AzTrials
AzTrials

Cardiovascular Disease and Lipoprotein(a)Phase 3Lp(a)HORIZONNCT04023552

Assessing the Impact of Lipoprotein (a) Lowering With Pelacarsen (TQJ230) on Major Cardiovascular Events in Patients With CVD

A Phase 3 study testing TQJ230 in people with Cardiovascular Disease and Lipoprotein(a), run by Novartis Pharmaceuticals at 902 sites in 43 countries.

Completed

Finished. The study has ended and is not enrolling. Results may be posted on the official record.

Official record

Search all trials

Trial summary

This is a pivotal phase 3 study designed to support an indication for the reduction of cardiovascular risk in patients with established CVD and elevated Lp(a) Read more about this study

Who is it for?
Ages 18 to 80 years
What is being tested?
TQJ230
Type of treatment
Injection or infusion
Could I receive a placebo?
Yes, some participants may receive a placebo
How many people
8,323 participants
Where
902 sitesin 43 countries
Study dates
12 Dec 2019to 16 Jul 2026
Phase
Phase 3

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

  • Ages 18 to 80 years
  • All sexes
  • No healthy volunteers
  • Adult, Older adult

Who may be able to join

  • Lp(a) ≥ 70 mg/dL at the screening visit, measured at the Central laboratory
  • Myocardial infarction: ≥ 3 months from screening and randomization to ≤ 10 years prior to the screening visit
  • Ischemic stroke: ≥ 3 months from screening and randomization to ≤ 10 years prior to the screening visit
  • Clinically significant symptomatic peripheral artery disease

Who cannot join

  • Uncontrolled hypertension
  • Heart failure New York Heart Association (NYHA) class IV
  • History of malignancy of any organ system
  • History of hemorrhagic stroke or other major bleeding
  • Platelet count ≤LLN
  • Active liver disease or hepatic dysfunction
Show all 9Show fewer
  • Significant kidney disease
  • Pregnant or nursing women
  • Other protocol-defined inclusion/exclusion criteria may apply at the end.

Trial locations and contacts

902 sites in 43 countries.

