Congenital Adrenal HyperplasiaPhase 3CAHtalystNCT04490915
Global Safety and Efficacy Registration Study of Crinecerfont for Congenital Adrenal Hyperplasia
A Phase 3 study testing Crinecerfont in people with Congenital Adrenal Hyperplasia, run by Neurocrine Biosciences at 70 sites in 18 countries.
Trial summary
This is a Phase 3 study to evaluate the efficacy, safety, and tolerability of crinecerfont versus placebo administered for 24 weeks in approximately 165 adult participants with classic CAH due to 21-hydroxylase deficiency. Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Congenital Adrenal Hyperplasia
- What is being tested?
- Crinecerfont
- Type of treatment
- Pill or oral medicine
- Could I receive a placebo?
- Yes, some participants may receive a placebo
- How many people
- 182 participants
- Where
- 70 sitesin 18 countries
- Study dates
- 16 Dec 2020to Aug 2027
- Phase
- Phase 3
- Are there results?
- Yes, posted in the registrySummary in the doctors' view
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Be willing and able to adhere to the study procedures, including all requirements at the study center and return for the follow-up visit.
- Have a medically confirmed diagnosis of classic CAH due to 21-hydroxylase deficiency.
- Be on a stable steroid regimen.
- Participants of childbearing potential must agree to use an acceptable method of contraception during the study.
Who cannot join
- Have a diagnosis of any of the other known forms of classic CAH.
- Have a history of bilateral adrenalectomy, hypopituitarism, or other condition requiring chronic glucocorticoid therapy.
- Have a clinically significant unstable medical condition or chronic disease other than CAH.
- Have a history of cancer unless considered cured.
- Are pregnant.
- Have a known history of clinically significant arrhythmia or abnormalities on ECG.
Show all 10Show fewer
- Have a known hypersensitivity to any corticotropin releasing hormone receptor antagonists.
- Have received any other investigational drug within 30 days before initial screening or plan to use an investigational drug (other than the study drug) during the study.
- Have current substance dependence, or current substance (drug) or alcohol abuse.
- Have had a blood loss ≥550 mL or donated blood or blood products within 8 weeks prior to the study.
Trial locations and contacts
70 sites in 18 countries.
70 sites in 18 countries
United States20 sites
Neurocrine Clinical Site
Ann Arbor, Michigan, 48109
Neurocrine Clinical Site
Atlanta, Georgia, 30329
Neurocrine Clinical Site
Aurora, Colorado, 80045
Neurocrine Clinical Site
Bethesda, Maryland, 20982
Neurocrine Clinical Site
Boston, Massachusetts, 02115
Neurocrine Clinical Site
Dallas, Texas, 75390
Neurocrine Clinical Site
Great Neck, New York, 11021
Neurocrine Clinical Site
Indianapolis, Indiana, 46202
Neurocrine Clinical Site
Los Angeles, California, 90027
Neurocrine Clinical Site
Minneapolis, Minnesota, 55454
Neurocrine Clinical Site
New York, New York, 10029
Neurocrine Clinical Site
Philadelphia, Pennsylvania, 19104
Neurocrine Clinical Site
Pittsburgh, Pennsylvania, 15224
Neurocrine Clinical Site
Rochester, Minnesota, 55905
Neurocrine Clinical Site
San Diego, California, 92123
Neurocrine Clinical Site
San Francisco, California, 94143
Neurocrine Clinical Site
Seattle, Washington, 98105
Neurocrine Clinical Site
St Louis, Missouri, 63110
Neurocrine Clinical Site
Tulsa, Oklahoma, 74135
Neurocrine Clinical Site
Winston-Salem, North Carolina, 27157
Italy9 sites
Neurocrine Clinical Site
Ancona, 60126
Neurocrine Clinical Site
Bologna, 40138
Neurocrine Clinical Site
Florence, 50139
Neurocrine Clinical Site
Messina, 98125
Neurocrine Clinical Site
Milan, 20132
Neurocrine Clinical Site
