Exercise TrainingNCT04295590
Impact of Augmenting Exercise Intensity vs. Frequency
A study testing Frequency comparison and Intensity comparison in people with Exercise Training, run by Brendon Gurd, PhD at 1 site in Canada.
Trial summary
The purpose of this study is to compare the impact of augmenting exercise intensity and augmenting exercise frequency on peak work rate. Participants will complete exercise tests and provide 8 skeletal muscle samples following a within-subjects randomized crossover design utilizing single-leg cycling. Read more about this study
- Who is it for?
- Ages 18 to 30 yearsHealthy volunteers can take part
- Conditions the study is for
- Exercise Training
- What is being tested?
- Frequency comparison and Intensity comparison
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 16 participants
- Where
- 1 siteCanada
- Study dates
- 30 Sep 2019to 10 Apr 2020
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 30 years
- All sexes
- Healthy volunteers accepted
- Adult
Who may be able to join
- Recreational active (<3 hours per week of aerobic exercise)
- Willing to provide skeletal muscle biopsies
Who cannot join
- Cardiovascular or metabolic disease
- Athletes or individuals exceeding 3 hours per week of aerobic exercise
- Smokers
Trial locations and contacts
1 site in 1 country.
Canada1 site
Queen's Muscle Physiology Lab in the School of Kinesiology and Health Studies at Queen's University
Kingston, Ontario, K7L 3N6
About this study
Official title: Impact of Augmenting Exercise Intensity vs. Frequency on Peak Work Rate
The purpose of this study is to compare the impact of augmenting exercise intensity and augmenting exercise frequency on peak work rate. Participants will complete exercise tests and provide 8 skeletal muscle samples following a within-subjects randomized crossover design utilizing single-leg cycling. Both training periods will be 4 weeks long and skeletal muscle biopsies will be collected from both legs before and after each training period. All exercise sessions will be supervised, take place in the investigator's laboratory, and occur on stationary bikes.
- Conditions
- Exercise Training
- Being tested
- Frequency comparison, Intensity comparison
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Frequency comparisonBehavioural
One leg assigned to low-frequency low-intensity (3 days per week of 11 x 1 min @ 73% peak work rate interspersed with 1-minute periods of active recovery). The other leg assigned to high-frequency low-intensity (5 days per week of 11 x 1 min @ 73% peak work rate interspersed with 1-minute periods of active recovery).
Intensity comparisonBehavioural
One leg assigned to low-frequency low-intensity (3 days per week of 11 x 1 min @ 73% peak work rate interspersed with 1-minute periods of active recovery). The other leg assigned to low-frequency high-intensity (3 days per week of 8 x 1 min @ 100% peak work rate interspersed with 1-minute periods of active recovery).
| Study group | Role | What they receive |
|---|---|---|
| Frequency then Intensity | Experimental | Training period 1: Frequency comparison Training period 2: Intensity comparison Receives: Behavioral: Frequency comparison; Behavioral: Intensity comparison |
| Intensity then Frequency | Experimental | Training period 1: Intensity comparison Training period 2: Frequency comparison Receives: Behavioral: Frequency comparison; Behavioral: Intensity comparison |
What is being measured
The primary outcome is the main question the study is designed to answer.
