SleepNCT04141722
Age-Related Changes in Sleep-Dependent Emotional Memory
A study testing Overnight sleep and Wake in people with Sleep and Age, run by University of Massachusetts, Amherst at 1 site in United States.
Trial summary
Memory influences emotional well being. Research has shown that having a negative emotional bias contributes to both emotion dysregulation and depression. Conversely, reactivating positive memories has been shown to reduce stress and symptoms of depression. Read more about this study
- Who is it for?
- Ages 18 to 80 yearsHealthy volunteers can take part
- Conditions the study is for
- Sleep, Age, Emotional Valence
- What is being tested?
- Overnight sleep and Wake
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 80 participants
- Where
- 1 siteUnited States
- Study dates
- 11 Dec 2018to 31 May 2020
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 80 years
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Who may be able to join
- 18-30 or 50-80 years of age
- Have no history of a sleep disorder
- Have no history of neurological disease or injury
- Have no history of psychiatric illness (anxiety or mood disorder, schizophrenia, etc.)
- No history of chemotherapy
- Not be taking medications which effect sleep
Show all 9Show fewer
- Habitually sleep more than 6 or more hours per night
- Be able to walk freely and independently
- Have normal to corrected-to-normal vision
Who cannot join
None listed.
Trial locations and contacts
1 site in 1 country.
United States1 site, 1 recruiting
- Recruiting
University of Massachusetts, Amherst
Amherst, Massachusetts, 01003
SomNeuro Laboratory, 413-545-4831, siestalab@gmail.com
About this study
Official title: AGE-RELATED CHANGES IN SLEEP-DEPENDENT EMOTIONAL MEMORY
Memory influences emotional well being. Research has shown that having a negative emotional bias contributes to both emotion dysregulation and depression. Conversely, reactivating positive memories has been shown to reduce stress and symptoms of depression. In young adults, sleep is widely implicated in emotional processing, including consolidation of emotional memories. Evidence suggests that aging is associated with changes in emotion, including a positive memory bias and enhanced emotional well-being. These changes have been termed the "age-related positivity effect." However, the influence of sleep on these measures has not been investigated in healthy older individuals. The objective of this research is to understand the role of sleep in emotional memory consolidation and emotional well-being across adulthood. We hypothesize that sleep contributes to the age-related positivity effect in memory and affect. Our alternative hypothesis is that age-related decreases in sleep are responsible for reduced emotional memory processing over healthy aging.
- Conditions
- Sleep, Age, Emotional Valence
- Being tested
- Overnight sleep, Wake
- Keywords
- Emotional Memory, Memory Consolidation, Age-Related Positivity Effect
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Overnight sleepBehavioural
Participant sent home to sleep overnight wearing PSG.
WakeBehavioural
Participant sent to go about normal daily routine, instructed not to nap, drink caffeine, or engage in strenuous exercise.
| Study group | Role | What they receive |
|---|---|---|
| Sleep | Experimental | Not described Receives: Behavioral: Overnight sleep |
| Wake | Experimental | Not described Receives: Behavioral: Wake |
What is being measured
The primary outcome is the main question the study is designed to answer.
Memory bias
Corrected recognition of positive versus negative pictures
Measured: 12 hr delay between encoding and recognition test
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted28 Oct 2019
- Study start11 Dec 2018
- Primary completion31 May 2020 (estimated)
- Study completion31 May 2020 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (10)Papers the sponsor has linked to this study.
- Other trials for SleepStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Basic science
- Allocation
- Non-randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Enrolment
- 80 participants (estimated)
Sponsor and investigators
- Lead sponsor
- University of Massachusetts, Amherst
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Rebecca Spencer, University of Massachusetts, Amherst
- Investigators
- Rebecca Spencer, Principal investigator, University of Massachusetts, Amherst
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT04141722
- Sponsor's protocol ID
- 1R56AG058685-01
- Status last verified
- Oct 2019
- First submitted
- 24 Oct 2019
- Last updated
- 28 Oct 2019
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Publications
Dalgleish T, Werner-Seidler A. Disruptions in autobiographical memory processing in depression and the emergence of memory therapeutics. Trends Cogn Sci. 2014 Nov;18(11):596-604. doi: 10.1016/j.tics.2014.06.010. Epub 2014 Jul 21.
