SleepNFS5NCT04044885
Investigating Preferred Nap Schedules for Adolescents
A study testing Nap in people with Sleep, run by Duke-NUS Graduate Medical School at 1 site in Singapore.
Trial summary
The aim of this study is to examine the neurobehavioural responses to two successive cycles of sleep manipulation nights and recovery nights in adolescents, and to determine the benefits of napping on cognitive performance, alertness and mood. Read more about this study
- Who is it for?
- Ages 15 to 19 yearsHealthy volunteers can take part
- Conditions the study is for
- Sleep
- What is being tested?
- Nap
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 54 participants
- Where
- 1 siteSingapore
- Study dates
- 1 Aug 2019to 31 Dec 2019
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 15 to 19 years
- All sexes
- Healthy volunteers accepted
- Child, Adult
Who may be able to join
- healthy
- no sleep disorder
- body mass index not greater than 30
Who cannot join
- smoker
- habitual short sleeper (time in bed during term time of less than 6 hours and no sign of -
- sleep extension of greater than 1 hour on weekends)
- consumption of more than 5 cups of caffeinated beverages a day
- travelling across more than 2 time zones in the month prior to the study protocol
- diagnosed with any psychiatric conditions
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Investigating the Preferred Nap Schedule for Adolescents With Adequate Sleep
The aim of this study is to examine the neurobehavioural responses to two successive cycles of sleep manipulation nights and recovery nights in adolescents, and to determine the benefits of napping on cognitive performance, alertness and mood. Using a split-sleep design, 60 participants, aged 15 to 19 years old, are divided into a nap and a no-nap group. Both groups undergo two cycles of sleep manipulation nights and recovery nights over a period of 15 days. The no-nap group receives an 8-hour sleep opportunity on sleep restriction nights, with no daytime nap opportunity. The nap group receives a 6.5-hour sleep opportunity on sleep restriction nights, and has a 1.5-hour nap opportunity the following afternoon.
Read the detailed description
The present study investigates whether a continuous stretch of night time sleep (8 hours) will lead to better neurobehavioural outcomes relative to nocturnal sleep restriction (6.5 hours) and daytime nap (1.5 hours) of the same total duration. The 15-day protocol is conducted in a dormitory on 60 high school students, aged 15 to 19 years old. Participants are assigned to a nap or no-nap group. Both groups start with two 9-hour adaptation and baseline nights, followed by two successive cycles of sleep restriction (6.5-h time in bed (TIB); 00:15-06:45 or 8-h TIB; 23:30-07:30) and recovery (9-h TIB; 23:00-08:00). Following each sleep-restricted night, the nap group receives a 1.5-h nap opportunity, while participants in the no-nap group watch a documentary. Throughout the protocol, sleep-wake patterns are assessed with actigraphy and polysomnography. Sleepiness levels, mood, vigilance, working memory / executive functions, and speed of processing are assessed 3 times daily (10:00, 16:15, and 20:00).
All participants stay in air-conditioned, twin-share bedrooms with en-suite bathrooms. Bedroom windows are fitted with blackout panels to ensure participants are not woken up prematurely by sunlight. Earplugs are provided, and participants are allowed to adjust the temperature of their bedrooms to their personal comfort. Three main meals are served each day, with snacks being provided for upon request. Caffeinated drinks, unscheduled sleep, and strenuous physical activities are prohibited.
Outside of scheduled sleep, meal, and cognitive testing times, participants spend the majority of their free time in a common room that is illuminated by natural and artificial lighting. They are allowed to read, play non-physically exerting games, watch videos, and interact with research staff and other participants. Participants are under constant supervision by the research staff.
- Conditions
- Sleep
- Being tested
- Nap
- Keywords
- Nap, Recovery sleep, Cognitive functions, Neurobehavioural functions, Mood, Subjective sleepiness
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
NapBehavioural
Looking at the difference between continuous sleep opportunities and split-sleep opportunities.
| Study group | Role | What they receive |
|---|---|---|
| Nap | Experimental | After each night with a 6.5-hour sleep opportunity, participants have a daytime nap opportunity of 1.5 hours. Receives: Behavioral: Nap |
| No nap | No intervention | After each night with a 8-hour sleep opportunity, participants do not have a daytime nap opportunity, but instead have free time. |
What is being measured
The primary outcome is the main question the study is designed to answer.