Peak work rate
Change in Highest work rate achieved (30s period) during incremental exercise tests
Measured: Before exercise training on two days (~7 and 6 days before first training session; ~24 hours apart), and after exercise on two days (~48-96 hours after the last training session; ~24 hours apart)
Secondary outcomes (2)
Peak oxygen uptake
Change in Highest oxygen uptake achieved (30s period) during incremental exercise tests
Measured: Before exercise training on two days (~7 and 6 days before first training session; ~24 hours apart), and after exercise on two days (~48-96 hours after the last training session; ~24 hours apart)
Maximal citrate synthase activity
Change in maximal citrate synthase activity
Measured: Before exercise training (~7 days before first training session), and after exercise training (~48-72 hours after the last training session)
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted4 Mar 2020
- Study start30 Sep 2019
- Primary completion10 Apr 2020 (estimated)
- Study completion10 Apr 2020 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Exercise TrainingStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Basic science
- Allocation
- Randomised
- Intervention model
- Crossover
- Masking
- Single blind
- Who is masked
- Outcomes assessor
- Enrolment
- 16 participants (actual)
Sponsor and investigators
- Lead sponsor
- Brendon Gurd, PhD
- Sponsor type
- University, hospital or other
- Collaborators
- Queen's University
- Responsible party
- Sponsor-investigator, Brendon Gurd, PhD, Queen's University
- Investigators
- Brendon J Gurd, PhD, Principal investigator, Queen's University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT04295590
- Sponsor's protocol ID
- UCD Study
- Status last verified
- Mar 2020
- First submitted
- 2 Mar 2020
- Last updated
- 4 Mar 2020
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 4 Mar 2020. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Impact of Augmenting Exercise Intensity vs. Frequency on Peak Work Rate
- ClinicalTrials.gov ID
- NCT04295590
- Acronym / sponsor ID
- UCD Study
- Conditions
- Exercise Training
- Study type
- Interventional
- Recruitment status
- Unknown status
- Enrolment
- 16 participants (actual)
- Lead sponsor
- Brendon Gurd, PhDUniversity, hospital or other
- Collaborators
- Queen's University
- Study start
- 30 Sep 2019 (actual)
- Primary completion
- 10 Apr 2020 (estimated)
- Study completion
- 10 Apr 2020 (estimated)
- First posted
- 4 Mar 2020 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The purpose of this study is to compare the impact of augmenting exercise intensity and augmenting exercise frequency on peak work rate. Participants will complete exercise tests and provide 8 skeletal muscle samples following a within-subjects randomized crossover design utilizing single-leg cycling. Both training periods will be 4 weeks long and skeletal muscle biopsies will be collected from both legs before and after each training period. All exercise sessions will be supervised, take place in the investigator's laboratory, and occur on stationary bikes.
Study design
- Primary purpose
- Basic science
- Allocation
- Randomised
- Intervention model
- Crossover
- Masking
- Single blind (outcomes assessor)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Frequency then Intensity | Experimental | Behavioral: Frequency comparison, Behavioral: Intensity comparisonTraining period 1: Frequency comparison Training period 2: Intensity comparison |
| Intensity then Frequency | Experimental | Behavioral: Frequency comparison, Behavioral: Intensity comparisonTraining period 1: Intensity comparison Training period 2: Frequency comparison |
Who may qualify
- Ages
- 18 to 30 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (2 listed)
- Recreational active (<3 hours per week of aerobic exercise)
- Willing to provide skeletal muscle biopsies
Key exclusion criteria (3 listed)
- Cardiovascular or metabolic disease
- Athletes or individuals exceeding 3 hours per week of aerobic exercise
- Smokers
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Frequency comparisonOne leg assigned to low-frequency low-intensity (3 days per week of 11 x 1 min @ 73% peak work rate interspersed with 1-minute periods of active recovery). The other leg assigned to high-frequency low-intensity (5 days per week of 11 x 1 min @ 73% peak work rate interspersed with 1-minute periods of active recovery). | Behavioural | Frequency then Intensity, Intensity then Frequency |
| Intensity comparisonOne leg assigned to low-frequency low-intensity (3 days per week of 11 x 1 min @ 73% peak work rate interspersed with 1-minute periods of active recovery). The other leg assigned to low-frequency high-intensity (3 days per week of 8 x 1 min @ 100% peak work rate interspersed with 1-minute periods of active recovery). | Behavioural | Frequency then Intensity, Intensity then Frequency |
Primary outcome
Peak work rate
Time frame: Before exercise training on two days (~7 and 6 days before first training session; ~24 hours apart), and after exercise on two days (~48-96 hours after the last training session; ~24 hours apart)
Change in Highest work rate achieved (30s period) during incremental exercise tests
2 secondary outcomes
Peak oxygen uptake
Time frame: Before exercise training on two days (~7 and 6 days before first training session; ~24 hours apart), and after exercise on two days (~48-96 hours after the last training session; ~24 hours apart)
Maximal citrate synthase activity
Time frame: Before exercise training (~7 days before first training session), and after exercise training (~48-72 hours after the last training session)
Results and safety
Results are not available in the source record.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 4 Mar 2020.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Brendon J Gurd, PhD principal investigator
Queen's University
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Frequency comparison and Intensity comparison in people with Exercise Training, run by Brendon Gurd, PhD at 1 site in Canada.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 2 inclusion and 3 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: status not confirmed, as of the sponsor's last update on 4 Mar 2020. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Canada. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
Results are not available in the source record.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Peak work rate (time frame: Before exercise training on two days (~7 and 6 days before first training session; ~24 hours apart), and after exercise on two days (~48-96 hours after the last training session; ~24 hours apart)). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 4 Mar 2020; AzTrials last refreshed its copy on 1 Nov 2026.