HypertrophyNCT04381390
Egg Consumption and Muscular Adaptations
A study testing Whole egg and resistance training and Egg whites and resistance training in people with Hypertrophy, run by Alexei Wong at 1 site in United States.
Trial summary
Eggs may be a viable alternative to various types of supplemental proteins given its similar ratings on various measures of dietary protein quality. The investigators hypothesis is that whole eggs would create a greater improvement in skeletal regulatory markers, hormonal responses and body composition than egg white… Read more about this study
- Who is it for?
- Ages 18 to 30 years, men onlyHealthy volunteers can take part
- Conditions the study is for
- Hypertrophy
- What is being tested?
- Whole egg and resistance training and Egg whites and resistance training
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 30 participants
- Where
- 1 siteUnited States
- Study dates
- 10 Sep 2018to 2 Oct 2019
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 30 years
- Men only
- Healthy volunteers accepted
- Adult
Who may be able to join
- performing resistance training at least three times a week for 1 year prior to the start of the study
- not taking any dietary supplements or medications for at least 1 year prior to the start of the study
- no known medical issues
- no alcohol consumption or smoking for at least 1 year prior to the start of the study
- no egg allergy/sensitivity.
Who cannot join
- non-willingness to continue nutritional or exercise protocols
- participation in exercise other than the prescribed resistance training program
- consumption of dietary supplement (other than egg) during the study period
- Missing more than one resistance training session or post-exercise egg consumption throughout the study period
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Comparison of Whole Eggs vs. Egg Whites Consumption on Regulatory Myokines, Muscular Strength, Hypertrophy, Power and Body Composition.
Eggs may be a viable alternative to various types of supplemental proteins given its similar ratings on various measures of dietary protein quality.
The investigators hypothesis is that whole eggs would create a greater improvement in skeletal regulatory markers, hormonal responses and body composition than egg white ingestion in resistance-trained men.
Read the detailed description
The aim of this investigation was to compare the effects of whole egg versus egg white ingestion (daily and after training sessions) during 12 weeks of resistance training on skeletal muscle regulatory markers, hormonal responses and body composition in resistance-trained men. Specific aims of the study are to:
To investigate the extent to which both whole egg and egg white ingestion will improve anabolic factors, fat free mass, fat mass and decrease catabolic markers after 12 weeks of resistance training in resistance-trained men.
- Conditions
- Hypertrophy
- Being tested
- Whole egg and resistance training, Egg whites and resistance training
- Medical subject headings
- Hypertrophy
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Whole egg and resistance trainingDietary supplement
This intervention consisted of whole egg consumption concomitant with 12 weeks of resistance training. Subject ingested three whole eggs per day immediately after resistance training.
Egg whites and resistance trainingDietary supplement
This intervention consisted of egg white consumption concomitant with 12 weeks of resistance training. Subject ingested an isonitrogenous quantity of six egg whites per day immediately after resistance training.
| Study group | Role | What they receive |
|---|---|---|
| Whole egg consumption | Experimental | This arm involved whole egg consumption concomitant with 12 weeks of resistance training. Subject ingested three whole eggs per day immediately after resistance training. Receives: Dietary Supplement: Whole egg and resistance training |
| Egg whites consumption | Experimental | This arm involved egg white consumption concomitant with 12 weeks of resistance training. Subject ingested an isonitrogenous quantity of six egg whites per day immediately after resistance training. Receives: Dietary Supplement: Egg whites and resistance training |
What is being measured
The primary outcome is the main question the study is designed to answer.
Circulatory Myokines levels
Fasting blood samples were collected from the antecubital vein using standard procedures and then analized to establish concentration of myostatin, follistatin, FGF-2, TGF-β1 and ACVA.
Measured: 12 weeks
Circulatory hormone levels
Fasting blood samples were collected from the antecubital vein using standard procedures and then analized to establish concentrations of testosterone, IGF-1, insulin and cortisol
Measured: 12 weeks
Muscle mass
Skeletal muscle mass will be evaluated using computed tomography
Measured: 12 weeks
Body fatness
Body fat will be evaluated using bioelectrical impedance
Measured: 12 weeks
Secondary outcomes (1)
Muscular Strength
Using 1 repetition maximum
Measured: 12 weeks
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted8 May 2020
- Study start10 Sep 2018
- Primary completion2 Oct 2019
- Study completion2 Oct 2019
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for HypertrophyStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Basic science
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind
- Who is masked
- Investigator
- Enrolment
- 30 participants (actual)
Sponsor and investigators
- Lead sponsor
- Alexei Wong
- Sponsor type
- University, hospital or other
- Collaborators
- Tehran University
- Responsible party
- Sponsor-investigator, Alexei Wong, Marymount University
- Investigators
- Alexei Wong, Principal investigator, Marymount University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT04381390
- Sponsor's protocol ID
- 11/27498
- Status last verified
- May 2020
- First submitted
- 1 May 2020
- Last updated
- 8 May 2020
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Publications
Bagheri R, Hooshmand Moghadam B, Ashtary-Larky D, Forbes SC, Candow DG, Galpin AJ, Eskandari M, Kreider RB, Wong A. Whole Egg Vs. Egg White Ingestion During 12 weeks of Resistance Training in Trained Young Males: A Randomized Controlled Trial. J Strength Cond Res. 2021 Feb 1;35(2):411-419. doi: 10.1519/JSC.0000000000003922.
