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Solid TumorPhase 1NCT03815682

RPTR-147 in Patients With Selected Solid Tumors and Lymphomas

A Phase 1 study testing Arm A: RPTR-147:1, Arm B: RPTR-147:1 and Pembrolizumab and Arm C: RPTR-147:2 in people with Solid Tumor and Lymphoma, run by Repertoire Immune Medicines at 7 sites in United States.

Terminated

Stopped early. The study ended before it was planned to and will not resume.

Official record
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Trial summary

The purpose of this study is to assess the safety and tolerability of escalating doses of RPTR-147 as a monotherapy and in combination with Pembrolizumab in patients with selected solid tumors and lymphomas. Read more about this study

Who is it for?
Ages 18 years and older
Conditions the study is for
Solid Tumor, Lymphoma
What is being tested?
Arm A: RPTR-147:1, Arm B: RPTR-147:1 and Pembrolizumab and Arm C: RPTR-147:2
Could I receive a placebo?
No, everyone receives an active treatment
How many people
23 participants
Where
7 sitesUnited States
Study dates
24 Oct 2018to 11 Oct 2022
Phase
Phase 1
Are there results?
None posted in the registry

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

  • Ages 18 years and older
  • All sexes
  • No healthy volunteers
  • Adult, Older adult

Who may be able to join

  • Patients eligible for inclusion in this study must meet all of the following criteria:
  • Be willing and able to provide written informed consent for the trial.
  • Written informed consent must be obtained prior to any study procedures.
  • Age ≥18 years (or ≥16 years at Dana Farber Cancer Institute).
  • Histologically- or cytologically-confirmed relapsed/refractory metastatic or locally-advanced solid tumor or lymphoma whose disease has progressed despite all appropriate curative or life-prolonging treatments, are intolerant to these therapies or have refused standard treatment.
  • Inclusion criteria: RPTR-147:1 (Arms A \& B) treatment groups
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  • Cohort enrollment may be limited to potentially immune-responsive tumor types meeting the above criterion during the first approximately 2 weeks of the enrollment period of each cohort due to their potential to respond to and activate RPTR-147:1:
  • NSCLC
  • Melanoma
  • Clear cell cancer of the kidney
  • HNSCC
  • Urothelial cancer
  • Lymphoma
  • Sarcomas
  • Ovarian Cancer
  • Based upon emerging data that will be discussed during the Safety Review Committee meetings, the patient population may be further limited based other factors
  • Inclusion criteria: RPTR-147:2 (Arm C) treatment group Patients with cancers known to be HPV-16 positive.
  • Patient must have documented HLA-typing results that meet the study requirements. The list of eligible HLA alleles will be updated on an ongoing basis by the Sponsor.
  • Once sufficient data has been collected for drug product analytics, or sufficient HLA coverage is obtained, the HLA-type eligibility requirement may be discontinued by the Sponsor.
  • For patients with solid tumors, use Response Evaluation Criteria in Solid Tumor (RECIST) v1.1: measurable disease (at least one measurable non-nodal lesion of at least 1.0 cm in longest diameter or nodal lesion of at least 1.5 cm in shortest diameter) documented within 10 weeks of their projected C1D1 visit.
  • For patients with lymphoma, use the Lugano classification: measurable disease defined as at least one lesion that can be accurately measured in at least two dimensions with spiral computed tomography (CT) scan documented within 10 weeks of their projected C1D1 visit. Minimum measurement must be >15 mm in the longest diameter.
  • NOTE: If there are no pre-existing radiologic assessments within 10 weeks of the projected C1D1 visit, other evidence of measurable disease may be considered sufficient to fulfill this criterion following documented discussion and approval from the Sponsor.
  • NOTE: Please note, for dosing/Screening Period 2, patients must have a radiological assessment per mRECIST v1.1 (solid tumor) or Lugano classification (lymphomas) within 28 days before receiving treatment with RPTR-147 to serve as the patient's baseline tumor assessment.
  • Eastern Cooperative Oncology Group (ECOG) Performance Status ≤1.
  • Have provided archival tumor tissue sample or newly obtained core or excisional biopsy, during screening period 2, of a tumor lesion not previously irradiated. Formalin-fixed, paraffin embedded (FFPE) tissue blocks are preferred to slides. Newly obtained biopsies are preferred to archived tissue. Further details can be found in the Laboratory Manual.
  • Note: If submitting unstained cut slides, newly cut slides should be submitted to the testing laboratory within 14 days from the date slides are cut.
  • RPTR-147:1 in combination with pembrolizumab (Arm B only) - Patients should have malignancies for which the response rate to anti-PD1/PDL1 monotherapy is <20% or, if they have malignancies for which anti-PD1/PDL1 are standard of care must have progressed on treatment with an anti-PD1/L1 monoclonal antibody (mAb) administered either as monotherapy, or in combination with other checkpoint inhibitors or other therapies. PD-1 treatment progression is defined by meeting all of the following criteria:
  • Has received at least 2 doses of an approved anti-PD-1/L1 mAb.
  • Has demonstrated disease progression (PD) after PD-1/L1 as defined by RECIST v1.1. The initial evidence of PD is to be confirmed by a second assessment no less than four weeks from the date of the first documented PD, in the absence of rapid clinical progression.
  • Progressive disease has been documented as per the following within 12 weeks from the last dose of anti-PD-1/L1 mAb.
  • A female participant is eligible to participate if she is not pregnant, not breastfeeding, and at least one of the following conditions applies:
  • Not a woman of childbearing potential (WOCBP)
  • A WOCBP who agrees to follow contraceptive guidance during the treatment period and for at least 120 days after the last dose of study treatment.
  • A male participant must agree to use contraception during the treatment period and for at least 165 days after the last dose of study treatment.

