ObesityNCT03715088
Impacts of Resistance Training on Acute Secretion of Irisin in Obese Older and Young Adults
A study testing Resistance Training Intervention in people with Obesity, run by University of New Brunswick at 1 site in Canada.
Trial summary
It is established that resistance training improves metabolic health; however, the mechanisms of this process are not fully understood. A biologically active substance, irisin, has recently received interest in the scientific community with respect to its effects on energy expenditure and weight loss. Read more about this study
- Who is it for?
- Ages 18 to 75 years
- Conditions the study is for
- Obesity
- What is being tested?
- Resistance Training Intervention
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 31 participants
- Where
- 1 siteCanada
- Study dates
- May 2016to Aug 2016
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 75 years
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Age between 18-35 or 60-75 years old
- Physically inactive (engaging in less than 150 minutes of moderate to vigorous aerobic exercise)
- No previous diagnosis of Type 2 diabetes
- Obese (BMI ≥30kg/m2)
Who cannot join
- BMI less than 30kg/m2
- History of Type 2 diabetes
- Physically active (engaging in atleast 150 minutes of moderate to vigorous aerobic exercise)
- Injury or condition that prevents performance of resistance training exercise.
Trial locations and contacts
1 site in 1 country.
Canada1 site
University of New Brunswick - Kinesiology
Fredericton, New Brunswick, E3B 5A3
About this study
It is established that resistance training improves metabolic health; however, the mechanisms of this process are not fully understood. A biologically active substance, irisin, has recently received interest in the scientific community with respect to its effects on energy expenditure and weight loss. The purpose of this study is to compare the different irisin release response during a resistance exercise training session. The study will compare individuals two different age groups (young adults: age 18-30; older adults: age 65-75) living with obesity.
Read the detailed description
Background: Worldwide, the number of individuals living with obesity has doubled over the past thirty years. The growing prevalence of obesity is concerning as obesity is known to be one of the main risk factors for many chronic conditions, such as Type 2 diabetes and cardiovascular diseases. Therefore, it is important that the impact of different types of exercise are understood to properly prescribe exercise interventions to individuals living with obesity. Recently, there has been increased interest for a biologically active substances that are secreted during muscle contraction, myokines, regarding their effects on metabolism during exercise. Specifically, a novel myokine, named irisin, has caught the attention of numerous researchers. Irisin has been shown to play an important role in increasing energy expenditure, reducing body weight, and improving glucose metabolism by adipocyte metabolism. As of now, the majority of research has focused on irisin release during endurance activity; however, there is limited research on irisin secretion during resistance exercise training.
Statement of Objectives: The purpose of this pilot study is to first determine whether irisin secretion increases during an acute session of resistance exercise training with obese individuals; and second, to determine whether changes in irisin levels during an acute bout of resistance exercise training can be seen in different age groups for obese individuals.
Methodology: Fifteen young and fifteen old participants will be recruited via advertisement in the local newspaper, on radio stations, and on posters. Inclusion criteria include individuals aged between either 18-30 or 65-75 years old, classified as obese according to their BMI (>30 kg/m2), inactive defined as engaging in less than 150 minutes of moderate to vigorous aerobic exercise, not currently engaged in a resistance exercise training program, no previous diagnosis of Type 2 diabetes, and having no injuries or conditions that would prevent them from performing a resistance exercise training session.
Primary Outcome Measure: The primary outcome measure in this study will be the change in irisin levels during resistance exercise training. A validated enzyme immunoassay kit from Phoenix Pharmaceutical Inc. (EK-067-16) will be used to measure irisin. Our group already has experience with this equipment and these procedures, which has been validated.
Resistance Exercise Session: Participants will come for their first visit at which time they they will perform a test to determine their maximal strength [1-repetition maximal (1-RM)] for each exercise included in the program. During their second visit, participants will perform 10 different resistance exercises consisting of three sets of 8-10 repetitions, at 80% of 1-RM. A 60-second rest will occur between sets. This exercise protocol was selected based on literature that suggests that the protocol and the intensity do not enhance mitochondria biogenesis. Also, this protocol was shown to be well tolerated by obese and older individuals.
