Cardiac ArrestDISPATCHNCT03633370
Multifaceted Intervention for Increasing Performance of CPR by Laypersons in Out-of-hospital Cardiac Arrest
A study testing Multifaceted intervention including 3 components in people with Cardiac Arrest, run by University Hospital, Grenoble at 15 sites in France.
Trial summary
Cardiac arrest (CA) early recognition is essential in order to rapidly activate emergency services and for bystanders to begin cardiopulmonary resuscitation (CPR). As soon as a call is received, EMS dispatchers should try to identify CA. This may be difficult, in a context of stress and distress of the person calling. Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Cardiac Arrest
- What is being tested?
- Multifaceted intervention including 3 components
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 2,481 participants
- Where
- 15 sitesFrance
- Study dates
- 27 Aug 2018to 20 Mar 2022
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- All adults with nontraumatic, out-of-hospital cardiac arrest diagnosed during the emergency medical service call
- Cardiac arrest located in urban area
Who cannot join
- Pregnant or breastfeeding women
- Patients under the law
- Patients deprived of liberty by court ruling or administrative ruling
- Traumatic cardiac arrest
- CA occurring under the eyes of a professional emergency services patrol on duty
- Cardiac arrest for which resuscitation seem unjustified (inevitable death, terminally ill irreversible condition, too long duration of cardiac arrest, non-resuscitation personal directive…)
Trial locations and contacts
15 sites in 1 country.
15 sites in 1 country
France15 sites
SAMU 80 - CHU Amiens Picardie
Amiens, 80054
SAMU 74 - CH Annecy Genevois
Annecy, 74370
SAMU 33 - CHU Hôpital Pellegrin
Bordeaux, 33076
SAMU 01 - CH Fleyriat
Bourg-en-Bresse, 01012
SAMU 29 - CHRU La Cavale Blanche
Brest, 29609
SAMU 73 - Centre Hospitalier Métropôle Savoie
Chambéry, 73011
SAMU 21 - CHU Dijon
Dijon, 21000
SAMU 38 - CHU Grenoble Alpes
Grenoble, 38043
Samu 85 - Chd Les Oudairies
La Roche-sur-Yon, 85025
SAMU 54 - CHU Nancy
Nancy, 54000
SAMU 44 - Hôtel Dieu
Nantes
SAMU 06 - CHU de Nice
Nice, 06001
SAMU 42 -CHU Saint-Etienne
Saint-Etienne, 42270
SAMU 31 - CHU Toulouse
Toulouse, 31000
SAMU 26 - CH de Valence
Valence, 26953
About this study
Official title: Multifaceted Intervention for Increasing Performance of Cardiopulmonary Resuscitation by Laypersons in Out-of-hospital Cardiac Arrest. A Stepped Wedge Cluster Randomized Controlled Trial
Cardiac arrest (CA) early recognition is essential in order to rapidly activate emergency services and for bystanders to begin cardiopulmonary resuscitation (CPR).
As soon as a call is received, EMS dispatchers should try to identify CA. This may be difficult, in a context of stress and distress of the person calling. Yet, it is vital for bystanders to initiate CPR. Survival can be multiplied by 2 to 4 if the bystanders initiate a CPR before the arrival of the emergency medical services.
Read more
This work aim to assess a multifaceted intervention combining 3 elements to improve the initial phone recognition of CA and raise the number of patients benefiting from CPR before EMS arrival on scene.
The first element is a dispatcher training to the early phone recognition of CA. This training will be based on the concept of active teaching, favouring the interactive work of learners in particular by listening to real dispatch recordings. It will be completed by continuing education with a distance teaching platform including the systematic listening of recorded CA calls.
The second element is based on the deployment of a software aiming to notify CA thanks to mobile phones. This system interfaced to a control software enables to request the participation of CPR-trained volunteers automatically. The volunteers have to be located in the patient's surroundings. The deployment of this mobile application will rely on first-aid volunteers, health personal and any trained volunteers willing to participate. A randomized control study in one city area proved the efficiency of a similar software to improve the proportion of CPR by bystanders.
The third element consists in a motivational feedback. A weekly overview of the management and the outcomes of patients who suffered CA will be broadcast to all the responders and volunteers in the mobile application.
- Conditions
- Cardiac Arrest
- Being tested
- Multifaceted intervention including 3 components
- Keywords
- Cardiac Arrest, Dispatcher, Cardiopulmonary Resuscitation
- Medical subject headings
- Heart Arrest
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Multifaceted intervention including 3 componentsOther
Multifaceted intervention including Dispatcher training to improve cardiac phone recognition, mobile application to send bystanders on cardiac arrest location before first professionals rescuers and motivational support for volunteer bystanders
| Study group | Role | What they receive |
|---|---|---|
| Control Group | No intervention | Usual management of patients according to international guidelines. Protocols of call acceptance, phone advice and sending of emergency services are not modified |
| Test Group | Other | Multifaceted intervention
1. Training using distance learning for medical regulation assistants to recognise cardiac arrest on phone
2. Activation of the location-software application to send bystanders on cardiac arrest location before the arrival of emergency medical services (EMS)
3. Motivation feed-back Volunteers will received feed-back regarding CPR initiated before EMS arrival and survival Receives: Other: Multifaceted intervention including 3 components |
What is being measured
The primary outcome is the main question the study is designed to answer.