Who cannot join

  • Patients eligible for this study must not meet any of the following criteria:
  • Previously identified hypersensitivity to components of RPTR-147 or excipients.
  • Pembrolizumab combination Arm B only - Has severe hypersensitivity (≥Grade 3) to pembrolizumab and/or any of its excipients.
  • Patients with T-cell lymphomas or small lymphocytic lymphoma.
  • Presence of active central nervous system (CNS) disease and/or carcinomatous meningitis. Participants with previously treated brain metastases may participate provided they are radiologically stable, i.e., without evidence of progression for at least 4 weeks by repeat imaging (note that the repeat imaging should be performed during study screening), clinically stable, and without requirement of steroid treatment for at least 14 days prior to first dose of study treatment.
  • Has received prior radiotherapy within 2 weeks of start of study treatment. Participants must have recovered from all radiation-related toxicities, not require corticosteroids, and not have had radiation pneumonitis. A 1-week washout is permitted for palliative radiation (≤2 weeks of radiotherapy) to non-CNS disease. For any interim radiotherapy received after the baseline tumor assessment, the target lesions must not be irradiated.
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  • Patient having out of range laboratory values defined as:
  • Creatinine clearance (calculated using Cockcroft-Gault formula, or measured) <40 mL/min
  • Total bilirubin >1.5 x upper limit of normal (ULN), except for patients with Gilbert's syndrome who are excluded if total bilirubin >3.0 x ULN or direct bilirubin >1.5 x ULN
  • Alanine aminotransferase (ALT) and Aspartate aminotransferase (AST) >3 x ULN, except for patients that have tumor involvement of the liver, who are excluded if ALT >5 x ULN
  • Absolute neutrophil count ≤1.0 x 109/L
  • ≥0.5 x 109/L and increasing following prior myelosuppressive treatment will be eligible
  • Screening Period 1 Only: Absolute lymphocyte count ≤1.0 x 109/L for solid tumor patients or ≤7.0 x 108/L for lymphoma patients prior to the apheresis procedure.
  • Platelet count ≤75 x 109/L absent platelet transfusion for 2 weeks
  • Hemoglobin (Hgb) ≤9 g/dL absent RBC transfusion for 2 weeks
  • ≥8 g/dL and increasing following prior myelosuppressive treatment will be eligible
  • Coagulation (prothrombin time [PT] or international normalized ratio [INR] and partial thromboplastin time [PTT] or activated partial thromboplastin time [aPTT])
  • >1.5 × ULN unless participant is receiving anticoagulant therapy as long as PT/INR and PTT/aPTT is within therapeutic range of intended use of anticoagulants
  • Potassium, magnesium, calcium or phosphate abnormality > CTCAE v5.0 Grade 1 despite appropriate oral replacement therapy
  • Screening Period 1 Only: Serum triglycerides >500 mg/dL due to potential interference with cell separation methods
  • Impaired cardiac function or clinically significant cardiac disease, including any of the following:
  • Clinically significant and/or uncontrolled heart disease such as congestive heart failure requiring treatment (New York Heart Association [NYHA] Grade ≥2), uncontrolled hypertension, or clinically significant arrhythmia
  • Acute myocardial infarction or unstable angina pectoris <6 months prior to study entry
  • Patients with active, known or suspected autoimmune disease that has required systemic treatment in the past 2 years (i.e., with use of disease modifying agents, corticosteroids, or immunosuppressive drugs).
  • Replacement therapy (e.g., thyroxine, insulin, or physiologic corticosteroid replacement therapy for adrenal or pituitary insufficiency) is not considered a form of systemic treatment and is allowed.
  • Patients with vitiligo, type 1 diabetes mellitus, residual hypothyroidism due to autoimmune condition only requiring hormone replacement, psoriasis not requiring systemic treatment, or conditions not expected to recur in the absence of an external trigger are permitted to enroll.
