Attempted SuicideHYPNOSNCT03793699
Evaluation of the Links Between Sleep Disorders and the Risk of Suicide Attempt
An observational study of Attempted Suicide, run by University Hospital, Lille at 1 site in France.
Trial summary
Several studies have demonstrated an association between sleep disorders such as insomnia and nightmares to suicidal ideations and behaviors. Nevertheless, some of these studies are methodologically questionable especially in the exploration of sleep disorders. Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Attempted Suicide
- How many people
- 24 participants
- Where
- 1 siteFrance
- Study dates
- 4 Feb 2019to 31 Dec 2022
- Phase
- Observational
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Study population: The population in the study is a population of adults having realized a suicide attempt and without histories of suicide attempt. She(it) will be compared with a population of adults having suicidal ideas without suicidal acting out and without histories of suicide attempt.
Who may be able to join
- Criterion specific to the studying group :
- Subjects hospitalized and whose indication of hospitalization is a suicide attempt by voluntary drug intoxication or phlebotomy during the last 72 hours, without any history of attempted suicide
- Criterion specific to the control group:
- Subjects hospitalized since less than 72 hours, and whose indication of hospitalization is the presence of suicidal ideas, without any history of attempted suicide
Who cannot join
- Pregnant of lactating women
- Diagnosed dementia pathology
- Proven intellectual disability
- Patient whose physical or mental state does not allow the passing of the tests of the study
- Under protective measures (guardianship/supervision)
- Refusal to participate in the study
- Diagnosed with chronic or severe psychiatric illness (psychotic disorder, bipolarity)
Trial locations and contacts
1 site in 1 country.
About this study
Several studies have demonstrated an association between sleep disorders such as insomnia and nightmares to suicidal ideations and behaviors.
Nevertheless, some of these studies are methodologically questionable especially in the exploration of sleep disorders. Furthermore, confounding factors such as depressive symptomatology are not controlled and the measurement of suicidal behavior has often been taken into account as a historical measure, not as a current event, which introduces uncertainties and a lack of precision regarding the temporality of the phenomena.
Read more
Today, while the links between sleep disorders and suicidal risk are well known, we have a lack of information on the importance and the role of sleep disorders as a precipitating factor. Indeed, few studies have evaluated the temporal link between sleep disorders and suicidal acts.
The objective of this study is to evaluate the links between acute and chronic sleep disorders and the risk of suicide attempt
Read the detailed description
Pilot, prospective, monocentric case-control study.
There are 2 groups of subjects :
- group of patients who have made a suicide attempt
- control group with only suicidal ideas
First visit V1 is performed within the first 72 hours of hospitalization. A re-assessment is scheduled 1 month after (V2).
At V1, collected parameters are : chronic sleep disorders, chronotype, specific sleep disorders in posttraumatic stress disorder, nightmares and the distress associated, childhood trauma, cognitive dysfunction, suicidal ideation and psychopathologic assessment.
At V2, we assess evolution of sleep disturbances and suicidal ideation.
- Conditions
- Attempted Suicide
- Keywords
- Suicide, Suicidal ideation, Sleep disorder
- Medical subject headings
- Suicide, Attempted, Suicide, Suicidal Ideation, Sleep Wake Disorders
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
| Study group | Role | What they receive |
|---|---|---|
| case group : realized a suicide attempt | adults having realized a suicide attempt and without histories of suicide attempt. | |
| control group : only suicidal ideas | adults having suicidal ideas without suicidal acting out and without histories of suicide attempt. |
What is being measured
The primary outcome is the main question the study is designed to answer.
Sleep disorders intensity by the Insomnia Severity Index (ISI)
ISI score in the last 2 weeks between a group of suicide attempts and a group with suicidal thoughts suicidal The Insomnia Severity Index has seven questions. The seven answers are added up to get a total score.
Measured: at the 48 hours after the hospitalization; at the maximum within 72 hours.