PubMed 25060510Ramirez S, Liu X, MacDonald CJ, Moffa A, Zhou J, Redondo RL, Tonegawa S. Activating positive memory engrams suppresses depression-like behaviour. Nature. 2015 Jun 18;522(7556):335-9. doi: 10.1038/nature14514.
PubMed 26085274Speer ME, Bhanji JP, Delgado MR. Savoring the past: positive memories evoke value representations in the striatum. Neuron. 2014 Nov 19;84(4):847-56. doi: 10.1016/j.neuron.2014.09.028. Epub 2014 Oct 30.
PubMed 25451197Baran B, Pace-Schott EF, Ericson C, Spencer RM. Processing of emotional reactivity and emotional memory over sleep. J Neurosci. 2012 Jan 18;32(3):1035-42. doi: 10.1523/JNEUROSCI.2532-11.2012.
PubMed 22262901Jones BJ, Schultz KS, Adams S, Baran B, Spencer RMC. Emotional bias of sleep-dependent processing shifts from negative to positive with aging. Neurobiol Aging. 2016 Sep;45:178-189. doi: 10.1016/j.neurobiolaging.2016.05.019. Epub 2016 May 27.
PubMed 27459938Leigland LA, Schulz LE, Janowsky JS. Age related changes in emotional memory. Neurobiol Aging. 2004 Sep;25(8):1117-24. doi: 10.1016/j.neurobiolaging.2003.10.015.
PubMed 15212836Charles ST, Mather M, Carstensen LL. Aging and emotional memory: the forgettable nature of negative images for older adults. J Exp Psychol Gen. 2003 Jun;132(2):310-24. doi: 10.1037/0096-3445.132.2.310.
PubMed 12825643Mather M, Carstensen LL. Aging and motivated cognition: the positivity effect in attention and memory. Trends Cogn Sci. 2005 Oct;9(10):496-502. doi: 10.1016/j.tics.2005.08.005.
PubMed 16154382Charles ST, Reynolds CA, Gatz M. Age-related differences and change in positive and negative affect over 23 years. J Pers Soc Psychol. 2001 Jan;80(1):136-51.
PubMed 11195886Mroczek DK, Kolarz CM. The effect of age on positive and negative affect: a developmental perspective on happiness. J Pers Soc Psychol. 1998 Nov;75(5):1333-49. doi: 10.1037//0022-3514.75.5.1333.
PubMed 9866191
Study at a glance
From the registry record, last updated by the sponsor on 28 Oct 2019. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- AGE-RELATED CHANGES IN SLEEP-DEPENDENT EMOTIONAL MEMORY
- ClinicalTrials.gov ID
- NCT04141722
- Acronym / sponsor ID
- 1R56AG058685-01
- Conditions
- Sleep, Age, Emotional Valence
- Keywords
- Emotional Memory, Memory Consolidation, Age-Related Positivity Effect
- Study type
- Interventional
- Recruitment status
- Unknown status
- Enrolment
- 80 participants (estimated)
- Lead sponsor
- University of Massachusetts, AmherstUniversity, hospital or other
- Study start
- 11 Dec 2018 (actual)
- Primary completion
- 31 May 2020 (estimated)
- Study completion
- 31 May 2020 (estimated)
- First posted
- 28 Oct 2019 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Memory influences emotional well being. Research has shown that having a negative emotional bias contributes to both emotion dysregulation and depression. Conversely, reactivating positive memories has been shown to reduce stress and symptoms of depression. In young adults, sleep is widely implicated in emotional processing, including consolidation of emotional memories. Evidence suggests that aging is associated with changes in emotion, including a positive memory bias and enhanced emotional well-being. These changes have been termed the "age-related positivity effect." However, the influence of sleep on these measures has not been investigated in healthy older individuals. The objective of this research is to understand the role of sleep in emotional memory consolidation and emotional well-being across adulthood. We hypothesize that sleep contributes to the age-related positivity effect in memory and affect. Our alternative hypothesis is that age-related decreases in sleep are responsible for reduced emotional memory processing over healthy aging.
