AzTrials
AzTrials

HealthyNCT03722953

Cerebrovascular Response to Acute Exercise

A study testing Aerobic Exercise in people with Healthy and Physical Activity, run by University of Wisconsin, Madison at 1 site in United States.

Completed

Finished. The study has ended and is not enrolling. Results may be posted on the official record.

Official record
Search all trials

Trial summary

Cerebrovascular function and peripheral vascular function will be measured in healthy young adults, before and after acute bouts of aerobic exercise at various intensities. Read more about this study

Who is it for?
Ages 20 to 40 yearsHealthy volunteers can take part
Conditions the study is for
Healthy, Physical Activity
What is being tested?
Aerobic Exercise
Could I receive a placebo?
No, everyone receives an active treatment
How many people
18 participants
Where
1 siteUnited States
Study dates
1 Dec 2018to 9 Mar 2020
Phase
Interventional
Are there results?
None posted in the registry

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

  • Ages 20 to 40 years
  • All sexes
  • Healthy volunteers accepted
  • Adult

Who may be able to join

  • Between 20-40 years old
  • BMI < 30 kg/m2
  • Recreationally active
  • Experience running on a treadmill

Who cannot join

  • Current smoker
  • History or evidence of: hepatic disease, renal disease, hematological disease, cardiovascular disease, stroke/neurovascular disease, diabetes
  • Taking blood pressure medication
  • History of depression or other mood related disorders
  • Part of a vulnerable population (e.g. pregnant women, prisoner, individuals lacking capacity to consent, etc.)

Trial locations and contacts

1 site in 1 country.

United States1 site

  • Gymnasium-Natatorium

    Madison, Wisconsin, 53706

Other trials in United States

About this study

Official title: The Role of Shear Stress in the Cerebrovascular Response to Acute Exercise

Cerebrovascular function and peripheral vascular function will be measured in healthy young adults, before and after acute bouts of aerobic exercise at various intensities.

Read the detailed description

Acute bouts of aerobic exercise have been shown to enhance vascular reactivity of the peripheral circulation; however, the effects of a single exercise session on the cerebral circulation are unknown. This study will measure cerebrovascular function and peripheral vascular function before and after aerobic exercise at high and low intensities.

The research aims are:

  1. To determine if a single bout of aerobic exercise acutely enhances cerebrovascular function
  2. To determine the effect of aerobic exercise intensity and dose on cerebrovascular function in healthy adults.
  3. To determine if the acute exercise-induced changes in cerebrovascular function are associated with acute exercise-induced changes in peripheral vascular function in healthy adults.
Being tested
Control, Aerobic Exercise
Keywords
Exercise, Treadmill, Vascular Function, Intensity
Medical subject headings
Motor Activity

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

  • ControlOther

    1. Ultrasound
    2. Blood Pressure
    3. Heart Rate
    4. Oxygen Saturation

  • Aerobic ExerciseOther

    1. Ultrasound
    2. Blood Pressure
    3. Heart Rate
    4. Oxygen Saturation
Study groups in NCT03722953
Study groupRoleWhat they receive
Aerobic ExerciseOtherControl: Cerebrovascular function and peripheral vascular function will be measured. Aerobic Exercise: Across four separate visits, participants will perform light intensity exercise, light intensity exercise plus an additional task, vigorous intensity exercise and vigorous intensity exercise to match the energy expenditure of light intensity exercise visit.
Receives: Other: Control; Other: Aerobic Exercise

What is being measured

The primary outcome is the main question the study is designed to answer.

  1. Cerebrovascular function

    Utilize ultrasound to measure a change in blood flow velocity in response to a breathing test

    Measured: Change in cerebrovascular function: measurements occur at baseline and 90 minutes post aerobic exercise to quantify magnitude of change.

  2. Peripheral vascular function

    Utilize ultrasound to measure a change in brachial artery diameter in response to reactive hyperemia

    Measured: Change in peripheral vascular function: measurements occur at baseline and 60 minutes post aerobic exercise to quantify magnitude of change.

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

  1. First posted29 Oct 2018
  2. Study start1 Dec 2018
  3. Primary completion9 Mar 2020
  4. Study completion9 Mar 2020

Resources

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design
Study type
Interventional
Phase
Phase N/A
Primary purpose
Basic science
Allocation
Not applicable
Intervention model
Single group
Masking
None (open label)
Enrolment
18 participants (actual)
IDs, dates and publications
ClinicalTrials.gov ID
NCT03722953
Sponsor's protocol ID
2018-0783
Other IDs
A176000, EDUC/KINESIOLOGY, Protocol Version 10/23/2018
Status last verified
Jun 2022
First submitted
15 Oct 2018
Last updated
2 Oct 2024
Results posted
No
Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
Individual data sharing
No

Publications

  • Barnes JN, Schmidt JE, Nicholson WT, Joyner MJ. Cyclooxygenase inhibition abolishes age-related differences in cerebral vasodilator responses to hypercapnia. J Appl Physiol (1985). 2012 Jun;112(11):1884-90. doi: 10.1152/japplphysiol.01270.2011. Epub 2012 Mar 22.

    PubMed 22442028

  • Richiardi J, Monsch AU, Haas T, Barkhof F, Van de Ville D, Radu EW, Kressig RW, Haller S. Altered cerebrovascular reactivity velocity in mild cognitive impairment and Alzheimer's disease. Neurobiol Aging. 2015 Jan;36(1):33-41. doi: 10.1016/j.neurobiolaging.2014.07.020. Epub 2014 Jul 24.

    PubMed 25146454

  • Sam K, Crawley AP, Conklin J, Poublanc J, Sobczyk O, Mandell DM, Venkatraghavan L, Duffin J, Fisher JA, Black SE, Mikulis DJ. Development of White Matter Hyperintensity Is Preceded by Reduced Cerebrovascular Reactivity. Ann Neurol. 2016 Aug;80(2):277-85. doi: 10.1002/ana.24712.