Secondary outcomes (6)
Correlation between Beck Suicide Intent Scale (BSIS) score and ISI score
Correlation between Beck Suicide Intent Scale (BSIS) score and ISI score The Suicide Intent Scale (SIS) wconsists of 15 questions which are scaled from 0-2, which take into account both the logistics of the suicide attempt as well as the intent. The scale has high reliability and validity. Completed suicides ranked higher in the severity of the logistics than attempted suicides (it was impossible to measure intent for the completed suicides), and those with multiple attempts had higher scores than those who only attempted suicide once
Measured: Baseline (visit inclusion) and at one month ago
Evolution of ISI score
Assess the evolution of sleep disturbances for each group by ISI Score
Measured: At one month +/- 15 days ant at 3 months +/-3 weeks
Chronotype classification by MCTQ
Exploratory descriptive measures in the 2 groups
Measured: at the 48 hours after the hospitalization; at the maximum within 72 hours;at 3 months +/-3 weeks
Pittsburg Sleep Quality Index (PSQI) score
PSQI score between the groups PSQI is a self-report questionnaire that assesses sleep quality over a 1-month time interval. The measure consists of 19 individual items, creating 7 components that produce one global score, and takes 5-10 minutes to complete.
Measured: at the 48 hours after the hospitalization; at the maximum within 72 hours,at 3 months +/-3 weeks
Childhood Trauma Questionnaire (CTQ) score
CTQ score between the groups The Childhood Trauma Questionnaire was developed as a screening tool for histories of abut and neglect. The self-report includes a 28-item test that measures 5 types of maltreatment - emotional, physical, and sexual abuse, and emotional and physical neglect.
Measured: at the 48 hours after the hospitalization; at the maximum within 72 hours.
Montréal Cognitive Assessment (MocA)
cognitive assessment by Moca test
Measured: at the 48 hours after the hospitalization; at the maximum within 72 hours.
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted4 Jan 2019
- Study start4 Feb 2019
- Primary completion31 Dec 2022
- Study completion31 Dec 2022
Why it stopped: sponsor decision COVID
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Attempted SuicideStudies of the same condition, open and under way.
- More trials run by University Hospital, LilleThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Case-control
- Time perspective
- Prospective
- Enrolment
- 24 participants (actual)
Sponsor and investigators
- Lead sponsor
- University Hospital, Lille
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
- Investigators
- Vincent JARDON, MD, Principal investigator, University Hospital, Lille
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT03793699
- Sponsor's protocol ID
- 2017_55
- Other IDs
- 2017-A03649-44
- Acronym
- HYPNOS
- Status last verified
- May 2026
- First submitted
- 16 Oct 2018
- Last updated
- 22 May 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 22 May 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Evaluation of the Links Between Sleep Disorders and the Risk of Suicide Attempt
- ClinicalTrials.gov ID
- NCT03793699
- Acronym / sponsor ID
- HYPNOS / 2017_55
- Conditions
- Attempted Suicide
- Keywords
- Suicide, Suicidal ideation, Sleep disorder
- Study type
- Observational
- Recruitment status
- TerminatedReason stopped: sponsor decision COVID
- Enrolment
- 24 participants (actual)
- Lead sponsor
- University Hospital, LilleUniversity, hospital or other
- Study start
- 4 Feb 2019 (actual)
- Primary completion
- 31 Dec 2022 (actual)
- Study completion
- 31 Dec 2022 (actual)
- First posted
- 4 Jan 2019 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Several studies have demonstrated an association between sleep disorders such as insomnia and nightmares to suicidal ideations and behaviors.
Nevertheless, some of these studies are methodologically questionable especially in the exploration of sleep disorders. Furthermore, confounding factors such as depressive symptomatology are not controlled and the measurement of suicidal behavior has often been taken into account as a historical measure, not as a current event, which introduces uncertainties and a lack of precision regarding the temporality of the phenomena.
