Metastatic Breast CancerIMPACTNCT04030728
Implementing Patients´ Competence in Oral Breast Cancer Therapy
An observational study of Metastatic Breast Cancer and Advanced Breast Cancer, run by Onco Medical Consult GmbH.
Trial summary
The aim of the IMPACT - Implementing Patients' competence in oral breast cancer therapy - study is to evaluate the effectiveness of a standardized patient education and coaching and optional eMBSR for therapy management provided by specially trained oncology nurses regarding persistence rate, side effects management… Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Metastatic Breast Cancer, Advanced Breast Cancer
- How many people
- 212 participants
- Where
- No sites listed yet
- Study dates
- Mar 2020to Dec 2021
- Phase
- Observational
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Study population: Patients who suffer from HR+, HER2- advanced or metastatic breast cancer treated with with orally administered commercially available, prescribed Abemaciclib in combination with an aromase inhibitor or fulvestrant as initial endocrine-based therapy or in women who have received prior endocrine therapy, thereby reflecting the current SmPC (Fachinformation Verzenios®). All treatments are prescribed and performed according to each center's medical practice. Any treatment choice or change in regimen is performed at the discretion of each treating physician.
Who may be able to join
- Adult breast cancer patients (age ≥18 years).
- Patients with HR+, HER2- advanced or metastatic breast cancer proven by clinical measures (i. e. standard imaging) whose disease has progressed after hormonal therapy in combination with fulvestrant, or alone in women whose disease has progressed after hormone therapy and prior chemotherapy (advanced disease must not be amenable to resection with curative intent).
- Patients treated with Abemaciclib according to the SmPC and each center´s medical practice.
- Informed consent prior to onset of documentation.
Who cannot join
- Patients with serious preexisting medical condition(s) that would preclude participation in this study (for example, interstitial lung disease, severe dyspnea at rest or requiring oxygen therapy, history of major surgical resection involving the stomach or small bowel, or preexisting Crohn's disease or ulcerative colitis or a preexisting chronic condition resulting in baseline Grade 2 or higher diarrhea).
- Females who are pregnant or lactating.
- Patients with active bacterial infections (requiring intravenous [IV] antibiotics at time of initiating study treatment), fungal infections, or detectable viral infections (such as known human immunodeficiency virus positivity or with known active hepatitis B or C [for example, hepatitis B surface antigen positive]. Screening is not required for enrollment.
- Patients with a personal history in the past 5 years of any of the following conditions: syncope of cardiovascular etiology, ventricular arrhythmia of pathological origin (including, but not limited to, ventricular tachycardia and ventricular fibrillation), or sudden cardiac arrest.
- Patients with contraindications against Abemaciclib according to respective SmPC´s.
- Patients who are not eligible for observation due to severe comorbidities other then mentioned above or unavailability according to the treating physician.
Trial locations and contacts
No sites are listed yet.
About this study
Official title: A Randomized, Controlled Study of Standardized Patient Coaching Versus Patient Management According to Local Practice for Patients With Hormone Receptor Positive HER2 Negative Metastatic Breast Cancer Treated With Abemaciclib
The aim of the IMPACT - Implementing Patients' competence in oral breast cancer therapy - study is to evaluate the effectiveness of a standardized patient education and coaching and optional eMBSR for therapy management provided by specially trained oncology nurses regarding persistence rate, side effects management and unplanned therapy interruptions in outpatient oncology care for patients under Abemaciclib treatment.
Read the detailed description
Breast cancer therapy has advanced by far over the last decade. Introduction of novel therapies as well as the introduction of mammography screening are thought to have reduced mortality over the last decade. More women are treated on an individual basis, trying to avoid toxic and non-effective therapies.
However, every year about 18.000 women are diagnosed with metastastic breast cancer in Germany. Breast cancer remains one of the main reasons for deaths among women and is the main reason for death due to cancer in younger women.
Once a tumor is metastasized, well balanced treatment decisions have to be made to take both into consideration, a high chance of tumor control and a low risk for side effects. Especially in the metastatic setting symptom control and quality of life need to be in the focus of the therapy and patient care.
