Paroxysmal Atrial FibrillationREAL RegistryNCT04088071
Real-world Experience of Catheter Ablation for the Treatment of Arrhythmias
An observational study of Paroxysmal Atrial Fibrillation and Persistent Atrial Fibrillation, run by Heart Rhythm Clinical and Research Solutions, LLC at 75 sites in 2 countries.
Trial summary
The primary purpose of this Registry is to assess procedural safety and long-term effectiveness of catheter ablations in the treatment of subjects with PAF, PsAF, and VA. The Registry will utilize real world clinical data obtained from the use of commercially available CARTO™ technologies under the authority of a… Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Paroxysmal Atrial Fibrillation, Persistent Atrial Fibrillation, Ventricular Arrhythmia
- What is being tested?
- Catheter ablation
- Type of treatment
- Medical device
- How many people
- 20,000 participants
- Where
- 75 sitesin 2 countries
- Study dates
- 1 Jan 2018to 31 Dec 2028
- How long will I take part?
- 1 Year
- Phase
- Observational
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Study population: Study population consists of adults age 18 years or older with symptomatic Paroxysmal and Persistent Atrial Fibrillation who are candidates for ablation in the REAL AF Cohort and adults age 18 years or older with documented ventricular arrhythmia appropriate for catheter ablation in the CORE VA Cohort.
Who may be able to join
- Symptomatic PAF (AF episode terminate spontaneously within 7 days) or PsAF (AF sustained beyond 7 days, but less than 365 days) subjects who, in the opinion of the investigator, are candidates for catheter ablation.
- >18 years of age.
- Will be treated with Biosense Webster Inc. ablation technologies
- All AF ablations performed with BWI catheters are included. This includes repeat ablations where the index procedure was performed with a non-BWI catheter.
- Able and willing to participate in baseline and follow up evaluations
- Willing and able to provide informed consent, if applicable.
Show all 11Show fewer
- Documented ventricular arrhythmia appropriate for catheter ablation.
- >18 years of age.
- Will be treated with Biosense Webster Inc. ablation technologies
- Able and willing to participate in baseline and follow up evaluations
- Willing and able to provide informed consent, if applicable.
Who cannot join
- Enrolled in an investigational drug or device clinical trial, or any trial that dictates the treatment plan
- Long-standing persistent AF (AF greater than one year)
- In the opinion of the investigator, any known contraindication to an ablation procedure
- CORE VA Cohort
- Enrolled in an investigational drug or device clinical trial, or any trial that dictates the treatment plan.
- In the opinion of the investigator, any known contraindication to an ablation procedure.
Trial locations and contacts
75 sites in 2 countries. Contact the study team or a site near you to ask about taking part.
Jose Osorio, MD contact
75 sites in 2 countries
United States71 sites, 66 recruiting
- Recruiting
Lovelace Health System
Albuquerque, New Mexico, 87102
Alexandra Ortiz
Sean Mazer, MD
- Recruiting
Mission Hospital
Asheville, North Carolina, 28801
Alex Boyd
Jason Lappe, MD
- Recruiting
Piedmont Healthcare