Milan, 20149
Neurocrine Clinical Site
Naples, 80131
Neurocrine Clinical Site
Padova, 35128
Neurocrine Clinical Site
Roma, 00161
France6 sites
Neurocrine Clinical Site
Angers, 49933
Neurocrine Clinical Site
Grenoble, 38700
Neurocrine Clinical Site
Le Kremlin-Bicêtre, 94270
Neurocrine Clinical Site
Nantes, 44093
Neurocrine Clinical Site
Paris, 75651
Neurocrine Clinical Site
Paris, 75679
Germany5 sites
Neurocrine Clinical Site
Dresden, 01307
Neurocrine Clinical Site
Essen, 45147
Neurocrine Clinical Site
Frankfurt, 60590
Neurocrine Clinical Site
Leipzig, 04103
Neurocrine Clinical Site
Munich, 80336
Greece4 sites
Neurocrine Clinical Site
Athens, 106 76
Neurocrine Clinical Site
Athens, 115 27
Neurocrine Clinical Site
Athens, 11527
Neurocrine Clinical Site
Thessaloniki, 54642
Israel4 sites
Neurocrine Clinical Site
Afula, 1834111
Neurocrine Clinical Site
Beersheba, 8410101
Neurocrine Clinical Site
Petah Tikva, 4941480
Neurocrine Clinical Site
Tel Aviv, 64239
United Kingdom4 sites
Neurocrine Clinical Site
Cardiff, CF14 4HH
Neurocrine Clinical Site
London, WC1B 5EH
Neurocrine Clinical Site
Manchester, M20 4BX
Neurocrine Clinical Site
Salford, M6 8HD
Poland3 sites
Neurocrine Clinical Site
Krakow, 31-011
Neurocrine Clinical Site
Poznan, 60-355
Neurocrine Clinical Site
Warsaw, 01-809
Austria2 sites
Neurocrine Clinical Site
Graz, 8036
Neurocrine Clinical Site
Vienna, 1090
Belgium2 sites
Neurocrine Clinical Site
Brussels, 1070
Neurocrine Clinical Site
Leuven, 3000
Bulgaria2 sites
Neurocrine Clinical Site
Sofia, 1431
Neurocrine Clinical Site
Sofia, 1606
Spain2 sites
Neurocrine Clinical Site
Madrid, 28034
Neurocrine Clinical Site
Seville, 41013
Sweden2 sites
Neurocrine Clinical Site
Gothenburg, 41345
Neurocrine Clinical Site
Stockholm, 17176
About this study
Official title: A Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Safety and Efficacy of Crinecerfont (NBI-74788) in Adult Subjects With Classic Congenital Adrenal Hyperplasia, Followed by Open-Label Treatment
This is a Phase 3 study to evaluate the efficacy, safety, and tolerability of crinecerfont versus placebo administered for 24 weeks in approximately 165 adult participants with classic CAH due to 21-hydroxylase deficiency. The study consists of a 24-week randomized, double-blind, placebo-controlled period, followed by 1 year of active treatment with crinecerfont. Subsequently, participants may elect to participate in the open-label extension (OLE) period. The duration of participation in the study is approximately 20 months for the core study and will be a variable amount of time per participant for the OLE (estimated to be approximately 3 years).
- Conditions
- Congenital Adrenal Hyperplasia
- Being tested
- Crinecerfont, Placebo
- Medical subject headings
- Adrenal Hyperplasia, Congenital
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
CrinecerfontDrug
Also called NBI-74788, Crenessity
CRF type 1 receptor antagonist
PlaceboDrug
Non-active dosage form
| Study group | Role | What they receive |
|---|---|---|
| Placebo | Placebo comparator | Placebo capsule, administered orally, twice daily for 24 weeks, followed by active treatment with crinecerfont for at least 1 year. Receives: Drug: Crinecerfont; Drug: Placebo |
| Crinecerfont | Experimental | Crinecerfont capsule, administered orally, twice daily for 24 weeks during the placebo-controlled treatment period, followed by active treatment with crinecerfont for at least 1 year. Receives: Drug: Crinecerfont |
What is being measured
The primary outcome is the main question the study is designed to answer.
Percent Change From Baseline in Glucocorticoid Daily Dose at Week 24
Least square (LS) mean and standard error (SE) were calculated using analysis of covariance (ANCOVA) model.