Modern anticancer strategies are designed against specific molecular targets with the goal of sparing normal, non-neoplastic tissues. Choosing specific molecular targets, however, is problematic. CDK4/6 (Cyclin dependent kinase 4 and 6) are important candidate targets for therapeutic intervention.
Traditionally, anticancer therapy has been dominated by intravenous drug therapy. However, oral agents, like CDK4/6 inhibitors, provide an attractive approach to this kind of treatment and use of oral treatments is increasing. Currently, there are three CDK4/6 inhibitors that have reached clinical practice in the management of ER+ HER2- advanced disease. One of them is Ademaciclib which is approved in the US since September 2017 for "adult patients who have hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative advanced or metastatic breast cancer that has progressed after taking therapy that alters a patient's hormones".
Oral agents for cancer treatment are increasingly prescribed due to their benefits. However, this type of therapy requires a high level of self-management competence by the patient. A standardized patient education provided by physicians and oncology nurses may influence the handling of the oral agents in a positive way regarding side effects and unplanned therapy interruptions.
When it comes to oral agents, the place of treatment is the patients' home. In this treatment setting, correct treatment management cannot be utilized without identifying a patient's needs to be empowered to become an expert of his/her treatment because cancer therapies are commonly difficult to handle and the medication often shows a high risk of side effects and interactions with other drugs. Care providers are challenged by the question of how mostly elderly and multimorbid patients and their supporting relatives can be enabled with essential competencies to manage their treatment by themselves. Before patients start their cancer therapy, they are usually provided with information about the treatment by their physician. However, patients often feel overwhelmed by all the details in this stressful situation and tend to have a reduced capacity to assimilate complex information. Education and additional support at the beginning and in the course of the treatment can be a useful approach for patients to better handle this situation.
Recent studies showed the positive impact of supportive care programs on patients provided by nurses. Patient-focused motivation techniques and education performed by nurses are suitable to strengthen the patients' understanding of risks and benefits from the anti-cancer treatment and oral agents. These care programs can prevent an incorrect medication intake due to misunderstandings, lead to a decrease of treatment-related symptoms like pain and fatigue and reduce critical events. In addition, patient education can facilitate supportive care through a better communication between patient and health care provider and may advance the early detection of adverse toxicity events and foster rapid symptom management.
Mindfulness based stress reduction (MBSR) shows a positive effect on mental health in breast cancer patients. The evidence confirms that MBSR reduces anxiety, depressiveness and stress of breast cancer patients and increases the health-related quality of life. A key ingredient to reduce the damaging effects of chronic stress, reducing distress, and improving quality of life is to have patients engage in behaviors that decrease sympathetic and increase parasympathetic arousal. Studies show that MBSR have a positive effect on many systems in our body and create fundamental changes in the way the brain functions. MBSR can affect neurotransmitters (i.e. glutamate, GABA) and neuromodulators (i.e. dopamine, serotonin, epinephrine), which are essential in maintaining a healthy balance between sympathetic and parasympathetic arousal, therefore, helping to manage the stress response.
The aim of the IMPACT - Implementing Patients' competence in oral breast cancer therapy - study is to evaluate the effectiveness of a standardized patient education and coaching and optional eMBSR for therapy management provided by specially trained oncology nurses regarding persistence rate, side effects management and unplanned therapy interruptions in outpatient oncology care for patients under Abemaciclib treatment.
- Conditions
- Metastatic Breast Cancer, Advanced Breast Cancer
- Keywords
- patient coaching, Advanced or metastatic breast cancer, Abemaciclib, hormone receptor positive (HR+), human epidermal growth factor receptor 2 (HER2) negative
- Medical subject headings
- Breast Neoplasms
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
| Study group | Role | What they receive |
|---|---|---|
| Group 1: Standardized coaching arm | Patients in this group receive a continuous standardized MOATT based patient education and coaching and optional eMBSR (electronic Mindfulness-Based Stress Reduction) within the first 24 weeks of Abemaciclib treatment. | |
| Group 2: Coaching according to local practice | Patients in this group receive a patient management according local routine. |
What is being measured
The primary outcome is the main question the study is designed to answer.
(Potential) difference in persistence rate after 24 weeks of Abemaciclib therapy in both study arms.
The primary objective of this study is to evaluate both study arms regarding the (potential) effect of patient management according to local routine versus continuous standardized patient education and coaching using the MOATT on persistence rate within the first 24 weeks of Abemaciclib treatment.