1.Change in sustained attention assessed with the Psychomotor Vigilance Task from morning to afternoon and then evening from baseline days to the first and second cycles of sleep restriction and recovery
Number of attention lapses (>500ms)
Measured: 3 times daily (10:00, 16:15, and 20:00) for 15 days
2.Change in working memory assessed with the 1-back task from morning to afternoon and then evening from baseline days to the first and second cycles of sleep restriction and recovery
Number of correct responses in the 1-back task
Measured: 3 times daily (10:00, 16:15, and 20:00) for 15 days
3.Change in executive functions assessed with the 3-back task from morning to afternoon and then evening from baseline days to the first and second cycles of sleep restriction and recovery
Number of correct responses in the 3-back task
Measured: 3 times daily (10:00, 16:15, and 20:00) for 15 days
4.Change in the level of subjective sleepiness assessed with the Karolinska Sleepiness Scale from morning to afternoon and then evening from baseline days to the first and second cycles of sleep restriction and recovery
Score on the Karolinska Sleepiness Scale (1-9 points)
Measured: 3 times daily (10:00, 16:15, and 20:00) for 15 days
5.Change in positive mood assessed with the Positive and Negative Affect Scale (PANAS) from morning to afternoon and then evening from baseline days to the first and second cycles of sleep restriction and recovery
Total score on the positive subscale of the PANAS
Measured: 3 times daily (10:00, 16:15, and 20:00) for 15 days
6.Change in negative mood assessed with the Positive and Negative Affect Scale (PANAS) from morning to afternoon and then evening from baseline days to the first and second cycles of sleep restriction and recovery
Total score on the negative subscale of the PANAS
Measured: 3 times daily (10:00, 16:15, and 20:00) for 15 days
7.Change in speed of processing assessed with the Mental Arithmetic Task from morning to afternoon and then evening from baseline days to the first and second cycles of sleep restriction and recovery
Number of correct responses in the task
Measured: 3 times daily (10:00, 16:15, and 20:00) for 15 days
8.Change in speed of processing assessed with the Symbol Digit Modalities Task from morning to afternoon and then evening from baseline days to the first and second cycles of sleep restriction and recovery
Number of correct responses in the task
Measured: 3 times daily (10:00, 16:15, and 20:00) for 15 days
11.Change in memory performance in picture-word association task over sleep restriction nights and recovery night
Score on picture-word association task
Measured: 12 times (morning and evening): after sleep restriction night 1, 2, 3, 4 and 5 (sleep restriction period 1) and after recovery night 2 (recovery period 1)
14.Effect of sleep versus wake during delay on memory for rewarded pictures, where the pictures will be encoded either before a 12-hr interval including a night of sleep or a day of wakefulness
Memory score of correctly remembered encoded pictures following the wake or sleep
Measured: Single session during the 15-day protocol, after baseline night 1 or before sleep restriction night 1 (first sleep restriction period)
15.Effect of sleep restriction on learning of novel material (about different animal species) across separate sessions
Memory score on test of learned material
Measured: Single session during the 15-day protocol, after recovery night 2 (first recovery period)
16.Effect of sleep restriction on memory of spatial locations
Performance in four mountains task
Measured: Single session during the 15-day protocol, after sleep restriction night 3 (first sleep restriction period)
18.Effect of sleep restriction on picture encoding
Memory score of correctly remembered encoded pictures of non-famous people, landscapes, scenes and objects
Measured: Single session during the 15-day protocol, after recovery night 2 (second recovery period)
19.Effect of sleep restriction on effort/temporal discounting
Choice preference (perform a longer duration task for a higher reward, or to take a break for a lower/no reward) in effort/temporal discounting task is measured
Measured: Three sessions during the 15-day protocol (after baseline night 1, after sleep restriction night 5 (first sleep restriction period) and after recovery night 2 (first recovery period))
Secondary outcomes (10)
Change in total sleep duration at night assessed with polysomnography from baseline nights to the first and second cycles of sleep restriction and recovery
Total duration of nocturnal sleep was determined to establish baseline sleep characteristics (first and second nights) and changes in the first sleep restriction period (third, fifth and seventh night), the first recovery period (eighth night), the second sleep restriction period (tenth and twelfth night), and the second recovery period (13th night).
