Nutrition PoorONCENCT04209569
One Nutrition in Complex Environments (ONCE)
A study testing Nutrition Impact and Positive Practice Circle (NIPP) in people with Nutrition Poor and Aflatoxins Toxicity, run by Tufts University at 1 site in Uganda.
Trial summary
This study asks the research question "Does enabling families (particularly mothers and other caregivers) to 'assess and act' on drivers of malnutrition through a targeted SBC+ package succeed in a sustained reduction of risk factors thereby improving child health and nutrition?" This study aims to implement and… Read more about this study
- Who is it for?
- Any ageHealthy volunteers can take part
- Conditions the study is for
- Nutrition Poor, Aflatoxins Toxicity, Water-Related Diseases
- What is being tested?
- Nutrition Impact and Positive Practice Circle (NIPP)
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 1,834 participants
- Where
- 1 siteUganda
- Study dates
- 17 Jan 2020to 30 Dec 2022
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages Any age
- All sexes
- Healthy volunteers accepted
- Child, Adult, Older adult
Who may be able to join
None listed.
Who cannot join
- Individuals in households without eligible children (i.e. without a child under age 2), or who will not be present in the selected communities during the intervention and data collection periods and/or who are not willing to participate through the entire 12-week cycle.
Trial locations and contacts
1 site in 1 country.
About this study
Official title: One Nutrition in Complex Environments (ONCE), a Cluster-randomized Trial of Nutrition Education and Access to Simple Supportive Technologies in Improving Agricultural Practices and Water Quality Management
This study asks the research question "Does enabling families (particularly mothers and other caregivers) to 'assess and act' on drivers of malnutrition through a targeted SBC+ package succeed in a sustained reduction of risk factors thereby improving child health and nutrition?" This study aims to implement and measure the effects of a multi-level multi-sectoral behavior change information intervention in Agago District of Northern Uganda and determine potential for scale up in a complex environment.
The study design is a three-arm cluster randomized controlled superiority design (cRCT) with a 1:1:1 allocation ratio. The study arms will be: Group 1: NIPP arm; Group 2: NIPP+ arm; and Group 3: Non-intervention control arm. A barrier analysis will be conducted to ensure appropriate targeting and contextualization of the NIPP and NIPP+ approaches prior to implementation. Each intervention arm will receive a 12-week intervention (NIPP or NIPP+) with active monitoring and longitudinal follow ups post intervention at 2, 6, and 12-months post-intervention. The total sample size for the Barrier Analysis will be a maximum of 450 caregivers; for the main intervention, 900 households (300/arm) will be purposely sampled from the randomly selected communities. Respondents for the qualitative portion will be purposely selected.
Read the detailed description
Objective: This study asks the research question "Does enabling families (particularly mothers and other caregivers) to 'assess and act' on drivers of malnutrition through a targeted SBC+ package succeed in a sustained reduction of risk factors thereby improving child health and nutrition?" This study aims to implement and measure the effects of a multi-level multi-sectoral behavior change information intervention in Agago District of Northern Uganda and determine potential for scale up in a complex environment.
Intervention: Through a collaboration between Tufts University, GOAL International, CIMMYT, and Cornell University, GOAL will implement Nutrition Impact and Positive Practice (NIPP) circles as the standard SBC intervention against which the hypotheses will be tested. GOAL will also implement a NIPP+ approach which will integrate additional interventions for water, sanitation, and hygiene (WASH), and use of improved agriculture inputs. These interventions will be measured by outcome indicators measuring aflatoxin exposure, water contamination, and knowledge transferred to action.
Design: The study design is a three-arm cluster randomized controlled superiority design (cRCT) with a 1:1:1 allocation ratio. The study arms will be: Group 1: NIPP arm; Group 2: NIPP+ arm; and Group 3: Non-intervention control arm. A barrier analysis will be conducted to ensure appropriate targeting and contextualization of the NIPP and NIPP+ approaches prior to implementation. Each intervention arm will receive a 12-week intervention (NIPP or NIPP+) with active monitoring and longitudinal follow ups post intervention at 2, 6, and 12-months post-intervention. The total sample size for the Barrier Analysis will be a maximum of 450 caregivers; for the main intervention, 900 households (300/arm) will be purposely sampled from the randomly selected communities. Respondents for the qualitative portion will be purposely selected.