Atlanta, Georgia, 30309
Mariam Nuhu
Sandeep Goyal, MD
- Recruiting
The Medical Center of Aurora
Aurora, Colorado, 80012
Chris Dutka
Christopher Porterfield, MD
- Recruiting
Texas Cardiac Arrhythmia Foundation
Austin, Texas, 78705
Deb Cardinal, dcardinal@austinheartbeat.com
J. David Burkhardt, MD
- Recruiting
University of Alabama at Birmingham
Birmingham, Alabama, 35233
Michelle Osoinak
William Maddox, MD
- Recruiting
Grandview Medical Center
Birmingham, Alabama, 35243
Susan Thorington
Anil Rajendra, MD
- Recruiting
Brigham and Women's Hospital
Boston, Massachusetts, 02115
Deborah Manuelian, 617-732-5087
Paul Zei, MD, PhD
- Recruiting
Valley Heart Rhythm Specialists
Chandler, Arizona, 85224
Gianani Cabrera
Huy Phan, MD
- Recruiting
University of Cincinnati
Cincinnati, Ohio, 45202
Stephanie Byrd
Srinivas Rajsheker, MD
- Recruiting
The Christ Hospital
Cincinnati, Ohio, 45219
Anne Voorhorst
Alexandru Costea, MD
- Recruiting
University of Missouri
Columbia, Missouri, 65212
Charles Donigian
Sandeep Gautam, MD
- Recruiting
Mount Carmel Columbus Cardiology Consultants
Columbus, Ohio, 43213
Elissa VanKirk, 614-546-4327
Lee Gemma, MD
- Recruiting
Baylor Scott & White Research Institute
Dallas, Texas, 75204
Kristina Perez
Aleem Mughal, MD
- Recruiting
Medical City Dallas Hospital
Dallas, Texas, 75320
Corryn Weatherred
Javier Sanchez, MD
- Recruiting
Henry Ford Health
Detroit, Michigan, 48202
Briita Wanhala
Arfaat Khan, MD
- Recruiting
Northshore University Health System
Evanston, Illinois, 60201
Marisa Durante
Mark Metzl, MD
- Recruiting
Colorado Heart and Vascular
Golden, Colorado, 80401
David Bailey
- Recruiting
Upstate Cardiology
Greenville, South Carolina, 29607
Ericka Calhoun
Matthew Sellers, MD
- Recruiting
Cardiovascular Associates of the Delaware Valley
Haddon Heights, New Jersey, 08035
Kaitlyn Downey
George Mark, MD
- Completed
The Queen's Medical Center
Honolulu, Hawaii, 97813
- Recruiting
Ascension St. Vincent's Hospital
Indianapolis, Indiana, 46260
Anne Renick
Parin Patel, MD
- Recruiting
University of Iowa
Iowa City, Iowa, 52242
Trisha Elliot
Paari Dominic, MD
- Recruiting
Mississippi Baptist Medical Center
Jackson, Mississippi, 39202
Sherrina N. Dixon
Greta Beatty
- Recruiting
Jackson-Madison County General Hospital
Jackson, Tennessee, 38305
Cindi Thompson, cindi.thompson@wth.org
Simon Okewole, MD
- Recruiting
Ascension St. Vincent's
Jacksonville, Florida, 32204
Jasmine Vestal
Saumil Oza, MD
- Recruiting
MercyHealth
Janesville, Wisconsin, 53548
Kaitlyn Phetteplace, MSN
Imdad Ahmed, MD
- Recruiting
Arrhythmia Research Group
Jonesboro, Arkansas, 72401
Kayla Rubino
Devi Nair, MD
- Recruiting
Lancaster General Hospital
Lancaster, Pennsylvania, 17602
Andrew Hershey
Sandeep Bansal, MD
- Recruiting
Capitol CArdiology
Lanham, Maryland, 20706
Iluyomade Adeusi
Mohit Rastogi, MD
- Active, not recruiting
McLaren Greater Lansing
Lansing, Michigan, 48910
- Recruiting
Sparrow Clinical Research
Lansing, Michigan, 48912
Jennifer Boak
Ali Sheikh, MD
- Recruiting
South Denver Cardiology
Littleton, Colorado, 80120
Kathy Siegel
Daniel Alyesh, MD
- Recruiting
Keck School of Medicine
Los Angeles, California, 90033
Silvia Perez
Ivan Ho, MD
- Recruiting
Norton Heart Specialists
Louisville, Kentucky, 40205
Tina Abell, RN, BSN
Kent Morris, MD