Measured: 24 weeks
Secondary outcomes (13)
Patient decided interruptions
Total time of patient decided interruptions in days during 24 weeks of Abemaciclib therapy in both study arms.
Measured: 24 weeks
eMSBR
The effect of eMSBR after 24 weeks of Abemaciclib therapy.
Measured: 24 weeks
Quality of life assessed by the FACT-B (Version 4.0) questionnaires.
After weeks 2, 6, 12, 18 and 24, quality of Life (QoL) will be assessed by the FACT-B (Version 4.0) questionnaires.
Measured: 24 weeks
Patient distress assessed via distress thermometer.
After weeks 2, 6, 12, 18 and 24, patient distress will be assessed via distress thermometer.
Measured: 24 weeks
To assess patient reported self-efficacy: patient diary
Self-efficacy will be patient reported and surveyed through a patient dairy.
Measured: 24 weeks
To assess patient reported side-effects.
Type and duration of side-effects will be patient reported and surveyed through a patient dairy.
Measured: 24 weeks
To assess patient reported health related stress.
Health related stress will be patient reported and surveyed via distress thermometer questionnaire.
Measured: 24 weeks
To assess patient reported therapy related knowledge.
Therapy related knowledge will be surveyed via MOATT (MASCC Oral Agent Teaching Tool).
Measured: 24 weeks
Incidence of therapy interruptions.
Amount of relevant events will be surveyed through patient self-reporting via patient diary.
Measured: 24 weeks
Duration of therapy interruptions.
Relevant events (in days) will be surveyed through patient self-reporting via patient diary.
Measured: 24 weeks
Safety and tolerability of Abemaciclib treatment: NCI Common Toxicity Criteria Version 5.0
Incidence of adverse events and serious adverse events will be reported according to NCI Common Toxicity Criteria Version 5.0.
Measured: 24 weeks
Efficacy between the two study arms at week 24 in routine clinical practice as assessed by Progression free survival rate (PFS).
Progression free survival (PFS) rate at 24 weeks of therapy. PFS is defined as time interval from start of therapy until progressive proven with clinical measures according to expertise and daily clinical routine or death from any cause, whichever comes first.
Measured: 24 weeks
Efficacy between the two study arms at week 24 in routine clinical practice as assessed by Overall survival rate (OS).
Overall survival (OS) rate at 24 months is defined as the time to death from therapy start of Abemaciclib.
Measured: 24 weeks
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted24 Jul 2019
- Study startMar 2020 (estimated)
- Primary completionSep 2021 (estimated)
- Study completionDec 2021 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (25)Papers the sponsor has linked to this study.
- Other trials for Metastatic Breast CancerStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Prospective
- Enrolment
- 212 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Onco Medical Consult GmbH
- Sponsor type
- Industry (pharma, biotech, devices)
- Collaborators
- Eli Lilly and Company, Institut fuer Frauengesundheit
- Responsible party
- Sponsor
- Investigators
- Hans Tesch, Prof. Dr. med., Principal investigator, Onkologie Bethanien FrankfurtManfred Welslau, Dr. med., Principal investigator, Onkologie Aschaffenburg
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT04030728
- Sponsor's protocol ID
- OMC2018/01
- Acronym
- IMPACT
- Status last verified
- Jan 2020
- First submitted
- 4 Jul 2019
- Last updated
- 5 Feb 2020
- Results posted
- No
- Data monitoring committee
- Yes
Publications
Bock K, Heywang-Kobrunner S, Regitz-Jedermann L, Hecht G, Kaab-Sanyal V. [Mammography screening in Germany. Current results and future challenges]. Radiologe. 2014 Mar;54(3):205-10. doi: 10.1007/s00117-013-2581-7. German.
PubMed 24623009Eisemann N, Waldmann A, Katalinic A. Epidemiology of Breast Cancer - Current Figures and Trends. Geburtshilfe Frauenheilkd. 2013 Feb;73(2):130-135. doi: 10.1055/s-0032-1328075.
