Colon CancerPACOSNCT03947840
Physical Activity and Its Impact on Colon Cancer Surgery
An observational study of Colon Cancer and Physical Activity, run by Umeå University at 1 site in Sweden.
Trial summary
This is a prospective clinical study that studies how the physical activity level before operation of colon cancer affects the outcome of complication and histology. The hypothesis is that patients who are more physical active have less postoperative complications and different histological immunological response… Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Colon Cancer, Physical Activity
- What is being tested?
- Physical activity
- Type of treatment
- Lifestyle or therapy programme
- How many people
- 85 participants
- Where
- 1 siteSweden
- Study dates
- 30 Jan 2019to 20 Feb 2024
- How long will I take part?
- 1 Year
- Phase
- Observational
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Study population: Patients who are going to surgery due to colon cancer.
Who may be able to join
- 18 years.
- Colon cancer which is going to surgery
Who cannot join
- Not able to do physical tests
- Severe disease that makes a risk to do tests.
- Not able to make informed consent due to psychic disease or dementia
Trial locations and contacts
1 site in 1 country.
Sweden1 site
Region Vasterbotten, centre of surgery
Umeå, Västerbotten County, 90185
About this study
Official title: Physical Activity and Its Impact on Colon Cancer Surgery: Clinical and Histological Effects
This is a prospective clinical study that studies how the physical activity level before operation of colon cancer affects the outcome of complication and histology.
The hypothesis is that patients who are more physical active have less postoperative complications and different histological immunological response around the tumor.
Read more
The investigators are testing the patients before the surgery with physical tests for fitness, strength and physical activity level. Questionnaires are also filled by the patients for pain, anxiety, depression and motivation for life style changes. Their body mass is analyzed with a DEXA (Dual-energy X-ray absorptiometry scan).
For one years the investigators are monitoring their activity and follow up for physical tests, DEXA and questionnaires is at 6 and 12 months.
The histology is analyzed after surgery to se if there is a different immunological response around the tumor.
- Conditions
- Colon Cancer, Physical Activity
- Being tested
- Physical activity
- Keywords
- Colon cancer, Physical activity
- Medical subject headings
- Colonic Neoplasms, Motor Activity
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Physical activityBehavioural
Se their physical activity level
What is being measured
The primary outcome is the main question the study is designed to answer.
Number of postoperative complications
To study if there are differences in postoperative complications in different active patients.
Measured: 1 year
Rate of immunological response
To study if there is a difference in immunological reaction among physical active patients.
Measured: 1 year
Secondary outcomes (1)
Rate of recovery in physical activity
To study if physical active patients have a faster postoperative recovery
Measured: 1 year
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted13 May 2019
- Study start30 Jan 2019
- Primary completion20 Feb 2024
- Study completion20 Feb 2024
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for Colon CancerStudies of the same condition, open and under way.
- More trials run by Umeå UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Prospective
- Enrolment
- 85 participants (actual)
- Target duration
- 1 Year
Sponsor and investigators
- Lead sponsor
- Umeå University
- Sponsor type
- University, hospital or other
- Collaborators
- Västerbotten County Council, Sweden
- Responsible party
- Sponsor
- Investigators
- Karin Strigård, Principal investigator, Umeå Universitet
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT03947840
- Sponsor's protocol ID
- PACOS
- Acronym
- PACOS
- Status last verified
- Feb 2024
- First submitted
- 9 May 2019
- Last updated
- 21 Feb 2024
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Undecided
Publications
Renman D, Edin S, Gunnarsson U, Blind N, Strigard K, Palmqvist R. Association of objectively assessed physical activity with immune cell infiltration of the tumor microenvironment in non-metastatic colon cancer. Int J Colorectal Dis. 2026 Sep 10;41(1):148. doi: 10.1007/s00384-026-05232-5.
PubMed 42720727
Study at a glance
From the registry record, last updated by the sponsor on 21 Feb 2024. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Physical Activity and Its Impact on Colon Cancer Surgery: Clinical and Histological Effects
- ClinicalTrials.gov ID
- NCT03947840
- Acronym / sponsor ID
- PACOS / PACOS
- Conditions
- Colon Cancer, Physical Activity
- Keywords
- Colon cancer, Physical activity
- Study type
- Observational
- Recruitment status
- Completed
- Enrolment
- 85 participants (actual)
- Lead sponsor
- Umeå UniversityUniversity, hospital or other
- Collaborators
- Västerbotten County Council, Sweden
- Study start
- 30 Jan 2019 (actual)
- Primary completion
- 20 Feb 2024 (actual)
- Study completion
- 20 Feb 2024 (actual)
- First posted
- 13 May 2019 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This is a prospective clinical study that studies how the physical activity level before operation of colon cancer affects the outcome of complication and histology.
The hypothesis is that patients who are more physical active have less postoperative complications and different histological immunological response around the tumor.
The investigators are testing the patients before the surgery with physical tests for fitness, strength and physical activity level. Questionnaires are also filled by the patients for pain, anxiety, depression and motivation for life style changes. Their body mass is analyzed with a DEXA (Dual-energy X-ray absorptiometry scan).
For one years the investigators are monitoring their activity and follow up for physical tests, DEXA and questionnaires is at 6 and 12 months.
The histology is analyzed after surgery to se if there is a different immunological response around the tumor.
Study design
- Observational model
- Cohort
- Time perspective
- Prospective
- Target follow-up
- 1 Year
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
- Study population
- Patients who are going to surgery due to colon cancer.
Key inclusion criteria (2 listed)
- 18 years.
- Colon cancer which is going to surgery
Key exclusion criteria (3 listed)
- Not able to do physical tests
- Severe disease that makes a risk to do tests.
- Not able to make informed consent due to psychic disease or dementia
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Physical activitySe their physical activity level | Behavioural | – |
Primary outcome
Number of postoperative complications
Time frame: 1 year
To study if there are differences in postoperative complications in different active patients.
Rate of immunological response
Time frame: 1 year
To study if there is a difference in immunological reaction among physical active patients.
1 secondary outcome
Rate of recovery in physical activity
Time frame: 1 year
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 21 Feb 2024.
- Derived from this study: PubMed 42720727Renman D, Edin S, Gunnarsson U, Blind N, Strigard K, Palmqvist R. Association of objectively assessed physical activity with immune cell infiltration of the tumor microenvironment in non-metastatic colon cancer. Int J Colorectal Dis. 2026 Sep 10;41(1):148. doi: 10.1007/s00384-026-05232-5.
- Individual participant dataSharing planned: Undecided
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Karin Strigård principal investigator
Umeå Universitet
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Colon Cancer and Physical Activity, run by Umeå University at 1 site in Sweden.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 2 inclusion and 3 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 21 Feb 2024. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Sweden. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Number of postoperative complications (time frame: 1 year). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT03947840, which also lists 1 linked publication.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 21 Feb 2024.