LymphomaNCT04270266
Mind-Body Medicine for the Improvement of Quality of Life in Adolescents and Young Adults Coping With Lymphoma
A study testing Educational Intervention, Meditation Therapy and Questionnaire Administration in people with Lymphoma, run by M.D. Anderson Cancer Center at 1 site in United States.
Trial summary
This trial studies how well a mind-body intervention works in improving overall quality of life in adolescents and young adults with lymphoma. A meditation based mind-body intervention may help lower distress, depressive symptoms, and anxiety in adolescents and young adults coping with lymphoma. Read more about this study
- Who is it for?
- Ages 18 to 39 years
- Conditions the study is for
- Lymphoma
- What is being tested?
- Educational Intervention, Meditation Therapy and Questionnaire Administration
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 71 participants
- Where
- 1 siteUnited States
- Study dates
- 6 Sep 2019to 21 Dec 2026
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 39 years
- All sexes
- No healthy volunteers
- Adult
Who may be able to join
- Participants between the ages of 18-39 diagnosed within 6 months with stage I-IV Lymphoma (all types)
- Eastern Cooperative Oncology Group (ECOG) performance status of 2 or below
- Having access to the internet
- Able to read, write and speak English
Who cannot join
- Major psychiatric or cognitive deficits that would impede the completion of self-report instruments as deemed by the clinical team
- Regular (self-defined) participation in psychotherapy or a formal cancer support group
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Mind-Body Medicine for Adolescents and Young Adults (AYA) Coping With Lymphoma
This trial studies how well a mind-body intervention works in improving overall quality of life in adolescents and young adults with lymphoma. A meditation based mind-body intervention may help lower distress, depressive symptoms, and anxiety in adolescents and young adults coping with lymphoma.
Read the detailed description
PRIMARY OBJECTIVE:
- Examine the feasibility of the mind-body intervention in adolescents and young adults (AYAs) with lymphoma.
SECONDARY OBJECTIVE:
- Establish the initial intervention efficacy regarding psychological distress and cancer symptoms (tertiary objective) relative to an attention control (AC) group.
EXPLORATORY OBJECTIVE:
- Explore mediation (e.g., mindfulness, compassion, social connection, inflammatory processes) and moderation (e.g., demographic and medical factors) of the intervention effects.
OUTLINE: Patients are randomized to 1 of 2 groups.
GROUP I: Patients attend meditation group sessions over 75 minutes once weekly for up to 5 weeks.
GROUP II: Patients attend educational group sessions over 75 minutes once weekly for up to 5 weeks.
After completion of study intervention, patients are followed at 6 and 12 weeks.
- Conditions
- Lymphoma
- Being tested
- Educational Intervention, Meditation Therapy, Questionnaire Administration
- Keywords
- All types of lymphoma
- Medical subject headings
- Lymphoma
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Educational InterventionOther
Also called Education for Intervention, Intervention by Education, Intervention through Education, Intervention, Educational
Attend educational sessions
Meditation TherapyOther
Also called Meditation
Attend meditation sessions
Questionnaire AdministrationOther
Ancillary studies
| Study group | Role | What they receive |
|---|---|---|
| Group I (meditation) | Experimental | Patients attend meditation group sessions over 75 minutes once weekly for up to 5 weeks. Receives: Other: Meditation Therapy; Other: Questionnaire Administration |
| Group II (educational) | Active comparator | Patients attend educational group sessions over 75 minutes once weekly for up to 5 weeks. Receives: Other: Educational Intervention; Other: Questionnaire Administration |
What is being measured
The primary outcome is the main question the study is designed to answer.
Mind-body intervention in (AYAs) Adolescents and Young Adults with Lymphoma Questionnaire
We will examine preliminary evidence of intervention efficacy. Meaning and Purpose (1-5) Strongly Disagree 1- Disagree 2, Neither agree or disagree 3, Agree 4, Strongly agree 5.
Day-to-Day Experiences (1-6) Almost Always-1, Very frequently-2, Somewhat Frequently -3, Somewhat Infrequently-4, Very Infrequently-5, Almost Never 6
Measured: Up to 12 weeks
Secondary outcomes (1)
Psychological distress and cancer symptoms (tertiary objective) relative to an attention control (AC) group Questionnaire
We will examine preliminary evidence of intervention efficacy. Meaning and Purpose (1-5) Strongly Disagree 1- Disagree 2, Neither agree or disagree 3, Agree 4, Strongly agree 5.
Day-to-Day Experiences (1-6) Almost Always-1, Very frequently-2, Somewhat Frequently -3, Somewhat Infrequently-4, Very Infrequently-5, Almost Never 6
Measured: Up to 12 weeks
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted17 Feb 2020
- Study start6 Sep 2019
- Primary completion21 Dec 2026 (estimated)
- Study completion21 Dec 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for LymphomaStudies of the same condition, open and under way.
- More trials run by M.D. Anderson Cancer CenterThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Supportive care
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Enrolment
- 71 participants (actual)
Sponsor and investigators
- Lead sponsor
- M.D. Anderson Cancer Center
- Sponsor type
- University, hospital or other
- Collaborators
- National Cancer Institute (NCI)
- Responsible party
- Sponsor
- Investigators
- Kathrin Milbury, Principal investigator, M.D. Anderson Cancer Center
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT04270266
- Sponsor's protocol ID
- 2019-0282
- Other IDs
- NCI-2019-05846, 2019-0282
- Status last verified
- Sep 2026
- First submitted
- 12 Sep 2019
- Last updated
- 14 Sep 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Publications
Cho D, Ahmed S, Snyder S, Kroll J, Chen M, Roth M, Milbury K. Group-Based Support Interventions for Adolescents and Young Adults With Lymphoma: A Pilot Randomized Controlled Trial. Psychooncology. 2025 Dec;34(12):e70343. doi: 10.1002/pon.70343.
