MalariaPhase 1NCT04323306
A Phase 1 Study to Assess the Safety, Tolerability, and Pharmacokinetic Profile of a Single Doses of MMV533.
A Phase 1 study testing MMV688533 in people with Malaria, run by Medicines for Malaria Venture at 1 site in Australia.
Trial summary
Phase 1, single -centre study in 2 parts. The study designs for each part are well established for first-in-human studies and are appropriate to assess safety, tolerability and preliminary pharmacokinetics. Read more about this study
- Who is it for?
- Ages 18 to 55 yearsHealthy volunteers can take part
- Conditions the study is for
- Malaria
- What is being tested?
- MMV688533
- Type of treatment
- Pill or oral medicine
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 72 participants
- Where
- 1 siteAustralia
- Study dates
- 12 Aug 2020to 27 Sep 2022
- Phase
- Phase 1
- Are there results?
- Yes, posted in the registrySummary in the doctors' view
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 55 years
- All sexes
- Healthy volunteers accepted
- Adult
Who may be able to join
- Males and females (of childbearing and non-childbearing potential) , between 18 and 55 years of age, inclusive. Women of childbearing potential (WOCBP) must use highly effective methods of birth control (see Inclusion #3).
- Females of non-childbearing potential:
- Natural (spontaneous) post-menopausal defined as being amenorrhoeic for at least 12 months without an alternative medical cause with a screening follicle stimulating hormone level (FSH) >25 IU/L (or at the local laboratory levels for post-menopause)
- Premenopausal with irreversible surgical sterilization by hysterectomy and/or bilateral oophorectomy or salpingectomy at least 6 months before screening (as determined by participant medical history)
- Women of childbearing potential that have or may have male sexual partners during the course of the study must agree to the use of a double method of contraception of a highly effective method of birth control combined with a barrier contraceptive (condom) when appropriate from screening visit to until 60 days after the last dose of IMP (covering a full menstrual cycle of 30 days starting after 5 half-lives of last dose of IMP. This duration is based on the predicted half-life of IMP, and may be amended once the actual half-life is calculated during this study). Note: Highly effective birth control methods include: combined (oestrogen and progestogen containing) oral/intravaginal/transdermal hormonal contraception associated with inhibition of ovulation, progestogen-only oral/injectable/implantable hormonal contraception associated with inhibition of ovulation, intrauterine device (IUD), intrauterine hormone-releasing system, bilateral tubal occlusion, vasectomised partner, or sexual abstinence or same sex relationship.
- Male participants who have, or may have female sexual partners during the course of the study must agree to use a double method of contraception including condom plus diaphragm, or condom plus stable insertable (implant or IUD), injectable, transdermal or combination oral contraceptive by the female partner, from the time of informed consent through to 90 days after the last dose of the IMP (covering a full spermatogenesis cycle of 60 days starting after 5 half-lives of last dose of IMP. This duration is based on the predicted half-life of IMP, and may be amended once the actual half-life is calculated during this study).
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- Abstinent male participants must agree to start a double method if they begin a sexual relationship with a female during the trial, and through to 90 days after the last dose of the IMP. Male participants with female partners that are surgically sterile or post-menopausal (defined as being amenorrhoeic for at least 12 months without an alternative medical cause), or male participants who have undergone sterilisation and have had testing to confirm the success of the sterilisation, may also be included and will not be required to use above described methods of contraception. Male participants must also agree not to donate sperm up to 3 months after dosing with the IMP.
- Total body weight greater than or equal to 50 kg, and body mass index (BMI) between 18 and 32 kg/m2 inclusive.
- Certified as healthy by a comprehensive clinical assessment (detailed medical history and complete physical examination).
- Normal vital signs after 5 minutes resting in supine position:
- Systolic blood pressure (SBP) - 90-140 mmHg,
- Diastolic blood pressure (DBP) - 40-90 mmHg,
- Heart rate (HR) 40-100 bpm.
