Tourette Syndrome in AdolescenceCADETSNCT04179435
Cognitive and Brain Development in Adolescents With Gilles de la Tourette Syndrome
A study testing Behavioral testing on cognitive computerized tasks, brain MRI and TMS in people with Tourette Syndrome in Adolescence, run by Institut National de la Santé Et de la Recherche Médicale, France at 1 site in France.
Trial summary
In children with neurodevelopmental disorders, adolescence is usually associated with a reshaping of the clinical picture and symptomatology. Tourette syndrome (TS) is a paradigmal neurodevelopmental syndrome characterised by involuntary paroxysmal movements (motor tics) and vocalisation (vocal tics) often associated… Read more about this study
- Who is it for?
- Ages 13 to 18 yearsHealthy volunteers can take part
- Conditions the study is for
- Tourette Syndrome in Adolescence
- What is being tested?
- Behavioral testing on cognitive computerized tasks, brain MRI and TMS
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 132 participants
- Where
- 1 siteFrance
- Study dates
- 11 Dec 2019to 18 Jun 2024
- Phase
- Interventional
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 13 to 18 years
- All sexes
- Healthy volunteers accepted
- Child, Adult
Who may be able to join
- Tourette syndrome
- Ages 13 - 18
- Acceptance to perform the Brain MRI
- Acceptance to perform the cognitive testing
- Acceptance to perform the TMS measures
Who cannot join
- Learning disability
- Incompatibility with MRI procedure (metal body implants, pregnancy)
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Développement Cognitif et cérébral Chez Les Adolescents Souffrants d'un Syndrome de Gilles de la Tourette
In children with neurodevelopmental disorders, adolescence is usually associated with a reshaping of the clinical picture and symptomatology. Tourette syndrome (TS) is a paradigmal neurodevelopmental syndrome characterised by involuntary paroxysmal movements (motor tics) and vocalisation (vocal tics) often associated with various psychiatric disorders. The neuronal and cognitive mechanisms associated with TS symptoms improvement during adolescence, or the persistence in adulthood remains unknown, and this is what we aim to address in this study.
Read the detailed description
Thus, the aims of the present project is threefold:
Aim 1: To evaluate the maturation of cognitive functions in adolescents with TS compared to typically developing adolescents.
To achieve this aim, three distinct cognitive dimensions will be assessed in all subjects (patients and controls): (i) reward sensitivity and habit formation; (ii) cognitive impulsivity and action control and (iii) self-agency.
Aim 2: To identify neuronal correlates of cognitive function and brain development in health and disease. To achieve this aim, we will use a combined behavioural (as described in Aim 1), (i) neuroimaging and (ii) TMS approaches.
Aim 3: To predict clinical outcome . In this part of the project we aim to identify behavioural, imaging or neurophysiological markers of clinical outcome in patients with TS.
- Conditions
- Tourette Syndrome in Adolescence
- Being tested
- Behavioral testing on cognitive computerized tasks, brain MRI, TMS
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Behavioral testing on cognitive computerized tasksBehavioural
Testing on cognitive computerized tasks
brain MRIOther
Brain MRI scans
TMSOther
Measure of the cortical inhibitory capacity using TMS measures
| Study group | Role | What they receive |
|---|---|---|
| Tourette syndrome | Other | Patients with Tourette syndrome aged 13 - 18 y.o. Interventions : Brain scans, cognitive testing, TMS measures Receives: Behavioral: Behavioral testing on cognitive computerized tasks; Other: brain MRI; Other: TMS |
| Controls | Other | Controls matched to Tourette syndrome group nterventions : Brain scans, cognitive testing, TMS measures Receives: Behavioral: Behavioral testing on cognitive computerized tasks; Other: brain MRI; Other: TMS |
What is being measured
The primary outcome is the main question the study is designed to answer.
Behavioral test main outcome measures [1]
reaction times
Measured: from 16 to 20 months
Behavioral test main outcome measures [2]
discounting factor
Measured: from 16 to 20 months
Behavioral test main outcome measures [3]
number of premature responses
Measured: from 16 to 20 months
Behavioral test main outcome measures [4]
agency composite scores
Measured: from 16 to 20 months
Brain MRI scan measures
whole brain structural connectivity, whole brain functional connectivity, brain cortical and subcortical structures volumes and morphology
Measured: from 16 to 20 months
Transcranial magnetic stimulation
Short Intracortical Inhibition (SICI) scores
Measured: from 16 to 20 months
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted27 Nov 2019
- Study start11 Dec 2019
- Primary completion18 Jun 2024
- Study completion18 Jun 2024
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for Tourette Syndrome in AdolescenceStudies of the same condition, open and under way.
- More trials run by Institut National de la Santé Et de la Recherche Médicale, FranceThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Basic science
- Allocation
- Non-randomised
- Intervention model
- Parallel groups
- Model description
- Between group comparison
- Masking
- None (open label)
- Enrolment
- 132 participants (actual)
Sponsor and investigators
- Sponsor type
- Other government
- Responsible party
- Sponsor
- Investigators
- Worbe Yulia, MD, PhD, Principal investigator, Institut National de la Santé Et de la Recherche Médicale, France
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT04179435
- Sponsor's protocol ID
- C19-11
- Other IDs
- 2019-A00992-55
- Acronym
- CADETS
- Status last verified
- Jun 2026
- First submitted
- 20 Nov 2019
- Last updated
- 18 Sep 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Publications
Atkinson-Clement C, Duflot M, Lastennet E, Patsalides L, Wasserman E, Sartoris TM, Tarrano C, Rosso C, Burbaud P, Deniau E, Czernecki V, Roze E, Hartmann A, Worbe Y. How does Tourette syndrome impact adolescents' daily living? A text mining study. Eur Child Adolesc Psychiatry. 2023 Dec;32(12):2623-2635. doi: 10.1007/s00787-022-02116-1. Epub 2022 Dec 2.
PubMed 36460852