- Recruiting
Centra Health, Inc. dba Stroobants Cardiovascular Center
Lynchburg, Virginia, 24501
Cindy Baumann
Matthew Sackett, MD
- Recruiting
University of Wisconsin
Madison, Wisconsin, 53792
Torrey Tiedman
Blake Fleeman, MD
- Recruiting
HCA Florida Mercy Hospital
Miami, Florida, 33133
Isabel Vital
Jose Osorio, MD
- Recruiting
Bon Secours St. Marys
Midlothian, Virginia, 23114
Kelly Patterson
An H Bui, MD
- Recruiting
Cardiology Associates of Mobile
Mobile, Alabama, 36695
Lynn Ward
Matthew Quin, MD
- Recruiting
Midwest Cardiovascular Institute
Naperville, Illinois, 60540
Sherri McCoy, 630-600-0700, sherri.mccoy@cardio.com
Kousik Krishnan, MD
- Recruiting
Naples Community Hospital
Naples, Florida, 34101
Anessa B Diers
Dinesh Sharma, MD
- Recruiting
Columbia University Medical Center / NewYork-Presbyterian Hospital (CUMC/NYPH)
New York, New York, 10032
Kate Dalton, 347-514-3666, keb2114@cumc.columbia.edu
Angelo Biviano, MD
- Recruiting
Oklahoma Heart Hospital
Oklahoma City, Oklahoma, 73120
Terri Knight
Charles Te, MD
- Recruiting
Ascension Sacred Heart
Pensacola, Florida, 32504
Ashley Corlies
Asim Ahmed, DO
- Recruiting
University of Pennsylvania, Penn Presbyterian Medical Center
Philadelphia, Pennsylvania, 19104
Katie Shoemaker
Benjamin D'Souza, MD
- Recruiting
Allegheny Health Network
Pittsburgh, Pennsylvania, 15222
Caitlin Phalunas
Joshua Silverstein, MD
- Recruiting
Maine Medical Center
Portland, Maine, 04102
Joanne Burgess
Jordan Leyton-Mange, MD
- Recruiting
Nuvance Health
Poughkeepsie, New York, 12601
Olatunde Olaniyi
David Steckman, MD
- Recruiting
CJW Medical Center
Richmond, Virginia, 23261
Ariana Dickens
Michael Rehorn, MD
- Terminated
Carolina Cardiology Associates and OnSite Clinical Solutions
Rock Hill, South Carolina, 29732
- Recruiting
William Beaumont Hospital
Royal Oak, Michigan, 48073
Greg Schlosser
Brian Williamson, MD
- Recruiting
Baptist Health Louisville
Saint Matthews, Kentucky, 40207
Karin Cryan
Kevin Parrott, MD
- Recruiting
St. Mark's Hospital
Salt Lake City, Utah, 84124
Sherry Fisher
Nischala Nannapaneni, MD
- Terminated
Santa Barbara Cottage Hospital
Santa Barbara, California, 93105
- Recruiting
Sarasota Memorial Hospital
Sarasota, Florida, 34239
Colleen Linder
Antonio Moretta, MD
- Recruiting
Memorial Health University Medical Center
Savannah, Georgia, 31404
Alta Castellino, BSN
Ritzie Anne Trinidad, MBA
- Recruiting
University of Washington-Seattle
Seattle, Washington, 98195
Shiva Tabaghi, MD, shiva102@uw.edu
Babak Nazer, MD
- Recruiting
Prairie Education and Research
Springfield, Illinois, 62704
Magen Kaler
Paban Saha, MD
- Recruiting
CoxHealth
Springfield, Missouri, 65807
Sam Atkinson
John Garner, MD
- Recruiting
Crouse Health System and Crouse Medical Practice
Syracuse, New York, 13210
Jennifer Peterson, 3154707111, jenniferapeterson@crousemed.com
Nikhil Joshi, MD
- Recruiting
MultiCare Institute for Research & Innovation
Tacoma, Washington, 98405
Kari Davidson
Tariq Salam, MD
- Recruiting
Baycare Health Tampa
Tampa, Florida, 33606
Christian Kelbaugh, 8132548055, christian.kelbaugh@baycare.org
Shalin Shah, MD
- Recruiting
Pima Heart and Vascular
Tucson, Arizona, 85741
Monica Varela, 5209756400, monica.varela@usheartandvascular.com
Jitender Munjal, MD
- Recruiting