- Standard 12-lead electrocardiogram (ECG) parameters after 10 minutes resting in supine position in the following ranges for both males and females: QT ≤ 500 msec, QTcF ≤450 msec, QTcB ≤450 msec, and PR interval ≤210 msec; and normal ECG tracing unless the Principal Investigator or delegate considers an ECG tracing abnormality to be not clinically significant.
- Having given written informed consent prior to undertaking any study-related procedure.
- Available for the duration of the study and for 2 weeks following the End of Study visit.
- In the opinion of the Principal Investigator or delegate, the individual has a high probability of adherence with and completion of the study, and willing and able to withdraw and refrain from restricted medications.
- Fluent in English and able to understand and comply with written and verbal protocol-related requirements.
- Willing to defer blood donations to a blood service for a minimum of 6 months after the End of Study visit.
Who cannot join
- Haematology, biochemistry or urinalysis results that are abnormal/outside of laboratory normal reference ranges AND are either:
- considered clinically significant by the Principal Investigator or delegate; OR
- considered not clinically significant by the Principal Investigator or delegate BUT ARE ALSO outside of the Sponsor-approved clinically acceptable laboratory ranges in Appendix 1 of the protocol.
- NOTE: Participants are not excluded if abnormal/out of laboratory normal reference range results are considered not clinically significant by the Principal Investigator or delegate AND are within the ranges specified in Appendix 1 of the protocol of .
- Positive serum pregnancy test at screening, positive urine pregnancy test upon admission or at other timepoints as specified by schedule of assessments.
- Male participants with a female partner(s) who is (are) pregnant or lactating from the time of the administration of study medication.
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- Any history or presence of clinically relevant cardiovascular, broncho-pulmonary, gastrointestinal, hepatic/ gallbladder*/ bile duct, renal, metabolic, haematological, neurological, musculoskeletal/rheumatologic, systemic, ocular, gynaecologic (if female), or infectious disease, or signs of acute illness. *including medical history of asymptomatic gallbladder stones.
- Any gastrointestinal surgery or any condition or disease that could affect drug absorption, distribution or excretion (eg, gastrectomy, cholecystectomy, diarrhoea).
- Severe recurring headaches (cluster or migrainous headaches) requiring prescription medication/s. History of recurrent nausea and/or vomiting (for vomiting only: more than twice a month).
- Participation in any research study involving blood sampling (more than 450 mL/unit of blood) or blood donation during the 8 weeks prior to IMP administration (Parts 1 and 2).
- Any documented evidence of current or past cardiovascular disease including cardiac arrhythmias or family history of congenital long QT syndrome, Brugada syndrome, or unexplained sudden cardiac death. Symptomatic postural hypotension at screening (confirmed on two consecutive readings), irrespective of the decrease in blood pressure, or asymptomatic postural hypotension defined as a decrease in systolic blood pressure ≥20 mmHg within 2-3 min when changing from supine to standing position.
- History or presence of diagnosed (by an allergist/immunologist) or treated (by a physician) food or known drug allergies, or any history of anaphylaxis or other severe allergic reactions including face, mouth, or throat swelling or any difficulty breathing. Participants with seasonal allergies/hay fever or allergy to animals or house dust mite that are untreated and asymptomatic at the time of dosing can be enrolled in the trial.
- History of convulsion (including drug or vaccine-induced episodes). A medical history of a single febrile convulsion during childhood is not an exclusion criterion.
- History of substance use disorder(s) within 5 years of screening, including alcohol consumption of more than 40g/4 units/4 standard drinks per day or any prior intravenous use of an illicit substance.
- Smoked >1 pack of cigarettes per day for >10 years, or who currently (within 14 days prior to IMP administration (Parts 1 and 2) smokes >5 cigarettes per day.