902 sites in 43 countries

United States287 sites

  • Novartis Investigative Site

    Akron, Ohio, 44304

  • Akron Hospital Summa Health System

    Akron, Ohio, 44309

  • Albany Medical College

    Albany, New York, 12206

  • Christus Health Central Louisiana

    Alexandria, Louisiana, 71301

  • Novartis Investigative Site

    Alexandria, Louisiana, 71301

  • SEC Clinical Research LLC

    Andalusia, Alabama, 36420

  • Novartis Investigative Site

    Atlanta, Georgia, 30084

  • Grady Health System

    Atlanta, Georgia, 30303

  • Novartis Investigative Site

    Atlanta, Georgia, 30309

  • Piedmont Heart Institute

    Atlanta, Georgia, 30309

  • Emory University

    Atlanta, Georgia, 30322

  • Novartis Investigative Site

    Atlanta, Georgia, 30324

  • Novartis Investigative Site

    Aurora, Colorado, 80045

  • Univ Of Color Anschutz Med Center

    Aurora, Colorado, 80045

  • Novartis Investigative Site

    Baltimore, Maryland, 21201

  • University of Maryland

    Baltimore, Maryland, 21201

  • Novartis Investigative Site

    Baltimore, Maryland, 21209

  • Sinai Ct for Throm Res and Drug Dev

    Baltimore, Maryland, 21209

  • Johns Hopkins Univ School of Med

    Baltimore, Maryland, 21287

  • Novartis Investigative Site

    Baltimore, Maryland, 21287

  • Novartis Investigative Site

    Baton Rouge, Louisiana, 70808

  • Belzoni Clinical Research

    Belzoni, Mississippi, 39038

  • Novartis Investigative Site

    Belzoni, Mississippi, 39038

  • Cardiovascular Res Found

    Beverly Hills, California, 90210

  • National Heart Institute

    Beverly Hills, California, 90211

  • Novartis Investigative Site

    Beverly Hills, California, 90211

  • Grandview Med Group Research LLC

    Birmingham, Alabama, 35243

  • Novartis Investigative Site

    Birmingham, Alabama, 35243

  • Excel Medical Clinical Trials LLC

    Boca Raton, Florida, 33434

  • Novartis Investigative Site

    Boca Raton, Florida, 33434

  • Novartis Investigative Site

    Bogalusa, Louisiana, 70427

  • Novartis Investigative Site

    Bossier City, Louisiana, 71111

  • MGH

    Boston, Massachusetts, 02114-2696

  • Novartis Investigative Site

    Boston, Massachusetts, 02114-2696

  • Brigham and Womens Hosp Harvard Med School

    Boston, Massachusetts, 02115

  • Novartis Investigative Site

    Boston, Massachusetts, 02115

  • Novartis Investigative Site

    Bountiful, Utah, 84010

  • Progressive Clinical Research

    Bountiful, Utah, 84010

  • Cardiovascular and Vein Center of Florida

    Bradenton, Florida, 34209

  • Novartis Investigative Site

    Bradenton, Florida, 34209

  • Bay Area Cardiology Assoc

    Brandon, Florida, 33511

  • Novartis Investigative Site

    Brandon, Florida, 33511

  • Bridgeport Hospital

    Bridgeport, Connecticut, 06610

  • Novartis Investigative Site

    Bridgeport, Connecticut, 06610

  • Aultman Hospital

    Canton, Ohio, 44710

  • Novartis Investigative Site

    Canton, Ohio, 44710

  • Novant Health Heart Vas Inst

    Charlotte, North Carolina, 28204

  • Novartis Investigative Site

    Charlotte, North Carolina, 28204

  • Rush University Medical Center

    Chicago, Illinois, 60612

  • Lindner Ctr At The Christ Hosp

    Cincinnati, Ohio, 45219

  • Novartis Investigative Site

    Cincinnati, Ohio, 45219

  • Novartis Investigative Site

    Cincinnati, Ohio, 45246

  • Velocity Clin Research Springdale

    Cincinnati, Ohio, 45246

  • Novartis Investigative Site

    Cincinnati, Ohio, 45267

  • University Of Cincinnati

    Cincinnati, Ohio, 45267

  • Novartis Investigative Site

    City of Saint Peters, Missouri, 63303

  • StudyMetrix Research

    City of Saint Peters, Missouri, 63303

  • Cleveland Clinic Foundation

    Cleveland, Ohio, 44195

  • Novartis Investigative Site

    Cleveland, Ohio, 44195

  • Johns Hopkins University

    Columbia, Maryland, 21044

  • Novartis Investigative Site

    Columbia, Maryland, 21044

  • Novartis Investigative Site

    Columbus, Ohio, 43210

  • Ohio State University

    Columbus, Ohio, 43210

  • Novartis Investigative Site

    Cottonwood, Arizona, 86326

  • Flourish Clinical Resrch Covin

    Covina, California, 91723

  • Novartis Investigative Site

    Covina, California, 91723

  • Cardiovascular Associates Research

    Covington, Louisiana, 70433

  • Louisiana Heart Center Research

    Covington, Louisiana, 70433

  • Novartis Investigative Site

    Covington, Louisiana, 70433

  • Novartis Investigative Site

    Dallas, Texas, 75226

  • Soltero Cardiovascular Research Center

    Dallas, Texas, 75226

  • North Texas Endocrine Center

    Dallas, Texas, 75231

  • Novartis Investigative Site

    Dallas, Texas, 75231

  • Novartis Investigative Site

    Dallas, Texas, 75235

  • SW Family Medicine Associates

    Dallas, Texas, 75235

  • UT Southwestern Medical Center

    Dallas, Texas, 75390

  • Novartis Investigative Site

    Danville, Virginia, 24541

  • Novartis Investigative Site

    Detroit, Michigan, 48201

  • Wayne State University

    Detroit, Michigan, 48201

  • Henry Ford Hospital

    Detroit, Michigan, 48202

  • Novartis Investigative Site

    Detroit, Michigan, 48202

  • Novartis Investigative Site

    Dunwoody, Georgia, 30338

  • Novartis Investigative Site

    Eunice, Louisiana, 70535

  • Inova Fairfax Hospital

    Falls Church, Virginia, 22042

  • Novartis Investigative Site

    Falls Church, Virginia, 22042

  • Virginia Heart

    Falls Church, Virginia, 22042

  • AA Medical Research Center

    Flint, Michigan, 48504

  • Novartis Investigative Site

    Flint, Michigan, 48504

  • Novartis Investigative Site

    Fort Lauderdale, Florida, 33312

  • Novartis Investigative Site

    Fort Mill, South Carolina, 29707

  • Piedmont Research Partners LLC

    Fort Mill, South Carolina, 29707

  • Anderson Medical Research

    Ft. Washington, Maryland, 20744

  • Novartis Investigative Site

    Ft. Washington, Maryland, 20744

  • Novartis Investigative Site

    Germantown, Tennessee, 38138

  • The Stern Cardiovascular Foundation

    Germantown, Tennessee, 38138

  • Mercy Gilbert Medical Center

    Gilbert, Arizona, 85297

  • Genesys Regional Medical Center

    Grand Blanc, Michigan, 48439

  • Novartis Investigative Site

    Grand Blanc, Michigan, 48439

  • Medication Management LLC

    Greensboro, North Carolina, 27405

  • Novartis Investigative Site

    Greensboro, North Carolina, 27405

  • Heart Clinic of Hammond

    Hammond, Louisiana, 70403

  • Novartis Investigative Site

    Hammond, Louisiana, 70403

  • Novartis Investigative Site

    Hartford, Connecticut, 06102-5037

  • Hartford Hospital

    Hartford, Connecticut, 06102

  • Novartis Investigative Site

    High Point, North Carolina, 27262

  • CV Consultants of South Broward

    Hollywood, Florida, 33021

  • CV Institute of the South

    Houma, Louisiana, 70360

  • Novartis Investigative Site

    Houma, Louisiana, 70360

  • Baylor College Of Medicine

    Houston, Texas, 77030

  • Novartis Investigative Site

    Houston, Texas, 77030

  • Diabetes Lipid Management Center

    Huntington Beach, California, 92648

  • Novartis Investigative Site

    Huntington Beach, California, 92648

  • Heart Center Research Llc

    Huntsville, Alabama, 35801

  • Novartis Investigative Site

    Huntsville, Alabama, 35801

  • Novartis Investigative Site

    Indianapolis, Indiana, 46202 4800

  • Krannert Institute of Cardiology

    Indianapolis, Indiana, 46202-4800

  • Novartis Investigative Site

    Iowa City, Iowa, 52242

  • Uni Of Iowa Hospitals And Clinics

    Iowa City, Iowa, 52242

  • University of Calif Irvine Med Cntr

    Irvine, California, 92660

  • Apex Cardiology Research Associates of Jackson

    Jackson, Tennessee, 38301

  • Novartis Investigative Site

    Jackson, Tennessee, 38301

  • Novartis Investigative Site

    Jacksonville, Florida, 32205

  • Westside Center for Clinical Research

    Jacksonville, Florida, 32205

  • East Coast Institute for Research

    Jacksonville, Florida, 32216

  • Jacksonville Center for Clinical Research

    Jacksonville, Florida, 32216

  • Novartis Investigative Site

    Jacksonville, Florida, 32216

  • Novartis Investigative Site

    Kalamazoo, Michigan, 49008

  • Western Michigan University

    Kalamazoo, Michigan, 49008

  • Novartis Investigative Site

    Kansas City, Kansas, 66160

  • University of Kansas Hospital

    Kansas City, Kansas, 66160