Study design
- Primary purpose
- Basic science
- Allocation
- Non-randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Sleep | Experimental | Behavioral: Overnight sleep |
| Wake | Experimental | Behavioral: Wake |
Who may qualify
- Ages
- 18 to 80 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (9 listed)
- 18-30 or 50-80 years of age
- Have no history of a sleep disorder
- Have no history of neurological disease or injury
- Have no history of psychiatric illness (anxiety or mood disorder, schizophrenia, etc.)
- No history of chemotherapy
Key exclusion criteria (0 listed)
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Overnight sleepParticipant sent home to sleep overnight wearing PSG. | Behavioural | Sleep |
| WakeParticipant sent to go about normal daily routine, instructed not to nap, drink caffeine, or engage in strenuous exercise. | Behavioural | Wake |
Primary outcome
Memory bias
Time frame: 12 hr delay between encoding and recognition test
Corrected recognition of positive versus negative pictures
Results and safety
Results are not available in the source record.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 28 Oct 2019.
- Background: PubMed 25060510Dalgleish T, Werner-Seidler A. Disruptions in autobiographical memory processing in depression and the emergence of memory therapeutics. Trends Cogn Sci. 2014 Nov;18(11):596-604. doi: 10.1016/j.tics.2014.06.010. Epub 2014 Jul 21.
- Background: PubMed 26085274Ramirez S, Liu X, MacDonald CJ, Moffa A, Zhou J, Redondo RL, Tonegawa S. Activating positive memory engrams suppresses depression-like behaviour. Nature. 2015 Jun 18;522(7556):335-9. doi: 10.1038/nature14514.
- Background: PubMed 25451197Speer ME, Bhanji JP, Delgado MR. Savoring the past: positive memories evoke value representations in the striatum. Neuron. 2014 Nov 19;84(4):847-56. doi: 10.1016/j.neuron.2014.09.028. Epub 2014 Oct 30.
- Background: PubMed 22262901Baran B, Pace-Schott EF, Ericson C, Spencer RM. Processing of emotional reactivity and emotional memory over sleep. J Neurosci. 2012 Jan 18;32(3):1035-42. doi: 10.1523/JNEUROSCI.2532-11.2012.
- Background: PubMed 27459938Jones BJ, Schultz KS, Adams S, Baran B, Spencer RMC. Emotional bias of sleep-dependent processing shifts from negative to positive with aging. Neurobiol Aging. 2016 Sep;45:178-189. doi: 10.1016/j.neurobiolaging.2016.05.019. Epub 2016 May 27.
- Background: PubMed 15212836Leigland LA, Schulz LE, Janowsky JS. Age related changes in emotional memory. Neurobiol Aging. 2004 Sep;25(8):1117-24. doi: 10.1016/j.neurobiolaging.2003.10.015.
- Background: PubMed 12825643Charles ST, Mather M, Carstensen LL. Aging and emotional memory: the forgettable nature of negative images for older adults. J Exp Psychol Gen. 2003 Jun;132(2):310-24. doi: 10.1037/0096-3445.132.2.310.
- Background: PubMed 16154382Mather M, Carstensen LL. Aging and motivated cognition: the positivity effect in attention and memory. Trends Cogn Sci. 2005 Oct;9(10):496-502. doi: 10.1016/j.tics.2005.08.005.
- Background: PubMed 11195886Charles ST, Reynolds CA, Gatz M. Age-related differences and change in positive and negative affect over 23 years. J Pers Soc Psychol. 2001 Jan;80(1):136-51.
- Background: PubMed 9866191Mroczek DK, Kolarz CM. The effect of age on positive and negative affect: a developmental perspective on happiness. J Pers Soc Psychol. 1998 Nov;75(5):1333-49. doi: 10.1037//0022-3514.75.5.1333.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Rebecca Spencer principal investigator
University of Massachusetts, Amherst
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Overnight sleep and Wake in people with Sleep and Age, run by University of Massachusetts, Amherst at 1 site in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 9 inclusion and 0 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: status not confirmed, as of the sponsor's last update on 28 Oct 2019. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
Results are not available in the source record.
How can a doctor refer a patient or contact the research team?
Contact Rebecca Spencer ((413) 545-5987, rspencer@psych.umass.edu), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Memory bias (time frame: 12 hr delay between encoding and recognition test). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT04141722, which also lists 10 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 28 Oct 2019.