Rh Negative Blood DonorNCT03741413
The Effect of Message Framing on Blood Donation-Study 1
A study testing Gain-frame SMS and Loss-frame SMS in people with Rh Negative Blood Donor, run by Guangzhou Blood Center at 1 site in China.
Trial summary
Rh negative blood group is a rare blood group in China, as it only accounts for 0.3-0.4 percent of the Han population. Therefore, low inventory is often found in blood collection and supply agencies in many regions in China. Read more about this study
- Who is it for?
- Ages 18 to 60 years
- Conditions the study is for
- Rh Negative Blood Donor
- What is being tested?
- Gain-frame SMS and Loss-frame SMS
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 2,074 participants
- Where
- 1 siteChina
- Study dates
- 18 Jul 2018to 18 Oct 2018
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 60 years
- All sexes
- No healthy volunteers
- Adult
Who may be able to join
- Rh- negative blood donors whose last donations were between January 1, 2015 and December 31, 2017.
Who cannot join
- Donors with an obviously invalid phone number. Donors whose serological results of the last donation were positive.
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Saving a Life or Preventing a Death: the Effect of Message Framing on Blood Donation Among Rh Negative Donors
Rh negative blood group is a rare blood group in China, as it only accounts for 0.3-0.4 percent of the Han population. Therefore, low inventory is often found in blood collection and supply agencies in many regions in China. On July 18, 2018 blood stockpile of O-negative and B-negative in Guangzhou Blood Center reached the warning line, and we took measures for emergency recruitment. O-negative and B-negative blood donors whose last donation dates were between January 1, 2015 and December 31, 2017 were identified and randomly assigned to three groups. Three different recruitment text messages were send to these groups respectively. At the same time, A-negative and AB-negative blood donors were marked as control group. We observed the re-donation rates among four groups within three months.
- Conditions
- Rh Negative Blood Donor
- Being tested
- Gain-frame SMS, Loss-frame SMS, Control SMS
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Gain-frame SMSOther
Emergency recruitment cell phone short messages that emphasizing donating blood can save patients' lives were sent to donors in this group.
Loss-frame SMSOther
Emergency recruitment cell phone short messages emphasizing that donating blood can prevent patients from death were sent to donors in this group.
Control SMSOther
Emergency recruitment cell phone short messages that only mentioning the low Rh-negative blood stockpile were sent to donors in this group.
| Study group | Role | What they receive |
|---|---|---|
| Gain-frame SMS | Experimental | SMS messages "Dear Rh negative blood donors: Hello! As the Rh negative O/B blood stockpile is low now, but patients who are this blood type are in urgent need. If you are available, we hope that you can offer a helping hand to save their lives. Thank you for your support." were send to donors in this group. Receives: Other: Gain-frame SMS |
| Loss-frame SMS | Experimental | SMS messages "Dear Rh negative blood donors: Hello! As the Rh negative O/B blood stockpile is low now, but patients who are this blood type are in urgent need. If you are available, we hope that you can offer a helping hand to prevent them from death. Thank you for your support." were send to donors in this group. Receives: Other: Loss-frame SMS |
| Control SMS | Experimental | SMS messages "Dear Rh negative blood donors: Hello! As the Rh negative O/B blood stockpile is low now, but patients who are this blood type are in urgent need. If you are available, we hope that you can donate blood again. Thank you for your support." were send to donors in this group. Receives: Other: Control SMS |
| Control group | No intervention | Donors in this group were not received SMS reminders. |
What is being measured
The primary outcome is the main question the study is designed to answer.
Re-donation rate
Intention-to-treat were applied. Re-donation rate was defined as the number of donors in each group devided by donors who re-donated within 3 months.