Analysis: This longitudinal study will collect data from all participants at 3 time points: baseline, endline, and sustainability (12-months post-intervention). The analysis will utilize Intent-to-Treat (ITT) approach using the initial randomization of the treatment arms. Using ITT will allow us to determine the overall impact of having the NIPP vs. NIPP+ vs. control, thus better mimicking real world program implementation and impact. Mixed effects models will be used to determine the role of time-variant and invariant individual (by gender) household, and community characteristics, as well as measures of exposure and integration on key outcome indicators. A difference-in-difference analysis (baseline/endline, baseline/sustainability, endline/sustainability) will also be used to triangulate findings.
Sub-study: a subset of reproductive age women will be purposively selected for enrollment into a validation sub-study that will examine the level of aflatoxin (AFB1-lysine concentration) exposure measured in venous blood compared to capillary blood compared to the innovative SAFE-phone method. This will serve as a validation and calibration sub-study to gauge the accuracy of the SAFE-Phone method compared to venous reference.
- Conditions
- Nutrition Poor, Aflatoxins Toxicity, Water-Related Diseases
- Being tested
- Nutrition Impact and Positive Practice Circle (NIPP)
- Keywords
- SBCC, child wasting, aflatoxin, coliform, Uganda
- Medical subject headings
- Malnutrition, Waterborne Diseases
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Nutrition Impact and Positive Practice Circle (NIPP)Behavioural
GOAL's NIPP approach is a gendered, grass-roots SBC approach, tackling a package of underlying behavioral determinants of malnutrition, irrespective of the particular manifestation. The approach is multi-sectoral in nature. It also has a strong monitoring, evaluation and adaptive learning component by design. The intervention approach (based on GOAL's NIPP approach) involves the creation of community, male and female circles in each community with messaging and activities targeted towards the three groups in varying intensities. While the male and female circles meet 2-3 times per week for a maximum period of 12 weeks while the community circles will meet for approximately three hours at any one time over a period of 2-7 days. (See GOAL NIPP Implementation Guidelines)
| Study group | Role | What they receive |
|---|---|---|
| NIPP | Active comparator | The NIPP group is a standard social behavior change (SBCC) intervention that tackles a set of underlying causes of malnutrition, with the potential to have both a curative and preventative impact on child malnutrition. The approach in this group/arm involves training and pragmatic behavior change education reinforced by practical activities over a 12-week period to both men and women in selected communities. It aims to utilize easy, viable and accessible solutions within the community that can be used to improve and protect household health and nutrition. The 12-week lesson plans for the circles are divided into 3 components, i) hands-on behavior change sessions that focus on the key pre-identified causes of malnutrition to improve awareness and practice ii) micro-gardening for improved household nutrition security and iii) participatory cooking demonstrations to stimulate improvements in nutritional status and care practices. Receives: Behavioral: Nutrition Impact and Positive Practice Circle (NIPP) |
| NIPP+ | Experimental | In addition to establishing the circles and implementing the three NIPP components also implemented in the NIPP arm, those randomized to the NIPP+ arm will be provided access to innovations to allow and encourage the households and communities to translate the knowledge into positive practices. The innovations and access to vendors who sell innovations will be made available during the training to the NIPP+ volunteers who will provide trainings and access to vendors during the circle meetings. Most of the additions will be made accessible at a subsidized/low cost. The NIPP+ officers from the program will support NIPP+ volunteers in collaboration with agricultural extension officers. Receives: Behavioral: Nutrition Impact and Positive Practice Circle (NIPP) |
| Control | No intervention | No Intervention |
What is being measured
The primary outcome is the main question the study is designed to answer.
Change in Aflatoxin Exposure in Maize
aflatoxin in parts per billion in a random sample of maize in a given household's maize supply
Measured: within 1-month of harvest immediately after the intervention and one year after the intervention.
Change in E. coli exposure in household
- coli measured in colonies/100 ml
Measured: prior to the intervention, immediately after the intervention, and 1 year following the intervention
Secondary outcomes (3)
Aflatoxin Exposure in blood serum
venous total (ng/ml) AFB1-lysine adduct concentrations
Measured: immediately after the intervention, and 1 year following the intervention
Aflatoxin Exposure in blood serum
albumin normalized (pg/mg) AFB1-lysine adduct concentrations
Measured: immediately after the intervention, and 1 year following the intervention
Change in Dietary Diversity - mother and child
24 hours recall applied to standard dietary diversity range
Measured: prior to the intervention, immediately after the intervention, and 1 year following the intervention and 2 and 6-months after the intervention
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted24 Dec 2019
- Study start17 Jan 2020
- Primary completion30 Dec 2022
- Study completion30 Dec 2022
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (41)Papers the sponsor has linked to this study.