- Conditions
- Obesity
- Being tested
- Resistance Training Intervention
- Keywords
- Irisin, Obesity, Resistance Training, Older Adults, Younger Adults, Myokines
- Medical subject headings
- Obesity
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Resistance Training InterventionBehavioural
Participants will perform 10 different resistance exercises consisting of three sets of 8-10 repetitions, at 80% of 1-RM, separated by 60-second rest intervals between sets. This exercise protocol was chosen based on literature that suggests that the protocol and intensity do not enhance mitochondria biogenesis. Also, it was well tolerated by obese and older individuals.
| Study group | Role | What they receive |
|---|---|---|
| Older Adults (BMI ≥30 kg/m2) | Experimental | Individuals aged 65-75 living with obesity will perform the Resistance Training Intervention. Receives: Behavioral: Resistance Training Intervention |
| Younger Adults (BMI ≥30 kg/m2) | Experimental | Individuals aged 18-30 living with obesity will perform Resistance Training Intervention. Receives: Behavioral: Resistance Training Intervention |
What is being measured
The primary outcome is the main question the study is designed to answer.
Irisin
The primary outcome is the change in irisin during an acute bout of resistance exercise training.
Measured: Baseline (0 minute), 15 minutes, 30 minutes, and 45 minutes during exercise and 45 minutes post exercise
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted22 Oct 2018
- Study startMay 2016
- Primary completionAug 2016
- Study completionAug 2016
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for ObesityStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Prevention
- Allocation
- Non-randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Enrolment
- 31 participants (actual)
Sponsor and investigators
- Lead sponsor
- University of New Brunswick
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Martin Senechal, University of New Brunswick
- Investigators
- Martin Senechal, PhD, Principal investigator, University of New Brunswick
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT03715088
- Sponsor's protocol ID
- UNB Fredericton
- Status last verified
- Jun 2018
- First submitted
- 18 Oct 2018
- Last updated
- 22 Oct 2018
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Publications
Rioux BV, Brunt KR, Eadie AL, Bouchard DR, Fox J, Senechal M. Impact of acute circuit training on irisin in younger and older overweight adults. Appl Physiol Nutr Metab. 2021 Oct;46(10):1248-1256. doi: 10.1139/apnm-2020-1087. Epub 2021 Apr 22.
PubMed 33887165
Study at a glance
From the registry record, last updated by the sponsor on 22 Oct 2018. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Impacts of Resistance Training on Acute Secretion of Irisin in Obese Older and Young Adults
- ClinicalTrials.gov ID
- NCT03715088
- Acronym / sponsor ID
- UNB Fredericton
- Conditions
- Obesity
- Keywords
- Irisin, Obesity, Resistance Training, Older Adults, Younger Adults, Myokines
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 31 participants (actual)
- Lead sponsor
- University of New BrunswickUniversity, hospital or other
- Study start
- May 2016 (actual)
- Primary completion
- Aug 2016 (actual)
- Study completion
- Aug 2016 (actual)
- First posted
- 22 Oct 2018 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
It is established that resistance training improves metabolic health; however, the mechanisms of this process are not fully understood. A biologically active substance, irisin, has recently received interest in the scientific community with respect to its effects on energy expenditure and weight loss. The purpose of this study is to compare the different irisin release response during a resistance exercise training session. The study will compare individuals two different age groups (young adults: age 18-30; older adults: age 65-75) living with obesity.
Detailed description
Background: Worldwide, the number of individuals living with obesity has doubled over the past thirty years. The growing prevalence of obesity is concerning as obesity is known to be one of the main risk factors for many chronic conditions, such as Type 2 diabetes and cardiovascular diseases. Therefore, it is important that the impact of different types of exercise are understood to properly prescribe exercise interventions to individuals living with obesity. Recently, there has been increased interest for a biologically active substances that are secreted during muscle contraction, myokines, regarding their effects on metabolism during exercise. Specifically, a novel myokine, named irisin, has caught the attention of numerous researchers. Irisin has been shown to play an important role in increasing energy expenditure, reducing body weight, and improving glucose metabolism by adipocyte metabolism. As of now, the majority of research has focused on irisin release during endurance activity; however, there is limited research on irisin secretion during resistance exercise training.