PubMed 24771909Kolberg HC, Luftner D, Lux MP, Maass N, Schutz F, Fasching PA, Fehm T, Janni W, Kummel S. Breast Cancer 2012 - New Aspects. Geburtshilfe Frauenheilkd. 2012 Jul;72(7):602-615. doi: 10.1055/s-0032-1315131.
PubMed 25324576Maass N, Schutz F, Fasching PA, Fehm T, Janni W, Kummel S, Kolberg HC, Luftner D, Wallwiener M, Lux MP. Breast Cancer Update 2014 - Focus on the Patient and the Tumour. Geburtshilfe Frauenheilkd. 2015 Feb;75(2):170-182. doi: 10.1055/s-0035-1545704.
PubMed 25797960Loehberg CR, Almstedt K, Jud SM, Haeberle L, Fasching PA, Hack CC, Lux MP, Thiel FC, Schrauder MG, Brunner M, Bayer CM, Hein A, Heusinger K, Heimrich J, Bani MR, Renner SP, Hartmann A, Beckmann MW, Wachter DL. Prognostic relevance of Ki-67 in the primary tumor for survival after a diagnosis of distant metastasis. Breast Cancer Res Treat. 2013 Apr;138(3):899-908. doi: 10.1007/s10549-013-2460-y. Epub 2013 Mar 12.
PubMed 23479421Fasching PA, Brucker SY, Fehm TN, Overkamp F, Janni W, Wallwiener M, Hadji P, Belleville E, Haberle L, Taran FA, Luftner D, Lux MP, Ettl J, Muller V, Tesch H, Wallwiener D, Schneeweiss A. Biomarkers in Patients with Metastatic Breast Cancer and the PRAEGNANT Study Network. Geburtshilfe Frauenheilkd. 2015 Jan;75(1):41-50. doi: 10.1055/s-0034-1396215.
PubMed 25684786Wadler S. Perspectives for cancer therapies with cdk2 inhibitors. Drug Resist Updat. 2001 Dec;4(6):347-67. doi: 10.1054/drup.2001.0224.
PubMed 12030783Banna GL, Collova E, Gebbia V, Lipari H, Giuffrida P, Cavallaro S, Condorelli R, Buscarino C, Tralongo P, Ferrau F. Anticancer oral therapy: emerging related issues. Cancer Treat Rev. 2010 Dec;36(8):595-605. doi: 10.1016/j.ctrv.2010.04.005. Epub 2010 Jun 8.
PubMed 20570443Schilder CM, Seynaeve C, Linn SC, Boogerd W, Beex LV, Gundy CM, Nortier JW, van de Velde CJ, van Dam FS, Schagen SB. Cognitive functioning of postmenopausal breast cancer patients before adjuvant systemic therapy, and its association with medical and psychological factors. Crit Rev Oncol Hematol. 2010 Nov;76(2):133-41. doi: 10.1016/j.critrevonc.2009.11.001. Epub 2009 Dec 24.
PubMed 20036141May P, Figgins B. Oral anticancer therapy: a comprehensive assessment of patient perceptions and challenges. J Community Support Oncol. 2016 Mar;14(3):112-6. doi: 10.12788/jcso.0226.
PubMed 27058868Molassiotis A, Brearley S, Saunders M, Craven O, Wardley A, Farrell C, Swindell R, Todd C, Luker K. Effectiveness of a home care nursing program in the symptom management of patients with colorectal and breast cancer receiving oral chemotherapy: a randomized, controlled trial. J Clin Oncol. 2009 Dec 20;27(36):6191-8. doi: 10.1200/JCO.2008.20.6755. Epub 2009 Nov 16.
PubMed 19917849Bordonaro S, Romano F, Lanteri E, Cappuccio F, Indorato R, Butera A, D'Angelo A, Ferrau F, Tralongo P. Effect of a structured, active, home-based cancer-treatment program for the management of patients on oral chemotherapy. Patient Prefer Adherence. 2014 Jun 25;8:917-23. doi: 10.2147/PPA.S62666. eCollection 2014.
PubMed 25028540Chau I, Legge S, Fumoleau P. The vital role of education and information in patients receiving capecitabine (Xeloda). Eur J Oncol Nurs. 2004;8 Suppl 1:S41-53. doi: 10.1016/j.ejon.2004.06.008.