- Any medication (including herbal such as St John´s Wort, vitamin supplements and over the counter [OTC]) within 5 half-lives prior to IMP administration (Parts 1 and 2), except occasional intakes (for acute pain) of ibuprofen at doses up to 1.8g/day, paracetamol at doses up to 4g/day, acetylsalicylic acid (300 to 650 mg orally every 4 to 6 hours as needed Maximum dose: 4g in 24 hours), diclofenac (diclofenac potassium liquid-filled capsules: 25mg orally 4 times a day; diclofenac free acid capsules: 18 or 35 mg orally 3 times a day; diclofenac potassium immediate-release tablets: 50mg orally 3 times a day [initial dose of 100mg orally followed by 50mg oral doses acceptable if required for better relief]) and contraceptives.
- Any individual who, in the judgement of the Principal Investigator or delegate, is likely to be noncompliant during the study, or unable to cooperate because of a language problem or poor mental development.
- Any individual in the exclusion period of a previous study according to applicable regulations.
- Any individual who cannot be contacted in case of emergency.
- Any individual who is the Investigator, or delegates, research assistant, pharmacist, study coordinator, project manager, or other staff thereof, directly involved in conducting the study.
- Any individual without a good peripheral venous access.
- Participation in any investigational product study within the 12 weeks preceding IMP administration (Parts 1 and 2) or 5 times the half-life of the Investigational product, whichever is longer.
- Positive serology test for hepatitis B (positive HB sAG or anti-HBc Ab), hepatitis C (anti-HCV) or human immune deficiency virus (HIV) (positive for anti-HIV1 and anti-HIV2 Ab).
- Positive urine drug test at screening or prior to IMP dosing. Any drug from the list of drugs tested unless there is an acceptable explanation to the Principal Investigator or delegate (eg, participant has stated in advance that they consumed a prescription of over the counter product which contained the detected drug) and/or the participant has a negative urine drug screen on retest. Any participant tested positive for paracetamol at screening may still be eligible for study participation, at the Principal Investigator's or delegate's discretion.
- Positive alcohol screen at screening or prior to IMP dosing.
- Any consumption of citrus fruits (grapefruit, Seville oranges) or their juices within 5 days prior to IMP administration.
- Use of antidepressant medication in the past 12 months prior to IMP administration in Part 1 and 2.
- Individuals with history of schizophrenia, bipolar disorder psychoses, disorders requiring lithium, attempted or planned suicide, or any other severe (disabling) chronic psychiatric diagnosis including generalised anxiety and obsessivecompulsive disorders.
- Individuals who have been hospitalised within five years prior to enrolment for either a psychiatric illness or due to danger to self or others.
- History of an episode of mild/moderate depression lasting more than 6 months that required pharmacological therapy and/or psychotherapy within the last 5 years; or any episode of major depression. The Beck Depression Inventory (BDIII) will be used as a validated tool for the assessment of depression at screening. In addition to the conditions listed above, individuals with a score of 20 or more on the BDI-II and/or a response of 1, 2 or 3 for item 9 of this inventory (related to suicidal ideation) will not be eligible for participation. These individuals will be referred to a general practitioner or medical specialist as appropriate. Individuals with a BDI-II score of 17 to 19 may be enrolled at the discretion of an Investigator if they do not have a history of the psychiatric conditions mentioned in this criterion and their mental state is not considered to pose additional risk to the health of the individual or to the execution of the trial and interpretation of the data gathered.
- History of malignancy of any organ system (other than localized basal cell carcinoma of the skin or in situ cervical cancer considered treated and cured), treated or untreated, within 5 years of screening, regardless of whether there is no evidence of local recurrence or metastases.
- Any vaccination within 28 days of screening.
- Any medical condition that in the opinion of the Principal Investigator or delegate would jeopardize the individual's involvement in the study.
- Specific to Part 2 only:
- Any individual who, in the opinion of the Principal Investigator or delegate, would be unwilling or unable to consume the pre-dose test meal during the fed arm.
- Individuals with food intolerance or food allergy are excluded. Vegetarian individuals must be excluded, unless they agree to eat a full diet during the study.
Trial locations and contacts
1 site in 1 country.
