and heart rate monitoring. Before each training session, a standard breakfast and meal will be consumed by all players as previously described.
Speed endurance training protocols Speed endurance training protocol A will consist of 1 set of 8 repetitions interspersed by 2,5 minutes of recovery with a work to rest ratio of 1:5 (25-30 seconds all out work) whereas speed endurance training protocol B will consist of 1 set of 8 repetitions interspersed by 4 minutes of recovery with a work to rest ratio of 1:8 (25-30 seconds all out work). Both training protocols will include the same exercise (drill), consisting of multiple linear sprints, changes of direction, ball contacts, passes, and shooting. Prior to the training sessions, a 15-min standard warm-up (free running, active stretching, ball contacts and sprints) will be performed.
Study design
- Primary purpose
- Screening
- Allocation
- Randomised
- Intervention model
- Crossover
- Masking
- None (open label)
- Number of arms
- 3
| Arm | Type | Receives |
|---|---|---|
| Speed endurance training protocol A | Experimental | Other: Speed endurance training protocol APerformance of two different speed endurance training protocols: Speed endurance training protocol A will consist of 1 set of 8 repetitions interspersed by 2,5 minutes of recovery with a work to rest ratio of 1:5 (25-30 seconds all out work). |
| Speed endurance training protocol B | Experimental | Other: Speed endurance training protocol BSpeed endurance training protocol B will consist of 1 set of 8 repetitions interspersed by 4 minutes of recovery with a work to rest ratio of 1:8 (25-30 seconds all out work) |
| Control condition | No intervention | –No training protocol will be performed, the participants will perform only the measurements for performance and muscle damage and neuromuscular fatigue |
Who may qualify
- Ages
- 18 to 25 years
- Sex
- Male only
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (3 listed)
- Absence of any musculoskeletal injury for at least 6 months prior to the study
- No use of any drugs or ergogenic supplements for at least 6 months prior to the study
- Absence of regular soccer training for the last 3 years
Key exclusion criteria (3 listed)
- Any recent incidence of musculoskeletal injury
- Use of any drugs or ergogenic supplements for the last 6 months
- Regular soccer training for the last 3 years
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Speed endurance training protocol A1 set of 8 repetitions interspersed by 2,5 minutes of recovery with a work to rest ratio of 1:5 (25-30 seconds all out work) | Other | Speed endurance training protocol A |
| Speed endurance training protocol B1 set of 8 repetitions interspersed by 4 minutes of recovery with a work to rest ratio of 1:8 (25-30 seconds all out work) | Other | Speed endurance training protocol B |
Primary outcome
Differences in changes in creatine kinase (CK) between the two training protocols
Time frame: Baseline, Day 1, Day 2, Day 3
Creatine kinase (CK) is a muscle damage marker
Differences in changes in delayed onset of muscle soreness (DOMS) between the two training protocols
Time frame: Pre-protocol, Day 1, Day 2, Day 3
Delayed onset of muscle soreness (DOMS) is a muscle damage marker
Differences in changes in maximal concentric strength between the two training protocols
Time frame: Baseline, Day 1, Day 2, Day 3
Maximal concentric strength is used as a muscle damage marker
Differences in changes in maximal eccentric strength between the two training protocols
Time frame: Baseline, Day 1, Day 2, Day 3
Maximal eccentric strength is used as a muscle damage marker
5 secondary outcomes
Differences in changes in countermovement jump between the two training protocols
Time frame: Baseline, Day 1, Day 2, Day 3
Differences in changes in Repeated Sprint Ability (RSA) between the two training protocols
Time frame: Baseline, Day 1, Day 2, Day 3
Differences in changes in maximal concentric strength between the two training protocols
Time frame: Baseline, Day 1, Day 2, Day 3
Differences in changes in maximal eccentric strength between the two training protocols
Time frame: Baseline, Day 1, Day 2, Day 3
Differences in changes in maximal isometric strength between the two training protocols
Time frame: Baseline, Hour 1, Hour 2, Hour 3
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 24 Sep 2020.
- Background: PubMed 12848386Mohr M, Krustrup P, Bangsbo J. Match performance of high-standard soccer players with special reference to development of fatigue. J Sports Sci. 2003 Jul;21(7):519-28. doi: 10.1080/0264041031000071182.
- Background: PubMed 24509482Ade JD, Harley JA, Bradley PS. Physiological response, time-motion characteristics, and reproducibility of various speed-endurance drills in elite youth soccer players: small-sided games versus generic running. Int J Sports Physiol Perform. 2014 May;9(3):471-9. doi: 10.1123/ijspp.2013-0390. Epub 2014 Feb 7.
- Background: PubMed 19996787Fatouros IG, Chatzinikolaou A, Douroudos II, Nikolaidis MG, Kyparos A, Margonis K, Michailidis Y, Vantarakis A, Taxildaris K, Katrabasas I, Mandalidis D, Kouretas D, Jamurtas AZ. Time-course of changes in oxidative stress and antioxidant status responses following a soccer game. J Strength Cond Res. 2010 Dec;24(12):3278-86. doi: 10.1519/JSC.0b013e3181b60444.
- Individual participant dataSharing planned: No
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Ioannis G Fatouros, PhD principal investigator
University of Thessaly
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Speed endurance training protocol A and Speed endurance training protocol B in people with Speed Endurance Training Protocol 1 and Speed Endurance Training Protocol 2, run by University of Thessaly at 1 site in Greece.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 3 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 24 Sep 2020. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Greece. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Differences in changes in creatine kinase (CK) between the two training protocols (time frame: Baseline, Day 1, Day 2, Day 3). The study lists 4 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT03602248, which also lists 3 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 24 Sep 2020; AzTrials last refreshed its copy on 6 Nov 2026.