Measured: Nocturnal sleep on nights 1 & 2 (baseline), 3, 5 & 7 (first sleep restriction period), 8 (first recovery period), 10 & 12 (second sleep restriction period), & 13 (second recovery period)
Change in N1 sleep duration at night assessed with polysomnography from baseline nights to the first and second cycles of sleep restriction and recovery
Duration of nocturnal N1 sleep was determined to establish baseline sleep characteristics (first and second nights) and changes in the first sleep restriction period (third, fifth and seventh night), the first recovery period (eighth night), the second sleep restriction period (tenth and twelfth night), and the second recovery period (13th night).
Measured: Nocturnal sleep on nights 1 & 2 (baseline), 3, 5 & 7 (first sleep restriction period), 8 (first recovery period), 10 & 12 (second sleep restriction period), & 13 (second recovery period)
Change in N2 sleep duration at night assessed with polysomnography from baseline nights to the first and second cycles of sleep restriction and recovery
Duration of nocturnal N2 sleep was determined to establish baseline sleep characteristics (first and second nights) and changes in the first sleep restriction period (third, fifth and seventh night), the first recovery period (eighth night), the second sleep restriction period (tenth and twelfth night), and the second recovery period (13th night).
Measured: Nocturnal sleep on nights 1 & 2 (baseline), 3, 5 & 7 (first sleep restriction period), 8 (first recovery period), 10 & 12 (second sleep restriction period), & 13 (second recovery period)
Change in N3 sleep duration at night assessed with polysomnography from baseline nights to the first and second cycles of sleep restriction and recovery
Duration of nocturnal N3 sleep was determined to establish baseline sleep characteristics (first and second nights) and changes in the first sleep restriction period (third, fifth and seventh night), the first recovery period (eighth night), the second sleep restriction period (tenth and twelfth night), and the second recovery period (13th night).
Measured: Nocturnal sleep on nights 1 & 2 (baseline), 3, 5 & 7 (first sleep restriction period), 8 (first recovery period), 10 & 12 (second sleep restriction period), & 13 (second recovery period)
Change in Rapid Eye Movement (REM) sleep duration at night assessed with polysomnography from baseline nights to the first and second cycles of sleep restriction and recovery
Duration of nocturnal REM sleep was determined to establish baseline sleep characteristics (first and second nights) and changes in the first sleep restriction period (third, fifth and seventh night), the first recovery period (eighth night), the second sleep restriction period (tenth and twelfth night), and the second recovery period (13th night).
Measured: Nocturnal sleep on nights 1 & 2 (baseline), 3, 5 & 7 (first sleep restriction period), 8 (first recovery period), 10 & 12 (second sleep restriction period), & 13 (second recovery period)
Change in total sleep duration during daytime naps assessed with polysomnography from the first to the second sleep restriction period
Total duration of sleep during the selected nap episodes was determined to track changes in this parameter from the first sleep restriction period (third, fifth and seventh day) to the second sleep restriction period (tenth and twelfth day)
Measured: Afternoon naps on days 4, 6 & 8 (first sleep restriction period), 11 & 13 (second sleep restriction period
Change in N1 sleep duration during daytime naps assessed with polysomnography from the first to the second sleep restriction period
Duration of N1 sleep during the selected nap episodes was determined to track changes in this parameter from the first sleep restriction period (third, fifth and seventh day) to the second sleep restriction period (tenth and twelfth day)
Measured: Afternoon naps on days 4, 6 & 8 (first sleep restriction period), 11 & 13 (second sleep restriction period
Change in N2 sleep duration during daytime naps assessed with polysomnography from the first to the second sleep restriction period
Duration of N2 sleep during the selected nap episodes was determined to track changes in this parameter from the first sleep restriction period (third, fifth and seventh day) to the second sleep restriction period (tenth and twelfth day)
Measured: Afternoon naps on days 4, 6 & 8 (first sleep restriction period), 11 & 13 (second sleep restriction period
Change in N3 sleep duration during daytime naps assessed with polysomnography from the first to the second sleep restriction period
Duration of N3 sleep during the selected nap episodes was determined to track changes in this parameter from the first sleep restriction period (third, fifth and seventh day) to the second sleep restriction period (tenth and twelfth day)
Measured: Afternoon naps on days 4, 6 & 8 (first sleep restriction period), 11 & 13 (second sleep restriction period
Change in REM sleep duration during daytime naps assessed with polysomnography from the first to the second sleep restriction period
Duration of REM sleep during the selected nap episodes was determined to track changes in this parameter from the first sleep restriction period (third, fifth and seventh day) to the second sleep restriction period (tenth and twelfth day)
Measured: Afternoon naps on days 4, 6 & 8 (first sleep restriction period), 11 & 13 (second sleep restriction period
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted5 Aug 2019
- Study start1 Aug 2019
- Primary completion10 Dec 2019
- Study completion31 Dec 2019
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (6)Papers the sponsor has linked to this study.