Community Memorial Hospital
Ventura, California, 93303
Jennifer Freeland
Jonathan Dukes, MD
- Completed
University HealthCare Alliance
Walnut Creek, California, 94598
- Recruiting
Valley Health
Winchester, Virginia, 22601
Janie Simpson
Emmanuel Ekanem, MD
- Recruiting
Novant Health Forsyth Medical Center
Winston-Salem, North Carolina, 27103
Patricia Reece
Nicholas Costa, MD
- Recruiting
Baycare Health System
Winterhaven, Florida, 33881
Lynda Argenzio
Rodrigo Bolanos, MD
- Recruiting
WellSpan Health
York, Pennsylvania, 17403
Elayne Grim
Matthew Singleton, MD
- Recruiting
Michigan Heart
Ypsilanti, Michigan, 48197
Elizabeth Goetz
Mohammad-Ali Jazayeri, MD
Canada4 sites, 4 recruiting
- Recruiting
Alberta Health
Edmonton, Alberta, T6G2B7
Wei Chen
Kenneth Quadros, MD
- Recruiting
Waterloo Wellington Cardiovascular Research Institute
Kitchener, Ontario, N2M 5N6
Mary Radyk, mradyk@wwcri.ca
Umjeet Jolly, MD
- Recruiting
Montreal Heart Institute
Montreal, Quebec, H1T 1C8
Caroline Girard, caroline.girard@icm-mhi.org
Martin Aguilar, MD
- Recruiting
Southlake Regional Health Centre
Newmarket, Ontario, L3Y2P6
Lynn Nyman
Yaariv Khaykin, MD
About this study
Official title: Real-world Experience of Catheter Ablation for the Treatment of Arrhythmias Symptomatic Using Novel CARTO Technologies: REAL Registry
The primary purpose of this Registry is to assess procedural safety and long-term effectiveness of catheter ablations in the treatment of subjects with PAF, PsAF, and VA. The Registry will utilize real world clinical data obtained from the use of commercially available CARTO™ technologies under the authority of a health care practitioner within a legitimate practitioner-subject relationship. Data from the registry will be used to assess clinical outcomes, including procedural efficiency, safety, and long-term effectiveness of catheter ablation with novel technologies for arrhythmia patients.
Read the detailed description
The REAL Registry is an observational, prospective, multi-center, non-randomized registry designed to obtain real-world clinical experience of ablation using Biosense Webster, Inc. (BWI) CARTO technologies (e.g., THERMOCOOL SMARTTOUCH®, THERMOCOOL SMARTTOUCH® SF, QDOT MICRO™, VARIPULSE™). Future new Biosense Webster, Inc. technologies, including new thermal and/or pulsed field ablation (PFA), may be included as they become commercially available.
Current clinical practice guidelines recommend ablation for ventricular arrhythmias (VA) and atrial fibrillation (AF)1,2. Therefore, REAL AF will include subjects with symptomatic paroxysmal AF (PAF), persistent AF (PsAF) who meet all eligibility criteria and in the opinion of the investigator, are candidates for AF catheter ablation. CORE-VA will include all subjects with documented ventricular arrhythmia appropriate for catheter ablation.
All subjects will be treated with commercially approved BWI ablation catheters, and the ablation procedure will be conducted based on the participating Site's current standard of care (SOC). Participation in the Registry does not influence treatment decisions. All consecutive subjects presenting at the Site considered for an ablation procedure should be screened by the Investigator or a designated member of the research team for eligibility.