About this study
Official title: A Two-part, Phase 1 Study to Assess the Safety, Tolerability, and Pharmacokinetic Profile of Ascending Single Doses of MMV533, Including a Pilot Food Evaluation in Healthy Participants.
Phase 1, single -centre study in 2 parts. The study designs for each part are well established for first-in-human studies and are appropriate to assess safety, tolerability and preliminary pharmacokinetics.
Read the detailed description
Part 1:
Double-blind, randomized, placebo-controlled, sequential ascending single dose study in healthy adult participants, 7 cohorts, and 1 additional cohort may be considered if needed according to the observed safety, tolerability, and pharmacokinetics results.
A sentinel dosing strategy will be implemented at each dose level to ensure the best conditions of safety. Each cohort will be divided into at least 2 subgroups. The first group (sentinel cohort) will include 2 participants that will be dosed on the first day, with 1 participant receiving MMV533 and 1 participant receiving placebo. The safety and tolerability data from the sentinel cohort up to and including 96 hours post-dose will be reviewed by the Principal Investigator, the Medical Monitor and the Sponsor´s Medical Director. Following a satisfactory safety review, dosing of the remaining participants in the cohort may proceed.
Part 2:
Open label, 2-period cross-over, randomized, pilot food effect study to provide preliminary information on the effect of a high-fat meal on the pharmacokinetics of a single-dose oral administration of MMV533 to healthy male and female participants aged between 18-55 years old. Part 2 may be conducted in parallel to or after completion of Part 1 at the discretion of the SRC. The dose will be selected by the SRC based on PK and safety results obtained in Part 1 and also taking into account the human efficacious dose/exposure predicted from preclinical efficacy studies in rodent malaria models.
- Conditions
- Malaria
- Being tested
- MMV688533
- Keywords
- Safety, Tolerability
- Medical subject headings
- Malaria
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
MMV688533Drug
Investigational medicinal product
| Study group | Role | What they receive |
|---|---|---|
| Cohort 1 SAD | Active comparator | 5 mg MMV533 with single ascending dose Receives: Drug: MMV688533 |
| Cohort 2 SAD | Active comparator | Single ascending dose to be determined after SRC review of previous cohort. Receives: Drug: MMV688533 |
| Cohort 3 SAD | Active comparator | Single ascending dose to be determined after SRC review of previous cohort. Receives: Drug: MMV688533 |
| Cohort 4 SAD | Active comparator | Single ascending dose to be determined after SRC review of previous cohort. Receives: Drug: MMV688533 |
| Cohort 5 SAD | Active comparator | Single ascending dose to be determined after SRC review of previous cohort. Receives: Drug: MMV688533 |
| Cohort 6 SAD | Active comparator | Single ascending dose to be determined after SRC review of previous cohort. Receives: Drug: MMV688533 |
| Cohort 7 SAD | Active comparator | Single ascending dose to be determined determine after SRT review of previous cohort. Dose will not exceed 400 mg. Receives: Drug: MMV688533 |
| Part 2: Food Effect | Active comparator | Open label, 2-period cross-over, randomized, pilot food effect study to provide preliminary information on the effect of a high-fat meal on the pharmacokinetics of a single-dose oral administration of MMV533 determined to be safe in Part 1. Receives: Drug: MMV688533 |
What is being measured
The primary outcome is the main question the study is designed to answer.
The Tolerability and Safety of Ascending Single Oral Doses of MMV533
Assessment of adverse events (AEs) /treatment-emergent adverse events (TEAEs) (treatment phase for Part 1 and 2 defined as from IMP administration up to and including EOS).
Measured: Safety data will be evaluated from baseline until 28 days after IMP/placebo administration
The Tolerability and Safety of Ascending Single Oral Doses of MMV533
Haematology: change from baseline
Measured: Change from baseline to 28 days post dose in Part 1 of the study and 21 days post dose in Part 2, Food effect study
The Tolerability and Safety of Ascending Single Oral Doses of MMV533
Biochemistry: number of participants with elevated Total Bile Acids considered as Clinically significant abnormalities
Measured: 24 hours to 648 hours post dose
The Tolerability and Safety of Ascending Single Oral Doses of MMV533
Urinalysis: parameters assessed: bilirubin, glucose, ketones, leucocytes, nitrite, blood, protein, urobilinogen, pH.