  • Has a history of (non-infectious) pneumonitis that required steroids or has current pneumonitis.
  • Has a diagnosis of immunodeficiency or is receiving chronic systemic steroid therapy (in dosing exceeding 10 mg daily of prednisone equivalent) or any other form of immunosuppressive therapy within 7 days prior to the first dose of study drug.
  • Has a known additional malignancy that is progressing or has required active treatment within the past 3 years.
  • Note: Participants with basal cell carcinoma of the skin, squamous cell carcinoma of the skin, or carcinoma in situ (e.g., breast carcinoma, cervical cancer in situ) that have undergone potentially curative therapy are not excluded.
  • Has a known history of human immunodeficiency virus (HIV) infection. No HIV testing is required unless mandated by local health authority.
  • Has a known history of Hepatitis B (defined as Hepatitis B surface antigen [HBsAg] reactive) or known active Hepatitis C virus (defined as HCV RNA [qualitative] is detected) infection.
  • Note: No testing for Hepatitis B and Hepatitis C is required unless mandated by local health authority.
  • Malignant disease, other than that being treated in this study expected to interfere with the assessment of efficacy in the opinion of the investigator.
  • Active infection requiring systemic therapy.
  • Patients requiring chronic treatment with systemic steroid therapy, other than replacement dose steroids in the setting of adrenal insufficiency. Topical, inhaled, nasal, or ophthalmic steroids are allowed.
  • Patients receiving systemic treatment with any immunosuppressive medication.
  • Use of any live vaccines against infectious diseases within 30 days of initiation of study treatment. Examples of live vaccines include, but are not limited to, the following: measles, mumps, rubella, varicella/zoster (chicken pox), yellow fever, rabies, Bacillus Calmette-Guérin (BCG), and typhoid vaccine. Seasonal influenza vaccines for injection are generally killed virus vaccines and are allowed; however, intranasal influenza vaccines (e.g., FluMist®) are live attenuated vaccines and are not allowed.
  • Major surgery within 4 weeks of the first dose of study treatment (mediastinoscopy, insertion of a central venous access device, and insertion of a feeding tube are not considered major surgery).
  • Note: If participant received major surgery, they must have recovered adequately from the toxicity and/or complications from the intervention prior to starting study treatment.
  • Is currently participating in or has participated in a study of an investigational agent or has used an investigational device within 4 weeks prior to the first dose of study treatment.
  • Note: Patients who have entered the follow-up phase of another investigational study may participate in this study as long as it has been 4 weeks after the last dose of the previous investigational agent.
  • Note: Patients may participate in other local biomarker studies following documented discussion and approval from Repertoire Immune Medicines.
  • Note: T-cell imaging agents may be permitted following documented discussion and approval with the Sponsor.
  • Presence of ≥CTCAE v5.0 Grade 2 toxicity from prior therapy (except alopecia, peripheral neuropathy, and ototoxicity, which are excluded if ≥CTCAE v5.0 Grade 3) due to prior cancer treatment.
  • Initiation of hematopoietic colony-stimulating growth factors (e.g. Granulocyte Colony Stimulating Factor [G-CSF], Granulocyte Macrophage Colony Stimulating Factor [GMCSF], Macrophage Colony Stimulating Factor [M-CSF]) ≤2 weeks prior to start of study drug. An erythroid stimulating agent is allowed as long as it was initiated at least 2 weeks prior to the first dose of study treatment.
  • An unresolved AE (must be ≤Grade 1 or the patient's baseline).
  • Prior treatment with CAR-T-cell therapy.