The objective of this registry is to assess clinical outcomes, including procedural efficiency, safety, long-term, effectiveness of RF ablations in the treatment of patients with Paroxysmal or Persistent atrial fibrillation. The outcomes of the registry are: 1) long term effectiveness defined as freedom from Arrhythmia recurrence post 90-day blanking period, 2) acute safety defined by serious complications within 7 days post ablation and up to 30 days post ablation.
Sites and Investigators considered for inclusion in the Registry will be assessed to determine if their practice patterns align, minimally, with what is outlined in VISIT SCHEDULE AND DATA COLLECTION of this protocol for the specific cohort in which the investigators will be enrolling. Investigators need to only align with the requirements of one cohort, but can participate in both, if qualified, and selected in each cohort. The Registry does not require any additional visits above what is considered standard of care follow-up for the Registry subject population.
- Being tested
- Catheter ablation
- Keywords
- CORE VA, REAL AF
- Medical subject headings
- Atrial Fibrillation
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Catheter ablationDevice
Ablation using Biosense Webster, Inc. (BWI) CARTO™ technologies (e.g., THERMOCOOL SMARTTOUCH® SF, QDOT MICRO™, VARIPULSE™). Future new Biosense Webster, Inc. technologies, including new thermal and/or pulsed field ablation (PFA), may be included as they become commercially available.
| Study group | Role | What they receive |
|---|---|---|
| REAL AF | Subjects with symptomatic PAF or PsAF who, in the opinion of the investigator, are candidates for ablation for AF, age 18 years or older, and are able and willing to comply with all pre-, post-, and follow-up testing and requirements. Receives: Device: Catheter ablation | |
| CORE VA | Subjects with documented ventricular arrhythmia appropriate for catheter ablation, greater than 18 years of age, will be treated with Biosense Webster Inc. ablation technologies, and are willing and able to participate in baseline and follow up evaluations. Receives: Device: Catheter ablation |
What is being measured
The primary outcome is the main question the study is designed to answer.
Effectiveness at 90 days
Freedom from arrhythmia recurrence at 90 days post procedure.
Measured: 90 days
Effectiveness at 12 months
Freedom from subject reported arrhythmia recurrence through 12 months post procedure.
Measured: 12 months
Long-term Safety
Incidence of late onset complications, 30 days post-ablation which are procedure and/or device related
Measured: 30 days post ablation
Secondary outcomes (7)
Arrhythmia recurrence
Recurrence seen during monitoring with Dual/ CRT Pacer or ICD; Event Monitor; LinQ; Holter; EKG; TTE
Measured: 12 months
Post-procedure arrhythmia treatments
Treatments for arrhythmia post-procedure
Measured: 12 months
Arrhythmia related symptoms
Presence of: weakness, fluttering, SOB, fatigue, dizziness, decrease in exercise tolerance, chest pain/pressure, heart racing/palpitations, and other (yes/no)
Measured: 12 months
AAD Usage
Antiarrhythmic drug use (and type) post procedure and 12 months
Measured: 12 months
OAC usage
Oral anticoagulant use at 12 months and drug type
Measured: 12 months
CHA2DS2VASC
An estimation of stroke risk for patients with Atrial Fibrillation. Composite score of: Age (<65= 0; 65-74=1; >75=2) + Sex (Female=1; Male=0) + Congestive Heart Failure (Yes =1; No=0) + Hypertension (Yes= 1; No= 0) + Stroke, Transient Ischemic Attack (TIA) or thromboembolism (Yes=2; No=0) + Vascular Disease (Yes=1; No=0) + Diabetes (Yes=1; No=0). Scores range from 0 to 9, with higher scores indicating greater risk for stroke.
Measured: 12 months
Patient reported outcome
How do you feel now compared to pre-ablation?
Measured: 12 months
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted12 Sep 2019
- Study start1 Jan 2018
- Primary completion31 Dec 2028 (estimated)
- Study completion31 Dec 2028 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (11)Papers the sponsor has linked to this study.