PubMed 41298073
Study at a glance
From the registry record, last updated by the sponsor on 14 Sep 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Mind-Body Medicine for Adolescents and Young Adults (AYA) Coping With Lymphoma
- ClinicalTrials.gov ID
- NCT04270266
- Acronym / sponsor ID
- 2019-0282
- Conditions
- Lymphoma
- Keywords
- All types of lymphoma
- Study type
- Interventional
- Recruitment status
- Active, not recruiting
- Enrolment
- 71 participants (actual)
- Lead sponsor
- M.D. Anderson Cancer CenterUniversity, hospital or other
- Collaborators
- National Cancer Institute (NCI)
- Study start
- 6 Sep 2019 (actual)
- Primary completion
- 21 Dec 2026 (estimated)
- Study completion
- 21 Dec 2026 (estimated)
- First posted
- 17 Feb 2020 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This trial studies how well a mind-body intervention works in improving overall quality of life in adolescents and young adults with lymphoma. A meditation based mind-body intervention may help lower distress, depressive symptoms, and anxiety in adolescents and young adults coping with lymphoma.
Detailed description
PRIMARY OBJECTIVE:
- Examine the feasibility of the mind-body intervention in adolescents and young adults (AYAs) with lymphoma.
SECONDARY OBJECTIVE:
- Establish the initial intervention efficacy regarding psychological distress and cancer symptoms (tertiary objective) relative to an attention control (AC) group.
EXPLORATORY OBJECTIVE:
- Explore mediation (e.g., mindfulness, compassion, social connection, inflammatory processes) and moderation (e.g., demographic and medical factors) of the intervention effects.
OUTLINE: Patients are randomized to 1 of 2 groups.
GROUP I: Patients attend meditation group sessions over 75 minutes once weekly for up to 5 weeks.
GROUP II: Patients attend educational group sessions over 75 minutes once weekly for up to 5 weeks.
After completion of study intervention, patients are followed at 6 and 12 weeks.
Study design
- Primary purpose
- Supportive care
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Group I (meditation) | Experimental | Other: Meditation Therapy, Other: Questionnaire AdministrationPatients attend meditation group sessions over 75 minutes once weekly for up to 5 weeks. |
| Group II (educational) | Active comparator | Other: Educational Intervention, Other: Questionnaire AdministrationPatients attend educational group sessions over 75 minutes once weekly for up to 5 weeks. |
Who may qualify
- Ages
- 18 to 39 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult
Key inclusion criteria (4 listed)
- Participants between the ages of 18-39 diagnosed within 6 months with stage I-IV Lymphoma (all types)
- Eastern Cooperative Oncology Group (ECOG) performance status of 2 or below
- Having access to the internet
- Able to read, write and speak English
Key exclusion criteria (2 listed)
- Major psychiatric or cognitive deficits that would impede the completion of self-report instruments as deemed by the clinical team
- Regular (self-defined) participation in psychotherapy or a formal cancer support group
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Educational InterventionAlso: Education for Intervention, Intervention by Education, Intervention through Education, Intervention, EducationalAttend educational sessions | Other | Group II (educational) |
| Meditation TherapyAlso: MeditationAttend meditation sessions | Other | Group I (meditation) |
| Questionnaire AdministrationAncillary studies | Other | Group I (meditation), Group II (educational) |
Primary outcome
Mind-body intervention in (AYAs) Adolescents and Young Adults with Lymphoma Questionnaire
Time frame: Up to 12 weeks
We will examine preliminary evidence of intervention efficacy. Meaning and Purpose (1-5) Strongly Disagree 1- Disagree 2, Neither agree or disagree 3, Agree 4, Strongly agree 5. Day-to-Day Experiences (1-6) Almost Always-1, Very frequently-2, Somewhat Frequently -3, Somewhat Infrequently-4, Very Infrequently-5, Almost Never 6
1 secondary outcome
Psychological distress and cancer symptoms (tertiary objective) relative to an attention control (AC) group Questionnaire
Time frame: Up to 12 weeks
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 14 Sep 2026.
- Derived from this study: PubMed 41298073Cho D, Ahmed S, Snyder S, Kroll J, Chen M, Roth M, Milbury K. Group-Based Support Interventions for Adolescents and Young Adults With Lymphoma: A Pilot Randomized Controlled Trial. Psychooncology. 2025 Dec;34(12):e70343. doi: 10.1002/pon.70343.
- University of Texas MD Anderson Cancer CenterLink provided by the sponsor.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Kathrin Milbury principal investigator
M.D. Anderson Cancer Center
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Educational Intervention, Meditation Therapy and Questionnaire Administration in people with Lymphoma, run by M.D. Anderson Cancer Center at 1 site in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 2 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: under way, not looking for participants, as of the sponsor's last update on 14 Sep 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Mind-body intervention in (AYAs) Adolescents and Young Adults with Lymphoma Questionnaire (time frame: Up to 12 weeks). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT04270266, which also lists 1 linked publication.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 14 Sep 2026; AzTrials last refreshed its copy on 8 Nov 2026.