  • Has undergone prior allogeneic HSCT
  • RPTR-147 Monotherapy: Patients who were required to discontinue PD-1/PD-L1, CTLA-4, or other immunomodulatory antibodies due to ≥Grade 3 irAE may be included following discussion with the Sponsor.
  • RPTR-147:1 in Combination with pembrolizumab: Has received prior therapy with an anti-PD-1, anti-PD-L1, or anti PD L2 agent or with an agent directed to another stimulatory or co-inhibitory T-cell receptor (e.g., CTLA-4, OX 40, CD137) and was discontinued from that treatment due to a Grade 3 or higher irAE.
  • Patients with a history of >3 lines of chemotherapy in the metastatic setting may be eligible for enrollment following discussion with the Sponsor.
  • Patients with a history of rapidly progressing disease on immunotherapy.
  • Prior clinical or radiological disease progression (excluding pseudoprogression) within 8 weeks after starting prior immunotherapy with PD-1/PDL-1, CTLA-4 inhibitors.
  • These patients may only be enrolled following discussion with the Sponsor to account for manufacturing time.
  • Prior therapy with PD-1/PDL-1, CTLA-4 or other immunomodulatory antibodies inhibitors:
  • ≤2 weeks prior to the apheresis procedure
  • ≤4 weeks prior to the first dose of study treatment
  • Systemic anti-cancer therapy within 5 half-lives or 2 weeks; whichever occurs first, of the apheresis procedure and the first dose of study treatment.
  • Systemic cytotoxic agents that have major delayed toxicity, e.g. mitomycin C and nitrosoureas, ≤6 weeks prior to the first dose of study treatment
  • Participants must have recovered from all AEs due to previous therapies to ≤Grade 1 or baseline. Participants with ≤Grade 2 neuropathy may be eligible.
  • Has a history or current evidence of any condition, therapy, or laboratory abnormality that might confound the results of the study, interfere with the participant's participation for the full duration of the study, or is not in the best interest of the participant to participate, in the opinion of the treating investigator.
  • Has known psychiatric or substance abuse disorders that would interfere with cooperating with the requirements of the study.
  • Is pregnant or breastfeeding or expecting to conceive or father children within the projected duration of the study, starting with the screening visit through 150 days after the last dose of study treatment.
  • Women of childbearing potential (WOCBP), defined as all women physiologically capable of becoming pregnant, unless they are using highly effective methods of contraception during study treatment and for 120 days after the last dose of study treatment. Highly effective contraception methods include:
  • Female sterilization, total hysterectomy, or tubal ligation at least 6 weeks before taking study treatment.
  • Male sterilization (at least 6 months prior to screening). For female patients on the study the vasectomized male partner should be the sole partner for that patient.
  • Use of oral (estrogen and progesterone), injected or implanted combined hormonal methods of contraception or placement of an intrauterine device (IUD) or intrauterine system (IUS) or other forms of hormonal contraception that have comparable efficacy (failure rate <1%), for example, hormone vaginal ring or transdermal hormone contraception.
  • In case of use of oral contraception, women should have been stable on the same pill for a minimum of 3 months before taking study treatment.
  • Women are considered post-menopausal and not of childbearing potential if they have had 12 months of natural amenorrhea with an appropriate clinical profile or have had surgical bilateral oophorectomy or tubal ligation at least 6 weeks prior to the first dose of study treatment.
  • A WOCBP who has a positive urine pregnancy test (e.g. within 72 hours) prior to treatment. If the urine test is positive or cannot be confirmed as negative, a serum pregnancy test will be required.