- Other trials for Nutrition PoorStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Prevention
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Model description
- The study design is a three-arm cluster randomized controlled superiority design (cRCT) with a 1:1:1 allocation ratio. The study arms will be: Group 1: NIPP arm; Group 2: NIPP+ arm; and Group 3: Non-intervention control arm. for the venous aflatoxin sub-study, 36 women will be purposively selected from the eligible communities.
- Masking
- None (open label)
- Enrolment
- 1,834 participants (actual)
Sponsor and investigators
- Lead sponsor
- Tufts University
- Sponsor type
- University, hospital or other
- Collaborators
- GOAL, Ireland, Centro Internacional de Mejoramiento de Maiz y Trigo Internacional, Mexico, Cornell University
- Responsible party
- Principal investigator, Shibani Ghosh, Tufts University
- Investigators
- Stacy P Griswold, MS, Study director, Tufts University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT04209569
- Sponsor's protocol ID
- 13426
- Acronym
- ONCE
- Status last verified
- Jan 2024
- First submitted
- 8 Dec 2019
- Last updated
- 31 Jan 2024
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Yes: This is undecided, presently
Publications
Akombi BJ, Agho KE, Hall JJ, Wali N, Renzaho AMN, Merom D. Stunting, Wasting and Underweight in Sub-Saharan Africa: A Systematic Review. Int J Environ Res Public Health. 2017 Aug 1;14(8):863. doi: 10.3390/ijerph14080863.
PubMed 28788108Bain R, Bartram J, Elliott M, Matthews R, McMahan L, Tung R, Chuang P, Gundry S. A summary catalogue of microbial drinking water tests for low and medium resource settings. Int J Environ Res Public Health. 2012 May;9(5):1609-25. doi: 10.3390/ijerph9051609. Epub 2012 May 4.
PubMed 22754460Baoua I.B., Amadou L., Ousmane B., Baributsa D. and Murdock L.L. PICS bags for post-harvest storage of maize grain in West Africa. J. Stored Prod. Res., 58 (2014), pp. 20-28
Bauby, AL. and Flachenberg, F. 2014. Achieving sustainability: linking CLTS with other approaches - an example of a thorough WASH intervention in South Eastern Chad. IN: Shaw, R.J., Anh, N.V. and Dang, T.H. (eds). Sustainable water and sanitation services for all in a fast changing world: Proceedings of the 37th WEDC International Conference, Hanoi, Vietnam, 15- 19 September 2014, 5pp
Channa H., Ricker-Gilbert J., De Groote H., Marenya P., Bauchet J., Woloshuk C. Assessing Kenyan farmers and traders demand for low cost moisture meters to reduce aflatoxin in maize. Research brief by Purdue University and CIMMYT Kenya.
Angood C, Khara T, Dolan C, Berkley JA; WaSt Technical Interest Group. Research Priorities on the Relationship between Wasting and Stunting. PLoS One. 2016 May 9;11(5):e0153221. doi: 10.1371/journal.pone.0153221. eCollection 2016.
PubMed 27159235Dangour AD, Watson L, Cumming O, Boisson S, Che Y, Velleman Y, Cavill S, Allen E, Uauy R. Interventions to improve water quality and supply, sanitation and hygiene practices, and their effects on the nutritional status of children. Cochrane Database Syst Rev. 2013 Aug 1;2013(8):CD009382. doi: 10.1002/14651858.CD009382.pub2.
PubMed 23904195Danso J.K., Osekre E.A., Opit G.P., Manu N., Armstrong P., Arthur F.H., Campbell J.F., Mbata G., and McNeill S.G. Post-harvest insect infestation and mycotoxin levels in maize markets in the Middle Belt of Ghana Journal of Stored Products Research 77 (2018) 9-15
Davis Jr., Thomas P. Barrier Analysis Facilitator's Guide: A Tool for Improving Behavior Change Communication in Child Survival and Community Development Programs, Washington, D.C.: Food for the Hungry. (2004).
ENN. Child wasting and stunting: time to overcome the separation. A Briefing Note for policy makers and programme implementers. Emergency Nutrition Network. June 2018.
FTF NIL Africa 2013. Baseline Report. Assessing the linkage between agriculture, food security, nutrition and health among women and children in rural Ugandan households. 66 pages. www.nutritioninnovationlab.org
GOAL. 2016. "Implementation guidelines for Nutrition Impact and Positive Practice (NIPP) approach." GOAL, Ireland
Hamoudi A, Jeuland M, Lombardo S, Patil S, Pattanayak SK, Rai S. The effect of water quality testing on household behavior: evidence from an experiment in rural India. Am J Trop Med Hyg. 2012 Jul;87(1):18-22. doi: 10.4269/ajtmh.2012.12-0051.
