BRazilian Asthmatics Patients EOSinophilic Profile (BRAEOS)

The SGRQ allows for the assessment of QoL of asthma patients. The questionnaire evaluates three domains: patient's perception of their recent respiratory problems (Symptoms score), disturbances to daily physical activity (Activity score) and disturbances of psycho-social function (Impact score). The score of each component and a total score can be computed. Scores are expressed as a percentage of overall impairment, where 100 represent the worst health status and 0 indicates the best status. Variables to collect: Symptoms score, Activity score, Impact score and Total score.

The ACQ 7 allows for the evaluation of asthma control. Subjects will be asked to respond to six questions pertaining to asthma-related symptoms and bronchodilator use on a 7-point scale (where 0=no impairment and 6=maximum impairment). The seventh question will be answered by the study's team at the research center and involves scoring the FEV1% predicted on a 7-point scale. The total ACQ 7 score is computed through the mean of the 7 questions and, as such, varies between 0 (totally controlled asthma) and 6 (severely uncontrolled asthma). Variables to collect include the responses to each of the questionnaire's individual items.

The Generalized Anxiety Disorder (GAD -7) is a self-administered patient questionnaire used as a screening tool and as a severity measure for patients with generalized anxiety disorder. It is composed by 7 items: (1) feeling nervous, (2) not being able to stop or control worrying, (3) worrying too much about different things, (4) trouble relaxing, (5) being so restless that it is hard to sit still, (6) becoming easily annoyed or irritable, and (7) feeling afraid as if something awful might happen. Through a 4-point Likert scale from 'not at all' to 'nearly every day', it is asked how often the patient has been bothered by any of the presented problems. The GAD-7 index is obtained by adding the scores from the questionnaire, after having assigned 0 to the least severe situation, 3 to the most severe one, and 1 and 2 to the intermediate ones. The cut off points 5, 10 and 15 allow to classify the anxiety as none/normal (0-4), mild (5-9), moderate (10-14), and severe (15-21).

The Patient Health Questionnaire (PHQ) is a self-administered instrument for common mental disorders. The PHQ-9 is the depression module from the full PHQ and consists of 9 questions that assess the presence of each of the symptoms for the episode of major depression. The PHQ-9 score can range from 0-27, since each of the 9 items can be scored from 0-3 corresponding to "no at all", "several days", "more than half the days" and "nearly every day" responses, respectively. Major depression is diagnosed if 5 or more symptoms have been present at least "more than half the days" in the past 2 weeks, and 1 of the symptoms is depressed mood or anhedonia. Other depression is diagnosed if 2, 3, or 4 symptoms have been present at least "more than half the days" in the past 2 weeks, and 1 of the symptoms is depressed mood or anhedonia. One of the 9 symptom ("thoughts that you would be better off dead or of hurting yourself in some way") counts if present at all, regardless of duration.

The WPAI assess the subject's ability to work and perform regular activities. The questionnaire inquiries about the number of days and hours missed from work or general activities. It also asks patients to rate, on a scale from 0 to 10, the degree to which asthma impairs productivity at work and their ability to perform normal daily activities. Higher values represent a more-severe impact. Variables to collect include the responses to each of the questionnaire's individual items.