- Other trials for SleepStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Basic science
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Enrolment
- 54 participants (actual)
Sponsor and investigators
- Lead sponsor
- Duke-NUS Graduate Medical School
- Sponsor type
- University, hospital or other
- Collaborators
- National Medical Research Council (NMRC), Singapore
- Responsible party
- Principal investigator, Michael WL Chee, MBBS, Duke-NUS Graduate Medical School
- Investigators
- Michael WL Chee, MBBS, Principal investigator, Duke-NUS Graduate Medical School
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT04044885
- Sponsor's protocol ID
- NFS5
- Acronym
- NFS5
- Status last verified
- Jul 2020
- First submitted
- 1 Aug 2019
- Last updated
- 23 Jul 2020
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Publications
Leong RLF, Tian L, Yu N, Teo TB, Ong JL, Chee MWL. Bidirectional associations between the duration and timing of nocturnal sleep and daytime naps in adolescents differ from weekdays to weekends. Sleep. 2024 Sep 9;47(9):zsae147. doi: 10.1093/sleep/zsae147.
PubMed 38938171Golkashani HA, Ghorbani S, Leong RLF, Ong JL, Chee MWL. Advantage conferred by overnight sleep on schema-related memory may last only a day. Sleep Adv. 2023 Apr 14;4(1):zpad019. doi: 10.1093/sleepadvances/zpad019. eCollection 2023.
PubMed 37193282Aghayan Golkashani H, Leong RLF, Ghorbani S, Ong JL, Fernandez G, Chee MWL. A sleep schedule incorporating naps benefits the transformation of hierarchical knowledge. Sleep. 2022 Apr 11;45(4):zsac025. doi: 10.1093/sleep/zsac025.
PubMed 35090173Lo JC, Koa TB, Ong JL, Gooley JJ, Chee MWL. Staying vigilant during recurrent sleep restriction: dose-response effects of time-in-bed and benefits of daytime napping. Sleep. 2022 Apr 11;45(4):zsac023. doi: 10.1093/sleep/zsac023.
PubMed 35089345Leong RLF, Yu N, Ong JL, Ng ASC, Jamaluddin SA, Cousins JN, Chee NIYN, Chee MWL. Memory performance following napping in habitual and non-habitual nappers. Sleep. 2021 Jun 11;44(6):zsaa277. doi: 10.1093/sleep/zsaa277.
PubMed 33313925Lo JC, Leong RLF, Ng ASC, Jamaluddin SA, Ong JL, Ghorbani S, Lau T, Chee NIYN, Gooley JJ, Chee MWL. Cognitive effects of split and continuous sleep schedules in adolescents differ according to total sleep opportunity. Sleep. 2020 Dec 14;43(12):zsaa129. doi: 10.1093/sleep/zsaa129.
PubMed 32619240
Study at a glance
From the registry record, last updated by the sponsor on 23 Jul 2020. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Investigating the Preferred Nap Schedule for Adolescents With Adequate Sleep
- ClinicalTrials.gov ID
- NCT04044885
- Acronym / sponsor ID
- NFS5 / NFS5
- Conditions
- Sleep
- Keywords
- Nap, Recovery sleep, Cognitive functions, Neurobehavioural functions, Mood, Subjective sleepiness
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 54 participants (actual)
- Lead sponsor
- Duke-NUS Graduate Medical SchoolUniversity, hospital or other
- Collaborators
- National Medical Research Council (NMRC), Singapore
- Study start
- 1 Aug 2019 (actual)
- Primary completion
- 10 Dec 2019 (actual)
- Study completion
- 31 Dec 2019 (actual)
- First posted
- 5 Aug 2019 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The aim of this study is to examine the neurobehavioural responses to two successive cycles of sleep manipulation nights and recovery nights in adolescents, and to determine the benefits of napping on cognitive performance, alertness and mood. Using a split-sleep design, 60 participants, aged 15 to 19 years old, are divided into a nap and a no-nap group. Both groups undergo two cycles of sleep manipulation nights and recovery nights over a period of 15 days. The no-nap group receives an 8-hour sleep opportunity on sleep restriction nights, with no daytime nap opportunity. The nap group receives a 6.5-hour sleep opportunity on sleep restriction nights, and has a 1.5-hour nap opportunity the following afternoon.