Today, while the links between sleep disorders and suicidal risk are well known, we have a lack of information on the importance and the role of sleep disorders as a precipitating factor. Indeed, few studies have evaluated the temporal link between sleep disorders and suicidal acts.
The objective of this study is to evaluate the links between acute and chronic sleep disorders and the risk of suicide attempt
Detailed description
Pilot, prospective, monocentric case-control study.
There are 2 groups of subjects :
- group of patients who have made a suicide attempt
- control group with only suicidal ideas
First visit V1 is performed within the first 72 hours of hospitalization. A re-assessment is scheduled 1 month after (V2).
At V1, collected parameters are : chronic sleep disorders, chronotype, specific sleep disorders in posttraumatic stress disorder, nightmares and the distress associated, childhood trauma, cognitive dysfunction, suicidal ideation and psychopathologic assessment.
At V2, we assess evolution of sleep disturbances and suicidal ideation.
Study design
- Observational model
- Case-control
- Time perspective
- Prospective
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| case group : realized a suicide attempt | – | –adults having realized a suicide attempt and without histories of suicide attempt. |
| control group : only suicidal ideas | – | –adults having suicidal ideas without suicidal acting out and without histories of suicide attempt. |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
- Study population
- The population in the study is a population of adults having realized a suicide attempt and without histories of suicide attempt. She(it) will be compared with a population of adults having suicidal ideas without suicidal acting out and without histories of suicide attempt.
Key inclusion criteria (4 listed)
- Subjects hospitalized and whose indication of hospitalization is a suicide attempt by voluntary drug intoxication or phlebotomy during the last 72 hours, without any history of attempted suicide
- Subjects hospitalized since less than 72 hours, and whose indication of hospitalization is the presence of suicidal ideas, without any history of attempted suicide
Key exclusion criteria (7 listed)
- Pregnant of lactating women
- Diagnosed dementia pathology
- Proven intellectual disability
- Patient whose physical or mental state does not allow the passing of the tests of the study
- Under protective measures (guardianship/supervision)
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Primary outcome
Sleep disorders intensity by the Insomnia Severity Index (ISI)
Time frame: at the 48 hours after the hospitalization; at the maximum within 72 hours.
ISI score in the last 2 weeks between a group of suicide attempts and a group with suicidal thoughts suicidal The Insomnia Severity Index has seven questions. The seven answers are added up to get a total score.
6 secondary outcomes
Correlation between Beck Suicide Intent Scale (BSIS) score and ISI score
Time frame: Baseline (visit inclusion) and at one month ago
Evolution of ISI score
Time frame: At one month +/- 15 days ant at 3 months +/-3 weeks
Chronotype classification by MCTQ
Time frame: at the 48 hours after the hospitalization; at the maximum within 72 hours;at 3 months +/-3 weeks
Pittsburg Sleep Quality Index (PSQI) score
Time frame: at the 48 hours after the hospitalization; at the maximum within 72 hours,at 3 months +/-3 weeks
Childhood Trauma Questionnaire (CTQ) score
Time frame: at the 48 hours after the hospitalization; at the maximum within 72 hours.
Montréal Cognitive Assessment (MocA)
Time frame: at the 48 hours after the hospitalization; at the maximum within 72 hours.
Results and safety
The study was stopped early (reason given: sponsor decision COVID). Results are not available in the source record.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 22 May 2026.
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Suicide
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Vincent JARDON, MD principal investigator
University Hospital, Lille
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Attempted Suicide, run by University Hospital, Lille at 1 site in France.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 7 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: stopped early, as of the sponsor's last update on 22 May 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in France. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study was stopped early (reason given: sponsor decision COVID). Results are not available in the source record.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Sleep disorders intensity by the Insomnia Severity Index (ISI) (time frame: at the 48 hours after the hospitalization; at the maximum within 72 hours.). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 22 May 2026.