  • Novartis Investigative Site

    La Jolla, California, 92037

  • Horizon Research Grp

    Lafayette, Louisiana, 70501

  • Lancaster General Health

    Lancaster, Pennsylvania, 17603

  • Novartis Investigative Site

    Lancaster, Pennsylvania, 17603

  • Dartmouth Hitchcock Medical Center

    Lebanon, New Hampshire, 03756

  • Novartis Investigative Site

    Lebanon, New Hampshire, 03756

  • Novartis Investigative Site

    Lincoln, Nebraska, 68526

  • Cardiology and Medicine Clinic PA

    Little Rock, Arkansas, 72204

  • Novartis Investigative Site

    Little Rock, Arkansas, 72204

  • Novartis Investigative Site

    Livingston, Texas, 77351

  • Memorial Care Health System

    Long Beach, California, 90806

  • Novartis Investigative Site

    Long Beach, California, 90806

  • Keck Medical Center USC

    Los Angeles, California, 90033

  • Novartis Investigative Site

    Los Angeles, California, 90033

  • Novartis Investigative Site

    Los Angeles, California, 90073

  • Carient Heart and Vascular

    Manassas, Virginia, 20109

  • Novartis Investigative Site

    Manassas, Virginia, 20109

  • Northwell Health

    Manhasset, New York, 11030

  • Novartis Investigative Site

    Manhasset, New York, 11030

  • Saint Johns Hospital

    Maplewood, Minnesota, 55109

  • Novartis Investigative Site

    Marion, Ohio, 43302

  • Rama Research LLC

    Marion, Ohio, 43302

  • Grace Research

    Marshall, Texas, 75670

  • Novartis Investigative Site

    Metairie, Louisiana, 70006

  • Omega Clinical Research

    Metairie, Louisiana, 70006

  • Infinite Clinical Research

    Miami, Florida, 33133

  • Novartis Investigative Site

    Miami, Florida, 33133

  • Novartis Investigative Site

    Milwaukee, Wisconsin, 53215

  • St Luke s Medical Center Aurora

    Milwaukee, Wisconsin, 53215

  • Minneapolis Heart Institute

    Minneapolis, Minnesota, 55407

  • Novartis Investigative Site

    Minneapolis, Minnesota, 55407

  • Novartis Investigative Site

    Minneapolis, Minnesota, 55455

  • University Of Minnesota

    Minneapolis, Minnesota, 55455

  • Mobile Heart Specialists

    Mobile, Alabama, 36608

  • Novartis Investigative Site

    Mobile, Alabama, 36608

  • West Virginia University Hospital

    Morgantown, West Virginia, 26506

  • Intermountain Medical Center

    Murray, Utah, 84107

  • Novartis Investigative Site

    Murray, Utah, 84107

  • Advanced Research for Health Improvement LLC

    Naples, Florida, 34102

  • Novartis Investigative Site

    Naples, Florida, 34102

  • Southwest Florida Research

    Naples, Florida, 34102

  • Novartis Investigative Site

    Nashville, Tennessee, 37232

  • Vanderbilt Univ Medi Cen

    Nashville, Tennessee, 37232

  • Tulane Uni Health Sciences Center

    New Orleans, Louisiana, 70112

  • Crescent City Physicians Inc

    New Orleans, Louisiana, 70115

  • Novartis Investigative Site

    New Orleans, Louisiana, 70115

  • New York Uni Med Ctr

    New York, New York, 10016

  • Novartis Investigative Site

    New York, New York, 10016

  • Novartis Investigative Site

    New York, New York, 10021

  • Weill Cornell Medical Center

    New York, New York, 10021

  • Icahn School of Med at Mt Sinai

    New York, New York, 10029

  • Novartis Investigative Site

    New York, New York, 10029

  • Novartis Investigative Site

    New York, New York, 10075

  • Lenox Hill Hospital

    New York, New York, 43210

  • York Clinical Research

    Norfolk, Virginia, 23504

  • Novartis Investigative Site

    Norfolk, Virginia, 23510

  • Novartis Investigative Site

    Northridge, California, 91325

  • Valley Clinical Trials

    Northridge, California, 91325

  • Novartis Investigative Site

    Omaha, Nebraska, 68114

  • Quality Clinical Research

    Omaha, Nebraska, 68114

  • CV Ins of the South

    Opelousas, Louisiana, 70570

  • Novartis Investigative Site

    Opelousas, Louisiana, 70570

  • Novartis Investigative Site

    Orange, California, 92868

  • Stanford University Medical Center

    Palo Alto, California, 94304

  • Advocate Lutheran General Childrens Hospital

    Park Ridge, Illinois, 60068

  • Novartis Investigative Site

    Park Ridge, Illinois, 60068

  • Alta Pharmaceutical Research Center

    Peachtree Corners, Georgia, 30092

  • McLaren Ctr Research Innovation

    Petoskey, Michigan, 49770

  • Novartis Investigative Site

    Petoskey, Michigan, 49770

  • Novartis Investigative Site

    Philadelphia, Pennsylvania, 19104

  • Perelman School of Medicine

    Philadelphia, Pennsylvania, 19104

  • Allegheny General Hospital

    Pittsburgh, Pennsylvania, 15212

  • Novartis Investigative Site

    Port Charlotte, Florida, 33952

  • Peace River Cardiovascular Center

    Port Charlotte, Florida, 33952

  • Novartis Investigative Site

    Port Orange, Florida, 32127

  • Progressive Medical Research

    Port Orange, Florida, 32127

  • Novartis Investigative Site

    Portland, Oregon, 97239

  • Oregon Health Sciences University

    Portland, Oregon, 97239

  • Cardiovascular Res of Knoxville LLC

    Powell, Tennessee, 37849

  • Novartis Investigative Site

    Powell, Tennessee, 37849

  • Miriam Hospital

    Providence, Rhode Island, 02906

  • Novartis Investigative Site

    Providence, Rhode Island, 02906

  • Accellacare US Inc

    Raleigh, North Carolina, 27609

  • Monument Health Clinical Research

    Rapid City, South Dakota, 57701

  • Novartis Investigative Site

    Rapid City, South Dakota, 57701

  • Dominion Medical Associates

    Richmond, Virginia, 23219

  • Novartis Investigative Site

    Richmond, Virginia, 23219

  • Novartis Investigative Site

    Ridgewood, New Jersey, 07450

  • The Valley Hospital

    Ridgewood, New Jersey, 07450

  • Northwell Health Physician Peconic

    Riverhead, New York, 11901

  • Rochester Regional Health

    Rochester, New York, 14621

  • Strong Memorial Hospital

    Rochester, New York, 14642

  • Adventist HealthCare Shady Grove Medical Center

    Rockville, Maryland, 20850

  • Novartis Investigative Site

    Rockville, Maryland, 20850

  • Central Michigan University

    Saginaw, Michigan, 48601

  • Novartis Investigative Site

    Saginaw, Michigan, 48601

  • East Coast Inst for Research LLC

    Saint Augustine, Florida, 32086

  • Novartis Investigative Site

    Saint Augustine, Florida, 32086

  • The University of Utah

    Salt Lake City, Utah, 84132-0001

  • University of California San Diego

    San Diego, California, 92103

  • UCSF

    San Francisco, California, 94115

  • Novartis Investigative Site

    San Francisco, California, 94158

  • Novartis Investigative Site

    Sanford, North Carolina, 27330

  • Helping Hands Medical Associates INC

    Santa Ana, California, 92704

  • Novartis Investigative Site

    Santa Ana, California, 92704

  • Maine Health Cardiology

    Scarborough, Maine, 04074

  • Novartis Investigative Site

    Scarborough, Maine, 04074

  • Harborview Medical Center

    Seattle, Washington, 98104

  • Novartis Investigative Site

    Seattle, Washington, 98104

  • Novartis Investigative Site

    Seattle, Washington, 98122

  • Swedish Medical Center-Cardiovascular Research

    Seattle, Washington, 98122

  • Novartis Investigative Site

    Seattle, Washington, 98195

  • Univ of Washington Medical Center

    Seattle, Washington, 98195

  • Jones Family Practice PA

    Shelby, North Carolina, 28150

  • Novartis Investigative Site

    Shelby, North Carolina, 28150

  • Grace Research Llc

    Shreveport, Louisiana, 71105

  • Novartis Investigative Site

    Shreveport, Louisiana, 71105

  • Louisiana Heart Center Research

    Slidell, Louisiana, 70458

  • Novartis Investigative Site

    Slidell, Louisiana, 70458

  • Novartis Investigative Site

    Southampton, New York, 11968

  • Novartis Investigative Site

    Southaven, Mississippi, 38671

  • Stern Cardiovascular Foundation Inc

    Southaven, Mississippi, 38671

  • Novartis Investigative Site

    St Louis, Missouri, 63110

  • Washington Univ School Of Medicine

    St Louis, Missouri, 63110

  • Mercy South

    St Louis, Missouri, 63128

  • Mercy Hospital St Louis

    St Louis, Missouri, 63141

  • Novartis Investigative Site

    Stanford, California, 94305

  • Manshadi Heart Institute

    Stockton, California, 95204

  • Novartis Investigative Site

    Stockton, California, 95204

  • Novartis Investigative Site

    Summerville, South Carolina, 29485

  • Palmetto Clinical Research