Detailed description
The present study investigates whether a continuous stretch of night time sleep (8 hours) will lead to better neurobehavioural outcomes relative to nocturnal sleep restriction (6.5 hours) and daytime nap (1.5 hours) of the same total duration. The 15-day protocol is conducted in a dormitory on 60 high school students, aged 15 to 19 years old. Participants are assigned to a nap or no-nap group. Both groups start with two 9-hour adaptation and baseline nights, followed by two successive cycles of sleep restriction (6.5-h time in bed (TIB); 00:15-06:45 or 8-h TIB; 23:30-07:30) and recovery (9-h TIB; 23:00-08:00). Following each sleep-restricted night, the nap group receives a 1.5-h nap opportunity, while participants in the no-nap group watch a documentary. Throughout the protocol, sleep-wake patterns are assessed with actigraphy and polysomnography. Sleepiness levels, mood, vigilance, working memory / executive functions, and speed of processing are assessed 3 times daily (10:00, 16:15, and 20:00).
All participants stay in air-conditioned, twin-share bedrooms with en-suite bathrooms. Bedroom windows are fitted with blackout panels to ensure participants are not woken up prematurely by sunlight. Earplugs are provided, and participants are allowed to adjust the temperature of their bedrooms to their personal comfort. Three main meals are served each day, with snacks being provided for upon request. Caffeinated drinks, unscheduled sleep, and strenuous physical activities are prohibited.
Outside of scheduled sleep, meal, and cognitive testing times, participants spend the majority of their free time in a common room that is illuminated by natural and artificial lighting. They are allowed to read, play non-physically exerting games, watch videos, and interact with research staff and other participants. Participants are under constant supervision by the research staff.
Study design
- Primary purpose
- Basic science
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Nap | Experimental | Behavioral: NapAfter each night with a 6.5-hour sleep opportunity, participants have a daytime nap opportunity of 1.5 hours. |
| No nap | No intervention | –After each night with a 8-hour sleep opportunity, participants do not have a daytime nap opportunity, but instead have free time. |
Who may qualify
- Ages
- 15 to 19 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Child, Adult
Key inclusion criteria (3 listed)
- healthy
- no sleep disorder
- body mass index not greater than 30
Key exclusion criteria (6 listed)
- smoker
- habitual short sleeper (time in bed during term time of less than 6 hours and no sign of -
- sleep extension of greater than 1 hour on weekends)
- consumption of more than 5 cups of caffeinated beverages a day
- travelling across more than 2 time zones in the month prior to the study protocol
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| NapLooking at the difference between continuous sleep opportunities and split-sleep opportunities. | Behavioural | Nap |
Primary outcome
1.Change in sustained attention assessed with the Psychomotor Vigilance Task from morning to afternoon and then evening from baseline days to the first and second cycles of sleep restriction and recovery
Time frame: 3 times daily (10:00, 16:15, and 20:00) for 15 days
Number of attention lapses (>500ms)
2.Change in working memory assessed with the 1-back task from morning to afternoon and then evening from baseline days to the first and second cycles of sleep restriction and recovery
Time frame: 3 times daily (10:00, 16:15, and 20:00) for 15 days
Number of correct responses in the 1-back task
3.Change in executive functions assessed with the 3-back task from morning to afternoon and then evening from baseline days to the first and second cycles of sleep restriction and recovery
Time frame: 3 times daily (10:00, 16:15, and 20:00) for 15 days
Number of correct responses in the 3-back task
4.Change in the level of subjective sleepiness assessed with the Karolinska Sleepiness Scale from morning to afternoon and then evening from baseline days to the first and second cycles of sleep restriction and recovery
Time frame: 3 times daily (10:00, 16:15, and 20:00) for 15 days
Score on the Karolinska Sleepiness Scale (1-9 points)
5.Change in positive mood assessed with the Positive and Negative Affect Scale (PANAS) from morning to afternoon and then evening from baseline days to the first and second cycles of sleep restriction and recovery