Measured: Baseline, Week 24
Secondary outcomes (11)
Change From Baseline in Serum Androstenedione at Week 4
Measured: Baseline, Week 4
Number of Participants Who Achieved a Reduction to Physiologic Glucocorticoid Dose While Maintaining Androstenedione Control at Week 24
Measured: Week 24
Change From Baseline in Homeostatic Model Assessment of Insulin Resistance (HOMA-IR) at Week 24
Measured: Baseline, Week 24
Percent Change From Baseline in Body Weight at Week 24
Measured: Baseline, Week 24
Change From Baseline in Percent Total Fat Mass at Week 24
Measured: Baseline, Week 24
Change From Baseline in Serum 17-hydroxyprogesterone (17-OHP) at Week 4
Measured: Baseline, Week 4
Change From Baseline in Blood Pressure at Week 24
Measured: Baseline, Week 24
Change From Baseline in Glucose Tolerance at Week 24
Measured: Baseline, Week 24
Change From Baseline in Waist Circumference at Week 24
Measured: Baseline, Week 24
Change From Baseline in Menstrual Regularity at Week 24
Measured: Baseline, Week 24
Change From Baseline in Testicular Adrenal Rest Tumor (TART) Volume at Week 24
Measured: Baseline, Week 24
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted29 Jul 2020
- Study start16 Dec 2020
- Primary completion19 Jul 2023
- Study completionAug 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Posted resultsParticipant flow, outcome measures and adverse events reported by the sponsor.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for Congenital Adrenal HyperplasiaStudies of the same condition, open and under way.
- More trials run by Neurocrine BiosciencesThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase 3
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Triple blind
- Who is masked
- Participant, Care provider, Investigator
- Enrolment
- 182 participants (actual)
Sponsor and investigators
- Lead sponsor
- Neurocrine Biosciences
- Sponsor type
- Industry (pharma, biotech, devices)
- Responsible party
- Sponsor
- Investigators
- Clinical Development Lead, Study director, Neurocrine Biosciences
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT04490915
- Sponsor's protocol ID
- NBI-74788-CAH3003
- Other IDs
- 2019-004873-17, 2023-509171-16-00, 2023, 2019
- Acronym
- CAHtalyst
- Status last verified
- Apr 2026
- First submitted
- 24 Jul 2020
- Last updated
- 11 May 2026
- Results posted
- Yes, on ClinicalTrials.gov
- Data monitoring committee
- Yes
- FDA-regulated drug
- Yes
- FDA-regulated device
- No
- Individual data sharing
- No
Publications
Auchus RJ, Hamidi O, Pivonello R, Bancos I, Russo G, Witchel SF, Isidori AM, Rodien P, Srirangalingam U, Kiefer FW, Falhammar H, Merke DP, Reisch N, Sarafoglou K, Cutler GB Jr, Sturgeon J, Roberts E, Lin VH, Chan JL, Farber RH; CAHtalyst Adult Trial Investigators. Phase 3 Trial of Crinecerfont in Adult Congenital Adrenal Hyperplasia. N Engl J Med. 2024 Aug 8;391(6):504-514. doi: 10.1056/NEJMoa2404656. Epub 2024 Jun 1.
PubMed 38828955
Study at a glance
From the registry record, last updated by the sponsor on 11 May 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- A Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Safety and Efficacy of Crinecerfont (NBI-74788) in Adult Subjects With Classic Congenital Adrenal Hyperplasia, Followed by Open-Label Treatment
- ClinicalTrials.gov ID
- NCT04490915
- Acronym / sponsor ID
- CAHtalyst / NBI-74788-CAH3003
- Conditions
- Congenital Adrenal Hyperplasia
- Phase
- Phase 3
- Study type
- Interventional
- Recruitment status
- Active, not recruiting
- Enrolment
- 182 participants (actual)
- Lead sponsor
- Neurocrine BiosciencesIndustry (pharma, biotech, devices)
- Study start
- 16 Dec 2020 (actual)
- Primary completion
- 19 Jul 2023 (actual)
- Study completion
- Aug 2027 (estimated)
- First posted
- 29 Jul 2020 (actual)
- Results
- Posted 5 Feb 2025
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This is a Phase 3 study to evaluate the efficacy, safety, and tolerability of crinecerfont versus placebo administered for 24 weeks in approximately 165 adult participants with classic CAH due to 21-hydroxylase deficiency. The study consists of a 24-week randomized, double-blind, placebo-controlled period, followed by 1 year of active treatment with crinecerfont. Subsequently, participants may elect to participate in the open-label extension (OLE) period. The duration of participation in the study is approximately 20 months for the core study and will be a variable amount of time per participant for the OLE (estimated to be approximately 3 years).
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Triple blind (participant, care provider, investigator)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Placebo | Placebo comparator | Drug: Crinecerfont, Drug: PlaceboPlacebo capsule, administered orally, twice daily for 24 weeks, followed by active treatment with crinecerfont for at least 1 year. |
| Crinecerfont | Experimental | Drug: CrinecerfontCrinecerfont capsule, administered orally, twice daily for 24 weeks during the placebo-controlled treatment period, followed by active treatment with crinecerfont for at least 1 year. |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (4 listed)
- Be willing and able to adhere to the study procedures, including all requirements at the study center and return for the follow-up visit.
