Patient With Ascending Aortic Aneurysm With Surgical Indication for ReplacementMECATHORNCT03746964
Prospective Evaluation of the Biomechanical Properties of the Thoracic Aorta Coupling Magnetic Resonance Imaging and In-vitro Elasticity Tests in Patients With Ascending Aortic Aneurysm
An observational study of Patient With Ascending Aortic Aneurysm With Surgical Indication for Replacement, run by Centre Hospitalier Universitaire Dijon at 1 site in France.
Trial summary
The biomechanical properties of the aorta are currently poorly understood. A better understanding would optimize surgical indications and monitoring techniques for patients with thoracic aortic aneurysms. Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Patient With Ascending Aortic Aneurysm With Surgical Indication for Replacement
- What is being tested?
- Cardiac MRI and in-vitro elasticity tests
- Type of treatment
- Surgery or procedure
- How many people
- 200 participants
- Where
- 1 siteFrance
- Study dates
- 17 Dec 2018to Feb 2027
- Phase
- Observational
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Study population: Patient in preoperative consultation in the cardiovascular and thoracic surgery department.
Who may be able to join
- Person who has given oral consent
- Patient with ascending aortic aneurysm with surgical indication for replacement
- Age > 18 years old
- Scheduled surgery
Who cannot join
- Person not affiliated to the national health insurance system
- Protected adult
- Pregnant or breastfeeding woman
- MRI Contraindication
- Emergency surgical procedure
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
France1 site, 1 recruiting
- Recruiting
Chu Dijon Bourogne
Dijon, 21000
Comlan BLITTI, +33 380293352, comlanmawuko.blitti@chu-dijon.fr
About this study
The biomechanical properties of the aorta are currently poorly understood. A better understanding would optimize surgical indications and monitoring techniques for patients with thoracic aortic aneurysms.
- Being tested
- Cardiac MRI, in-vitro elasticity tests
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Cardiac MRIProcedure or surgery
Preoperative cardiac MRI
in-vitro elasticity testsOther
in-vitro elasticity tests performed on a segment of ascending aorta collected during surgery
What is being measured
The primary outcome is the main question the study is designed to answer.
aortic compliance by cardiac MRI
Measured: Before surgery
In-vitro testing of the elasticity of the aortic wall fragment collected during surgery.
Measured: through study completion, an average of 12 months
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted20 Nov 2018
- Study start17 Dec 2018
- Primary completionDec 2026 (estimated)
- Study completionFeb 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Patient With Ascending Aortic Aneurysm With Surgical Indication for ReplacementStudies of the same condition, open and under way.
- More trials run by Centre Hospitalier Universitaire DijonThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Prospective
- Enrolment
- 200 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Centre Hospitalier Universitaire Dijon
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT03746964
- Sponsor's protocol ID
- MORGANT 2018 MECATHOR
- Acronym
- MECATHOR
- Status last verified
- Jan 2026
- First submitted
- 16 Nov 2018
- Last updated
- 9 Jan 2026
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 9 Jan 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Prospective Evaluation of the Biomechanical Properties of the Thoracic Aorta Coupling Magnetic Resonance Imaging and In-vitro Elasticity Tests in Patients With Ascending Aortic Aneurysm
- ClinicalTrials.gov ID
- NCT03746964
- Acronym / sponsor ID
- MECATHOR / MORGANT 2018 MECATHOR
- Study type
- Observational
- Recruitment status
- Recruiting
- Enrolment
- 200 participants (estimated)
- Lead sponsor
- Centre Hospitalier Universitaire DijonUniversity, hospital or other
- Study start
- 17 Dec 2018 (actual)
- Primary completion
- Dec 2026 (estimated)
- Study completion
- Feb 2027 (estimated)
- First posted
- 20 Nov 2018 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The biomechanical properties of the aorta are currently poorly understood. A better understanding would optimize surgical indications and monitoring techniques for patients with thoracic aortic aneurysms.
Study design
- Observational model
- Cohort
- Time perspective
- Prospective
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
- Study population
- Patient in preoperative consultation in the cardiovascular and thoracic surgery department.
Key inclusion criteria (4 listed)
- Person who has given oral consent
- Patient with ascending aortic aneurysm with surgical indication for replacement
- Age > 18 years old
- Scheduled surgery
Key exclusion criteria (5 listed)
- Person not affiliated to the national health insurance system
- Protected adult
- Pregnant or breastfeeding woman
- MRI Contraindication
- Emergency surgical procedure
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Cardiac MRIPreoperative cardiac MRI | Procedure or surgery | – |
| in-vitro elasticity testsin-vitro elasticity tests performed on a segment of ascending aorta collected during surgery | Other | – |
Primary outcome
aortic compliance by cardiac MRI
Time frame: Before surgery
In-vitro testing of the elasticity of the aortic wall fragment collected during surgery.
Time frame: through study completion, an average of 12 months
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 9 Jan 2026.
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Patient With Ascending Aortic Aneurysm With Surgical Indication for Replacement, run by Centre Hospitalier Universitaire Dijon at 1 site in France.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 5 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 9 Jan 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in France. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Comlan BLITTI (+33 3 80 29 33 52, comlanmawuko.blitti@chu-dijon.fr), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
aortic compliance by cardiac MRI (time frame: Before surgery). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 9 Jan 2026.