PubMed 22764286Harding KL, Aguayo VM, Webb P. Factors associated with wasting among children under five years old in South Asia: Implications for action. PLoS One. 2018 Jul 3;13(7):e0198749. doi: 10.1371/journal.pone.0198749. eCollection 2018.
PubMed 29969457Headey D, Nguyen P, Kim S, Rawat R, Ruel M, Menon P. Is Exposure to Animal Feces Harmful to Child Nutrition and Health Outcomes? A Multicountry Observational Analysis. Am J Trop Med Hyg. 2017 Apr;96(4):961-969. doi: 10.4269/ajtmh.16-0270. Epub 2016 Dec 19.
PubMed 27994099
Study at a glance
From the registry record, last updated by the sponsor on 31 Jan 2024. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- One Nutrition in Complex Environments (ONCE), a Cluster-randomized Trial of Nutrition Education and Access to Simple Supportive Technologies in Improving Agricultural Practices and Water Quality Management
- ClinicalTrials.gov ID
- NCT04209569
- Acronym / sponsor ID
- ONCE / 13426
- Conditions
- Nutrition Poor, Aflatoxins Toxicity, Water-Related Diseases
- Keywords
- SBCC, child wasting, aflatoxin, coliform, Uganda
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 1,834 participants (actual)
- Lead sponsor
- Tufts UniversityUniversity, hospital or other
- Collaborators
- GOAL, Ireland, Centro Internacional de Mejoramiento de Maiz y Trigo Internacional, Mexico, Cornell University
- Study start
- 17 Jan 2020 (actual)
- Primary completion
- 30 Dec 2022 (actual)
- Study completion
- 30 Dec 2022 (actual)
- First posted
- 24 Dec 2019 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study asks the research question "Does enabling families (particularly mothers and other caregivers) to 'assess and act' on drivers of malnutrition through a targeted SBC+ package succeed in a sustained reduction of risk factors thereby improving child health and nutrition?" This study aims to implement and measure the effects of a multi-level multi-sectoral behavior change information intervention in Agago District of Northern Uganda and determine potential for scale up in a complex environment.
The study design is a three-arm cluster randomized controlled superiority design (cRCT) with a 1:1:1 allocation ratio. The study arms will be: Group 1: NIPP arm; Group 2: NIPP+ arm; and Group 3: Non-intervention control arm. A barrier analysis will be conducted to ensure appropriate targeting and contextualization of the NIPP and NIPP+ approaches prior to implementation. Each intervention arm will receive a 12-week intervention (NIPP or NIPP+) with active monitoring and longitudinal follow ups post intervention at 2, 6, and 12-months post-intervention. The total sample size for the Barrier Analysis will be a maximum of 450 caregivers; for the main intervention, 900 households (300/arm) will be purposely sampled from the randomly selected communities. Respondents for the qualitative portion will be purposely selected.
Detailed description
Objective: This study asks the research question "Does enabling families (particularly mothers and other caregivers) to 'assess and act' on drivers of malnutrition through a targeted SBC+ package succeed in a sustained reduction of risk factors thereby improving child health and nutrition?" This study aims to implement and measure the effects of a multi-level multi-sectoral behavior change information intervention in Agago District of Northern Uganda and determine potential for scale up in a complex environment.
Intervention: Through a collaboration between Tufts University, GOAL International, CIMMYT, and Cornell University, GOAL will implement Nutrition Impact and Positive Practice (NIPP) circles as the standard SBC intervention against which the hypotheses will be tested. GOAL will also implement a NIPP+ approach which will integrate additional interventions for water, sanitation, and hygiene (WASH), and use of improved agriculture inputs. These interventions will be measured by outcome indicators measuring aflatoxin exposure, water contamination, and knowledge transferred to action.
Design: The study design is a three-arm cluster randomized controlled superiority design (cRCT) with a 1:1:1 allocation ratio. The study arms will be: Group 1: NIPP arm; Group 2: NIPP+ arm; and Group 3: Non-intervention control arm. A barrier analysis will be conducted to ensure appropriate targeting and contextualization of the NIPP and NIPP+ approaches prior to implementation. Each intervention arm will receive a 12-week intervention (NIPP or NIPP+) with active monitoring and longitudinal follow ups post intervention at 2, 6, and 12-months post-intervention. The total sample size for the Barrier Analysis will be a maximum of 450 caregivers; for the main intervention, 900 households (300/arm) will be purposely sampled from the randomly selected communities. Respondents for the qualitative portion will be purposely selected.