    Summerville, South Carolina, 29485

  • Novartis Investigative Site

    Summit, New Jersey, 07901

  • Overlook Medical Center

    Summit, New Jersey, 07901

  • Clinical Research Inst of Arizona

    Sun City West, Arizona, 85375

  • Novartis Investigative Site

    Sun City West, Arizona, 85375

  • Novartis Investigative Site

    Temple, Texas, 76508

  • Cardiovascular Consultants of S GA

    Thomasville, Georgia, 31792

  • Novartis Investigative Site

    Thomasville, Georgia, 31792

  • Northwest Houston Clinical Research PLLC

    Tomball, Texas, 77375

  • Novartis Investigative Site

    Tomball, Texas, 77375

  • Cotton O Neil Clinical Res Center

    Topeka, Kansas, 66606

  • Novartis Investigative Site

    Topeka, Kansas, 66606

  • Eclipse Clinical Research

    Tucson, Arizona, 85745

  • Novartis Investigative Site

    Tucson, Arizona, 85745

  • Chase Medical Research LLC

    Waterbury, Connecticut, 06708

  • Novartis Investigative Site

    Waterbury, Connecticut, 06708

  • Cardiology Partners Clinical Research Institute

    Wellington, Florida, 33449

  • Novartis Investigative Site

    Wellington, Florida, 33449

  • Interv Cardiology Med Grp

    West Hills, California, 91307

  • Novartis Investigative Site

    West Hills, California, 91307

  • Novartis Investigative Site

    Winston-Salem, North Carolina, 27157

  • Wake Forest University Baptist Medical Center

    Winston-Salem, North Carolina, 27157

  • Metro Health Univ of MI Health

    Wyoming, Michigan, 49519

  • Novartis Investigative Site

    Wyoming, Michigan, 49519

  • Cardiology Consultants of Philadelphia

    Yardley, Pennsylvania, 19067

  • Novartis Investigative Site

    Yardley, Pennsylvania, 19067

  • Southern Clinical Research

    Zachary, Louisiana, 70791

Other trials in United States

Germany55 sites

  • Novartis Investigative Site

    Aachen, 52074

  • Novartis Investigative Site

    Bad Homburg, 61348

  • Novartis Investigative Site

    Bad Krozingen, 79189

  • Novartis Investigative Site

    Bad Oeynhausen, 32545

  • Novartis Investigative Site

    Bamberg, 96049

  • Novartis Investigative Site

    Berlin, 10367

  • Novartis Investigative Site

    Berlin, 10559

  • Novartis Investigative Site

    Berlin, 10787

  • Novartis Investigative Site

    Berlin, 10789

  • Novartis Investigative Site

    Berlin, 13347

  • Novartis Investigative Site

    Berlin, 13353

  • Novartis Investigative Site

    Bielefeld, 33604

  • Novartis Investigative Site

    Chemnitz, Saxony, 09113

  • Novartis Investigative Site

    Chemnitz, 09111

  • Novartis Investigative Site

    Cologne, North Rhine-Westphalia, 50733

  • Novartis Investigative Site

    Cologne, North Rhine-Westphalia, 50937

  • Novartis Investigative Site

    Dessau, 06846

  • Novartis Investigative Site

    Dortmund, 44137

  • Novartis Investigative Site

    Dresden, Saxony, 01099

  • Novartis Investigative Site

    Dresden, Saxony, 01307

  • Novartis Investigative Site

    Dresden, 01069

  • Novartis Investigative Site

    Dresden, 01277

  • Novartis Investigative Site

    Dresden, 01307

  • Novartis Investigative Site

    Essen, North Rhine-Westphalia, 45355

  • Novartis Investigative Site

    Essen, 45277

  • Novartis Investigative Site

    Essen, 45355

  • Novartis Investigative Site

    Essen, 45359

  • Novartis Investigative Site

    Frankfurt am Main, Hesse, 60590

  • Novartis Investigative Site

    Frankfurt am Main, Hesse, 60594

  • Novartis Investigative Site

    Gelnhausen, 63571

  • Novartis Investigative Site

    Hamburg, 22041

  • Novartis Investigative Site

    Hamburg, 22607

  • Novartis Investigative Site

    Hanover, Lower Saxony, 30159

  • Novartis Investigative Site

    Jena, Thuringia, 07740

  • Novartis Investigative Site

    Kassel, 34121

  • Novartis Investigative Site

    Künzing, Bavaria, 94550

  • Novartis Investigative Site

    Leipzig, Saxony, 04103

  • Novartis Investigative Site

    Leipzig, Saxony, 04107

  • Novartis Investigative Site

    Löhne, North Rhine-Westphalia, 32584

  • Novartis Investigative Site

    Lüneburg, 21339

  • Novartis Investigative Site

    Magdeburg, 39120

  • Novartis Investigative Site

    Mannheim, Baden-Wurttemberg, 68305

  • Novartis Investigative Site

    Mannheim, 68165

  • Novartis Investigative Site

    Meissen, 01662

  • Novartis Investigative Site

    Muehldorf Am Inn, Bavaria, 84453

  • Novartis Investigative Site

    München, 80636

  • Novartis Investigative Site

    Munich, Bavaria, 81377

  • Novartis Investigative Site

    Münster, 48149

  • Novartis Investigative Site

    Potsdam, 14471

  • Novartis Investigative Site

    Rüdersdorf, 15562

  • Novartis Investigative Site

    Saint Ingbert, Saarland, 66386

  • Novartis Investigative Site

    Ulm, 89077

  • Novartis Investigative Site

    Warendorf, 48231

  • Novartis Investigative Site

    Weiden in Der Oberpfalz, Bavaria, 92637

  • Novartis Investigative Site

    Wittenberg, Saxony-Anhalt, 06886

Other trials in Germany

Russia39 sites

  • Novartis Investigative Site

    Chelyabinsk, 454047

  • Novartis Investigative Site

    Ivanovo, 153012

  • Novartis Investigative Site

    Izhevsk, 426061

  • Novartis Investigative Site

    Kemerovo, 650002

  • Novartis Investigative Site

    Kirov, 610035

  • Novartis Investigative Site

    Krasnodar, 350086

  • Novartis Investigative Site

    Moscow, 101990

  • Novartis Investigative Site

    Moscow, 117198

  • Novartis Investigative Site

    Moscow, 117997

  • Novartis Investigative Site

    Moscow, 121552

  • Novartis Investigative Site

    Moscow, 127473

  • Novartis Investigative Site

    Moscow, 141060

  • Novartis Investigative Site

    Moscow, 143420

  • Novartis Investigative Site

    Novosibirsk, 630090

  • Novartis Investigative Site

    Perm, 614097

  • Novartis Investigative Site

    Petrozavodsk, 185019

  • Novartis Investigative Site

    Rostov-on-Don, 344022

  • Novartis Investigative Site

    Ryazan, 390039

  • Novartis Investigative Site

    Saint Petersburg, Russia, 195197

  • Novartis Investigative Site

    Saint Petersburg, Russia, 198328

  • Novartis Investigative Site

    Saint Petersburg, 191015

  • Novartis Investigative Site

    Saint Petersburg, 192007

  • Novartis Investigative Site

    Saint Petersburg, 194354

  • Novartis Investigative Site

    Saint Petersburg, 195197

  • Novartis Investigative Site

    Saint Petersburg, 196143

  • Novartis Investigative Site

    Saint Petersburg, 197110

  • Novartis Investigative Site

    Saint Petersburg, 197136

  • Novartis Investigative Site

    Saint Petersburg, 197341

  • Novartis Investigative Site

    Samara, 443070

  • Novartis Investigative Site

    Saratov, 410012

  • Novartis Investigative Site

    Saratov, 410028

  • Novartis Investigative Site

    Sochy, 354002

  • Novartis Investigative Site

    Tomsk, 634009

  • Novartis Investigative Site

    Ulyanovsk, 432063

  • Novartis Investigative Site

    Vsevolozhsk, 188643

  • Novartis Investigative Site

    Yaroslavl, 150062

  • Novartis Investigative Site

    Yekaterinburg, 620028

  • Novartis Investigative Site

    Yekaterinburg, 620137

  • Novartis Investigative Site

    Yekaterinburg, 620144

Other trials in Russia

United Kingdom39 sites

  • Novartis Investigative Site

    Birmingham, B9 5SS

  • Novartis Investigative Site

    Bournemouth, BH7 7DW

  • Novartis Investigative Site

    Bristol, BS2 8HW

  • Novartis Investigative Site

    Bromwich, B71 4HJ

  • Novartis Investigative Site

    Cardiff, Wales, CF5 4AD

  • Novartis Investigative Site

    Cardiff, CF64 2XX

  • Novartis Investigative Site

    Chertsey, Surrey, KT16 0PZ

  • Novartis Investigative Site

    Chesterfield, S40 4AA

  • Novartis Investigative Site

    Chichester, West Sussex, PO19 6SE

  • Novartis Investigative Site

    Dorchester, Dorset, DT1 2JY

  • Novartis Investigative Site

    Dundee, DD1 9SY

  • Novartis Investigative Site

    Edinburgh, EH16 4SA

  • Novartis Investigative Site

    Glasgow, G20 7BE

  • Novartis Investigative Site

    Hardwick, Stockton on Tees, TS19 8PE

  • Novartis Investigative Site

    Harrow, Middlesex, HA1 3UJ

  • Novartis Investigative Site

    Leicester, LE3 9QP

  • Novartis Investigative Site

    Liverpool, L7 8XP

  • Novartis Investigative Site

    London, GBR, EC1M 6BQ

  • Novartis Investigative Site