Time frame: 3 times daily (10:00, 16:15, and 20:00) for 15 days
Total score on the positive subscale of the PANAS
6.Change in negative mood assessed with the Positive and Negative Affect Scale (PANAS) from morning to afternoon and then evening from baseline days to the first and second cycles of sleep restriction and recovery
Time frame: 3 times daily (10:00, 16:15, and 20:00) for 15 days
Total score on the negative subscale of the PANAS
7.Change in speed of processing assessed with the Mental Arithmetic Task from morning to afternoon and then evening from baseline days to the first and second cycles of sleep restriction and recovery
Time frame: 3 times daily (10:00, 16:15, and 20:00) for 15 days
Number of correct responses in the task
8.Change in speed of processing assessed with the Symbol Digit Modalities Task from morning to afternoon and then evening from baseline days to the first and second cycles of sleep restriction and recovery
Time frame: 3 times daily (10:00, 16:15, and 20:00) for 15 days
Number of correct responses in the task
11.Change in memory performance in picture-word association task over sleep restriction nights and recovery night
Time frame: 12 times (morning and evening): after sleep restriction night 1, 2, 3, 4 and 5 (sleep restriction period 1) and after recovery night 2 (recovery period 1)
Score on picture-word association task
14.Effect of sleep versus wake during delay on memory for rewarded pictures, where the pictures will be encoded either before a 12-hr interval including a night of sleep or a day of wakefulness
Time frame: Single session during the 15-day protocol, after baseline night 1 or before sleep restriction night 1 (first sleep restriction period)
Memory score of correctly remembered encoded pictures following the wake or sleep
15.Effect of sleep restriction on learning of novel material (about different animal species) across separate sessions
Time frame: Single session during the 15-day protocol, after recovery night 2 (first recovery period)
Memory score on test of learned material
16.Effect of sleep restriction on memory of spatial locations
Time frame: Single session during the 15-day protocol, after sleep restriction night 3 (first sleep restriction period)
Performance in four mountains task
18.Effect of sleep restriction on picture encoding
Time frame: Single session during the 15-day protocol, after recovery night 2 (second recovery period)
Memory score of correctly remembered encoded pictures of non-famous people, landscapes, scenes and objects
19.Effect of sleep restriction on effort/temporal discounting
Time frame: Three sessions during the 15-day protocol (after baseline night 1, after sleep restriction night 5 (first sleep restriction period) and after recovery night 2 (first recovery period))
Choice preference (perform a longer duration task for a higher reward, or to take a break for a lower/no reward) in effort/temporal discounting task is measured
10 secondary outcomes
Change in total sleep duration at night assessed with polysomnography from baseline nights to the first and second cycles of sleep restriction and recovery
Time frame: Nocturnal sleep on nights 1 & 2 (baseline), 3, 5 & 7 (first sleep restriction period), 8 (first recovery period), 10 & 12 (second sleep restriction period), & 13 (second recovery period)
Change in N1 sleep duration at night assessed with polysomnography from baseline nights to the first and second cycles of sleep restriction and recovery
Time frame: Nocturnal sleep on nights 1 & 2 (baseline), 3, 5 & 7 (first sleep restriction period), 8 (first recovery period), 10 & 12 (second sleep restriction period), & 13 (second recovery period)
Change in N2 sleep duration at night assessed with polysomnography from baseline nights to the first and second cycles of sleep restriction and recovery
Time frame: Nocturnal sleep on nights 1 & 2 (baseline), 3, 5 & 7 (first sleep restriction period), 8 (first recovery period), 10 & 12 (second sleep restriction period), & 13 (second recovery period)
Change in N3 sleep duration at night assessed with polysomnography from baseline nights to the first and second cycles of sleep restriction and recovery
Time frame: Nocturnal sleep on nights 1 & 2 (baseline), 3, 5 & 7 (first sleep restriction period), 8 (first recovery period), 10 & 12 (second sleep restriction period), & 13 (second recovery period)