Trial locations and contacts

7 sites in 1 country.

7 sites in 1 country

United States7 sites

  • Dana Farber Cancer Institute

    Boston, Massachusetts, 02215

  • Karmanos Cancer Institute

    Detroit, Michigan, 48201

  • City of Hope

    Duarte, California, 91010

  • MD Anderson Cancer Center

    Houston, Texas, 77030

  • Carolina BioOncology Institute

    Huntersville, North Carolina, 28078

  • Sarah Cannon Research Institute

    Nashville, Tennessee, 37203

  • Yale Cancer Center

    New Haven, Connecticut, 06511

Other trials in United States

About this study

Official title: A Phase 1/2 Study of Deep IL-15 Loaded T-Cells Alone and in Combination With Pembrolizumab in Patients With Select Solid Tumors and Lymphomas

The purpose of this study is to assess the safety and tolerability of escalating doses of RPTR-147 as a monotherapy and in combination with Pembrolizumab in patients with selected solid tumors and lymphomas.

Read the detailed description

This is a first-in-human, open-label, multicenter, dose escalation study designed to determine the safety and tolerability of RPTR-147 as a monotherapy and in combination with Pembrolizumab in patients with selected solid tumors or lymphomas.

The study will include 2 dosing periods: A Dose Escalation (Phase 1) followed by an Expansion (Phase 2).

Being tested
Arm A: RPTR-147:1, Arm B: RPTR-147:1 and Pembrolizumab, Arm C: RPTR-147:2
Keywords
HPV-16 E6/E7 positive solid tumors, Melanoma
Medical subject headings
Lymphoma, Melanoma

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

  • Arm A: RPTR-147:1Biological

    Escalating doses of RPTR-147:1 as a monotherapy

  • Arm B: RPTR-147:1 and PembrolizumabBiological

    Escalating doses of RPTR-147:1 in combination with Pembrolizumab

  • Arm C: RPTR-147:2Biological

    Escalating doses of RPTR-147:2 in patients with HPV positive tumors

Study groups in NCT03815682
Study groupRoleWhat they receive
RPTR-147:1ExperimentalArm A: Escalating doses of RPTR-147:1 as a monotherapy in solid tumors and lymphomas
Receives: Biological: Arm A: RPTR-147:1
RPTR-147:1 and PembrolizumabExperimentalArm B: Escalating doses of RPTR-147:1 in combination with Pembrolizumab in patients with solid tumors and lymphomas
Receives: Biological: Arm B: RPTR-147:1 and Pembrolizumab
RPTR-147:2ExperimentalArm C: Escalating doses of RPTR-147:2 in patients with HPV-16 positive tumors
Receives: Biological: Arm C: RPTR-147:2

What is being measured

The primary outcome is the main question the study is designed to answer.