- Other trials for Paroxysmal Atrial FibrillationStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Other
- Enrolment
- 20,000 participants (estimated)
- Target duration
- 1 Year
Sponsor and investigators
- Lead sponsor
- Heart Rhythm Clinical and Research Solutions, LLC
- Sponsor type
- University, hospital or other
- Collaborators
- Biosense Webster, Inc.
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT04088071
- Sponsor's protocol ID
- CTP-1
- Other IDs
- Ventricular Arrhythmia, Atrial Fibrillation
- Acronym
- REAL Registry
- Status last verified
- Sep 2026
- First submitted
- 26 Aug 2019
- Last updated
- 22 Sep 2026
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- Yes
Publications
Sharma E, Varley A, Osorio J, Thorne C, Varosy P, Metzl M, Rajendra A, Oza S, Morales G, Magnano A, D'Souza B, Sackett M, Sellers M, Silva J, Silverstein J, Ho J, Hoskins M, Kuk R, Romero J, Zei PC. Procedural Trends in Catheter Ablation of Persistent Atrial Fibrillation: Insights From the Real-AF Registry. Circ Arrhythm Electrophysiol. 2023 Jun;16(6):e011828. doi: 10.1161/CIRCEP.123.011828. Epub 2023 May 31. No abstract available.
PubMed 37254771Kreidieh O, Varley AL, Romero J, Singh D, Silverstein J, Thosani A, Varosy P, Hebsur S, Godfrey BE, Schrappe G, Justice L, Zei PC, Osorio J. Practice Patterns of Operators Participating in the Real-World Experience of Catheter Ablation for Treatment of Symptomatic Paroxysmal and Persistent Atrial Fibrillation (REAL-AF) Registry. J Interv Card Electrophysiol. 2022 Nov;65(2):429-440. doi: 10.1007/s10840-022-01205-0. Epub 2022 Apr 19.
PubMed 35438393Varley AL, Kreidieh O, Godfrey BE, Whitmire C, Thorington S, D'Souza B, Kang S, Hebsur S, Ravindran BK, Zishiri E, Gidney B, Sellers MB, Singh D, Salam T, Metzl M, Ro A, Nazari J, Fisher WG, Costea A, Magnano A, Oza S, Morales G, Rajendra A, Silverstein J, Zei PC, Osorio J. A prospective multi-site registry of real-world experience of catheter ablation for treatment of symptomatic paroxysmal and persistent atrial fibrillation (Real-AF): design and objectives. J Interv Card Electrophysiol. 2021 Dec;62(3):487-494. doi: 10.1007/s10840-021-01031-w. Epub 2021 Jul 2.
PubMed 34212280Osorio J, Miranda-Arboleda AF, Velasco A, Varley AL, Rajendra A, Morales GX, Hoyos C, Matos C, Thorne C, D'Souza B, Silverstein JR, Metzl MD, Hebsur S, Costea AI, Kang S, Sellers M, Singh D, Salam T, Nazari J, Ro AS, Mazer S, Moretta A, Oza SR, Magnano AR, Sackett M, Dukes J, Patel P, Goyal SK, Senn T, Newton D, Romero JE, Zei PC; REAL-AF Investigators. Real-world data of radiofrequency catheter ablation in paroxysmal atrial fibrillation: Short- and long-term clinical outcomes from the prospective multicenter REAL-AF Registry. Heart Rhythm. 2024 Nov;21(11):2083-2091. doi: 10.1016/j.hrthm.2024.04.090. Epub 2024 May 19.
PubMed 38768839Kreidieh O, Hunter TD, Goyal S, Varley AL, Thorne C, Osorio J, Silverstein J, Varosy P, Metzl M, Leyton-Mange J, Singh D, Rajendra A, Moretta A, Zei PC; Investigators of the REAL AF registry. Predictors of first pass isolation of the pulmonary veins in real world ablations: An analysis of 2671 patients from the REAL-AF registry. J Cardiovasc Electrophysiol. 2024 Mar;35(3):440-450. doi: 10.1111/jce.16190. Epub 2024 Jan 28.