    London, Greater London, EN3 4GS

  • Novartis Investigative Site

    London, W12 0HS

  • Novartis Investigative Site

    Londonderry, BT47 6SB

  • Novartis Investigative Site

    Manchester, M13 9WL

  • Novartis Investigative Site

    Middlesbrough, TS4 3BW

  • Novartis Investigative Site

    Middlesex, UB9 6JH

  • Novartis Investigative Site

    Newcastle upon Tyne, Tyne and Wear, NE7 7DN

  • Novartis Investigative Site

    Newport, NP20 2UB

  • Novartis Investigative Site

    Norwich, NR4 7UY

  • Novartis Investigative Site

    Plymouth, PL6 8DH

  • Novartis Investigative Site

    Portadown, Nothern Ireland, BT63 5QQ

  • Novartis Investigative Site

    Preston, Lancashire, PR2 9QB

  • Novartis Investigative Site

    Rhyl, LL18 5UJ

  • Novartis Investigative Site

    Rochdale, North Manchester, OL11 4AU

  • Novartis Investigative Site

    Sheffield, S5 7AU

  • Novartis Investigative Site

    Sunderland, Tyne and Wear, SR4 7TP

  • Novartis Investigative Site

    Swansea, SA2 8QA

  • Novartis Investigative Site

    Taunton, Somerset, TA1 5DA

  • Novartis Investigative Site

    Tyne and Wear, NE29 8NH

  • Novartis Investigative Site

    Wiltshire, SN15 2SB

  • Novartis Investigative Site

    Wrexham, LL13 7TD

Other trials in United Kingdom

Czechia38 sites

  • Novartis Investigative Site

    Brandýs nad Labem, 250 01

  • Novartis Investigative Site

    Brno, 602 00

  • Novartis Investigative Site

    Brno, 625 00

  • Novartis Investigative Site

    Broumov, 550 01

  • Novartis Investigative Site

    Český Krumlov, 381 01

  • Novartis Investigative Site

    Chlumec nad Cidlinou, 503 51

  • Novartis Investigative Site

    CZE, 110 00

  • Novartis Investigative Site

    Hlučín, 748 01

  • Novartis Investigative Site

    Hodonín, 695 01

  • Novartis Investigative Site

    Jihlava, 586 01

  • Novartis Investigative Site

    Kolín, 280 20

  • Novartis Investigative Site

    Kroměříž, Czech Republic, 767 55

  • Novartis Investigative Site

    Liberec, 460 01

  • Novartis Investigative Site

    Liberec, 460 05

  • Novartis Investigative Site

    Louny, Czech Republic, 440 01

  • Novartis Investigative Site

    Mariánské Lázně, 353 01

  • Novartis Investigative Site

    Mělník, 276 01

  • Novartis Investigative Site

    Most, 434 01

  • Novartis Investigative Site

    Olomouc, 779 00

  • Novartis Investigative Site

    Ostrava, Czech Republic, 725 27

  • Novartis Investigative Site

    Ostrava, Zabreh, 700 30

  • Novartis Investigative Site

    Ostrava, 700 30

  • Novartis Investigative Site

    Ostrava, 710 00

  • Novartis Investigative Site

    Pardubice, 532 03

  • Novartis Investigative Site

    Polička, 57201

  • Novartis Investigative Site

    Prague, 101 00

  • Novartis Investigative Site

    Prague, 110 00

  • Novartis Investigative Site

    Prague, 128 08

  • Novartis Investigative Site

    Prague, 158 00

  • Novartis Investigative Site

    Přerov, 751 52

  • Novartis Investigative Site

    Slaný, 274 01

  • Novartis Investigative Site

    Svitavy, 568 25

  • Novartis Investigative Site

    Třebíč, 674 01

  • Novartis Investigative Site

    Trutnov, 460 63

  • Novartis Investigative Site

    Uherské Hradiště, 686 01

  • Novartis Investigative Site

    Ústí nad Labem, Czech Republic, 400 01

  • Novartis Investigative Site

    Valašské Meziříčí, 75742

  • Novartis Investigative Site

    Zlín, 760 01

Other trials in Czechia

China36 sites

  • Novartis Investigative Site

    Baotou, Inner Mongolia, 014040

  • Novartis Investigative Site

    Beijing, Beijing Municipality, 100013

  • Novartis Investigative Site

    Beijing, 100050

  • Novartis Investigative Site

    Beijing, 100191

  • Novartis Investigative Site

    Beijing, 100730

  • Novartis Investigative Site

    Changchun, Jilin, 130021

  • Novartis Investigative Site

    Changsha, Hunan, 410003

  • Novartis Investigative Site

    Changsha, Hunan, 410008

  • Novartis Investigative Site

    Changsha, Hunan, 410011

  • Novartis Investigative Site

    Chengdu, Sichuan, 610041

  • Novartis Investigative Site

    Dalian, Liaoning, 116011

  • Novartis Investigative Site

    Foshan, Guangdong, 528000

  • Novartis Investigative Site

    Guangzhou, Guangdong, 510080

  • Novartis Investigative Site

    Hangzhou, Zhejiang, 310014

  • Novartis Investigative Site

    Hangzhou, Zhejiang, 310016

  • Novartis Investigative Site

    Harbin, Heilongjiang, 150000

  • Novartis Investigative Site

    Jinan, Shandong, 250013

  • Novartis Investigative Site

    Lanzhou, Gansu, 730030

  • Novartis Investigative Site

    Nanjing, Jiangsu, 210009

  • Novartis Investigative Site

    Nanjing, Jiangsu, 210029

  • Novartis Investigative Site

    Nanjing, Jiangsu, 211166

  • Novartis Investigative Site

    Shanghai, 200025

  • Novartis Investigative Site

    Shanghai, 200040

  • Novartis Investigative Site

    Shanghai, 200065

  • Novartis Investigative Site

    Shanghai, 200120

  • Novartis Investigative Site

    Shenyang, Liaoning, 110004

  • Novartis Investigative Site

    Shenyang, Liaoning, 110016

  • Novartis Investigative Site

    Suzhou, Jiangsu, 215004

  • Novartis Investigative Site

    Tianjin, 030045

  • Novartis Investigative Site

    Tianjin, 300052

  • Novartis Investigative Site

    Tianjin, 300121

  • Novartis Investigative Site

    Ürümqi, Xinjiang, 830054

  • Novartis Investigative Site

    Wenzhou, Zhejiang, 325000

  • Novartis Investigative Site

    Xiamen, 361004

  • Novartis Investigative Site

    Xian, Shanxi, 710061

  • Novartis Investigative Site

    Xuzhou, Jiangsu, 221003

Other trials in China

India36 sites

  • Novartis Investigative Site

    Ahmedabad, Gujarat, 380054

  • Novartis Investigative Site

    Ahmedabad, Gujarat, 380060

  • Novartis Investigative Site

    Belagavi, Karnataka, 590010

  • Novartis Investigative Site

    Bikaner, Rajasthan, 334003

  • Novartis Investigative Site

    Chennai, Tamil Nadu, 600006

  • Novartis Investigative Site

    Coimbatore, Tamil Nadu, 641009

  • Novartis Investigative Site

    Coimbatore, Tamil Nadu, 641037

  • Novartis Investigative Site

    Dehradun, Uttarakhand, 248001

  • Novartis Investigative Site

    Ghaziabad, Uttar Pradesh, 201012

  • Novartis Investigative Site

    Guntur, Andhra Pradesh, 522001

  • Novartis Investigative Site

    Hyderabad, Andhra Pradesh, 500033

  • Novartis Investigative Site

    Hyderabad, Telangana, 500034

  • Novartis Investigative Site

    Hyderabad, Telangana, 500082

  • Novartis Investigative Site

    Kochi, Kerala, 682018

  • Novartis Investigative Site

    Kochi, Kerala, 682027

  • Novartis Investigative Site

    Kochi, Kerala, 682041

  • Novartis Investigative Site

    Kozhikode, Kerala, 673008

  • Novartis Investigative Site

    Lucknow, Uttar Pradesh, 226003

  • Novartis Investigative Site

    Mangalore, Karnataka, 575018

  • Novartis Investigative Site

    Manipal, Karnataka, 576104

  • Novartis Investigative Site

    Mumbai, Maharashtra, 401107

  • Novartis Investigative Site

    Mysore, 570015

  • Novartis Investigative Site

    Nagpur, Maharashtra, 440008

  • Novartis Investigative Site

    Nagpur, Maharashtra, 440009

  • Novartis Investigative Site

    Nagpur, Maharashtra, 440012

  • Novartis Investigative Site

    Nagpur, Maharashtra, 440033

  • Novartis Investigative Site

    Nashik, Maharashtra, 422005

  • Novartis Investigative Site

    New Delhi, National Capital Territory of Delhi, 110060

  • Novartis Investigative Site

    New Delhi, National Capital Territory of Delhi, 110075

  • Novartis Investigative Site

    New Delhi, 110025

  • Novartis Investigative Site

    Pune, Maharashtra, 411001

  • Novartis Investigative Site

    Pune, Maharashtra, 411004

  • Novartis Investigative Site

    Pune, Maharashtra, 411045

  • Novartis Investigative Site

    Secunderabad, Telangana, 500003

  • Novartis Investigative Site

    Vadodara, Gujarat, 390022

  • Novartis Investigative Site

    Varanasi, Uttar Pradesh, 221010

Other trials in India

Japan35 sites

  • Novartis Investigative Site

    Asahi, Chiba, 2892511

  • Novartis Investigative Site

    Bunkyo Ku, Tokyo, 1138431

  • Novartis Investigative Site

    Chuo Ku, Tokyo, 1048560

  • Novartis Investigative Site

    Chuo-ku, Tokyo, 1030027

  • Novartis Investigative Site

    Fukuoka, Fukuoka, 8140180

  • Novartis Investigative Site