Statement of Objectives: The purpose of this pilot study is to first determine whether irisin secretion increases during an acute session of resistance exercise training with obese individuals; and second, to determine whether changes in irisin levels during an acute bout of resistance exercise training can be seen in different age groups for obese individuals.
Methodology: Fifteen young and fifteen old participants will be recruited via advertisement in the local newspaper, on radio stations, and on posters. Inclusion criteria include individuals aged between either 18-30 or 65-75 years old, classified as obese according to their BMI (>30 kg/m2), inactive defined as engaging in less than 150 minutes of moderate to vigorous aerobic exercise, not currently engaged in a resistance exercise training program, no previous diagnosis of Type 2 diabetes, and having no injuries or conditions that would prevent them from performing a resistance exercise training session.
Primary Outcome Measure: The primary outcome measure in this study will be the change in irisin levels during resistance exercise training. A validated enzyme immunoassay kit from Phoenix Pharmaceutical Inc. (EK-067-16) will be used to measure irisin. Our group already has experience with this equipment and these procedures, which has been validated.
Resistance Exercise Session: Participants will come for their first visit at which time they they will perform a test to determine their maximal strength [1-repetition maximal (1-RM)] for each exercise included in the program. During their second visit, participants will perform 10 different resistance exercises consisting of three sets of 8-10 repetitions, at 80% of 1-RM. A 60-second rest will occur between sets. This exercise protocol was selected based on literature that suggests that the protocol and the intensity do not enhance mitochondria biogenesis. Also, this protocol was shown to be well tolerated by obese and older individuals.
Study design
- Primary purpose
- Prevention
- Allocation
- Non-randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Older Adults (BMI ≥30 kg/m2) | Experimental | Behavioral: Resistance Training InterventionIndividuals aged 65-75 living with obesity will perform the Resistance Training Intervention. |
| Younger Adults (BMI ≥30 kg/m2) | Experimental | Behavioral: Resistance Training InterventionIndividuals aged 18-30 living with obesity will perform Resistance Training Intervention. |
Who may qualify
- Ages
- 18 to 75 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (4 listed)
- Age between 18-35 or 60-75 years old
- Physically inactive (engaging in less than 150 minutes of moderate to vigorous aerobic exercise)
- No previous diagnosis of Type 2 diabetes
- Obese (BMI ≥30kg/m2)
Key exclusion criteria (4 listed)
- BMI less than 30kg/m2
- History of Type 2 diabetes
- Physically active (engaging in atleast 150 minutes of moderate to vigorous aerobic exercise)
- Injury or condition that prevents performance of resistance training exercise.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Resistance Training InterventionParticipants will perform 10 different resistance exercises consisting of three sets of 8-10 repetitions, at 80% of 1-RM, separated by 60-second rest intervals between sets. This exercise protocol was chosen based on literature that suggests that the protocol and intensity do not enhance mitochondria biogenesis. Also, it was well tolerated by obese and older individuals. | Behavioural | Older Adults (BMI ≥30 kg/m2), Younger Adults (BMI ≥30 kg/m2) |
Primary outcome
Irisin
Time frame: Baseline (0 minute), 15 minutes, 30 minutes, and 45 minutes during exercise and 45 minutes post exercise
The primary outcome is the change in irisin during an acute bout of resistance exercise training.
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 22 Oct 2018.
- Derived from this study: PubMed 33887165Rioux BV, Brunt KR, Eadie AL, Bouchard DR, Fox J, Senechal M. Impact of acute circuit training on irisin in younger and older overweight adults. Appl Physiol Nutr Metab. 2021 Oct;46(10):1248-1256. doi: 10.1139/apnm-2020-1087. Epub 2021 Apr 22.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Martin Senechal, PhD principal investigator
University of New Brunswick
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Resistance Training Intervention in people with Obesity, run by University of New Brunswick at 1 site in Canada.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 4 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 22 Oct 2018. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Canada. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Irisin (time frame: Baseline (0 minute), 15 minutes, 30 minutes, and 45 minutes during exercise and 45 minutes post exercise). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT03715088, which also lists 1 linked publication.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 22 Oct 2018.