Analysis: This longitudinal study will collect data from all participants at 3 time points: baseline, endline, and sustainability (12-months post-intervention). The analysis will utilize Intent-to-Treat (ITT) approach using the initial randomization of the treatment arms. Using ITT will allow us to determine the overall impact of having the NIPP vs. NIPP+ vs. control, thus better mimicking real world program implementation and impact. Mixed effects models will be used to determine the role of time-variant and invariant individual (by gender) household, and community characteristics, as well as measures of exposure and integration on key outcome indicators. A difference-in-difference analysis (baseline/endline, baseline/sustainability, endline/sustainability) will also be used to triangulate findings.
Sub-study: a subset of reproductive age women will be purposively selected for enrollment into a validation sub-study that will examine the level of aflatoxin (AFB1-lysine concentration) exposure measured in venous blood compared to capillary blood compared to the innovative SAFE-phone method. This will serve as a validation and calibration sub-study to gauge the accuracy of the SAFE-Phone method compared to venous reference.
Study design
- Primary purpose
- Prevention
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 3
- Model description
- The study design is a three-arm cluster randomized controlled superiority design (cRCT) with a 1:1:1 allocation ratio. The study arms will be: Group 1: NIPP arm; Group 2: NIPP+ arm; and Group 3: Non-intervention control arm. for the venous aflatoxin sub-study, 36 women will be purposively selected from the eligible communities.
| Arm | Type | Receives |
|---|---|---|
| NIPP | Active comparator | Behavioral: Nutrition Impact and Positive Practice Circle (NIPP)The NIPP group is a standard social behavior change (SBCC) intervention that tackles a set of underlying causes of malnutrition, with the potential to have both a curative and preventative impact on child malnutrition. The approach in this group/arm involves training and pragmatic behavior change education reinforced by practical activities over a 12-week period to both men and women in selected communities. It aims to utilize easy, viable and accessible solutions within the community that can be used to improve and protect household health and nutrition. The 12-week lesson plans for the circles are divided into 3 components, i) hands-on behavior change sessions that focus on the key pre-identified causes of malnutrition to improve awareness and practice ii) micro-gardening for improved household nutrition security and iii) participatory cooking demonstrations to stimulate improvements in nutritional status and care practices. |
| NIPP+ | Experimental | Behavioral: Nutrition Impact and Positive Practice Circle (NIPP)In addition to establishing the circles and implementing the three NIPP components also implemented in the NIPP arm, those randomized to the NIPP+ arm will be provided access to innovations to allow and encourage the households and communities to translate the knowledge into positive practices. The innovations and access to vendors who sell innovations will be made available during the training to the NIPP+ volunteers who will provide trainings and access to vendors during the circle meetings. Most of the additions will be made accessible at a subsidized/low cost. The NIPP+ officers from the program will support NIPP+ volunteers in collaboration with agricultural extension officers. |
| Control | No intervention | –No Intervention |
Who may qualify
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Child, Adult, Older adult
Key inclusion criteria (0 listed)
Key exclusion criteria (1 listed)
- Individuals in households without eligible children (i.e. without a child under age 2), or who will not be present in the selected communities during the intervention and data collection periods and/or who are not willing to participate through the entire 12-week cycle.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Nutrition Impact and Positive Practice Circle (NIPP)GOAL's NIPP approach is a gendered, grass-roots SBC approach, tackling a package of underlying behavioral determinants of malnutrition, irrespective of the particular manifestation. The approach is multi-sectoral in nature. It also has a strong monitoring, evaluation and adaptive learning component by design. The intervention approach (based on GOAL's NIPP approach) involves the creation of community, male and female circles in each community with messaging and activities targeted towards the three groups in varying intensities. While the male and female circles meet 2-3 times per week for a maximum period of 12 weeks while the community circles will meet for approximately three hours at any one time over a period of 2-7 days. (See GOAL NIPP Implementation Guidelines) | Behavioural | NIPP, NIPP+ |
Primary outcome
Change in Aflatoxin Exposure in Maize
Time frame: within 1-month of harvest immediately after the intervention and one year after the intervention.
aflatoxin in parts per billion in a random sample of maize in a given household's maize supply
Change in E. coli exposure in household
Time frame: prior to the intervention, immediately after the intervention, and 1 year following the intervention
e. coli measured in colonies/100 ml
3 secondary outcomes
Aflatoxin Exposure in blood serum
Time frame: immediately after the intervention, and 1 year following the intervention
Aflatoxin Exposure in blood serum
Time frame: immediately after the intervention, and 1 year following the intervention
Change in Dietary Diversity - mother and child
Time frame: prior to the intervention, immediately after the intervention, and 1 year following the intervention and 2 and 6-months after the intervention
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 31 Jan 2024.