PubMed 38282445Costea A, Diaz JC, Osorio J, Matos CD, Hoyos C, Goyal S, Te C, D'Souza B, Rastogi M, Lopez-Cabanillas N, Ibanez LC, Thorne C, Varley AL, Zei PC, Sauer WH, Romero JE. 50-W vs 40-W During High-Power Short-Duration Ablation for Paroxysmal Atrial Fibrillation: A Multicenter Prospective Study. JACC Clin Electrophysiol. 2023 Dec;9(12):2573-2583. doi: 10.1016/j.jacep.2023.08.005. Epub 2023 Oct 4.
PubMed 37804258Osorio J, Zei PC, Diaz JC, Varley AL, Morales GX, Silverstein JR, Oza SR, D'Souza B, Singh D, Moretta A, Metzl MD, Hoyos C, Matos CD, Rivera E, Magnano A, Salam T, Nazari J, Thorne C, Costea A, Thosani A, Rajendra A, Romero JE. High-Frequency Low-Tidal Volume Ventilation Improves Long-Term Outcomes in AF Ablation: A Multicenter Prospective Study. JACC Clin Electrophysiol. 2023 Aug;9(8 Pt 2):1543-1554. doi: 10.1016/j.jacep.2023.05.015. Epub 2023 May 18.
PubMed 37294263Rajendra A, Osorio J, Diaz JC, Hoyos C, Rivera E, Matos CD, Costea A, Varley AL, Thorne C, Hoskins M, Goyal S, Oza S, Magnano A, D'Souza B, Silverstein J, Metzl M, Zei PC, Romero JE. Performance of the REAL-AF Same-Day Discharge Protocol in Patients Undergoing Catheter Ablation of Atrial Fibrillation. JACC Clin Electrophysiol. 2023 Aug;9(8 Pt 2):1515-1526. doi: 10.1016/j.jacep.2023.04.014. Epub 2023 May 18.
PubMed 37204358Rajendra A, Hunter TD, Morales GX, Zei P, Boo LM, Varley A, Osorio J. Steerable sheath visualizable under 3D electroanatomical mapping facilitates paroxysmal atrial fibrillation ablation with minimal fluoroscopy. J Interv Card Electrophysiol. 2023 Mar;66(2):381-388. doi: 10.1007/s10840-022-01332-8. Epub 2022 Aug 10.
PubMed 35947317Osorio J, Varley A, Kreidieh O, Godfrey B, Schrappe G, Rajendra A, Silverstein J, Romero J, Rodriguez D, Morales G, Zei P. High-Frequency, Low-Tidal-Volume Mechanical Ventilation Safely Improves Catheter Stability and Procedural Efficiency During Radiofrequency Ablation of Atrial Fibrillation. Circ Arrhythm Electrophysiol. 2022 Apr;15(4):e010722. doi: 10.1161/CIRCEP.121.010722. Epub 2022 Mar 25. No abstract available.
PubMed 35333095Zhang Z, Hincapie D, Thorne C, Varley A, Justice L, Osorio J, Moretta A, Silverstein J, Rajendra A, Morales G, Goyal S, Khaykin Y, Sadek M, D'Souza B, Ahmed I, Jazayeri MA, Varahan S, Sackett M, McHugh J, Costea A, Black AL, Yao Y, Sauer WH, Zei PC; REAL-AF Investigators. Real-world data of sex differences in atrial fibrillation catheter ablation: Insights from a prospective multicenter registry. Heart Rhythm O2. 2026 Apr 13;7(7):1259-1273. doi: 10.1016/j.hroo.2026.04.005. eCollection 2026 Jul.
PubMed 42488154