Number of participants with clinically significant findings.
Measured: Part 1: 28 days post IMP administration and for Part 2: 21 days post IMP administration
The Tolerability and Safety of Ascending Single Oral Doses of MMV533
Vital signs: respiratory rate supine and standing. Change from baseline.
Measured: Part 1 is 28 days post IMP and for Part 2, 21 days post IMP administration
The Tolerability and Safety of Ascending Single Oral Doses of MMV533
Vital signs: heart rate supine and standing. Change from baseline.
Measured: Part 1 is 28 days post IMP and for Part 2, 21 days post IMP administration
The Tolerability and Safety of Ascending Single Oral Doses of MMV533
Measurements of 12-lead triplicate ECG: QTcB and QTcF interval prolongations.
Measured: Part 1: 28 days post IMP whereas for Part 2: 21 days post IMP administration
The Tolerability and Safety of Ascending Single Oral Doses of MMV533
Biochemistry: number of participants with Low Hemoglobin considered as Clinically significant abnormality
Measured: 24 hours to 648 hours post dose
The Tolerability and Safety of Ascending Single Oral Doses of MMV533
Vital signs: blood pressures, supine and standing. Change from baseline.
Measured: Part 1 is 28 days post IMP and for Part 2, 21 days post IMP administration
The Tolerability and Safety of Ascending Single Oral Doses of MMV533
Vital signs: body temperature. Change from baseline.
Measured: Part 1 is 28 days post IMP and for Part 2, 21 days post IMP administration
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted26 Mar 2020
- Study start12 Aug 2020
- Primary completion27 Sep 2022
- Study completion27 Sep 2022
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Posted resultsParticipant flow, outcome measures and adverse events reported by the sponsor.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for MalariaStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase 1
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Sequential
- Model description
- Part 1: 8 participants per cohort for 7-8 cohorts (56-64 participants total). Single ascending dose commencing at 5 mg with maximum 400 mg as determined by Safety Review Committee (SRC). Part 2: Open label, 2-period cross-over, randomized, pilot food effect study to provide preliminary information on the effect of a high-fat meal on the pharmacokinetics of a single-dose oral administration of MMV533
- Masking
- Quadruple blind
- Who is masked
- Participant, Care provider, Investigator, Outcomes assessor
- Enrolment
- 72 participants (actual)
Sponsor and investigators
- Lead sponsor
- Medicines for Malaria Venture
- Sponsor type
- University, hospital or other
- Collaborators
- Nucleus Network Ltd, Southern Star Research
- Responsible party
- Sponsor
- Investigators
- Jason Lickliter, MD, Principal investigator, Nucleus Network Corporate
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT04323306
- Sponsor's protocol ID
- MMV-MMV533_19_01
- Status last verified
- Oct 2024
- First submitted
- 12 Mar 2020
- Last updated
- 17 Oct 2024
- Results posted
- Yes, on ClinicalTrials.gov
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Publications
Bestgen B, Jones S, Thathy V, Kuemmerle A, Barcelo C, Haouala A, Gossen D, Marx MW, Di Resta I, Szramowska M, Webster RA, Llewellyn S, Ritacco DA, Yeo T, Leroy D, Barber BE, Fidock DA, Griffin P, Lickliter J, Chalon S. Safety, tolerability, pharmacokinetics, and antimalarial activity of MMV533: a phase 1a first-in-human, randomised, ascending dose and food effect study, and a phase 1b Plasmodium falciparum volunteer infection study. Lancet Infect Dis. 2025 May;25(5):507-518. doi: 10.1016/S1473-3099(24)00664-9. Epub 2024 Dec 18.