  1. Number of subjects with dose limiting toxicities

    Safety of RPTR-147:1 as a monotherapy

    Measured: At the end of cycle 1 (Each cycle is 28 days)

  2. Number of subjects with dose limiting toxicities

    Safety of RPTR-147:1 in combination with pembrolizumab

    Measured: At the end of cycle 1 (Each cycle is 21 days)

  3. Number of subjects with dose limiting toxicities

    Safety of RPTR-147:2 as a monotherapy

    Measured: At the end of cycle 1 (Each cycle is 21 days)

  4. Frequency of dose interruptions

    Tolerability of RPTR-147:1 as a monotherapy

    Measured: At the end of cycle 1 (Each cycle is 28 days)

  5. Frequency of dose interruptions

    Tolerability of RPTR-147:1 in combination with pembrolizumab

    Measured: At the end of cycle 1 (Each cycle is 21 days)

  6. Frequency of dose interruptions

    Tolerability of RPTR-147:2 in patients with HPV positive tumors

    Measured: At the end of cycle 1 (Each cycle is 21 days)

Secondary outcomes (5)

  1. Best overall response

    Per modified RECIST v1.1 (solid tumor) or Lugano classification (lymphoma)

    Measured: Baseline through approximately 6 months after RPTR-147 last dose as monotherapy and in combination with pembrolizumab

  2. Progression free survival

    Per modified RECIST v1.1 (solid tumor) or Lugano classification (lymphoma)

    Measured: Baseline through approximately 6 months after RPTR-147 last dose as monotherapy and in combination with pembrolizumab

  3. Maximum observed serum concentration of RPTR-147 as monotherapy and in combination with pembrolizumab

    Maximum observed serum concentration

    Measured: Baseline through approximately 1 year

  4. Area under the serum concentration-time curve

    Area under the serum concentration-time curve

    Measured: Baseline through approximately 1 year

  5. Immunogenicity of RPTR-147 as monotherapy and in combination with pembrolizumab

    Number of subject with anti-RPTR-147/Pembrolizumab antibodies

    Measured: Pre-dose through approximately 1 year after RPTR-147/Pembrolizumab last dose

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

  1. First posted24 Jan 2019
  2. Study start24 Oct 2018
  3. Primary completion7 Sep 2022
  4. Study completion11 Oct 2022

Why it stopped: Development program terminated

Resources

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design
Study type
Interventional
Phase
Phase 1
Primary purpose
Treatment
Allocation
Non-randomised
Intervention model
Single group
Masking
None (open label)
Enrolment
23 participants (actual)
IDs, dates and publications
ClinicalTrials.gov ID
NCT03815682
Sponsor's protocol ID
TT-101
Other IDs
KEYNOTE KN-948
Status last verified
Dec 2022
First submitted
14 Jan 2019
Last updated
6 Dec 2022
Results posted
No
Data monitoring committee
No
FDA-regulated drug
Yes
FDA-regulated device
No
Individual data sharing
No

Questions about this trial

What is this clinical trial studying?

A Phase 1 study testing Arm A: RPTR-147:1, Arm B: RPTR-147:1 and Pembrolizumab and Arm C: RPTR-147:2 in people with Solid Tumor and Lymphoma, run by Repertoire Immune Medicines at 7 sites in United States.

The full registered description is in the About this study section and the official record.

Who may be eligible to take part?

The sponsor lists 34 inclusion and 71 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.

Is this clinical trial currently recruiting?

The record says: stopped early, as of the sponsor's last update on 6 Dec 2022. Status can change between updates, so confirm with the study contact before making plans.

Where is the study taking place?

The record lists 7 sites in United States. Whether a site is taking part right now should be confirmed with that site. See every site.

What are the possible benefits and risks?

They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.

What does this phase mean?

Phase 1 studies test a treatment in a small group of people for the first time or in a new way, mainly to check safety and find the right dose.

Not every study follows the same path, and some studies (observational studies, device studies) have no phase.

Are results available for this study?

The study was stopped early (reason given: Development program terminated). Results are not available in the source record.

How can a doctor refer a patient or contact the research team?

The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.

What does the primary outcome measure?

Number of subjects with dose limiting toxicities (time frame: At the end of cycle 1 (Each cycle is 28 days)). The study lists 6 primary outcomes in all. It is what the study was designed to measure, not a finding.

Where can I read the original study information?

On the ClinicalTrials.gov record for NCT03815682.

Does a listing mean the treatment is approved or proven to work?

No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.

How often is this information updated?

AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 6 Dec 2022.

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