PubMed 15341881Temel JS, Greer JA, Admane S, Gallagher ER, Jackson VA, Lynch TJ, Lennes IT, Dahlin CM, Pirl WF. Longitudinal perceptions of prognosis and goals of therapy in patients with metastatic non-small-cell lung cancer: results of a randomized study of early palliative care. J Clin Oncol. 2011 Jun 10;29(17):2319-26. doi: 10.1200/JCO.2010.32.4459. Epub 2011 May 9.
PubMed 21555700Campbell CP. An oral cancer therapy nurse navigator role. Can Nurse. 2016 Apr;112(3):26-7. No abstract available.
PubMed 27373026
Study at a glance
From the registry record, last updated by the sponsor on 5 Feb 2020. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- A Randomized, Controlled Study of Standardized Patient Coaching Versus Patient Management According to Local Practice for Patients With Hormone Receptor Positive HER2 Negative Metastatic Breast Cancer Treated With Abemaciclib
- ClinicalTrials.gov ID
- NCT04030728
- Acronym / sponsor ID
- IMPACT / OMC2018/01
- Conditions
- Metastatic Breast Cancer, Advanced Breast Cancer
- Keywords
- patient coaching, Advanced or metastatic breast cancer, Abemaciclib, hormone receptor positive (HR+), human epidermal growth factor receptor 2 (HER2) negative
- Study type
- Observational
- Recruitment status
- Unknown status
- Enrolment
- 212 participants (estimated)
- Lead sponsor
- Onco Medical Consult GmbHIndustry (pharma, biotech, devices)
- Collaborators
- Eli Lilly and Company, Institut fuer Frauengesundheit
- Study start
- Mar 2020 (estimated)
- Primary completion
- Sep 2021 (estimated)
- Study completion
- Dec 2021 (estimated)
- First posted
- 24 Jul 2019 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The aim of the IMPACT - Implementing Patients' competence in oral breast cancer therapy - study is to evaluate the effectiveness of a standardized patient education and coaching and optional eMBSR for therapy management provided by specially trained oncology nurses regarding persistence rate, side effects management and unplanned therapy interruptions in outpatient oncology care for patients under Abemaciclib treatment.
Detailed description
Breast cancer therapy has advanced by far over the last decade. Introduction of novel therapies as well as the introduction of mammography screening are thought to have reduced mortality over the last decade. More women are treated on an individual basis, trying to avoid toxic and non-effective therapies.
However, every year about 18.000 women are diagnosed with metastastic breast cancer in Germany. Breast cancer remains one of the main reasons for deaths among women and is the main reason for death due to cancer in younger women.
Once a tumor is metastasized, well balanced treatment decisions have to be made to take both into consideration, a high chance of tumor control and a low risk for side effects. Especially in the metastatic setting symptom control and quality of life need to be in the focus of the therapy and patient care.
Modern anticancer strategies are designed against specific molecular targets with the goal of sparing normal, non-neoplastic tissues. Choosing specific molecular targets, however, is problematic. CDK4/6 (Cyclin dependent kinase 4 and 6) are important candidate targets for therapeutic intervention.
Traditionally, anticancer therapy has been dominated by intravenous drug therapy. However, oral agents, like CDK4/6 inhibitors, provide an attractive approach to this kind of treatment and use of oral treatments is increasing. Currently, there are three CDK4/6 inhibitors that have reached clinical practice in the management of ER+ HER2- advanced disease. One of them is Ademaciclib which is approved in the US since September 2017 for "adult patients who have hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative advanced or metastatic breast cancer that has progressed after taking therapy that alters a patient's hormones".
Oral agents for cancer treatment are increasingly prescribed due to their benefits. However, this type of therapy requires a high level of self-management competence by the patient. A standardized patient education provided by physicians and oncology nurses may influence the handling of the oral agents in a positive way regarding side effects and unplanned therapy interruptions.
When it comes to oral agents, the place of treatment is the patients' home. In this treatment setting, correct treatment management cannot be utilized without identifying a patient's needs to be empowered to become an expert of his/her treatment because cancer therapies are commonly difficult to handle and the medication often shows a high risk of side effects and interactions with other drugs. Care providers are challenged by the question of how mostly elderly and multimorbid patients and their supporting relatives can be enabled with essential competencies to manage their treatment by themselves. Before patients start their cancer therapy, they are usually provided with information about the treatment by their physician. However, patients often feel overwhelmed by all the details in this stressful situation and tend to have a reduced capacity to assimilate complex information. Education and additional support at the beginning and in the course of the treatment can be a useful approach for patients to better handle this situation.