PubMed 33306586
Study at a glance
From the registry record, last updated by the sponsor on 8 May 2020. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Comparison of Whole Eggs vs. Egg Whites Consumption on Regulatory Myokines, Muscular Strength, Hypertrophy, Power and Body Composition.
- ClinicalTrials.gov ID
- NCT04381390
- Acronym / sponsor ID
- 11/27498
- Conditions
- Hypertrophy
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 30 participants (actual)
- Lead sponsor
- Alexei WongUniversity, hospital or other
- Collaborators
- Tehran University
- Study start
- 10 Sep 2018 (actual)
- Primary completion
- 2 Oct 2019 (actual)
- Study completion
- 2 Oct 2019 (actual)
- First posted
- 8 May 2020 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Eggs may be a viable alternative to various types of supplemental proteins given its similar ratings on various measures of dietary protein quality.
The investigators hypothesis is that whole eggs would create a greater improvement in skeletal regulatory markers, hormonal responses and body composition than egg white ingestion in resistance-trained men.
Detailed description
The aim of this investigation was to compare the effects of whole egg versus egg white ingestion (daily and after training sessions) during 12 weeks of resistance training on skeletal muscle regulatory markers, hormonal responses and body composition in resistance-trained men. Specific aims of the study are to:
To investigate the extent to which both whole egg and egg white ingestion will improve anabolic factors, fat free mass, fat mass and decrease catabolic markers after 12 weeks of resistance training in resistance-trained men.
Study design
- Primary purpose
- Basic science
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (investigator)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Whole egg consumption | Experimental | Dietary Supplement: Whole egg and resistance trainingThis arm involved whole egg consumption concomitant with 12 weeks of resistance training. Subject ingested three whole eggs per day immediately after resistance training. |
| Egg whites consumption | Experimental | Dietary Supplement: Egg whites and resistance trainingThis arm involved egg white consumption concomitant with 12 weeks of resistance training. Subject ingested an isonitrogenous quantity of six egg whites per day immediately after resistance training. |
Who may qualify
- Ages
- 18 to 30 years
- Sex
- Male only
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (5 listed)
- performing resistance training at least three times a week for 1 year prior to the start of the study
- not taking any dietary supplements or medications for at least 1 year prior to the start of the study
- no known medical issues
- no alcohol consumption or smoking for at least 1 year prior to the start of the study
- no egg allergy/sensitivity.
Key exclusion criteria (4 listed)
- non-willingness to continue nutritional or exercise protocols
- participation in exercise other than the prescribed resistance training program
- consumption of dietary supplement (other than egg) during the study period
- Missing more than one resistance training session or post-exercise egg consumption throughout the study period
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Whole egg and resistance trainingThis intervention consisted of whole egg consumption concomitant with 12 weeks of resistance training. Subject ingested three whole eggs per day immediately after resistance training. | Dietary supplement | Whole egg consumption |
| Egg whites and resistance trainingThis intervention consisted of egg white consumption concomitant with 12 weeks of resistance training. Subject ingested an isonitrogenous quantity of six egg whites per day immediately after resistance training. | Dietary supplement | Egg whites consumption |
Primary outcome
Circulatory Myokines levels
Time frame: 12 weeks
Fasting blood samples were collected from the antecubital vein using standard procedures and then analized to establish concentration of myostatin, follistatin, FGF-2, TGF-β1 and ACVA.
Circulatory hormone levels
Time frame: 12 weeks
Fasting blood samples were collected from the antecubital vein using standard procedures and then analized to establish concentrations of testosterone, IGF-1, insulin and cortisol
Muscle mass
Time frame: 12 weeks
Skeletal muscle mass will be evaluated using computed tomography
Body fatness
Time frame: 12 weeks
Body fat will be evaluated using bioelectrical impedance
1 secondary outcome
Muscular Strength
Time frame: 12 weeks
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 8 May 2020.
- Derived from this study: PubMed 33306586Bagheri R, Hooshmand Moghadam B, Ashtary-Larky D, Forbes SC, Candow DG, Galpin AJ, Eskandari M, Kreider RB, Wong A. Whole Egg Vs. Egg White Ingestion During 12 weeks of Resistance Training in Trained Young Males: A Randomized Controlled Trial. J Strength Cond Res. 2021 Feb 1;35(2):411-419. doi: 10.1519/JSC.0000000000003922.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Alexei Wong principal investigator
Marymount University
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Whole egg and resistance training and Egg whites and resistance training in people with Hypertrophy, run by Alexei Wong at 1 site in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 5 inclusion and 4 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 8 May 2020. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Circulatory Myokines levels (time frame: 12 weeks). The study lists 4 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT04381390, which also lists 1 linked publication.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 8 May 2020.