Overweight and ObesityNCT03927638
Differences in Sitting Versus Standing on Metabolic and Cardiovascular Measurements
An observational study of Overweight and Obesity, run by Montclair State University at 1 site in United States.
Trial summary
This investigations examined the effect that posture has on metabolic and cardiovascular measurements. Further, it will explore the potential for body weight status or physical activity to influence these relationships. All subjects will complete a seated condition and a standing condition in a counterbalanced manner. Read more about this study
- Who is it for?
- Ages 18 to 50 years
- Conditions the study is for
- Overweight and Obesity
- What is being tested?
- sit/stand
- Type of treatment
- Lifestyle or therapy programme
- How many people
- 80 participants
- Where
- 1 siteUnited States
- Study dates
- 11 Nov 2018to 15 May 2028
- Phase
- Observational
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 50 years
- All sexes
- No healthy volunteers
- Adult
Study population: Healthy subjects between the ages of 18 and 50 years.
Who may be able to join
- healthy adult
Who cannot join
- Have a history of cancer, cardiac issues, hypertension, pulmonary disease, stroke, neurological or muscular dystrophy, uncontrolled diabetes, or any life threatening chronic conditions.
- Are currently being treated for infectious mononucleosis, hepatitis, pneumonia, or other infectious diseases.
- Are unable or unwilling to stand in one position continuously for 15-20 minutes at a time.
- Use nicotine products, or non-contraceptive hormonal therapy (birth control is okay).
- Are pregnant or trying to become pregnant.
- Are not between 18 and 50 years of age.
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
United States1 site
Montclair State University
Montclair, New Jersey, 07043
About this study
This investigations examined the effect that posture has on metabolic and cardiovascular measurements. Further, it will explore the potential for body weight status or physical activity to influence these relationships. All subjects will complete a seated condition and a standing condition in a counterbalanced manner.
Read the detailed description
The purpose of the present study was to evaluate both metabolic and cardiovascular responses to acute bouts of computer work while sitting and standing. Cardiovascular measurements were made using continuous non-invasive blood pressure monitoring and metabolic measurements were made using indirect calorimetry. Subjects will be grouped and analyzed based upon the weight status of the subject. All subjects will complete a seated condition and a standing condition in a counterbalanced manner. Investigators hypothesize that metabolic and cardiovascular responses will be elevated in the standing condition compared to sitting.
- Conditions
- Overweight and Obesity
- Being tested
- sit/stand
- Medical subject headings
- Overweight, Obesity
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
sit/standBehavioural
Subjects will be asked to both sit and stand during a single trial.
| Study group | Role | What they receive |
|---|---|---|
| Normal Weight | Group is determined based upon subjects weight status. Subjects will preform computer work in the seated and standing position in a counterbalanced manner while metabolic and cardiovascular measurements are made. Receives: Behavioral: sit/stand | |
| Overweight/Obese | Group is determined based upon subjects weight status. Subjects will preform computer work in the seated and standing position in a counterbalanced manner while metabolic and cardiovascular measurements are made. Receives: Behavioral: sit/stand |
What is being measured
The primary outcome is the main question the study is designed to answer.
Heart Rate
Using human non-invasive blood pressure continuous monitoring placed on the middle finger of the non-dominant hand will be used to measure heart rate based upon beat-by-beat finger pressure.
Measured: Approximately 15 minutes in each condition (sitting and standing)
Systolic Blood Pressure (SBP)
Using human non-invasive blood pressure continuous monitoring placed on the middle finger of the non-dominant hand will be used to measure SBP based upon beat-by-beat finger pressure.
Measured: Approximately 15 minutes in each condition (sitting and standing)
Diastolic Blood Pressure (DBP)
Using human non-invasive blood pressure continuous monitoring placed on the middle finger of the non-dominant hand will be used to measure DBP based upon beat-by-beat finger pressure.
Measured: Approximately 15 minutes in each condition (sitting and standing)
Oxygen Consumption
Oxygen consumption will be measured using indirect calorimetry.
Measured: Approximately 15 minutes in each condition (sitting and standing)
Carbon Dioxide Production
Carbon Dioxide will be measured using indirect calorimetry.