PubMed 39708824
Study at a glance
From the registry record, last updated by the sponsor on 17 Oct 2024. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- A Two-part, Phase 1 Study to Assess the Safety, Tolerability, and Pharmacokinetic Profile of Ascending Single Doses of MMV533, Including a Pilot Food Evaluation in Healthy Participants.
- ClinicalTrials.gov ID
- NCT04323306
- Acronym / sponsor ID
- MMV-MMV533_19_01
- Conditions
- Malaria
- Keywords
- Safety, Tolerability
- Phase
- Phase 1
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 72 participants (actual)
- Lead sponsor
- Medicines for Malaria VentureUniversity, hospital or other
- Collaborators
- Nucleus Network Ltd, Southern Star Research
- Study start
- 12 Aug 2020 (actual)
- Primary completion
- 27 Sep 2022 (actual)
- Study completion
- 27 Sep 2022 (actual)
- First posted
- 26 Mar 2020 (actual)
- Results
- Posted 17 Oct 2024
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Phase 1, single -centre study in 2 parts. The study designs for each part are well established for first-in-human studies and are appropriate to assess safety, tolerability and preliminary pharmacokinetics.
Detailed description
Part 1:
Double-blind, randomized, placebo-controlled, sequential ascending single dose study in healthy adult participants, 7 cohorts, and 1 additional cohort may be considered if needed according to the observed safety, tolerability, and pharmacokinetics results.
A sentinel dosing strategy will be implemented at each dose level to ensure the best conditions of safety. Each cohort will be divided into at least 2 subgroups. The first group (sentinel cohort) will include 2 participants that will be dosed on the first day, with 1 participant receiving MMV533 and 1 participant receiving placebo. The safety and tolerability data from the sentinel cohort up to and including 96 hours post-dose will be reviewed by the Principal Investigator, the Medical Monitor and the Sponsor´s Medical Director. Following a satisfactory safety review, dosing of the remaining participants in the cohort may proceed.
Part 2:
Open label, 2-period cross-over, randomized, pilot food effect study to provide preliminary information on the effect of a high-fat meal on the pharmacokinetics of a single-dose oral administration of MMV533 to healthy male and female participants aged between 18-55 years old. Part 2 may be conducted in parallel to or after completion of Part 1 at the discretion of the SRC. The dose will be selected by the SRC based on PK and safety results obtained in Part 1 and also taking into account the human efficacious dose/exposure predicted from preclinical efficacy studies in rodent malaria models.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Sequential
- Masking
- Quadruple blind (participant, care provider, investigator, outcomes assessor)
- Number of arms
- 8
- Model description
- Part 1: 8 participants per cohort for 7-8 cohorts (56-64 participants total). Single ascending dose commencing at 5 mg with maximum 400 mg as determined by Safety Review Committee (SRC). Part 2: Open label, 2-period cross-over, randomized, pilot food effect study to provide preliminary information on the effect of a high-fat meal on the pharmacokinetics of a single-dose oral administration of MMV533
| Arm | Type | Receives |
|---|---|---|
| Cohort 1 SAD | Active comparator | Drug: MMV6885335 mg MMV533 with single ascending dose |
| Cohort 2 SAD | Active comparator | Drug: MMV688533Single ascending dose to be determined after SRC review of previous cohort. |
| Cohort 3 SAD | Active comparator | Drug: MMV688533Single ascending dose to be determined after SRC review of previous cohort. |
| Cohort 4 SAD | Active comparator | Drug: MMV688533Single ascending dose to be determined after SRC review of previous cohort. |
| Cohort 5 SAD | Active comparator | Drug: MMV688533Single ascending dose to be determined after SRC review of previous cohort. |
| Cohort 6 SAD | Active comparator | Drug: MMV688533Single ascending dose to be determined after SRC review of previous cohort. |
| Cohort 7 SAD | Active comparator | Drug: MMV688533Single ascending dose to be determined determine after SRT review of previous cohort. Dose will not exceed 400 mg. |
| Part 2: Food Effect | Active comparator | Drug: MMV688533Open label, 2-period cross-over, randomized, pilot food effect study to provide preliminary information on the effect of a high-fat meal on the pharmacokinetics of a single-dose oral administration of MMV533 determined to be safe in Part 1. |
Who may qualify
- Ages
- 18 to 55 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (19 listed)
- Males and females (of childbearing and non-childbearing potential) , between 18 and 55 years of age, inclusive. Women of childbearing potential (WOCBP) must use highly effective methods of birth control (see Inclusion #3).