- Background: PubMed 28788108Akombi BJ, Agho KE, Hall JJ, Wali N, Renzaho AMN, Merom D. Stunting, Wasting and Underweight in Sub-Saharan Africa: A Systematic Review. Int J Environ Res Public Health. 2017 Aug 1;14(8):863. doi: 10.3390/ijerph14080863.
- Background: PubMed 22754460Bain R, Bartram J, Elliott M, Matthews R, McMahan L, Tung R, Chuang P, Gundry S. A summary catalogue of microbial drinking water tests for low and medium resource settings. Int J Environ Res Public Health. 2012 May;9(5):1609-25. doi: 10.3390/ijerph9051609. Epub 2012 May 4.
- BackgroundBaoua I.B., Amadou L., Ousmane B., Baributsa D. and Murdock L.L. PICS bags for post-harvest storage of maize grain in West Africa. J. Stored Prod. Res., 58 (2014), pp. 20-28
- BackgroundBauby, AL. and Flachenberg, F. 2014. Achieving sustainability: linking CLTS with other approaches - an example of a thorough WASH intervention in South Eastern Chad. IN: Shaw, R.J., Anh, N.V. and Dang, T.H. (eds). Sustainable water and sanitation services for all in a fast changing world: Proceedings of the 37th WEDC International Conference, Hanoi, Vietnam, 15- 19 September 2014, 5pp
- BackgroundChanna H., Ricker-Gilbert J., De Groote H., Marenya P., Bauchet J., Woloshuk C. Assessing Kenyan farmers and traders demand for low cost moisture meters to reduce aflatoxin in maize. Research brief by Purdue University and CIMMYT Kenya.
- Background: PubMed 27159235Angood C, Khara T, Dolan C, Berkley JA; WaSt Technical Interest Group. Research Priorities on the Relationship between Wasting and Stunting. PLoS One. 2016 May 9;11(5):e0153221. doi: 10.1371/journal.pone.0153221. eCollection 2016.
- Background: PubMed 23904195Dangour AD, Watson L, Cumming O, Boisson S, Che Y, Velleman Y, Cavill S, Allen E, Uauy R. Interventions to improve water quality and supply, sanitation and hygiene practices, and their effects on the nutritional status of children. Cochrane Database Syst Rev. 2013 Aug 1;2013(8):CD009382. doi: 10.1002/14651858.CD009382.pub2.
- BackgroundDanso J.K., Osekre E.A., Opit G.P., Manu N., Armstrong P., Arthur F.H., Campbell J.F., Mbata G., and McNeill S.G. Post-harvest insect infestation and mycotoxin levels in maize markets in the Middle Belt of Ghana Journal of Stored Products Research 77 (2018) 9-15
- BackgroundDavis Jr., Thomas P. Barrier Analysis Facilitator's Guide: A Tool for Improving Behavior Change Communication in Child Survival and Community Development Programs, Washington, D.C.: Food for the Hungry. (2004).
- BackgroundENN. Child wasting and stunting: time to overcome the separation. A Briefing Note for policy makers and programme implementers. Emergency Nutrition Network. June 2018.
- BackgroundFTF NIL Africa 2013. Baseline Report. Assessing the linkage between agriculture, food security, nutrition and health among women and children in rural Ugandan households. 66 pages. www.nutritioninnovationlab.org
- BackgroundGOAL. 2016. "Implementation guidelines for Nutrition Impact and Positive Practice (NIPP) approach." GOAL, Ireland
- Individual participant dataSharing planned: Yes. This is undecided, presently
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Stacy P Griswold, MS study director
Tufts University
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Nutrition Impact and Positive Practice Circle (NIPP) in people with Nutrition Poor and Aflatoxins Toxicity, run by Tufts University at 1 site in Uganda.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 0 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 31 Jan 2024. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Uganda. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Change in Aflatoxin Exposure in Maize (time frame: within 1-month of harvest immediately after the intervention and one year after the intervention.). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT04209569, which also lists 41 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 31 Jan 2024.