Recent studies showed the positive impact of supportive care programs on patients provided by nurses. Patient-focused motivation techniques and education performed by nurses are suitable to strengthen the patients' understanding of risks and benefits from the anti-cancer treatment and oral agents. These care programs can prevent an incorrect medication intake due to misunderstandings, lead to a decrease of treatment-related symptoms like pain and fatigue and reduce critical events. In addition, patient education can facilitate supportive care through a better communication between patient and health care provider and may advance the early detection of adverse toxicity events and foster rapid symptom management.
Mindfulness based stress reduction (MBSR) shows a positive effect on mental health in breast cancer patients. The evidence confirms that MBSR reduces anxiety, depressiveness and stress of breast cancer patients and increases the health-related quality of life. A key ingredient to reduce the damaging effects of chronic stress, reducing distress, and improving quality of life is to have patients engage in behaviors that decrease sympathetic and increase parasympathetic arousal. Studies show that MBSR have a positive effect on many systems in our body and create fundamental changes in the way the brain functions. MBSR can affect neurotransmitters (i.e. glutamate, GABA) and neuromodulators (i.e. dopamine, serotonin, epinephrine), which are essential in maintaining a healthy balance between sympathetic and parasympathetic arousal, therefore, helping to manage the stress response.
The aim of the IMPACT - Implementing Patients' competence in oral breast cancer therapy - study is to evaluate the effectiveness of a standardized patient education and coaching and optional eMBSR for therapy management provided by specially trained oncology nurses regarding persistence rate, side effects management and unplanned therapy interruptions in outpatient oncology care for patients under Abemaciclib treatment.
Study design
- Observational model
- Cohort
- Time perspective
- Prospective
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Group 1: Standardized coaching arm | – | –Patients in this group receive a continuous standardized MOATT based patient education and coaching and optional eMBSR (electronic Mindfulness-Based Stress Reduction) within the first 24 weeks of Abemaciclib treatment. |
| Group 2: Coaching according to local practice | – | –Patients in this group receive a patient management according local routine. |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
- Study population
- Patients who suffer from HR+, HER2- advanced or metastatic breast cancer treated with with orally administered commercially available, prescribed Abemaciclib in combination with an aromase inhibitor or fulvestrant as initial endocrine-based therapy or in women who have received prior endocrine therapy, thereby reflecting the current SmPC (Fachinformation Verzenios®). All treatments are prescribed and performed according to each center's medical practice. Any treatment choice or change in regimen is performed at the discretion of each treating physician.
Key inclusion criteria (4 listed)
- Adult breast cancer patients (age ≥18 years).
- Patients with HR+, HER2- advanced or metastatic breast cancer proven by clinical measures (i. e. standard imaging) whose disease has progressed after hormonal therapy in combination with fulvestrant, or alone in women whose disease has progressed after hormone therapy and prior chemotherapy (advanced disease must not be amenable to resection with curative intent).
- Patients treated with Abemaciclib according to the SmPC and each center´s medical practice.
- Informed consent prior to onset of documentation.
Key exclusion criteria (6 listed)
- Patients with serious preexisting medical condition(s) that would preclude participation in this study (for example, interstitial lung disease, severe dyspnea at rest or requiring oxygen therapy, history of major surgical resection involving the stomach or small bowel, or preexisting Crohn's disease or ulcerative colitis or a preexisting chronic condition resulting in baseline Grade 2 or higher diarrhea).
- Females who are pregnant or lactating.
- Patients with active bacterial infections (requiring intravenous [IV] antibiotics at time of initiating study treatment), fungal infections, or detectable viral infections (such as known human immunodeficiency virus positivity or with known active hepatitis B or C [for example, hepatitis B surface antigen positive]. Screening is not required for enrollment.
- Patients with a personal history in the past 5 years of any of the following conditions: syncope of cardiovascular etiology, ventricular arrhythmia of pathological origin (including, but not limited to, ventricular tachycardia and ventricular fibrillation), or sudden cardiac arrest.