- Females of non-childbearing potential:
- Women of childbearing potential that have or may have male sexual partners during the course of the study must agree to the use of a double method of contraception of a highly effective method of birth control combined with a barrier contraceptive (condom) when appropriate from screening visit to until 60 days after the last dose of IMP (covering a full menstrual cycle of 30 days starting after 5 half-lives of last dose of IMP. This duration is based on the predicted half-life of IMP, and may be amended once the actual half-life is calculated during this study). Note: Highly effective birth control methods include: combined (oestrogen and progestogen containing) oral/intravaginal/transdermal hormonal contraception associated with inhibition of ovulation, progestogen-only oral/injectable/implantable hormonal contraception associated with inhibition of ovulation, intrauterine device (IUD), intrauterine hormone-releasing system, bilateral tubal occlusion, vasectomised partner, or sexual abstinence or same sex relationship.
- Male participants who have, or may have female sexual partners during the course of the study must agree to use a double method of contraception including condom plus diaphragm, or condom plus stable insertable (implant or IUD), injectable, transdermal or combination oral contraceptive by the female partner, from the time of informed consent through to 90 days after the last dose of the IMP (covering a full spermatogenesis cycle of 60 days starting after 5 half-lives of last dose of IMP. This duration is based on the predicted half-life of IMP, and may be amended once the actual half-life is calculated during this study).
- Abstinent male participants must agree to start a double method if they begin a sexual relationship with a female during the trial, and through to 90 days after the last dose of the IMP. Male participants with female partners that are surgically sterile or post-menopausal (defined as being amenorrhoeic for at least 12 months without an alternative medical cause), or male participants who have undergone sterilisation and have had testing to confirm the success of the sterilisation, may also be included and will not be required to use above described methods of contraception. Male participants must also agree not to donate sperm up to 3 months after dosing with the IMP.
Key exclusion criteria (36 listed)
- Haematology, biochemistry or urinalysis results that are abnormal/outside of laboratory normal reference ranges AND are either:
- NOTE: Participants are not excluded if abnormal/out of laboratory normal reference range results are considered not clinically significant by the Principal Investigator or delegate AND are within the ranges specified in Appendix 1 of the protocol of .
- Positive serum pregnancy test at screening, positive urine pregnancy test upon admission or at other timepoints as specified by schedule of assessments.
- Male participants with a female partner(s) who is (are) pregnant or lactating from the time of the administration of study medication.
- Any history or presence of clinically relevant cardiovascular, broncho-pulmonary, gastrointestinal, hepatic/ gallbladder*/ bile duct, renal, metabolic, haematological, neurological, musculoskeletal/rheumatologic, systemic, ocular, gynaecologic (if female), or infectious disease, or signs of acute illness. *including medical history of asymptomatic gallbladder stones.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| MMV688533Investigational medicinal product | Drug | Cohort 1 SAD, Cohort 2 SAD, Cohort 3 SAD, Cohort 4 SAD, Cohort 5 SAD, Cohort 6 SAD, Cohort 7 SAD, Part 2: Food Effect |
Primary outcome
The Tolerability and Safety of Ascending Single Oral Doses of MMV533
Time frame: Safety data will be evaluated from baseline until 28 days after IMP/placebo administration
Assessment of adverse events (AEs) /treatment-emergent adverse events (TEAEs) (treatment phase for Part 1 and 2 defined as from IMP administration up to and including EOS).
