HealthyNCT03723733
Compensatory Brain Mechanisms for Amygdala-associated Cognitive Dysfunction: Potential Role of the Cortical Mirror Neuron System
An observational study of Healthy, run by University of Electronic Science and Technology of China at 1 site in China.
Trial summary
Identify if the mirror neuron system, or other networks, can compensate for amygdala dysfunction, using behavior and structural/functional MRI. Read more about this study
- Who is it for?
- Ages 17 to 30 yearsHealthy volunteers can take part
- Conditions the study is for
- Healthy
- What is being tested?
- screen high and low triat subjects
- Type of treatment
- Lifestyle or therapy programme
- How many people
- 350 participants
- Where
- 1 siteChina
- Study dates
- Jul 2016to Dec 2019
- Phase
- Observational
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 17 to 30 years
- All sexes
- Healthy volunteers accepted
- Child, Adult
Study population: sutduents from University of Electronic Science and Technology of China
Who may be able to join
- Healthy subjects
Who cannot join
- history of head injury
- claustrophobia;
- medical or psychiatric illness
- female subjects were pregnant or taking oral contraceptives.
- taking any form of medication and drunk any caffeine-containing beverages on the day of the experiment.
Trial locations and contacts
1 site in 1 country.
Keith Kendrick, Dr. contact
China1 site, 1 recruiting
- Recruiting
China, Sichuan
Chengdu, Sichuan, 611731
Lei Xu, gracetsui.uestc@outlook.com
About this study
Identify if the mirror neuron system, or other networks, can compensate for amygdala dysfunction, using behavior and structural/functional MRI.
Read the detailed description
In the present study, investigators aim to investigate amygdala dysfunction \& potential compensation in individuals with high and low traits (e.g. Autism, Anxiety, Depression traits, Alexithymia), high and low stress or protective factors in the environment (social network, early life stress) and different molecular genetic make-up. On the neural level, functional and structural connectivity as well as task-related BOLD activation will be assessed.
- Conditions
- Healthy
- Being tested
- screen high and low triat subjects
- Keywords
- amygdala, mirror neuron system, brain network
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
screen high and low triat subjectsBehavioural
use a range of questionniares to screen screen high and low triat subjects (eg. Autism, Anxiety, Depression traits and social network size)
What is being measured
The primary outcome is the main question the study is designed to answer.
brain activity and connectivity during social and cognitive tasks
brain activity and connectivity was measured by the fMRI scanner
Measured: 2 hours
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted29 Oct 2018
- Study startJul 2016
- Primary completionSep 2019 (estimated)
- Study completionDec 2019 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for HealthyStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Cross-sectional
- Enrolment
- 350 participants (estimated)
Sponsor and investigators
- Lead sponsor
- University of Electronic Science and Technology of China
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Keith Kendrick, University of Electronic Science and Technology of China
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT03723733
- Sponsor's protocol ID
- UESTC-neuSCAN-28
- Status last verified
- Oct 2018
- First submitted
- 26 Oct 2018
- Last updated
- 29 Oct 2018
- Results posted
- No
Study at a glance
From the registry record, last updated by the sponsor on 29 Oct 2018. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Compensatory Brain Mechanisms for Amygdala-associated Cognitive Dysfunction: Potential Role of the Cortical Mirror Neuron System
- ClinicalTrials.gov ID
- NCT03723733
- Acronym / sponsor ID
- UESTC-neuSCAN-28
- Conditions
- Healthy
- Keywords
- amygdala, mirror neuron system, brain network
- Study type
- Observational
- Recruitment status
- Unknown status
- Enrolment
- 350 participants (estimated)
- Lead sponsor
- University of Electronic Science and Technology of ChinaUniversity, hospital or other
- Study start
- Jul 2016 (actual)
- Primary completion
- Sep 2019 (estimated)
- Study completion
- Dec 2019 (estimated)
- First posted
- 29 Oct 2018 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Identify if the mirror neuron system, or other networks, can compensate for amygdala dysfunction, using behavior and structural/functional MRI.
Detailed description
In the present study, investigators aim to investigate amygdala dysfunction \& potential compensation in individuals with high and low traits (e.g. Autism, Anxiety, Depression traits, Alexithymia), high and low stress or protective factors in the environment (social network, early life stress) and different molecular genetic make-up. On the neural level, functional and structural connectivity as well as task-related BOLD activation will be assessed.
Study design
- Observational model
- Cohort
- Time perspective
- Cross-sectional
Who may qualify
- Ages
- 17 to 30 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Child, Adult
- Study population
- sutduents from University of Electronic Science and Technology of China
Key inclusion criteria (1 listed)
- Healthy subjects
Key exclusion criteria (5 listed)
- history of head injury
- claustrophobia;
- medical or psychiatric illness
- female subjects were pregnant or taking oral contraceptives.
- taking any form of medication and drunk any caffeine-containing beverages on the day of the experiment.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| screen high and low triat subjectsuse a range of questionniares to screen screen high and low triat subjects (eg. Autism, Anxiety, Depression traits and social network size) | Behavioural | – |
Primary outcome
brain activity and connectivity during social and cognitive tasks
Time frame: 2 hours
brain activity and connectivity was measured by the fMRI scanner
Results and safety
Results are not available in the source record.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 29 Oct 2018.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Keith Kendrick, Dr. contact
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Healthy, run by University of Electronic Science and Technology of China at 1 site in China.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 1 inclusion and 5 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: status not confirmed, as of the sponsor's last update on 29 Oct 2018. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in China. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
Results are not available in the source record.
How can a doctor refer a patient or contact the research team?
Contact Keith Kendrick, Dr. (k.kendrick.uestc@gmail.com), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
brain activity and connectivity during social and cognitive tasks (time frame: 2 hours). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 29 Oct 2018.