- Patients with contraindications against Abemaciclib according to respective SmPC´s.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Primary outcome
(Potential) difference in persistence rate after 24 weeks of Abemaciclib therapy in both study arms.
Time frame: 24 weeks
The primary objective of this study is to evaluate both study arms regarding the (potential) effect of patient management according to local routine versus continuous standardized patient education and coaching using the MOATT on persistence rate within the first 24 weeks of Abemaciclib treatment.
13 secondary outcomes
Patient decided interruptions
Time frame: 24 weeks
eMSBR
Time frame: 24 weeks
Quality of life assessed by the FACT-B (Version 4.0) questionnaires.
Time frame: 24 weeks
Patient distress assessed via distress thermometer.
Time frame: 24 weeks
To assess patient reported self-efficacy: patient diary
Time frame: 24 weeks
To assess patient reported side-effects.
Time frame: 24 weeks
To assess patient reported health related stress.
Time frame: 24 weeks
To assess patient reported therapy related knowledge.
Time frame: 24 weeks
Incidence of therapy interruptions.
Time frame: 24 weeks
Duration of therapy interruptions.
Time frame: 24 weeks
Safety and tolerability of Abemaciclib treatment: NCI Common Toxicity Criteria Version 5.0
Time frame: 24 weeks
Efficacy between the two study arms at week 24 in routine clinical practice as assessed by Progression free survival rate (PFS).
Time frame: 24 weeks
Efficacy between the two study arms at week 24 in routine clinical practice as assessed by Overall survival rate (OS).
Time frame: 24 weeks
Results and safety
Results are not available in the source record.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 5 Feb 2020.
- Background: PubMed 24623009Bock K, Heywang-Kobrunner S, Regitz-Jedermann L, Hecht G, Kaab-Sanyal V. [Mammography screening in Germany. Current results and future challenges]. Radiologe. 2014 Mar;54(3):205-10. doi: 10.1007/s00117-013-2581-7. German.
- Background: PubMed 24771909Eisemann N, Waldmann A, Katalinic A. Epidemiology of Breast Cancer - Current Figures and Trends. Geburtshilfe Frauenheilkd. 2013 Feb;73(2):130-135. doi: 10.1055/s-0032-1328075.
- Background: PubMed 25324576Kolberg HC, Luftner D, Lux MP, Maass N, Schutz F, Fasching PA, Fehm T, Janni W, Kummel S. Breast Cancer 2012 - New Aspects. Geburtshilfe Frauenheilkd. 2012 Jul;72(7):602-615. doi: 10.1055/s-0032-1315131.
- Background: PubMed 25797960Maass N, Schutz F, Fasching PA, Fehm T, Janni W, Kummel S, Kolberg HC, Luftner D, Wallwiener M, Lux MP. Breast Cancer Update 2014 - Focus on the Patient and the Tumour. Geburtshilfe Frauenheilkd. 2015 Feb;75(2):170-182. doi: 10.1055/s-0035-1545704.
- Background: PubMed 23479421Loehberg CR, Almstedt K, Jud SM, Haeberle L, Fasching PA, Hack CC, Lux MP, Thiel FC, Schrauder MG, Brunner M, Bayer CM, Hein A, Heusinger K, Heimrich J, Bani MR, Renner SP, Hartmann A, Beckmann MW, Wachter DL. Prognostic relevance of Ki-67 in the primary tumor for survival after a diagnosis of distant metastasis. Breast Cancer Res Treat. 2013 Apr;138(3):899-908. doi: 10.1007/s10549-013-2460-y. Epub 2013 Mar 12.
- Background: PubMed 25684786Fasching PA, Brucker SY, Fehm TN, Overkamp F, Janni W, Wallwiener M, Hadji P, Belleville E, Haberle L, Taran FA, Luftner D, Lux MP, Ettl J, Muller V, Tesch H, Wallwiener D, Schneeweiss A. Biomarkers in Patients with Metastatic Breast Cancer and the PRAEGNANT Study Network. Geburtshilfe Frauenheilkd. 2015 Jan;75(1):41-50. doi: 10.1055/s-0034-1396215.