    Funabashi, Chiba, 2738588

  • Novartis Investigative Site

    Hachiōji, Tokyo, 1920918

  • Novartis Investigative Site

    Hirosaki, Aomori, 0368563

  • Novartis Investigative Site

    Ishikawa, 9208641

  • Novartis Investigative Site

    Itabashi-ku, Tokyo, 1738610

  • Novartis Investigative Site

    Kahoku-gun, Ishikawa-ken, 9200293

  • Novartis Investigative Site

    Kawaguchi, Saitama, 3330842

  • Novartis Investigative Site

    Kawasaki, Kanagawa, 2120021

  • Novartis Investigative Site

    Kitakyushu, Fukuoka, 8028555

  • Novartis Investigative Site

    Komatsu, Ishikawa-ken, 9230961

  • Novartis Investigative Site

    Kure, Hiroshima, 7370023

  • Novartis Investigative Site

    Matsudo, Chiba, 2702251

  • Novartis Investigative Site

    Miyhazaki, Miyazaki, 8802102

  • Novartis Investigative Site

    Nagaoka, Niigata, 9408621

  • Novartis Investigative Site

    Nagoya, Aichi-ken, 4538511

  • Novartis Investigative Site

    Ōgaki, Gifu, 5038502

  • Novartis Investigative Site

    Ōmihachiman, Shiga, 5230082

  • Novartis Investigative Site

    Osaka, Osaka, 5300001

  • Novartis Investigative Site

    Osaka, Osaka, 5438922

  • Novartis Investigative Site

    Ōta-ku, Tokyo, 1438541

  • Novartis Investigative Site

    Sagamihara, Kanagawa, 2520375

  • Novartis Investigative Site

    Sayama, Saitama, 3501305

  • Novartis Investigative Site

    Sendai, Miyagi, 9810914

  • Novartis Investigative Site

    Seto, Aichi-ken, 4898642

  • Novartis Investigative Site

    Shinagawa-ku, Tokyo, 1428666

  • Novartis Investigative Site

    Takamatsu, Kagawa-ken, 7608557

  • Novartis Investigative Site

    Toshima-ku, Tokyo, 1710014

  • Novartis Investigative Site

    Tsuchiura, Ibaraki, 3000028

  • Novartis Investigative Site

    Yokohama, Kanagawa, 2320024

  • Novartis Investigative Site

    Yokohama, Kanagawa, 2360037

Other trials in Japan

Slovakia31 sites

  • Novartis Investigative Site

    Banská Bystrica, 974 05

  • Novartis Investigative Site

    Bardejov, 085 01

  • Novartis Investigative Site

    Bratislava, 821 07

  • Novartis Investigative Site

    Bratislava, 833 05

  • Novartis Investigative Site

    Bratislava, 833 48

  • Novartis Investigative Site

    Bratislava, 841 08

  • Novartis Investigative Site

    Bratislava, 851 01

  • Novartis Investigative Site

    Bratislava, 851 07

  • Novartis Investigative Site

    Brezno, Slovakia, 977 01

  • Novartis Investigative Site

    Dolný Kubín, 026 01

  • Novartis Investigative Site

    Handlová, 972 51

  • Novartis Investigative Site

    Kláštor pod Znievom, 038 43

  • Novartis Investigative Site

    Komárno, 945 01

  • Novartis Investigative Site

    Komárno, 945 05

  • Novartis Investigative Site

    Košice, Slovakia, 040 01

  • Novartis Investigative Site

    Košice, 040 01

  • Novartis Investigative Site

    Košice, 040 22

  • Novartis Investigative Site

    Lučenec, 984 01

  • Novartis Investigative Site

    Nitra, 949 01

  • Novartis Investigative Site

    Nitra, 949 11

  • Novartis Investigative Site

    Nitra, 950 01

  • Novartis Investigative Site

    Nové Zámky, 940 01

  • Novartis Investigative Site

    Nové Zámky, 940 02

  • Novartis Investigative Site

    Piešťany, 921 01

  • Novartis Investigative Site

    Považská Bystrica, 017 01

  • Novartis Investigative Site

    Prešov, 080 01

  • Novartis Investigative Site

    Rimavská Sobota, 979 01

  • Novartis Investigative Site

    Rožňava, 048 01

  • Novartis Investigative Site

    Svidník, 089 01

  • Novartis Investigative Site

    Trnava, Slovakia, 917 02

  • Novartis Investigative Site

    Žilina, 010 01

Other trials in Slovakia

Brazil30 sites

  • Novartis Investigative Site

    Aracaju, Sergipe, 49055-530

  • Novartis Investigative Site

    Belo Horizonte, Minas Gerais, 30150-270

  • Novartis Investigative Site

    Belo Horizonte, Minas Gerais, 30220-330

  • Novartis Investigative Site

    Blumenau, Santa Catarina, 89020-430

  • Novartis Investigative Site

    Brasília, Federal District, 70390-700

  • Novartis Investigative Site

    Campinas, São Paulo, 13060-080

  • Novartis Investigative Site

    Campinas, São Paulo, 13092133

  • Novartis Investigative Site

    Canoas, Rio Grande do Sul, 92425-900

  • Novartis Investigative Site

    Curitiba, Paraná, 80230-130

  • Novartis Investigative Site

    Curitiba, Paraná, 80730-150

  • Novartis Investigative Site

    Goiânia, Goiás, 74605-020

  • Novartis Investigative Site

    Juiz de Fora, Minas Gerais, 36033-318

  • Novartis Investigative Site

    Maceió, Alagoas, 57051-160

  • Novartis Investigative Site

    Porto Alegre, Rio Grande do Sul, 90160-093

  • Novartis Investigative Site

    Porto Alegre, Rio Grande do Sul, 90880-480

  • Novartis Investigative Site

    Ribeirão Preto, São Paulo, 14026-020

  • Novartis Investigative Site

    Rio de Janeiro, 20241-180

  • Novartis Investigative Site

    Salvador, Estado de Bahia, 40170-130

  • Novartis Investigative Site

    Santo André, São Paulo, 09060-870

  • Novartis Investigative Site

    Santo André, São Paulo, 09090-790

  • Novartis Investigative Site

    Sao Jose Rio Preto, São Paulo, 15015-750

  • Novartis Investigative Site

    Sao Jose Rio Preto, São Paulo, 15090-000

  • Novartis Investigative Site

    São Paulo, São Paulo, 01323-000

  • Novartis Investigative Site

    São Paulo, São Paulo, 04005-003

  • Novartis Investigative Site

    São Paulo, São Paulo, 04023-900

  • Novartis Investigative Site

    São Paulo, São Paulo, 04266-010

  • Novartis Investigative Site

    São Paulo, São Paulo, 05403-000

  • Novartis Investigative Site

    São Paulo, São Paulo, 05403-900

  • Novartis Investigative Site

    Uberlândia, Minas Gerais, 38400-500

  • Novartis Investigative Site

    Vitória, Espírito Santo, 29055-450

Other trials in Brazil

Netherlands25 sites

  • Novartis Investigative Site

    Alkmaar, North Holland, 1815 JD

  • Novartis Investigative Site

    Amersfoort, 3813 TZ

  • Novartis Investigative Site

    Amsterdam, North Holland, 1090 HM

  • Novartis Investigative Site

    Amsterdam, North Holland, 1105 AZ

  • Novartis Investigative Site

    Apeldoorn, Gelderland, 7334 DZ

  • Novartis Investigative Site

    Arnhem, Gelderland, 6815 AD

  • Novartis Investigative Site

    Delft, South Holland, 2625 AD

  • Novartis Investigative Site

    Deventer, Overijssel, 7416 SE

  • Novartis Investigative Site

    Enschede, 7512KZ

  • Novartis Investigative Site

    Gouda, 2803 HH

  • Novartis Investigative Site

    Groningen, Provincie Groningen, 9728 NZ

  • Novartis Investigative Site

    Hardenberg, 7770 SE

  • Novartis Investigative Site

    Heemstede, North Holland, 2035 RC

  • Novartis Investigative Site

    Heerlen, Limburg, 6419 PC

  • Novartis Investigative Site

    Leiden, South Holland, 2333 ZA

  • Novartis Investigative Site

    Leiderdorp, South Holland, 2353 GA

  • Novartis Investigative Site

    Nijmegen, Gerlderland, 6532 SZ

  • Novartis Investigative Site

    Nijmegen, 6525 GA

  • Novartis Investigative Site

    Sneek, Provincie Friesland, 8601 ZK

  • Novartis Investigative Site

    The Hague, South Holland, 2545 AA

  • Novartis Investigative Site

    Tiel, Gelderland, 4002 WP

  • Novartis Investigative Site

    Tilburg, North Brabant, 5042 AD

  • Novartis Investigative Site

    Utrecht, 3584 CX

  • Novartis Investigative Site

    Venlo, 5912 BL

  • Novartis Investigative Site

    Zwolle, Overijssel, 8025 AB

Other trials in Netherlands

Italy21 sites

  • Novartis Investigative Site

    Ancona, AN, 60128

  • Novartis Investigative Site

    Bergamo, BG, 24127

  • Novartis Investigative Site

    Bologna, BO, 40138

  • Novartis Investigative Site

    Brescia, BS, 25123

  • Novartis Investigative Site

    Cona, FE, 44124

  • Novartis Investigative Site

    Florence, FI, 50134

  • Novartis Investigative Site

    Milan, MI, 20132

  • Novartis Investigative Site

    Milan, MI, 20138

  • Novartis Investigative Site

    Milan, MI, 20149

  • Novartis Investigative Site

    Milan, MI, 20162

  • Novartis Investigative Site

    Naples, 80131

  • Novartis Investigative Site

    Palermo, PA, 90127

  • Novartis Investigative Site

    Perugia, PG, 06129

  • Novartis Investigative Site

    Pisa, PI, 56124

  • Novartis Investigative Site

    Pisa, PI, 56126

  • Novartis Investigative Site

    Pozzilli, IS, 86077

  • Novartis Investigative Site

