Current VaperNCT04358315
Consumer Assessment of Tobacco Flavor and Odor
An observational study of Current Vaper and Healthy Subject, run by Roswell Park Cancer Institute at 1 site in United States.
Trial summary
This trial studies consumer assessments of tobacco flavor and odor. This study will compare the ability of expert and consumer panels to identify and characterize flavors, determine threshold detection levels for individual and mixed flavors, and identify the dominant flavor of mixtures. Read more about this study
- Who is it for?
- Ages 21 to 55 yearsHealthy volunteers can take part
- Conditions the study is for
- Current Vaper, Healthy Subject
- What is being tested?
- Behavioral Intervention and Questionnaire Administration
- Type of treatment
- Lifestyle or therapy programme
- How many people
- 29 participants
- Where
- 1 siteUnited States
- Study dates
- 3 Apr 2023to 9 Dec 2025
- Phase
- Observational
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 21 to 55 years
- All sexes
- Healthy volunteers accepted
- Adult
Study population: Current daily vapers and nonusers in the greater Buffalo and Rochester areas
Who may be able to join
- CONSUMER USER: Current daily vapers of products containing nicotine
- CONSUMER USER: No concurrent use of other tobacco products
- CONSUMER USER: General good health
- CONSUMER USER: No allergies
- CONSUMER USER: No self-reported taste or smell deficits
- CONSUMER USER: Not pregnant or lactating
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- CONSUMER USER: No medications known to interfere with taste/smell
- CONSUMER USER: Passing scores on the Brief Smell Identification Test (B-SIT), phenylthiocarbamine (PTC) and 6-n-propylthiouracil (PROP) smell and taste tests
- CONSUMER USER: No positive diagnosis of COVID-19 within 30 days
- CONSUMER NONUSER: No use of tobacco or nicotine products in the last year
- CONSUMER NONUSER: General good health
- CONSUMER NONUSER: No allergies
- CONSUMER NONUSER: No self-reported taste or smell deficits
- CONSUMER NONUSER: Not pregnant or lactating
- CONSUMER NONUSER: No medications known to interfere with taste/smell
- CONSUMER NONUSER: Passing scores on the Brief Smell Identification Test (B-SIT), phenylthiocarbamine (PTC) and 6-n-propylthiouracil (PROP) smell and taste tests
- CONSUMER NONUSER: No positive diagnosis of COVID-19 within 30 days
Who cannot join
- CONSUMER USER: Outside age range
- CONSUMER USER: Not current daily vapers
- CONSUMER USER: Concurrent use of other tobacco products
- CONSUMER USER: Fair or poor general health
- CONSUMER USER: Allergies
- CONSUMER USER: Self-reported taste or smell deficits
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- CONSUMER USER: Pregnant or lactating
- CONSUMER USER: Medications known to interfere with taste/smell
- CONSUMER USER: Failing scores on the Brief Smell Identification Test (B-SIT), phenylthiocarbamine (PTC) and 6-n-propylthiouracil (PROP) smell and taste tests
- CONSUMER USER: Positive diagnosis of COVID-19 within 30 days
- CONSUMER NONUSER: Outside age range
- CONSUMER NONUSER: Use of tobacco or nicotine products in the last year
- CONSUMER NONUSER: Fair or poor general health
- CONSUMER NONUSER: Allergies
- CONSUMER NONUSER: Self-reported taste or smell deficits
- CONSUMER NONUSER: Pregnant or lactating
- CONSUMER NONUSER: Medications known to interfere with taste/smell
- CONSUMER NONUSER: Failing scores on the Brief Smell Identification Test (B-SIT), phenylthiocarbamine (PTC) and 6-n-propylthiouracil (PROP) smell and taste tests
- CONSUMER NONUSER: Positive diagnosis of COVID-19 within 30 days
Trial locations and contacts
1 site in 1 country.
United States1 site
Roswell Park Cancer Institute
Buffalo, New York, 14263
About this study
This trial studies consumer assessments of tobacco flavor and odor. This study will compare the ability of expert and consumer panels to identify and characterize flavors, determine threshold detection levels for individual and mixed flavors, and identify the dominant flavor of mixtures.
Read the detailed description
PRIMARY OBJECTIVE:
- Develop consumer (untrained) sensory panels to identify and assess characterizing flavors in electronic (e)-liquids.
OUTLINE:
Non-user panelists smell and user panelists puff flavored e-liquids and answer questions about the products.
- Conditions
- Current Vaper, Healthy Subject
- Being tested
- Behavioral Intervention, Questionnaire Administration
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Behavioral InterventionBehavioural
Also called Behavior Conditioning Therapy, behavior modification, Behavior or Life Style Modifications, Behavior Therapy
Smell or puff e-liquids
Questionnaire AdministrationOther
Ancillary studies
| Study group | Role | What they receive |
|---|---|---|
| Observational (smell or puff e-liquids) | All panel participants smell and user panelists puff flavored e-liquids and answer questions about the products. Receives: Behavioral: Behavioral Intervention; Other: Questionnaire Administration |
What is being measured
The primary outcome is the main question the study is designed to answer.