- Background: PubMed 12030783Wadler S. Perspectives for cancer therapies with cdk2 inhibitors. Drug Resist Updat. 2001 Dec;4(6):347-67. doi: 10.1054/drup.2001.0224.
- Background: PubMed 20570443Banna GL, Collova E, Gebbia V, Lipari H, Giuffrida P, Cavallaro S, Condorelli R, Buscarino C, Tralongo P, Ferrau F. Anticancer oral therapy: emerging related issues. Cancer Treat Rev. 2010 Dec;36(8):595-605. doi: 10.1016/j.ctrv.2010.04.005. Epub 2010 Jun 8.
- Background: PubMed 20036141Schilder CM, Seynaeve C, Linn SC, Boogerd W, Beex LV, Gundy CM, Nortier JW, van de Velde CJ, van Dam FS, Schagen SB. Cognitive functioning of postmenopausal breast cancer patients before adjuvant systemic therapy, and its association with medical and psychological factors. Crit Rev Oncol Hematol. 2010 Nov;76(2):133-41. doi: 10.1016/j.critrevonc.2009.11.001. Epub 2009 Dec 24.
- Background: PubMed 27058868May P, Figgins B. Oral anticancer therapy: a comprehensive assessment of patient perceptions and challenges. J Community Support Oncol. 2016 Mar;14(3):112-6. doi: 10.12788/jcso.0226.
- Background: PubMed 19917849Molassiotis A, Brearley S, Saunders M, Craven O, Wardley A, Farrell C, Swindell R, Todd C, Luker K. Effectiveness of a home care nursing program in the symptom management of patients with colorectal and breast cancer receiving oral chemotherapy: a randomized, controlled trial. J Clin Oncol. 2009 Dec 20;27(36):6191-8. doi: 10.1200/JCO.2008.20.6755. Epub 2009 Nov 16.
- Background: PubMed 25028540Bordonaro S, Romano F, Lanteri E, Cappuccio F, Indorato R, Butera A, D'Angelo A, Ferrau F, Tralongo P. Effect of a structured, active, home-based cancer-treatment program for the management of patients on oral chemotherapy. Patient Prefer Adherence. 2014 Jun 25;8:917-23. doi: 10.2147/PPA.S62666. eCollection 2014.
Related trials for Metastatic Breast Cancer
RecruitingPhase 2
Gene Signatures to Guide HR+MBC Therapy in a Diverse Cohort
Invasive Mammary Carcinoma, Metastatic Breast Cancer
Not yet recruiting
Augmented-Reality ICG Fluorescence Second-Look for Residual Nodal Disease After Axillary Dissection in Breast Cancer
Breast Cancer, Breast Neoplasms
RecruitingPhase 2
BrAin Metastasis in tripLe Negateive Breast Cancer: IvoneScimab and Trop2 ADC
Triple-Negative Breast Cancer (TNBC), Brain Metastases
RecruitingPhase 1/2
A Study Evaluating the Efficacy and Safety of Multiple Treatment Combinations in Patients With Metastatic or Locally Advanced Breast Cancer
Metastatic Breast Cancer
RecruitingObservational study
Collection of CSF Samples From Participants With Metastatic Triple Negative Breast Cancer (TNBC) and HER2+ Breast Cancer With no Prior History Nor Active Radiographically Detectable Brain Metastases
Breast Cancer, Breast Carcinoma
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Hans Tesch, Prof. Dr. med. principal investigator
Onkologie Bethanien Frankfurt
Manfred Welslau, Dr. med. principal investigator
Onkologie Aschaffenburg
Questions about this trial
What is this clinical trial studying?
An observational study of Metastatic Breast Cancer and Advanced Breast Cancer, run by Onco Medical Consult GmbH.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 6 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: status not confirmed, as of the sponsor's last update on 5 Feb 2020. Status can change between updates, so confirm with the study contact before making plans.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
Results are not available in the source record.
How can a doctor refer a patient or contact the research team?
Contact Jenny Palmrich (0049 69 560056 182, jenny.palmrich@chop-studien.de), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
(Potential) difference in persistence rate after 24 weeks of Abemaciclib therapy in both study arms. (time frame: 24 weeks). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT04030728, which also lists 25 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 5 Feb 2020.