    Roma, RM, 00161

  • Novartis Investigative Site

    Roma, RM, 00189

  • Novartis Investigative Site

    Rozzano, MI, 20089

  • Novartis Investigative Site

    Salerno, SA, 84131

  • Novartis Investigative Site

    Varese, VA, 21100

Other trials in Italy

Spain19 sites

  • Novartis Investigative Site

    A Coruña, 15001

  • Novartis Investigative Site

    Badalona, Barcelona, 08916

  • Novartis Investigative Site

    Barcelona, 08025

  • Novartis Investigative Site

    Barcelona, 08036

  • Novartis Investigative Site

    Cáceres, Extremadura, 10003

  • Novartis Investigative Site

    Córdoba, 14004

  • Novartis Investigative Site

    Huelva, 21080

  • Novartis Investigative Site

    L'Hospitalet de Llobregat, Barcelona, 08907

  • Novartis Investigative Site

    Madrid, 28040

  • Novartis Investigative Site

    Madrid, 28041

  • Novartis Investigative Site

    Málaga, 29010

  • Novartis Investigative Site

    Reus, Tarragona, 43204

  • Novartis Investigative Site

    Santander, Cantabria, 39008

  • Novartis Investigative Site

    Santiago Compostela, A Coruna, 15706

  • Novartis Investigative Site

    Seville, Andalusia, 41014

  • Novartis Investigative Site

    Seville, 41009

  • Novartis Investigative Site

    Seville, 41013

  • Novartis Investigative Site

    Valencia, 46010

  • Novartis Investigative Site

    Zaragoza, 50009

Other trials in Spain

Argentina18 sites

  • Novartis Investigative Site

    Caba, C1427CCL

  • Novartis Investigative Site

    CABA, Buenos Aires, C1056ABI

  • Novartis Investigative Site

    CABA, Buenos Aires, C1280AEB

  • Novartis Investigative Site

    CABA, Buenos Aires, C1407FWE

  • Novartis Investigative Site

    CABA, Buenos Aires, C1426ABP

  • Novartis Investigative Site

    Capital Federal, C1023AAB

  • Novartis Investigative Site

    Córdoba, Córdoba Province, X5016KET

  • Novartis Investigative Site

    Córdoba, X5002HWE

  • Novartis Investigative Site

    Corrientes, W3400CDS

  • Novartis Investigative Site

    Mar del Plata, Buenos Aires, B7600ENA

  • Novartis Investigative Site

    Mar del Plata, Buenos Aires, B7600JXA

  • Novartis Investigative Site

    Ramos Mejía, Buenos Aires, B1704ETD

  • Novartis Investigative Site

    Rosario, Santa Fe Province, S2000CVD

  • Novartis Investigative Site

    Rosario, Santa Fe Province, S2000DTB

  • Novartis Investigative Site

    San Luis, D5702JRS

  • Novartis Investigative Site

    San Miguel de Tucumán, San Miguel de Tucuman, T4000ICL

  • Novartis Investigative Site

    San Miguel Tucuman, Tucumán Province, T4000IFL

  • Novartis Investigative Site

    Santa Fe, Santa Fe Province, S3000FWO

Other trials in Argentina

Canada16 sites

  • Novartis Investigative Site

    Lévis, Quebec, G6V 4Z5

  • Novartis Investigative Site

    Montreal, Quebec, H1T 1C8

  • Novartis Investigative Site

    Montreal, Quebec, H2X 1R9

  • Novartis Investigative Site

    Montreal, Quebec, H3T 1E2

  • Novartis Investigative Site

    Montreal, Quebec, H4A 3J1

  • Novartis Investigative Site

    Oakville, Ontario, L6K 3W7

  • Novartis Investigative Site

    Québec, Quebec, G1R 2J6

  • Novartis Investigative Site

    Québec, Quebec, G1V 4G2

  • Novartis Investigative Site

    Québec, Quebec, G1V 4G5

  • Novartis Investigative Site

    Québec, Quebec, G1V 4W2

  • Novartis Investigative Site

    Terrebonne, Quebec, J6V 2H2

  • Novartis Investigative Site

    Toronto, Ontario, M9V 4B4

  • Novartis Investigative Site

    Vancouver, British Columbia, V5Z 1M9

  • Novartis Investigative Site

    Vancouver, British Columbia, V6Z 1Y6

  • Novartis Investigative Site

    Victoria, British Columbia, V8R4R2

  • Novartis Investigative Site

    Victoria, British Columbia, V8T 5G4

Other trials in Canada

France13 sites

  • Novartis Investigative Site

    Bron, 69677

  • Novartis Investigative Site

    Chambray-lès-Tours, 37170

  • Novartis Investigative Site

    Compiègne, 60321

  • Novartis Investigative Site

    Grenoble, 38043

  • Novartis Investigative Site

    Le Coudray, 28630

  • Novartis Investigative Site

    Lille, 59000

  • Novartis Investigative Site

    Nantes, 44093

  • Novartis Investigative Site

    Paris, 75012

  • Novartis Investigative Site

    Paris, 75015

  • Novartis Investigative Site

    Paris, 75018

  • Novartis Investigative Site

    Toulouse, 31054

  • Novartis Investigative Site

    Tourcoing, 59208

  • Novartis Investigative Site

    Valenciennes, 59300

Other trials in France

Hungary13 sites

  • Novartis Investigative Site

    Baja, 6500

  • Novartis Investigative Site

    Budapest, 1083

  • Novartis Investigative Site

    Budapest, 1097

  • Novartis Investigative Site

    Budapest, 1145

  • Novartis Investigative Site

    Budapest, 1204

  • Novartis Investigative Site

    Debrecen, Hajdu Bihar Megye, 4032

  • Novartis Investigative Site

    Kistarcsa, 2143

  • Novartis Investigative Site

    Makó, 6900

  • Novartis Investigative Site

    Miskolc, 3526

  • Novartis Investigative Site

    Nyíregyháza, 4400

  • Novartis Investigative Site

    Pécs, Baranya, 7623

  • Novartis Investigative Site

    Szeged, 6725

  • Novartis Investigative Site

    Székesfehérvár, 8000

Other trials in Hungary

Poland12 sites

  • Novartis Investigative Site

    Bielsko-Biala, 43-316

  • Novartis Investigative Site

    Chrzanów, 32-500

  • Novartis Investigative Site

    Gdansk, 80-214

  • Novartis Investigative Site

    Gdynia, 81-157

  • Novartis Investigative Site

    Kędzierzyn-Koźle, 47-220

  • Novartis Investigative Site

    Krakow, 30-082

  • Novartis Investigative Site

    Krakow, 31-216

  • Novartis Investigative Site

    Lodz, 91-347

  • Novartis Investigative Site

    Lodz, 93-338

  • Novartis Investigative Site

    Poznan, 60-589

  • Novartis Investigative Site

    Sochaczew, 96-500

  • Novartis Investigative Site

    Tarnów, 33-100

Other trials in Poland

South Korea12 sites

  • Novartis Investigative Site

    Bundang Gu, Gyeonggi-do, 13620

  • Novartis Investigative Site

    Busan, 49201

  • Novartis Investigative Site

    Daegu, Dalseo gu, 42602

  • Novartis Investigative Site

    Gwangju, 61469

  • Novartis Investigative Site

    Incheon, Korea, 405 760

  • Novartis Investigative Site

    Seoul, Korea, 02841

  • Novartis Investigative Site

    Seoul, Korea, 08308

  • Novartis Investigative Site

    Seoul, Seoul, 03080

  • Novartis Investigative Site

    Seoul, 03181

  • Novartis Investigative Site

    Seoul, 06591

  • Novartis Investigative Site

    Suwon, Gyeonggi-do, 16499

  • Novartis Investigative Site

    Wŏnju, Gangwon-do, 26426

Other trials in South Korea

Romania10 sites

  • Novartis Investigative Site

    Baia Mare, Maramureş, 430123

  • Novartis Investigative Site

    Baia Mare, Maramureş, 430222

  • Novartis Investigative Site

    Brasov, 500283

  • Novartis Investigative Site

    Bucharest, 010192

  • Novartis Investigative Site

    Bucharest, 050098

  • Novartis Investigative Site

    Buzău, Buzău, 120133

  • Novartis Investigative Site

    Craiova, Dolj, 200513

  • Novartis Investigative Site

    Iași, Jud Iasi, 700732

  • Novartis Investigative Site

    Iași, 700503

  • Novartis Investigative Site

    Timișoara, Timiș County, 300362

Other trials in Romania

Taiwan9 sites

  • Novartis Investigative Site

    Hsinchu, 30069

  • Novartis Investigative Site

    Kaohsiung City, 80756

  • Novartis Investigative Site

    Kaohsiung City, 833

  • Novartis Investigative Site

    Keelung, 20401

  • Novartis Investigative Site

    Taichung, Taiwan ROC, 40201

  • Novartis Investigative Site

    Tainan, 71004

  • Novartis Investigative Site

    Taipei, 11217

  • Novartis Investigative Site

    Taoyuan, 33305

  • Novartis Investigative Site

    Yilan, 26058

Other trials in Taiwan

Turkey (Türkiye)9 sites

  • Novartis Investigative Site

    Ankara, Bilkent-Cankaya, 06800

  • Novartis Investigative Site

    Eskişehir, Odunpazari, 26040

  • Novartis Investigative Site

    Istanbul, Fatih, 34098

  • Novartis Investigative Site

    Istanbul, Kadikoy, 34668

  • Novartis Investigative Site

    Izmir, Balcova, 35340

  • Novartis Investigative Site

    Izmir, 35100

  • Novartis Investigative Site

    Mersin, Yenisehir, 33110

  • Novartis Investigative Site

    Samsun, Ilkadim, 55090

  • Novartis Investigative Site

    Samsun, Samsun, 55080

Other trials in Turkey (Türkiye)