The Tolerability and Safety of Ascending Single Oral Doses of MMV533
Time frame: Change from baseline to 28 days post dose in Part 1 of the study and 21 days post dose in Part 2, Food effect study
Haematology: change from baseline
The Tolerability and Safety of Ascending Single Oral Doses of MMV533
Time frame: 24 hours to 648 hours post dose
Biochemistry: number of participants with elevated Total Bile Acids considered as Clinically significant abnormalities
The Tolerability and Safety of Ascending Single Oral Doses of MMV533
Time frame: Part 1: 28 days post IMP administration and for Part 2: 21 days post IMP administration
Urinalysis: parameters assessed: bilirubin, glucose, ketones, leucocytes, nitrite, blood, protein, urobilinogen, pH. Number of participants with clinically significant findings.
The Tolerability and Safety of Ascending Single Oral Doses of MMV533
Time frame: Part 1 is 28 days post IMP and for Part 2, 21 days post IMP administration
Vital signs: respiratory rate supine and standing. Change from baseline.
The Tolerability and Safety of Ascending Single Oral Doses of MMV533
Time frame: Part 1 is 28 days post IMP and for Part 2, 21 days post IMP administration
Vital signs: heart rate supine and standing. Change from baseline.
The Tolerability and Safety of Ascending Single Oral Doses of MMV533
Time frame: Part 1: 28 days post IMP whereas for Part 2: 21 days post IMP administration
Measurements of 12-lead triplicate ECG: QTcB and QTcF interval prolongations.
The Tolerability and Safety of Ascending Single Oral Doses of MMV533
Time frame: 24 hours to 648 hours post dose
Biochemistry: number of participants with Low Hemoglobin considered as Clinically significant abnormality
The Tolerability and Safety of Ascending Single Oral Doses of MMV533
Time frame: Part 1 is 28 days post IMP and for Part 2, 21 days post IMP administration
Vital signs: blood pressures, supine and standing. Change from baseline.
The Tolerability and Safety of Ascending Single Oral Doses of MMV533
Time frame: Part 1 is 28 days post IMP and for Part 2, 21 days post IMP administration
Vital signs: body temperature. Change from baseline.
Results and safety
Loading the posted results from ClinicalTrials.gov…
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 17 Oct 2024.
- Posted resultsParticipant flow, baseline, all outcome measures and adverse events.
- Derived from this study: PubMed 39708824Bestgen B, Jones S, Thathy V, Kuemmerle A, Barcelo C, Haouala A, Gossen D, Marx MW, Di Resta I, Szramowska M, Webster RA, Llewellyn S, Ritacco DA, Yeo T, Leroy D, Barber BE, Fidock DA, Griffin P, Lickliter J, Chalon S. Safety, tolerability, pharmacokinetics, and antimalarial activity of MMV533: a phase 1a first-in-human, randomised, ascending dose and food effect study, and a phase 1b Plasmodium falciparum volunteer infection study. Lancet Infect Dis. 2025 May;25(5):507-518. doi: 10.1016/S1473-3099(24)00664-9. Epub 2024 Dec 18.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Jason Lickliter, MD principal investigator
Nucleus Network Corporate
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A Phase 1 study testing MMV688533 in people with Malaria, run by Medicines for Malaria Venture at 1 site in Australia.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 19 inclusion and 36 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 17 Oct 2024. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Australia. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
What does this phase mean?
Phase 1 studies test a treatment in a small group of people for the first time or in a new way, mainly to check safety and find the right dose.
Not every study follows the same path, and some studies (observational studies, device studies) have no phase.
Are results available for this study?
Yes. Results are posted in the registry (first posted 17 Oct 2024). A summary is in the For doctors view, and the full results are on ClinicalTrials.gov.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
The Tolerability and Safety of Ascending Single Oral Doses of MMV533 (time frame: Safety data will be evaluated from baseline until 28 days after IMP/placebo administration). The study lists 10 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT04323306, which also lists 1 linked publication.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 17 Oct 2024; AzTrials last refreshed its copy on 1 Nov 2026.