- Have a medically confirmed diagnosis of classic CAH due to 21-hydroxylase deficiency.
- Be on a stable steroid regimen.
- Participants of childbearing potential must agree to use an acceptable method of contraception during the study.
Key exclusion criteria (10 listed)
- Have a diagnosis of any of the other known forms of classic CAH.
- Have a history of bilateral adrenalectomy, hypopituitarism, or other condition requiring chronic glucocorticoid therapy.
- Have a clinically significant unstable medical condition or chronic disease other than CAH.
- Have a history of cancer unless considered cured.
- Are pregnant.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| CrinecerfontAlso: NBI-74788, CrenessityCRF type 1 receptor antagonist | Drug | Crinecerfont, Placebo |
| PlaceboNon-active dosage form | Drug | Placebo |
Primary outcome
Percent Change From Baseline in Glucocorticoid Daily Dose at Week 24
Time frame: Baseline, Week 24
Least square (LS) mean and standard error (SE) were calculated using analysis of covariance (ANCOVA) model.
11 secondary outcomes
Change From Baseline in Serum Androstenedione at Week 4
Time frame: Baseline, Week 4
Number of Participants Who Achieved a Reduction to Physiologic Glucocorticoid Dose While Maintaining Androstenedione Control at Week 24
Time frame: Week 24
Change From Baseline in Homeostatic Model Assessment of Insulin Resistance (HOMA-IR) at Week 24
Time frame: Baseline, Week 24
Percent Change From Baseline in Body Weight at Week 24
Time frame: Baseline, Week 24
Change From Baseline in Percent Total Fat Mass at Week 24
Time frame: Baseline, Week 24
Change From Baseline in Serum 17-hydroxyprogesterone (17-OHP) at Week 4
Time frame: Baseline, Week 4
Change From Baseline in Blood Pressure at Week 24
Time frame: Baseline, Week 24
Change From Baseline in Glucose Tolerance at Week 24
Time frame: Baseline, Week 24
Change From Baseline in Waist Circumference at Week 24
Time frame: Baseline, Week 24
Change From Baseline in Menstrual Regularity at Week 24
Time frame: Baseline, Week 24
Change From Baseline in Testicular Adrenal Rest Tumor (TART) Volume at Week 24
Time frame: Baseline, Week 24
Results and safety
Loading the posted results from ClinicalTrials.gov…
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 11 May 2026.
- Posted resultsParticipant flow, baseline, all outcome measures and adverse events.
- Derived from this study: PubMed 38828955Auchus RJ, Hamidi O, Pivonello R, Bancos I, Russo G, Witchel SF, Isidori AM, Rodien P, Srirangalingam U, Kiefer FW, Falhammar H, Merke DP, Reisch N, Sarafoglou K, Cutler GB Jr, Sturgeon J, Roberts E, Lin VH, Chan JL, Farber RH; CAHtalyst Adult Trial Investigators. Phase 3 Trial of Crinecerfont in Adult Congenital Adrenal Hyperplasia. N Engl J Med. 2024 Aug 8;391(6):504-514. doi: 10.1056/NEJMoa2404656. Epub 2024 Jun 1.
- Study website - CAHtalyst StudyLink provided by the sponsor.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Clinical Development Lead study director
Neurocrine Biosciences
70 sites in 18 countries: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A Phase 3 study testing Crinecerfont in people with Congenital Adrenal Hyperplasia, run by Neurocrine Biosciences at 70 sites in 18 countries.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 10 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: under way, not looking for participants, as of the sponsor's last update on 11 May 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 70 sites in United States, Italy, France, Germany, Greece and 13 more countries. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. Some participants in this study may receive a placebo. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
What does this phase mean?
Phase 3 studies compare the treatment with the current standard treatment or a placebo in a large group, to confirm how well it works and watch for side effects.
Not every study follows the same path, and some studies (observational studies, device studies) have no phase.
Are results available for this study?
Yes. Results are posted in the registry (first posted 5 Feb 2025). A summary is in the For doctors view, and the full results are on ClinicalTrials.gov.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Percent Change From Baseline in Glucocorticoid Daily Dose at Week 24 (time frame: Baseline, Week 24). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT04490915, which also lists 1 linked publication.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 11 May 2026.