Belgium8 sites

  • Novartis Investigative Site

    Aalst, Oost Vlaanderen, 9300

  • Novartis Investigative Site

    Bruges, 8000

  • Novartis Investigative Site

    Brussels, Brussels Capital, 1070

  • Novartis Investigative Site

    Dendermonde, 9200

  • Novartis Investigative Site

    Genk, Limburg, 3600

  • Novartis Investigative Site

    Huy, 4500

  • Novartis Investigative Site

    Kortrijk, West-Vlaanderen, 8500

  • Novartis Investigative Site

    Mechelen, 2800

Other trials in Belgium

Bulgaria8 sites

  • Novartis Investigative Site

    Blagoevgrad, Bulgaria, 2700

  • Novartis Investigative Site

    Burgas, 8001

  • Novartis Investigative Site

    Pernik, 2300

  • Novartis Investigative Site

    Pleven, 5800

  • Novartis Investigative Site

    Plovdiv, 4000

  • Novartis Investigative Site

    Rousse, 7002

  • Novartis Investigative Site

    Sofia, 1233

  • Novartis Investigative Site

    Sofia, 1750

Other trials in Bulgaria

Colombia8 sites

  • Novartis Investigative Site

    Barranquilla, Colombia, 080020

  • Novartis Investigative Site

    Bogotá, 111211

  • Novartis Investigative Site

    Bucaramanga, Santander Department, 681017

  • Novartis Investigative Site

    Cali, Valle del Cauca Department, 760001

  • Novartis Investigative Site

    Cali, Valle del Cauca Department, 760032

  • Novartis Investigative Site

    Medellín, Antioquia, 050001

  • Novartis Investigative Site

    Medellín, 050037

  • Novartis Investigative Site

    San Gil, 684031

Other trials in Colombia

Australia7 sites

  • Novartis Investigative Site

    Camperdown, New South Wales, 2050

  • Novartis Investigative Site

    Chemside, Queensland, 4032

  • Novartis Investigative Site

    Clayton, Victoria, 3168

  • Novartis Investigative Site

    Liverpool, 2170

  • Novartis Investigative Site

    Perth, Western Australia, 6000

  • Novartis Investigative Site

    Southport, Queensland, 4215

  • Novartis Investigative Site

    Woolloongabba, Queensland, 4102

Other trials in Australia

Denmark7 sites

  • Novartis Investigative Site

    Aarhus N, 8200

  • Novartis Investigative Site

    Copenhagen, 2100

  • Novartis Investigative Site

    Esbjerg, 6700

  • Novartis Investigative Site

    Gistrup, 9260

  • Novartis Investigative Site

    Herlev, 2730

  • Novartis Investigative Site

    Roskilde, 4000

  • Novartis Investigative Site

    Viborg, 8800

Other trials in Denmark

Greece7 sites

  • Novartis Investigative Site

    Athens, 115 21

  • Novartis Investigative Site

    Athens, 115 27

  • Novartis Investigative Site

    Athens, 142 33

  • Novartis Investigative Site

    Chalcis, 341 00

  • Novartis Investigative Site

    Ioannina, 455 00

  • Novartis Investigative Site

    Larissa, 411 10

  • Novartis Investigative Site

    Thessaloniki, 54636

Other trials in Greece

Israel7 sites

  • Novartis Investigative Site

    Beersheba, 8457108

  • Novartis Investigative Site

    Haifa, 3104802

  • Novartis Investigative Site

    Haifa, 3436212

  • Novartis Investigative Site

    Holon, 5822012

  • Novartis Investigative Site

    Jerusalem, 9112001

  • Novartis Investigative Site

    Petah Tikva, 4941492

  • Novartis Investigative Site

    Ramat Gan, 5265601

Other trials in Israel

Austria6 sites

  • Novartis Investigative Site

    Graz, 8036

  • Novartis Investigative Site

    Innsbruck, 6020

  • Novartis Investigative Site

    Linz, 4021

  • Novartis Investigative Site

    Salzburg, 5020

  • Novartis Investigative Site

    Vienna, 1090

  • Novartis Investigative Site

    Vienna, 1210

Other trials in Austria

Chile6 sites

  • Novartis Investigative Site

    Santiago, RM, 7500588

  • Novartis Investigative Site

    Santiago, Santiago Metropolitan, 7500710

  • Novartis Investigative Site

    Santiago, Santiago Metropolitan, 8331143

  • Novartis Investigative Site

    Santiago, Santiago Metropolitan, 8380465

  • Novartis Investigative Site

    Santiago, 7500710

  • Novartis Investigative Site

    Santiago, 8380456

Other trials in Chile

Switzerland6 sites

  • Novartis Investigative Site

    Basel, 4031

  • Novartis Investigative Site

    Bern, 3010

  • Novartis Investigative Site

    Geneva, 1211

  • Novartis Investigative Site

    Lausanne, 1011

  • Novartis Investigative Site

    Liestal, 4410

  • Novartis Investigative Site

    Zurich, 8091

Other trials in Switzerland

Mexico5 sites

  • Novartis Investigative Site

    Aguascalientes, Aguascalientes, 20230

  • Novartis Investigative Site

    Cuernavaca, Morelos, 62250

  • Novartis Investigative Site

    Culiacan Sinaloa, 80230

  • Novartis Investigative Site

    Distrito Federal, 14080

  • Novartis Investigative Site

    San Luis Potosí City, San Luis Potosí, 78200

Other trials in Mexico

South Africa5 sites

  • Novartis Investigative Site

    Cape Town, Western Cape, 7500

  • Novartis Investigative Site

    Cape Town, Western Cape, 7925

  • Novartis Investigative Site

    Cape Town, 6665

  • Novartis Investigative Site

    George, Western Cape, 6529

  • Novartis Investigative Site

    Soweto, Gauteng, 2013

Other trials in South Africa

Guatemala3 sites

  • Novartis Investigative Site

    Guatemala City, Departamento de Guatemala, 01001

  • Novartis Investigative Site

    Guatemala City, 01010

  • Novartis Investigative Site

    Guatemala City, 01011

Other trials in Guatemala

Portugal3 sites

  • Novartis Investigative Site

    Coimbra, 3004-561

  • Novartis Investigative Site

    Guimarães, 4835-044

  • Novartis Investigative Site

    Setúbal, 2910-549

Other trials in Portugal

Sweden3 sites

  • Novartis Investigative Site

    Gothenburg, 413 46

  • Novartis Investigative Site

    Lund, 222 21

  • Novartis Investigative Site

    Stockholm, 14186

Other trials in Sweden

Hong Kong2 sites

  • Novartis Investigative Site

    Hong Kong, 999077

  • Novartis Investigative Site

    Shatin, 999077

Other trials in Hong Kong

Iceland2 sites

  • Novartis Investigative Site

    Kopavogur, 201

  • Novartis Investigative Site

    Reykjavik, 101

Other trials in Iceland

Norway2 sites

  • Novartis Investigative Site

    Oslo, 0514

  • Novartis Investigative Site

    Skedsmokorset, 2020

Other trials in Norway

Puerto Rico2 sites

  • Novartis Investigative Site

    Ponce, 00717-1322

  • Research and Cardiovascular Corp

    Ponce, 00717-1322

Other trials in Puerto Rico

Peru1 site

  • Novartis Investigative Site

    San Miguel, Lima region, 15088

Other trials in Peru

Slovenia1 site

  • Novartis Investigative Site

    Ljubljana, 1000

Other trials in Slovenia

About this study

Official title: A Randomized Double-blind, Placebo-controlled, Multicenter Trial Assessing the Impact of Lipoprotein (a) Lowering With Pelacarsen (TQJ230) on Major Cardiovascular Events in Patients With Established Cardiovascular Disease

This is a pivotal phase 3 study designed to support an indication for the reduction of cardiovascular risk in patients with established CVD and elevated Lp(a)

Being tested
TQJ230, Placebo
Keywords
Lipoprotein(a),, Lp(a),, CVD,, myocardial infarction,, PAD,, Stroke,, Pelacarsen
Medical subject headings
Cardiovascular Diseases, Myocardial Infarction, Stroke

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

  • TQJ230Drug

    TQJ230 80 mg injected monthly administered subcutaneously

  • PlaceboDrug

    Also called Placebo to match TQJ230

    Placebo to match TQJ230 prefilled syringe to be injected subcutaneously

Study groups in NCT04023552
Study groupRoleWhat they receive
TQJ230ExperimentalTQJ230 80 mg injected monthly administered subcutaneously
Receives: Drug: TQJ230
PlaceboPlacebo comparatorMonthly subcutaneous injections.
Receives: Drug: Placebo

What is being measured

The primary outcome is the main question the study is designed to answer.

  1. Time to first occurrence of clinical endpoint committee confirmed expanded major adverse cardiovascular events in patients with elevated Lp(a) ≥ 70 mg/dL

    Demonstrate the superiority of pelacarsen (TQJ230) compared to placebo in reducing the risk of expanded MACE (cardiovascular death, non-fatal MI, non-fatal stroke and urgent coronary re-vascularization requiring hospitalization) in the overall study population with established CVD and (Lp(a) ≥ 70 mg/dL)

    Measured: approximately 4 years

  2. Time to the first occurrence of clinical endpoint committee confirmed expanded major adverse cardiovascular events in a population of patients with elevated Lp(a) ≥ 90 mg/dL.

    Demonstrate the superiority of pelacarsen (TQJ230) compared to placebo in reducing the risk of expanded MACE (cardiovascular death, non-fatal MI, non-fatal stroke and urgent coronary re-vascularization requiring hospitalization) in the overall study population with established CVD and (Lp(a) ≥ 90 mg/dL)

    Measured: approximately 4 years

Secondary outcomes (4)

  1. Time to the first occurrence of the clinical endpoint committee confirmed composite endpoint of major adverse cardiovascular events (CV death, non-fatal MI, and non-fatal stroke)

    Demonstrate the superiority of pelacarsen (TQJ230) compared to placebo in reducing the risk of the MACE composite of CV death, nonfatal MI and non-fatal stroke.

    Measured: approximately 4 years

  2. Time to the first occurrence of the clinical endpoint committee confirmed composite endpoint of coronary heart disease: coronary heart disease death, non-fatal MI, urgent coronary re-vascularization requiring hospitalization

    Demonstrate the superiority of pelacarsen (TQJ230) compared to placebo in reducing the risk of the composite of coronary heart disease (CHD) outcomes: death due to CHD, nonfatal MI and urgent coronary revascularization requiring hospitalization.

    Measured: approximately 4 years

  3. Time to Clinical endpoint Committee confirmed all-cause death

    Evaluation by clinical endpoint committee the rate of all-cause death

    Measured: approximately 4 years

  4. Change in Lp(a) in the log scale from baseline

    Demonstrate the superiority of pelacarsen (TQJ230) compared to placebo in lowering the Lp(a) level at 1 year

    Measured: Baseline, year 1

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

  1. First posted17 Jul 2019
  2. Study start12 Dec 2019
  3. Primary completion16 Jul 2026
  4. Study completion16 Jul 2026

Resources

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design
Study type
Interventional
Phase
Phase 3
Primary purpose
Treatment
Allocation
Randomised
Intervention model
Parallel groups
Masking
Double blind
Who is masked
Participant, Investigator
Enrolment
8,323 participants (actual)
IDs, dates and publications
ClinicalTrials.gov ID
NCT04023552
Sponsor's protocol ID
CTQJ230A12301
Other IDs
CTQJ230A12301, 2019-001076-11, 2019
Acronym
Lp(a)HORIZON
Status last verified
Aug 2026
First submitted
16 Jul 2019
Last updated
28 Aug 2026
Results posted
No
Data monitoring committee
Yes
FDA-regulated drug
Yes
FDA-regulated device
No
Individual data sharing
Yes: Novartis is committed to sharing with qualified external researchers, access to patient -level data and supporting clinical documents from eligible studies. These requests are reviewed and approved by an independent review panel on the basis of scientific merit. All data provided is anonymized to respect the privacy of patients who have participated in the trial in line with the applicable laws and regulations. This trial data availability is according to the criteria and process described on www.clinicalstudydatarequest.com.
Expanded access
Available

Publications

  • Byambaa E, Roshanravan B, Berglund L. Lipoprotein(a) and CKD: Insights into New Therapeutic Opportunities. Clin J Am Soc Nephrol. 2026 Aug 1;21(8):1469-1481. doi: 10.2215/CJN.0000000968. Epub 2025 Dec 2.

    PubMed 41329869

  • Cho L, Nicholls SJ, Nordestgaard BG, Landmesser U, Tsimikas S, Blaha MJ, Leitersdorf E, Lincoff AM, Lesogor A, Manning B, Kozlovski P, Cao H, Wang J, Nissen SE. Design and Rationale of Lp(a)HORIZON Trial: Assessing the Effect of Lipoprotein(a) Lowering With Pelacarsen on Major Cardiovascular Events in Patients With CVD and Elevated Lp(a). Am Heart J. 2025 Sep;287:1-9. doi: 10.1016/j.ahj.2025.03.019. Epub 2025 Apr 2.

    PubMed 40185318

  • Nicholls SJ, Nelson AJ, Michael LF. Oral agents for lowering lipoprotein(a). Curr Opin Lipidol. 2024 Dec 1;35(6):275-280. doi: 10.1097/MOL.0000000000000953. Epub 2024 Sep 25.

    PubMed 39329200

  • Burvill A, Watts GF, Norman R, Ademi Z. Early health technology assessment of gene silencing therapies for lowering lipoprotein(a) in the secondary prevention of coronary heart disease. J Clin Lipidol. 2024 Nov-Dec;18(6):e946-e956. doi: 10.1016/j.jacl.2024.08.012. Epub 2024 Aug 31.

    PubMed 39322524

  • Dimitriadis K, Theofilis P, Iliakis P, Pyrpyris N, Dri E, Sakalidis A, Soulaidopoulos S, Tsioufis P, Fragkoulis C, Chrysohoou C, Tsiachris D, Tsioufis K. Management of dyslipidemia in coronary artery disease: the present and the future. Coron Artery Dis. 2024 Sep 1;35(6):516-524. doi: 10.1097/MCA.0000000000001375. Epub 2024 Apr 29.

    PubMed 38682459

  • Karp A, Jacobs M, Barris B, Labkowsky A, Frishman WH. Lipoprotein(a): A Review of Risk Factors, Measurements, and Novel Treatment Modalities. Cardiol Rev. 2025 Jul-Aug 01;33(4):352-358. doi: 10.1097/CRD.0000000000000667. Epub 2024 Feb 28.

    PubMed 38415744

  • Tsimikas S, Reeves RR, Patel MP. Always Present, But Now Rediscovered: Lp(a) as a Predictor of Long-Term Outcomes in PCI. JACC Cardiovasc Interv. 2021 Sep 27;14(18):2069-2072. doi: 10.1016/j.jcin.2021.08.032. No abstract available.

    PubMed 34556281

  • Plakogiannis R, Sorbera M, Fischetti B, Chen M. The Role of Antisense Therapies Targeting Lipoprotein(a). J Cardiovasc Pharmacol. 2021 Jul 1;78(1):e5-e11. doi: 10.1097/FJC.0000000000001045.

    PubMed 34232223

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