    PubMed 27352039

  • Shin HK, Jones PB, Garcia-Alloza M, Borrelli L, Greenberg SM, Bacskai BJ, Frosch MP, Hyman BT, Moskowitz MA, Ayata C. Age-dependent cerebrovascular dysfunction in a transgenic mouse model of cerebral amyloid angiopathy. Brain. 2007 Sep;130(Pt 9):2310-9. doi: 10.1093/brain/awm156. Epub 2007 Jul 16.

    PubMed 17638859

  • Barnes JN, Taylor JL, Kluck BN, Johnson CP, Joyner MJ. Cerebrovascular reactivity is associated with maximal aerobic capacity in healthy older adults. J Appl Physiol (1985). 2013 May 15;114(10):1383-7. doi: 10.1152/japplphysiol.01258.2012. Epub 2013 Mar 7.

    PubMed 23471946

  • Tarumi T, Zhang R. Cerebral hemodynamics of the aging brain: risk of Alzheimer disease and benefit of aerobic exercise. Front Physiol. 2014 Jan 21;5:6. doi: 10.3389/fphys.2014.00006. eCollection 2014.

    PubMed 24478719

  • Mitchell GF. Effects of central arterial aging on the structure and function of the peripheral vasculature: implications for end-organ damage. J Appl Physiol (1985). 2008 Nov;105(5):1652-60. doi: 10.1152/japplphysiol.90549.2008. Epub 2008 Sep 4.

    PubMed 18772322

  • Ranjan V, Xiao Z, Diamond SL. Constitutive NOS expression in cultured endothelial cells is elevated by fluid shear stress. Am J Physiol. 1995 Aug;269(2 Pt 2):H550-5. doi: 10.1152/ajpheart.1995.269.2.H550.

    PubMed 7544542

  • LASSEN NA. Cerebral blood flow and oxygen consumption in man. Physiol Rev. 1959 Apr;39(2):183-238. doi: 10.1152/physrev.1959.39.2.183. No abstract available.

    PubMed 13645234

  • Endres M, Gertz K, Lindauer U, Katchanov J, Schultze J, Schrock H, Nickenig G, Kuschinsky W, Dirnagl U, Laufs U. Mechanisms of stroke protection by physical activity. Ann Neurol. 2003 Nov;54(5):582-90. doi: 10.1002/ana.10722.

    PubMed 14595647

  • Tinken TM, Thijssen DH, Hopkins N, Black MA, Dawson EA, Minson CT, Newcomer SC, Laughlin MH, Cable NT, Green DJ. Impact of shear rate modulation on vascular function in humans. Hypertension. 2009 Aug;54(2):278-85. doi: 10.1161/HYPERTENSIONAHA.109.134361. Epub 2009 Jun 22.

    PubMed 19546374

  • Dawson EA, Green DJ, Cable NT, Thijssen DH. Effects of acute exercise on flow-mediated dilatation in healthy humans. J Appl Physiol (1985). 2013 Dec;115(11):1589-98. doi: 10.1152/japplphysiol.00450.2013. Epub 2013 Sep 12.

    PubMed 24030665

  • Iadecola C, Zhang F. Nitric oxide-dependent and -independent components of cerebrovasodilation elicited by hypercapnia. Am J Physiol. 1994 Feb;266(2 Pt 2):R546-52. doi: 10.1152/ajpregu.1994.266.2.R546.

    PubMed 7511352

  • Molina C, Sabin JA, Montaner J, Rovira A, Abilleira S, Codina A. Impaired cerebrovascular reactivity as a risk marker for first-ever lacunar infarction: A case-control study. Stroke. 1999 Nov;30(11):2296-301. doi: 10.1161/01.str.30.11.2296.

    PubMed 10548661

  • Buratti L, Viticchi G, Falsetti L, Balucani C, Altamura C, Petrelli C, Provinciali L, Vernieri F, Silvestrini M. Thresholds of impaired cerebral hemodynamics that predict short-term cognitive decline in asymptomatic carotid stenosis. J Cereb Blood Flow Metab. 2016 Oct;36(10):1804-1812. doi: 10.1177/0271678X15613526. Epub 2015 Oct 27.

    PubMed 26661219

Questions about this trial

What is this clinical trial studying?

A study testing Aerobic Exercise in people with Healthy and Physical Activity, run by University of Wisconsin, Madison at 1 site in United States.

The full registered description is in the About this study section and the official record.

Who may be eligible to take part?

The sponsor lists 4 inclusion and 5 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.

Is this clinical trial currently recruiting?

The record says: finished, as of the sponsor's last update on 2 Oct 2024. Status can change between updates, so confirm with the study contact before making plans.

Where is the study taking place?

The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.

What are the possible benefits and risks?

They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.

Are results available for this study?

The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.

How can a doctor refer a patient or contact the research team?

The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.

What does the primary outcome measure?

Cerebrovascular function (time frame: Change in cerebrovascular function: measurements occur at baseline and 90 minutes post aerobic exercise to quantify magnitude of change.). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.

Where can I read the original study information?

On the ClinicalTrials.gov record for NCT03722953, which also lists 25 linked publications.

Does a listing mean the treatment is approved or proven to work?

No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.

How often is this information updated?

AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 2 Oct 2024; AzTrials last refreshed its copy on 28 Oct 2026.

AzTrials uses cookies for analytics and advertising. You can accept or reject them; the site works either way. Privacy Policy.

Free account

Keep searching with a free account

You’ve used your 3 free searches for this session. Log in or create a free AzTrials account to keep searching clinical trials and save the ones you want to follow.

Create a free accountLog in