Measured: 3 months
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted14 Nov 2018
- Study start18 Jul 2018
- Primary completion18 Oct 2018
- Study completion18 Oct 2018
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Rh Negative Blood DonorStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Health services research
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Enrolment
- 2,074 participants (actual)
Sponsor and investigators
- Lead sponsor
- Guangzhou Blood Center
- Sponsor type
- Other government
- Responsible party
- Principal investigator, OUYANG Jian, Guangzhou Blood Center
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT03741413
- Sponsor's protocol ID
- Message framing effect
- Status last verified
- May 2020
- First submitted
- 11 Nov 2018
- Last updated
- 5 May 2020
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 5 May 2020. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Saving a Life or Preventing a Death: the Effect of Message Framing on Blood Donation Among Rh Negative Donors
- ClinicalTrials.gov ID
- NCT03741413
- Acronym / sponsor ID
- Message framing effect
- Conditions
- Rh Negative Blood Donor
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 2,074 participants (actual)
- Lead sponsor
- Guangzhou Blood CenterOther government
- Study start
- 18 Jul 2018 (actual)
- Primary completion
- 18 Oct 2018 (actual)
- Study completion
- 18 Oct 2018 (actual)
- First posted
- 14 Nov 2018 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Rh negative blood group is a rare blood group in China, as it only accounts for 0.3-0.4 percent of the Han population. Therefore, low inventory is often found in blood collection and supply agencies in many regions in China. On July 18, 2018 blood stockpile of O-negative and B-negative in Guangzhou Blood Center reached the warning line, and we took measures for emergency recruitment. O-negative and B-negative blood donors whose last donation dates were between January 1, 2015 and December 31, 2017 were identified and randomly assigned to three groups. Three different recruitment text messages were send to these groups respectively. At the same time, A-negative and AB-negative blood donors were marked as control group. We observed the re-donation rates among four groups within three months.
Study design
- Primary purpose
- Health services research
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 4
| Arm | Type | Receives |
|---|---|---|
| Gain-frame SMS | Experimental | Other: Gain-frame SMSSMS messages "Dear Rh negative blood donors: Hello! As the Rh negative O/B blood stockpile is low now, but patients who are this blood type are in urgent need. If you are available, we hope that you can offer a helping hand to save their lives. Thank you for your support." were send to donors in this group. |
| Loss-frame SMS | Experimental | Other: Loss-frame SMSSMS messages "Dear Rh negative blood donors: Hello! As the Rh negative O/B blood stockpile is low now, but patients who are this blood type are in urgent need. If you are available, we hope that you can offer a helping hand to prevent them from death. Thank you for your support." were send to donors in this group. |
| Control SMS | Experimental | Other: Control SMSSMS messages "Dear Rh negative blood donors: Hello! As the Rh negative O/B blood stockpile is low now, but patients who are this blood type are in urgent need. If you are available, we hope that you can donate blood again. Thank you for your support." were send to donors in this group. |
| Control group | No intervention | –Donors in this group were not received SMS reminders. |
Who may qualify
- Ages
- 18 to 60 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult
Key inclusion criteria (1 listed)
- Rh- negative blood donors whose last donations were between January 1, 2015 and December 31, 2017.
Key exclusion criteria (1 listed)
- Donors with an obviously invalid phone number. Donors whose serological results of the last donation were positive.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Gain-frame SMSEmergency recruitment cell phone short messages that emphasizing donating blood can save patients' lives were sent to donors in this group. | Other | Gain-frame SMS |
| Loss-frame SMSEmergency recruitment cell phone short messages emphasizing that donating blood can prevent patients from death were sent to donors in this group. | Other | Loss-frame SMS |
| Control SMSEmergency recruitment cell phone short messages that only mentioning the low Rh-negative blood stockpile were sent to donors in this group. | Other | Control SMS |
Primary outcome
Re-donation rate
Time frame: 3 months
Intention-to-treat were applied. Re-donation rate was defined as the number of donors in each group devided by donors who re-donated within 3 months.
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 5 May 2020.
- Individual participant dataSharing planned: No
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Gain-frame SMS and Loss-frame SMS in people with Rh Negative Blood Donor, run by Guangzhou Blood Center at 1 site in China.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 1 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 5 May 2020. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in China. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Re-donation rate (time frame: 3 months). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 5 May 2020.