Intensive Care Unit DeliriumNCT04056338
Gut Microbiome and ICU Delirium Post Cardiac Surgeries
An observational study of Intensive Care Unit Delirium, run by Second Affiliated Hospital, Zhejiang University, School of Medicine at 1 site in China.
Trial summary
ICU delirium are assessed by clinical nurses twice every day. Delirious patients are matched with patients according to their disease, gender and age range(±3 years). Stool samples for gene sequencing are collected. Gut barrier function are studied with several serum biomarkers (endotoxin, etc.). Read more about this study
- Who is it for?
- Ages 18 to 90 years
- Conditions the study is for
- Intensive Care Unit Delirium
- How many people
- 60 participants
- Where
- 1 siteChina
- Study dates
- 1 Jan 2019to 30 Dec 2019
- Phase
- Observational
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 90 years
- All sexes
- No healthy volunteers
- Adult, Older adult
Study population: Patients after cardiac surgery and admitted to CSICU are recruited.
Who may be able to join
- to have had heart valve surgery or coronary artery bypass grafting (CABG)
- to have no planned transfer to another ward or hospital within 24 hours after surgery
- to have no preoperative cognitive impairment and can speak and read Chinese
- more than 18 years old
Who cannot join
- to have a hearing or visual impairment that could impact delirium assessment
- to have a history of alcohol or drug abuse
- to have a preoperative intestinal irritation syndrome or history of gastrointestinal disease
- to have received antibiotics or probiotics within 28 days before admission
- to have a life expectancy less than 24 hours
- to have an experience of ICU hospitalization, mechanical ventilation in the past 30 days
- to have a cardiac surgery or hypoxic brain injury in the past 3 months.
Trial locations and contacts
1 site in 1 country.
China1 site
Second Affiliated Hospital, School of Medicine, Zhejiang University
Hangzhou, Zhejiang, 310009
About this study
Official title: Gut Microbiome and Gut Barrier Function in ICU Delirium Post Cardiac Surgery
ICU delirium are assessed by clinical nurses twice every day. Delirious patients are matched with patients according to their disease, gender and age range(±3 years). Stool samples for gene sequencing are collected. Gut barrier function are studied with several serum biomarkers (endotoxin, etc.). Ecological analyses, regression models and mediation equation will be performed.
Read the detailed description
ICU delirium are assessed by clinical nurses twice every day using Confusion Assessment Method for the ICU (CAM-ICU). Delirious patients are matched with patients according to their disease, gender and age range(±3 years). Stool samples for gene sequencing are collected within 24 hours after surgeries. Gut barrier function are studied with several serum biomarkers (endotoxin, etc.). Ecological analyses, regression models and mediation equation will be performed.
- Conditions
- Intensive Care Unit Delirium
- Being tested
- No intervention
- Keywords
- delirium
- Medical subject headings
- Delirium
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
No interventionOther
No intervention.
| Study group | Role | What they receive |
|---|---|---|
| Delirium | Patients with delirium as assessed by the bedside nurse using Confusion Assessment Method for the ICU. | |
| Non-delirium | Patients without delirium. Receives: Other: No intervention |
What is being measured
The primary outcome is the main question the study is designed to answer.
Gut microbiome
Rectal swabs or stool samples for bacterical DNA extraction and 16S rRNA gene sequencing will be collected. Diversity and composition of gut microbiome will be compared between delirious and non-delirious patients.
Measured: within 24 hours of delirium
Secondary outcomes (1)
Gut barrier biomarkers
Blood sample will be collected to analyze the level of three gut barrier biomarkers (endotoxin, D-lactate and diamine oxidase).
Measured: within 24 hours of matched samples
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted14 Aug 2019
- Study start1 Jan 2019
- Primary completion30 Dec 2019
- Study completion30 Dec 2019
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Intensive Care Unit DeliriumStudies of the same condition, open and under way.
- More trials run by Second Affiliated Hospital, Zhejiang University, School of MedicineThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Other
- Time perspective
- Prospective
- Enrolment
- 60 participants (actual)
Sponsor and investigators
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
- Investigators
- Jingfen Jin, Study director, SAHZU
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT04056338
- Sponsor's protocol ID
- 2018001113
- Status last verified
- Jan 2021
- First submitted
- 31 Jul 2019
- Last updated
- 29 Jan 2021
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 29 Jan 2021. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Gut Microbiome and Gut Barrier Function in ICU Delirium Post Cardiac Surgery
- ClinicalTrials.gov ID
- NCT04056338
- Acronym / sponsor ID
- 2018001113
- Conditions
- Intensive Care Unit Delirium
- Keywords
- delirium
- Study type
- Observational
- Recruitment status
- Completed
- Enrolment
- 60 participants (actual)
- Lead sponsor
- Second Affiliated Hospital, Zhejiang University, School of MedicineUniversity, hospital or other
- Study start
- 1 Jan 2019 (actual)
- Primary completion
- 30 Dec 2019 (actual)
- Study completion
- 30 Dec 2019 (actual)
- First posted
- 14 Aug 2019 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
ICU delirium are assessed by clinical nurses twice every day. Delirious patients are matched with patients according to their disease, gender and age range(±3 years). Stool samples for gene sequencing are collected. Gut barrier function are studied with several serum biomarkers (endotoxin, etc.). Ecological analyses, regression models and mediation equation will be performed.
Detailed description
ICU delirium are assessed by clinical nurses twice every day using Confusion Assessment Method for the ICU (CAM-ICU). Delirious patients are matched with patients according to their disease, gender and age range(±3 years). Stool samples for gene sequencing are collected within 24 hours after surgeries. Gut barrier function are studied with several serum biomarkers (endotoxin, etc.). Ecological analyses, regression models and mediation equation will be performed.
Study design
- Observational model
- Other
- Time perspective
- Prospective
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Delirium | – | –Patients with delirium as assessed by the bedside nurse using Confusion Assessment Method for the ICU. |
| Non-delirium | – | Other: No interventionPatients without delirium. |
Who may qualify
- Ages
- 18 to 90 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
- Study population
- Patients after cardiac surgery and admitted to CSICU are recruited.
Key inclusion criteria (4 listed)
- to have had heart valve surgery or coronary artery bypass grafting (CABG)
- to have no planned transfer to another ward or hospital within 24 hours after surgery
- to have no preoperative cognitive impairment and can speak and read Chinese
- more than 18 years old
Key exclusion criteria (7 listed)
- to have a hearing or visual impairment that could impact delirium assessment
- to have a history of alcohol or drug abuse
- to have a preoperative intestinal irritation syndrome or history of gastrointestinal disease
- to have received antibiotics or probiotics within 28 days before admission
- to have a life expectancy less than 24 hours
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| No interventionNo intervention. | Other | Non-delirium |
Primary outcome
Gut microbiome
Time frame: within 24 hours of delirium
Rectal swabs or stool samples for bacterical DNA extraction and 16S rRNA gene sequencing will be collected. Diversity and composition of gut microbiome will be compared between delirious and non-delirious patients.
1 secondary outcome
Gut barrier biomarkers
Time frame: within 24 hours of matched samples
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 29 Jan 2021.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Jingfen Jin study director
SAHZU
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Intensive Care Unit Delirium, run by Second Affiliated Hospital, Zhejiang University, School of Medicine at 1 site in China.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 7 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 29 Jan 2021. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in China. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Gut microbiome (time frame: within 24 hours of delirium). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 29 Jan 2021.