Change in Rapid Eye Movement (REM) sleep duration at night assessed with polysomnography from baseline nights to the first and second cycles of sleep restriction and recovery
Time frame: Nocturnal sleep on nights 1 & 2 (baseline), 3, 5 & 7 (first sleep restriction period), 8 (first recovery period), 10 & 12 (second sleep restriction period), & 13 (second recovery period)
Change in total sleep duration during daytime naps assessed with polysomnography from the first to the second sleep restriction period
Time frame: Afternoon naps on days 4, 6 & 8 (first sleep restriction period), 11 & 13 (second sleep restriction period
Change in N1 sleep duration during daytime naps assessed with polysomnography from the first to the second sleep restriction period
Time frame: Afternoon naps on days 4, 6 & 8 (first sleep restriction period), 11 & 13 (second sleep restriction period
Change in N2 sleep duration during daytime naps assessed with polysomnography from the first to the second sleep restriction period
Time frame: Afternoon naps on days 4, 6 & 8 (first sleep restriction period), 11 & 13 (second sleep restriction period
Change in N3 sleep duration during daytime naps assessed with polysomnography from the first to the second sleep restriction period
Time frame: Afternoon naps on days 4, 6 & 8 (first sleep restriction period), 11 & 13 (second sleep restriction period
Change in REM sleep duration during daytime naps assessed with polysomnography from the first to the second sleep restriction period
Time frame: Afternoon naps on days 4, 6 & 8 (first sleep restriction period), 11 & 13 (second sleep restriction period
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 23 Jul 2020.
- Derived from this study: PubMed 38938171Leong RLF, Tian L, Yu N, Teo TB, Ong JL, Chee MWL. Bidirectional associations between the duration and timing of nocturnal sleep and daytime naps in adolescents differ from weekdays to weekends. Sleep. 2024 Sep 9;47(9):zsae147. doi: 10.1093/sleep/zsae147.
- Derived from this study: PubMed 37193282Golkashani HA, Ghorbani S, Leong RLF, Ong JL, Chee MWL. Advantage conferred by overnight sleep on schema-related memory may last only a day. Sleep Adv. 2023 Apr 14;4(1):zpad019. doi: 10.1093/sleepadvances/zpad019. eCollection 2023.
- Derived from this study: PubMed 35090173Aghayan Golkashani H, Leong RLF, Ghorbani S, Ong JL, Fernandez G, Chee MWL. A sleep schedule incorporating naps benefits the transformation of hierarchical knowledge. Sleep. 2022 Apr 11;45(4):zsac025. doi: 10.1093/sleep/zsac025.
- Derived from this study: PubMed 35089345Lo JC, Koa TB, Ong JL, Gooley JJ, Chee MWL. Staying vigilant during recurrent sleep restriction: dose-response effects of time-in-bed and benefits of daytime napping. Sleep. 2022 Apr 11;45(4):zsac023. doi: 10.1093/sleep/zsac023.
- Derived from this study: PubMed 33313925Leong RLF, Yu N, Ong JL, Ng ASC, Jamaluddin SA, Cousins JN, Chee NIYN, Chee MWL. Memory performance following napping in habitual and non-habitual nappers. Sleep. 2021 Jun 11;44(6):zsaa277. doi: 10.1093/sleep/zsaa277.
- Derived from this study: PubMed 32619240Lo JC, Leong RLF, Ng ASC, Jamaluddin SA, Ong JL, Ghorbani S, Lau T, Chee NIYN, Gooley JJ, Chee MWL. Cognitive effects of split and continuous sleep schedules in adolescents differ according to total sleep opportunity. Sleep. 2020 Dec 14;43(12):zsaa129. doi: 10.1093/sleep/zsaa129.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Michael WL Chee, MBBS principal investigator
Duke-NUS Graduate Medical School
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Nap in people with Sleep, run by Duke-NUS Graduate Medical School at 1 site in Singapore.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 6 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 23 Jul 2020. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Singapore. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
1.Change in sustained attention assessed with the Psychomotor Vigilance Task from morning to afternoon and then evening from baseline days to the first and second cycles of sleep restriction and recovery (time frame: 3 times daily (10:00, 16:15, and 20:00) for 15 days). The study lists 14 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT04044885, which also lists 6 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 23 Jul 2020.