Treatment of RabiesEarly Phase 1NCT04261322
Rabies Treatment by Exposure of Patient to X-Ray
A Early Phase 1 study testing x ray exposure in people with Treatment of Rabies, run by National Institute For Research On Endemic Diseases And Liver, Egypt.
Trial summary
x-ray has been proven to kill Rabies virus in vitro, so the investigators can use it in treatment of rabies infected patients. Read more about this study
- Who is it for?
- Any age
- Conditions the study is for
- Treatment of Rabies
- What is being tested?
- x ray exposure
- Type of treatment
- Surgery or procedure
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 4 participants
- Where
- No sites listed yet
- Study dates
- Mar 2020to Jul 2020
- Phase
- Early Phase 1
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages Any age
- All sexes
- No healthy volunteers
- Child, Adult, Older adult
Who may be able to join
- patient bitten by rabid animal with signs and symptoms
Who cannot join
- bitten by non rabid animal
Trial locations and contacts
No sites are listed yet.
About this study
Official title: Effect of X-ray on Rabies Virus in Vivo
x-ray has been proven to kill Rabies virus in vitro, so the investigators can use it in treatment of rabies infected patients.
Read the detailed description
x-ray has been proven to kill Rabies virus in vitro, so the investigators can use it in treatment of rabies infected patients.
this can be done by exposure of infected , manifested patient who didn't receive prophylaxis or delayed in receiving immunoglobulins .
also can be applied to patients who have the injury in upper body near the CNS..
it's just an idea and the investigators need help to approve its effect and the investigators believe it will really work and give a new, rapid , cheap and very effective treatment to a 100% fatal disease..
the investigator also predict good results when x ray applied to some localized infections beside its current lines of treatment..
- Conditions
- Treatment of Rabies
- Being tested
- x ray exposure
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
x ray exposureRadiation
exposure of whole body to x ray
| Study group | Role | What they receive |
|---|---|---|
| rabies patient 1 | Experimental | not received immunoglobulins and symptomatic Receives: Radiation: x ray exposure |
| rabies patient 2 | Experimental | received immunoglobulins and symptomatic Receives: Radiation: x ray exposure |
| rabies patient 3 | Experimental | not received immunoglobulins and not yet symptomatic Receives: Radiation: x ray exposure |
| rabies patient 4 | Experimental | received immunoglobulins and not symptomatic Receives: Radiation: x ray exposure |
What is being measured
The primary outcome is the main question the study is designed to answer.
the number of rabies infected, symptomatic patients who survived after x-ray exposure
detecting effect of x-ray exposure on treating Rabies
Measured: 7 month
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted7 Feb 2020
- Study startMar 2020 (estimated)
- Primary completionJul 2020 (estimated)
- Study completionJul 2020 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Treatment of RabiesStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Early Phase 1
- Primary purpose
- Treatment
- Allocation
- Non-randomised
- Intervention model
- Parallel groups
- Masking
- Double blind
- Who is masked
- Participant, Investigator
- Enrolment
- 4 participants (estimated)
Sponsor and investigators
- Lead sponsor
- National Institute For Research On Endemic Diseases And Liver, Egypt
- Sponsor type
- Other government
- Responsible party
- Principal investigator, Ahmed Samir Mohammed El Behwashy, National Institute For Research On Endemic Diseases And Liver, Egypt
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT04261322
- Sponsor's protocol ID
- X-Ray as a treatment of Rabies
- Status last verified
- Feb 2020
- First submitted
- 13 Jan 2020
- Last updated
- 18 Feb 2020
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Undecided
Study at a glance
From the registry record, last updated by the sponsor on 18 Feb 2020. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Effect of X-ray on Rabies Virus in Vivo
- ClinicalTrials.gov ID
- NCT04261322
- Acronym / sponsor ID
- X-Ray as a treatment of Rabies
- Conditions
- Treatment of Rabies
- Phase
- Early Phase 1
- Study type
- Interventional
- Recruitment status
- Unknown status
- Enrolment
- 4 participants (estimated)
- Lead sponsor
- National Institute For Research On Endemic Diseases And Liver, EgyptOther government
- Study start
- Mar 2020 (estimated)
- Primary completion
- Jul 2020 (estimated)
- Study completion
- Jul 2020 (estimated)
- First posted
- 7 Feb 2020 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
x-ray has been proven to kill Rabies virus in vitro, so the investigators can use it in treatment of rabies infected patients.
Detailed description
x-ray has been proven to kill Rabies virus in vitro, so the investigators can use it in treatment of rabies infected patients.
this can be done by exposure of infected , manifested patient who didn't receive prophylaxis or delayed in receiving immunoglobulins .
also can be applied to patients who have the injury in upper body near the CNS..
it's just an idea and the investigators need help to approve its effect and the investigators believe it will really work and give a new, rapid , cheap and very effective treatment to a 100% fatal disease..
the investigator also predict good results when x ray applied to some localized infections beside its current lines of treatment..
Study design
- Primary purpose
- Treatment
- Allocation
- Non-randomised
- Intervention model
- Parallel groups
- Masking
- Double blind (participant, investigator)
- Number of arms
- 4
| Arm | Type | Receives |
|---|---|---|
| rabies patient 1 | Experimental | Radiation: x ray exposurenot received immunoglobulins and symptomatic |
| rabies patient 2 | Experimental | Radiation: x ray exposurereceived immunoglobulins and symptomatic |
| rabies patient 3 | Experimental | Radiation: x ray exposurenot received immunoglobulins and not yet symptomatic |
| rabies patient 4 | Experimental | Radiation: x ray exposurereceived immunoglobulins and not symptomatic |
Who may qualify
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Child, Adult, Older adult
Key inclusion criteria (1 listed)
- patient bitten by rabid animal with signs and symptoms
Key exclusion criteria (1 listed)
- bitten by non rabid animal
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| x ray exposureexposure of whole body to x ray | Radiation | rabies patient 1, rabies patient 2, rabies patient 3, rabies patient 4 |
Primary outcome
the number of rabies infected, symptomatic patients who survived after x-ray exposure
Time frame: 7 month
detecting effect of x-ray exposure on treating Rabies
Results and safety
Results are not available in the source record.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 18 Feb 2020.
- Individual participant dataSharing planned: Undecided
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Questions about this trial
What is this clinical trial studying?
A Early Phase 1 study testing x ray exposure in people with Treatment of Rabies, run by National Institute For Research On Endemic Diseases And Liver, Egypt.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 1 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: status not confirmed, as of the sponsor's last update on 18 Feb 2020. Status can change between updates, so confirm with the study contact before making plans.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
What does this phase mean?
Early Phase 1 (sometimes called Phase 0) studies give a very small amount of a treatment to a few people, mainly to see how the body handles it.
Not every study follows the same path, and some studies (observational studies, device studies) have no phase.
Are results available for this study?
Results are not available in the source record.
How can a doctor refer a patient or contact the research team?
Contact Ahmed Samir El-Behwashy, fellowship (01001814806, ahmedelsamir@gmail.com), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
the number of rabies infected, symptomatic patients who survived after x-ray exposure (time frame: 7 month). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 18 Feb 2020; AzTrials last refreshed its copy on 8 Nov 2026.