ResuscitationNCT03759210
Outcome After Out of Hospital Cardiac Arrest in Bern, Switzerland
An observational study of Resuscitation and Outcome, Fatal, run by Insel Gruppe AG, University Hospital Bern at 1 site in Switzerland.
Trial summary
Sudden cardiac arrests is one of the most frequent causes of death. In Switzerland every year 8000-10.000 people suffer from a cardiac arrest. The EuReCa ONE Study showed regional differences in incidence and chances of survival after cardiac arrests in Europe. Read more about this study
- Who is it for?
- Any ageHealthy volunteers can take part
- Conditions the study is for
- Resuscitation, Outcome, Fatal, Out-Of-Hospital Cardiac Arrest
- How many people
- 1,000 participants
- Where
- 1 siteSwitzerland
- Study dates
- 15 Dec 2018to 1 Jun 2024
- Phase
- Observational
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages Any age
- All sexes
- Healthy volunteers accepted
- Child, Adult, Older adult
Study population: All OHCA cases in the region of Bern, Switzerland in the year 2015-2017
Who may be able to join
- All OHCA in the region of Bern, Switzerland in the year 2015-2017
Who cannot join
- if patient has previously declined to be included in a study (advance directive)
Trial locations and contacts
1 site in 1 country.
Switzerland1 site, 1 recruiting
- Recruiting
Department of Anaesthesiology and Pain Medicine
Bern
Sabine Nabecker
About this study
Sudden cardiac arrests is one of the most frequent causes of death. In Switzerland every year 8000-10.000 people suffer from a cardiac arrest. The EuReCa ONE Study showed regional differences in incidence and chances of survival after cardiac arrests in Europe. The current European Resuscitation Council (ERC) resuscitation guidelines 2015 recommend extracorporeal membrane oxygenation (ECMO) as treatment option for therapy refractory out-of-hospital cardiac arrests (OHCA). ECMO used under cardiopulmonary resuscitation (CPR) is called eCPR (extracorporeal CPR). In the year 2018 eCPR is started to be used in Bern, Switzerland. This study investigates retrospectively the survival and neurologic outcome of patients after OHCA in the region of Bern, Switzerland from 2015-2018. The data will be used as baseline for a prospective evaluation of eCPR cases.
The prospective Evaluation of e CPR will last from 2018 - 2022.
- Medical subject headings
- Out-of-Hospital Cardiac Arrest
What is being measured
The primary outcome is the main question the study is designed to answer.
Neurologic Outcome after 30 days
CPC 1 - 5 (Cerebral Performance Category Scale)
Measured: 30 days after OHCA
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted29 Nov 2018
- Study start15 Dec 2018
- Primary completion30 Dec 2023 (estimated)
- Study completion1 Jun 2024 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for ResuscitationStudies of the same condition, open and under way.
- More trials run by Insel Gruppe AG, University Hospital BernThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Prospective
- Enrolment
- 1,000 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Insel Gruppe AG, University Hospital Bern
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
- Investigators
- Robert Greif, Prof., M.D., Study chair, University Hospital Bern, Bern, SwitzerlandSabine Nabecker, M.D., Principal investigator, University Hospital Bern, Bern, Switzerland
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT03759210
- Sponsor's protocol ID
- 2018-01488
- Other IDs
- 2018
- Status last verified
- Jul 2023
- First submitted
- 28 Nov 2018
- Last updated
- 19 Jul 2023
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Publications
Ebert F, Abt M, Fehr T, Seidl K, Huber M, Ludwig R, Iten M, Greif R, Nabecker S, Fuchs A. Long-term neurological outcome following out-of-hospital cardiac arrest in Switzerland: a single-centre observational study. Front Med (Lausanne). 2026 Jan 2;12:1716369. doi: 10.3389/fmed.2025.1716369. eCollection 2025.
PubMed 41551516
Study at a glance
From the registry record, last updated by the sponsor on 19 Jul 2023. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Outcome After Out of Hospital Cardiac Arrest in Bern, Switzerland
- ClinicalTrials.gov ID
- NCT03759210
- Acronym / sponsor ID
- 2018-01488
- Study type
- Observational
- Recruitment status
- Unknown status
- Enrolment
- 1,000 participants (estimated)
- Lead sponsor
- Insel Gruppe AG, University Hospital BernUniversity, hospital or other
- Study start
- 15 Dec 2018 (actual)
- Primary completion
- 30 Dec 2023 (estimated)
- Study completion
- 1 Jun 2024 (estimated)
- First posted
- 29 Nov 2018 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Sudden cardiac arrests is one of the most frequent causes of death. In Switzerland every year 8000-10.000 people suffer from a cardiac arrest. The EuReCa ONE Study showed regional differences in incidence and chances of survival after cardiac arrests in Europe. The current European Resuscitation Council (ERC) resuscitation guidelines 2015 recommend extracorporeal membrane oxygenation (ECMO) as treatment option for therapy refractory out-of-hospital cardiac arrests (OHCA). ECMO used under cardiopulmonary resuscitation (CPR) is called eCPR (extracorporeal CPR). In the year 2018 eCPR is started to be used in Bern, Switzerland. This study investigates retrospectively the survival and neurologic outcome of patients after OHCA in the region of Bern, Switzerland from 2015-2018. The data will be used as baseline for a prospective evaluation of eCPR cases.
The prospective Evaluation of e CPR will last from 2018 - 2022.
Study design
- Observational model
- Cohort
- Time perspective
- Prospective
Who may qualify
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Child, Adult, Older adult
- Study population
- All OHCA cases in the region of Bern, Switzerland in the year 2015-2017
Key inclusion criteria (1 listed)
- All OHCA in the region of Bern, Switzerland in the year 2015-2017
Key exclusion criteria (1 listed)
- if patient has previously declined to be included in a study (advance directive)
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Primary outcome
Neurologic Outcome after 30 days
Time frame: 30 days after OHCA
CPC 1 - 5 (Cerebral Performance Category Scale)
Results and safety
Results are not available in the source record.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 19 Jul 2023.
- Derived from this study: PubMed 41551516Ebert F, Abt M, Fehr T, Seidl K, Huber M, Ludwig R, Iten M, Greif R, Nabecker S, Fuchs A. Long-term neurological outcome following out-of-hospital cardiac arrest in Switzerland: a single-centre observational study. Front Med (Lausanne). 2026 Jan 2;12:1716369. doi: 10.3389/fmed.2025.1716369. eCollection 2025.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Robert Greif, Prof., M.D. study chair
University Hospital Bern, Bern, Switzerland
Sabine Nabecker, M.D. principal investigator
University Hospital Bern, Bern, Switzerland
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Resuscitation and Outcome, Fatal, run by Insel Gruppe AG, University Hospital Bern at 1 site in Switzerland.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 1 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: status not confirmed, as of the sponsor's last update on 19 Jul 2023. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Switzerland. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
Results are not available in the source record.
How can a doctor refer a patient or contact the research team?
Contact Sabine Nabecker, M.D. (+41 31 632 39 65, sabine.nabecker@insel.ch), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Neurologic Outcome after 30 days (time frame: 30 days after OHCA). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT03759210, which also lists 1 linked publication.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 19 Jul 2023.