CPR initiated by bystanders before the arrival of first professionals rescuers
Proportion of patients who's received CPR initiated by bystander before EMS arrival.
Measured: Day 0
Secondary outcomes (8)
Survival at 72h after out-of-hospital cardiac arrest
survival at 72h
Measured: 72 hours
Return of Spontaneous Circulation
Proportion of patients who's recovered a spontaneous circulation after CPR
Measured: Day 0
Survival to hospital admission
Vital status at hospital admission
Measured: Day 0
Survival to hospital discharge
Vital status at hospital discharge
Measured: up to 30 days
Survival at 30 days
Vital status at 30 days
Measured: 30 days
Neurological functional status CPC
As measured by Cerebral Performance Category (CPC) at hospital discharge and at 30 days Score less or equal to 2 will be considered as favorable neurological outcome
Measured: up to 30 days
Neurological functional status mRS
As measured by modified Rankin Scale (mRS) at hospital discharge and at 30 days:
modified Rankin Scale (mRS): 0 - No symptoms.
- - No significant disability. Able to carry out all usual activities, despite some symptoms.
- - Slight disability. Able to look after own affairs without assistance, but unable to carry out all previous activities.
- - Moderate disability. Requires some help, but able to walk unassisted.
- - Moderately severe disability. Unable to attend to own bodily needs without assistance, and unable to walk unassisted.
- - Severe disability. Requires constant nursing care and attention, bedridden, incontinent.
- - Dead Score less or equal to 3 will be considered as favorable neurological outcome
Measured: 30 days
First recorded rhythm
First recorded cardiac rhythm by EMS
Measured: 30 min
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted16 Aug 2018
- Study start27 Aug 2018
- Primary completion1 Mar 2022
- Study completion20 Mar 2022
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for Cardiac ArrestStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Sequential
- Model description
- A Stepped Wedge Cluster Randomized Controlled Trial
- Masking
- Single blind
- Who is masked
- Outcomes assessor
- Enrolment
- 2,481 participants (actual)
Sponsor and investigators
- Lead sponsor
- University Hospital, Grenoble
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
- Investigators
- Monique Sorentino, Study director, CHU Grenoble Alpes
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT03633370
- Sponsor's protocol ID
- DISPATCH
- Acronym
- DISPATCH
- Status last verified
- May 2023
- First submitted
- 19 Jul 2018
- Last updated
- 17 May 2023
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Yes: Study protocol will be submitted for publication. IPD will be shared with other researcher.
Publications
Debaty G, Ribes S, Ray P, Chouihed T, Desseigne N, Usseglio P, Serre P, Pradeau C, Bounes V, Roupioz T, Lucas AS, Giolito D, Zamour C, Boyer C, Hubert H, Savary D, Tazarourte K, Freund Y, Watson SI, Hemming K, Lamhaut L, Labarere J. A multifaceted intervention to increase bystander CPR rates after out-of-hospital cardiac arrest in France: a stepped-wedge, cluster-randomised, controlled trial. Lancet Public Health. 2026 Nov;11(11):e878-e888. doi: 10.1016/S2468-2667(26)00200-8.
PubMed 42901186
Study at a glance
From the registry record, last updated by the sponsor on 17 May 2023. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Multifaceted Intervention for Increasing Performance of Cardiopulmonary Resuscitation by Laypersons in Out-of-hospital Cardiac Arrest. A Stepped Wedge Cluster Randomized Controlled Trial
- ClinicalTrials.gov ID
- NCT03633370
- Acronym / sponsor ID
- DISPATCH / DISPATCH
- Conditions
- Cardiac Arrest
- Keywords
- Cardiac Arrest, Dispatcher, Cardiopulmonary Resuscitation
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 2,481 participants (actual)
- Lead sponsor
- University Hospital, GrenobleUniversity, hospital or other
- Study start
- 27 Aug 2018 (actual)
- Primary completion
- 1 Mar 2022 (actual)
- Study completion
- 20 Mar 2022 (actual)
- First posted
- 16 Aug 2018 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Cardiac arrest (CA) early recognition is essential in order to rapidly activate emergency services and for bystanders to begin cardiopulmonary resuscitation (CPR).
As soon as a call is received, EMS dispatchers should try to identify CA. This may be difficult, in a context of stress and distress of the person calling. Yet, it is vital for bystanders to initiate CPR. Survival can be multiplied by 2 to 4 if the bystanders initiate a CPR before the arrival of the emergency medical services.
This work aim to assess a multifaceted intervention combining 3 elements to improve the initial phone recognition of CA and raise the number of patients benefiting from CPR before EMS arrival on scene.