Measured: Approximately 15 minutes in each condition (sitting and standing)
Ventilation
Ventilation will be measured using indirect calorimetry.
Measured: Approximately 15 minutes in each condition (sitting and standing)
Respiratory Exchange Ration (RER)
RER will be calculated using oxygen and carbon dioxide value measure from indirect calorimetry.
Measured: Approximately 15 minutes in each condition (sitting and standing)
Secondary outcomes (8)
Height
Standard stadiometer will be used to measure height in meters.
Measured: 1 minute
Weight
Standard scale will be used to measure weight in kilograms.
Measured: 1 minute
Body Mass Index (BMI)
Height in meters and weight in kilograms will be used to calculate BMI using the formula BMI = kg/m^2.
Measured: 1 minute
Body Composition
Body composition will be measured using air displacement plethysmography.
Measured: Approximately 15 minutes
Total Peripheral Resistance (TPR)
Using human non-invasive blood pressure continuous monitoring placed on the middle finger of the non-dominant hand will be uses to estimate TPR based upon beat-by-beat finger pressure.
Measured: Approximately 15 minutes in each condition (sitting and standing)
Stroke Volume
Using human non-invasive blood pressure continuous monitoring placed on the middle finger of the non-dominant hand will be used to estimate TPR based upon beat-by-beat finger pressure.
Measured: Approximately 15 minutes in each condition (sitting and standing)
Cardiac Output (Q)
Using human non-invasive blood pressure continuous monitoring placed on the middle finger of the non-dominant hand will be used to estimate Q based upon beat-by-beat finger pressure.
Measured: Approximately 15 minutes in each condition (sitting and standing)
Muscle Oxygen Saturation
Using Near-inferred spectroscopy muscle oxygen consumption will be monitored.
Measured: Approximately 15 minutes in each condition (sitting and standing)
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted25 Apr 2019
- Study start11 Nov 2018
- Primary completion15 May 2028 (estimated)
- Study completion15 May 2028 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for Overweight and ObesityStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Cross-sectional
- Enrolment
- 80 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Montclair State University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Peter A. Hosick, Montclair State University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT03927638
- Sponsor's protocol ID
- 17-18-861
- Status last verified
- Oct 2024
- First submitted
- 22 Apr 2019
- Last updated
- 31 Jan 2025
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Publications
Hosick PA, Willett JM, Matthews EL. Cardiovascular strain and metabolic rate are higher following 15 minutes of standing versus seated computer work. Eur J Prev Cardiol. 2020 Dec;27(19):2131-2133. doi: 10.1177/2047487319867402. Epub 2019 Jul 29. No abstract available.
PubMed 31357884
Study at a glance
From the registry record, last updated by the sponsor on 31 Jan 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Differences in Sitting Versus Standing on Metabolic and Cardiovascular Measurements
- ClinicalTrials.gov ID
- NCT03927638
- Acronym / sponsor ID
- 17-18-861
- Conditions
- Overweight and Obesity
- Study type
- Observational
- Recruitment status
- Enrolling by invitation
- Enrolment
- 80 participants (estimated)
- Lead sponsor
- Montclair State UniversityUniversity, hospital or other
- Study start
- 11 Nov 2018 (actual)
- Primary completion
- 15 May 2028 (estimated)
- Study completion
- 15 May 2028 (estimated)
- First posted
- 25 Apr 2019 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This investigations examined the effect that posture has on metabolic and cardiovascular measurements. Further, it will explore the potential for body weight status or physical activity to influence these relationships. All subjects will complete a seated condition and a standing condition in a counterbalanced manner.
Detailed description
The purpose of the present study was to evaluate both metabolic and cardiovascular responses to acute bouts of computer work while sitting and standing. Cardiovascular measurements were made using continuous non-invasive blood pressure monitoring and metabolic measurements were made using indirect calorimetry. Subjects will be grouped and analyzed based upon the weight status of the subject. All subjects will complete a seated condition and a standing condition in a counterbalanced manner. Investigators hypothesize that metabolic and cardiovascular responses will be elevated in the standing condition compared to sitting.