Flavor identification and evaluation
Subjects will be asked to identify various concentrations of flavored e-liquids
Measured: Up to 12 months
Specific flavor detection thresholds
Subjects will rate intensity of odors of e liquids
Measured: Up to 12 months
Flavor combination thresholds
Subjects will rate a combination of two e-liquids combined
Measured: Up to 12 months
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted24 Apr 2020
- Study start3 Apr 2023
- Primary completion9 Dec 2024
- Study completion9 Dec 2025
Why it stopped: PI request
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Current VaperStudies of the same condition, open and under way.
- More trials run by Roswell Park Cancer InstituteThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Prospective
- Enrolment
- 29 participants (actual)
Sponsor and investigators
- Lead sponsor
- Roswell Park Cancer Institute
- Sponsor type
- University, hospital or other
- Collaborators
- National Cancer Institute (NCI), University of Rochester
- Responsible party
- Sponsor
- Investigators
- Richard J O'Connor, Principal investigator, Roswell Park Cancer Institute
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT04358315
- Sponsor's protocol ID
- I 80518
- Other IDs
- NCI-2019-06320, I 80518, U54CA228110
- Status last verified
- Jan 2026
- First submitted
- 13 Apr 2020
- Last updated
- 6 Jan 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 6 Jan 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Consumer Assessment of Tobacco Flavor and Odor
- ClinicalTrials.gov ID
- NCT04358315
- Acronym / sponsor ID
- I 80518
- Conditions
- Current Vaper, Healthy Subject
- Study type
- Observational
- Recruitment status
- TerminatedReason stopped: PI request
- Enrolment
- 29 participants (actual)
- Lead sponsor
- Roswell Park Cancer InstituteUniversity, hospital or other
- Collaborators
- National Cancer Institute (NCI), University of Rochester
- Study start
- 3 Apr 2023 (actual)
- Primary completion
- 9 Dec 2024 (actual)
- Study completion
- 9 Dec 2025 (actual)
- First posted
- 24 Apr 2020 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This trial studies consumer assessments of tobacco flavor and odor. This study will compare the ability of expert and consumer panels to identify and characterize flavors, determine threshold detection levels for individual and mixed flavors, and identify the dominant flavor of mixtures.
Detailed description
PRIMARY OBJECTIVE:
- Develop consumer (untrained) sensory panels to identify and assess characterizing flavors in electronic (e)-liquids.
OUTLINE:
Non-user panelists smell and user panelists puff flavored e-liquids and answer questions about the products.
Study design
- Observational model
- Cohort
- Time perspective
- Prospective
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| Observational (smell or puff e-liquids) | – | Behavioral: Behavioral Intervention, Other: Questionnaire AdministrationAll panel participants smell and user panelists puff flavored e-liquids and answer questions about the products. |
Who may qualify
- Ages
- 21 to 55 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
- Study population
- Current daily vapers and nonusers in the greater Buffalo and Rochester areas
Key inclusion criteria (17 listed)
- CONSUMER USER: Current daily vapers of products containing nicotine
- CONSUMER USER: No concurrent use of other tobacco products
- CONSUMER USER: General good health
- CONSUMER USER: No allergies
- CONSUMER USER: No self-reported taste or smell deficits
Key exclusion criteria (19 listed)
- CONSUMER USER: Outside age range
- CONSUMER USER: Not current daily vapers
- CONSUMER USER: Concurrent use of other tobacco products
- CONSUMER USER: Fair or poor general health
- CONSUMER USER: Allergies
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Behavioral InterventionAlso: Behavior Conditioning Therapy, behavior modification, Behavior or Life Style Modifications, Behavior TherapySmell or puff e-liquids | Behavioural | Observational (smell or puff e-liquids) |
| Questionnaire AdministrationAncillary studies | Other | Observational (smell or puff e-liquids) |
Primary outcome
Flavor identification and evaluation
Time frame: Up to 12 months
Subjects will be asked to identify various concentrations of flavored e-liquids
Specific flavor detection thresholds
Time frame: Up to 12 months
Subjects will rate intensity of odors of e liquids
Flavor combination thresholds
Time frame: Up to 12 months
Subjects will rate a combination of two e-liquids combined
Results and safety
The study was stopped early (reason given: PI request). Results are not available in the source record.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 6 Jan 2026.
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Richard J O'Connor principal investigator
Roswell Park Cancer Institute
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Current Vaper and Healthy Subject, run by Roswell Park Cancer Institute at 1 site in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 17 inclusion and 19 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: stopped early, as of the sponsor's last update on 6 Jan 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study was stopped early (reason given: PI request). Results are not available in the source record.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Flavor identification and evaluation (time frame: Up to 12 months). The study lists 3 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 6 Jan 2026.