The first element is a dispatcher training to the early phone recognition of CA. This training will be based on the concept of active teaching, favouring the interactive work of learners in particular by listening to real dispatch recordings. It will be completed by continuing education with a distance teaching platform including the systematic listening of recorded CA calls.
The second element is based on the deployment of a software aiming to notify CA thanks to mobile phones. This system interfaced to a control software enables to request the participation of CPR-trained volunteers automatically. The volunteers have to be located in the patient's surroundings. The deployment of this mobile application will rely on first-aid volunteers, health personal and any trained volunteers willing to participate. A randomized control study in one city area proved the efficiency of a similar software to improve the proportion of CPR by bystanders.
The third element consists in a motivational feedback. A weekly overview of the management and the outcomes of patients who suffered CA will be broadcast to all the responders and volunteers in the mobile application.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Sequential
- Masking
- Single blind (outcomes assessor)
- Number of arms
- 2
- Model description
- A Stepped Wedge Cluster Randomized Controlled Trial
| Arm | Type | Receives |
|---|---|---|
| Control Group | No intervention | –Usual management of patients according to international guidelines. Protocols of call acceptance, phone advice and sending of emergency services are not modified |
| Test Group | Other | Other: Multifaceted intervention including 3 componentsMultifaceted intervention 1. Training using distance learning for medical regulation assistants to recognise cardiac arrest on phone 2. Activation of the location-software application to send bystanders on cardiac arrest location before the arrival of emergency medical services (EMS) 3. Motivation feed-back Volunteers will received feed-back regarding CPR initiated before EMS arrival and survival |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (2 listed)
- All adults with nontraumatic, out-of-hospital cardiac arrest diagnosed during the emergency medical service call
- Cardiac arrest located in urban area
Key exclusion criteria (6 listed)
- Pregnant or breastfeeding women
- Patients under the law
- Patients deprived of liberty by court ruling or administrative ruling
- Traumatic cardiac arrest
- CA occurring under the eyes of a professional emergency services patrol on duty
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Multifaceted intervention including 3 componentsMultifaceted intervention including Dispatcher training to improve cardiac phone recognition, mobile application to send bystanders on cardiac arrest location before first professionals rescuers and motivational support for volunteer bystanders | Other | Test Group |
Primary outcome
CPR initiated by bystanders before the arrival of first professionals rescuers
Time frame: Day 0
Proportion of patients who's received CPR initiated by bystander before EMS arrival.
8 secondary outcomes
Survival at 72h after out-of-hospital cardiac arrest
Time frame: 72 hours
Return of Spontaneous Circulation
Time frame: Day 0
Survival to hospital admission
Time frame: Day 0
Survival to hospital discharge
Time frame: up to 30 days
Survival at 30 days
Time frame: 30 days
Neurological functional status CPC
Time frame: up to 30 days
Neurological functional status mRS
Time frame: 30 days
First recorded rhythm
Time frame: 30 min
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 17 May 2023.
- Derived from this study: PubMed 42901186Debaty G, Ribes S, Ray P, Chouihed T, Desseigne N, Usseglio P, Serre P, Pradeau C, Bounes V, Roupioz T, Lucas AS, Giolito D, Zamour C, Boyer C, Hubert H, Savary D, Tazarourte K, Freund Y, Watson SI, Hemming K, Lamhaut L, Labarere J. A multifaceted intervention to increase bystander CPR rates after out-of-hospital cardiac arrest in France: a stepped-wedge, cluster-randomised, controlled trial. Lancet Public Health. 2026 Nov;11(11):e878-e888. doi: 10.1016/S2468-2667(26)00200-8.
- Individual participant dataSharing planned: Yes. Study protocol will be submitted for publication. IPD will be shared with other researcher.
Related trials for Cardiac Arrest
Active, not recruiting
RACE-CARS - RAndomized Cluster Evaluation of Cardiac ARrest Systems
Cardiac Arrest
Not yet recruiting
Generative AI and Gamified Simulation-Based Train-the-Trainer Basic Life Support Training for High School Teachers in Vietnam
Cardiac Arrest, Cardiopulmonary Resuscitation
RecruitingObservational study
Cardiac Arrest - Ultrasound Detection of Occult Perfusion
Cardiac Arrest, Out-Of-Hospital, Hypotension
Not yet recruiting
The OXY-VENT Study
Cardiac Arrest (CA), Cardiopulmonary Resuscitation (CPR)
Not yet recruitingObservational study
Therapeutic Outcomes of In-Hospital Resuscitation of Patients Admitted to the Internal Medicine Wards
Survival to Discharge With Good Neurologic Outcome Among in Hospital Cardiac Arrest Patients
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Monique Sorentino study director
CHU Grenoble Alpes
15 sites in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Multifaceted intervention including 3 components in people with Cardiac Arrest, run by University Hospital, Grenoble at 15 sites in France.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 2 inclusion and 6 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 17 May 2023. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 15 sites in France. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
CPR initiated by bystanders before the arrival of first professionals rescuers (time frame: Day 0). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT03633370, which also lists 1 linked publication.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 17 May 2023.