Study design
- Observational model
- Cohort
- Time perspective
- Cross-sectional
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Normal Weight | – | Behavioral: sit/standGroup is determined based upon subjects weight status. Subjects will preform computer work in the seated and standing position in a counterbalanced manner while metabolic and cardiovascular measurements are made. |
| Overweight/Obese | – | Behavioral: sit/standGroup is determined based upon subjects weight status. Subjects will preform computer work in the seated and standing position in a counterbalanced manner while metabolic and cardiovascular measurements are made. |
Who may qualify
- Ages
- 18 to 50 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult
- Study population
- Healthy subjects between the ages of 18 and 50 years.
Key inclusion criteria (1 listed)
- healthy adult
Key exclusion criteria (6 listed)
- Have a history of cancer, cardiac issues, hypertension, pulmonary disease, stroke, neurological or muscular dystrophy, uncontrolled diabetes, or any life threatening chronic conditions.
- Are currently being treated for infectious mononucleosis, hepatitis, pneumonia, or other infectious diseases.
- Are unable or unwilling to stand in one position continuously for 15-20 minutes at a time.
- Use nicotine products, or non-contraceptive hormonal therapy (birth control is okay).
- Are pregnant or trying to become pregnant.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| sit/standSubjects will be asked to both sit and stand during a single trial. | Behavioural | Normal Weight, Overweight/Obese |
Primary outcome
Heart Rate
Time frame: Approximately 15 minutes in each condition (sitting and standing)
Using human non-invasive blood pressure continuous monitoring placed on the middle finger of the non-dominant hand will be used to measure heart rate based upon beat-by-beat finger pressure.
Systolic Blood Pressure (SBP)
Time frame: Approximately 15 minutes in each condition (sitting and standing)
Using human non-invasive blood pressure continuous monitoring placed on the middle finger of the non-dominant hand will be used to measure SBP based upon beat-by-beat finger pressure.
Diastolic Blood Pressure (DBP)
Time frame: Approximately 15 minutes in each condition (sitting and standing)
Using human non-invasive blood pressure continuous monitoring placed on the middle finger of the non-dominant hand will be used to measure DBP based upon beat-by-beat finger pressure.
Oxygen Consumption
Time frame: Approximately 15 minutes in each condition (sitting and standing)
Oxygen consumption will be measured using indirect calorimetry.
Carbon Dioxide Production
Time frame: Approximately 15 minutes in each condition (sitting and standing)
Carbon Dioxide will be measured using indirect calorimetry.
Ventilation
Time frame: Approximately 15 minutes in each condition (sitting and standing)
Ventilation will be measured using indirect calorimetry.
Respiratory Exchange Ration (RER)
Time frame: Approximately 15 minutes in each condition (sitting and standing)
RER will be calculated using oxygen and carbon dioxide value measure from indirect calorimetry.
8 secondary outcomes
Height
Time frame: 1 minute
Weight
Time frame: 1 minute
Body Mass Index (BMI)
Time frame: 1 minute
Body Composition
Time frame: Approximately 15 minutes
Total Peripheral Resistance (TPR)
Time frame: Approximately 15 minutes in each condition (sitting and standing)
Stroke Volume
Time frame: Approximately 15 minutes in each condition (sitting and standing)
Cardiac Output (Q)
Time frame: Approximately 15 minutes in each condition (sitting and standing)
Muscle Oxygen Saturation
Time frame: Approximately 15 minutes in each condition (sitting and standing)
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 31 Jan 2025.
- Background: PubMed 31357884Hosick PA, Willett JM, Matthews EL. Cardiovascular strain and metabolic rate are higher following 15 minutes of standing versus seated computer work. Eur J Prev Cardiol. 2020 Dec;27(19):2131-2133. doi: 10.1177/2047487319867402. Epub 2019 Jul 29. No abstract available.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Overweight and Obesity, run by Montclair State University at 1 site in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 1 inclusion and 6 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: enrolling by invitation, as of the sponsor's last update on 31 Jan 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Heart Rate (time frame: Approximately 15 minutes in each condition (sitting and standing)). The study lists 7 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT03927638, which also lists 1 linked publication.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 31 Jan 2025; AzTrials last refreshed its copy on 6 Nov 2026.