Ventricular ArrhythmiaIVTCCNCT04520347
IVTCC 2.0: A Prospective Multicenter Ventricular Tachycardia Catheter Ablation Registry
An observational study of Ventricular Arrhythmia and Ventricular Tachycardia, run by University of California, Los Angeles at 41 sites in 7 countries.
Trial summary
This is a prospective multi-center international registry. The objective of this registry is to collect prospective data on patients undergoing catheter ablation for Ventricular Tachycardia (VT) and Premature Ventricular Contractions (PVC). Read more about this study
- Who is it for?
- Any age
- Conditions the study is for
- Ventricular Arrhythmia, Ventricular Tachycardia, Premature Ventricular Contraction (PVC)
- How many people
- 10,000 participants
- Where
- 41 sitesin 7 countries
- Study dates
- 1 Dec 2018to Nov 2027
- How long will I take part?
- 10 Years
- Phase
- Observational
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages Any age
- All sexes
- No healthy volunteers
- Child, Adult, Older adult
Study population: Patients with ventricular arrhythmias that undergo catheter ablation for ventricular tachycardia or premature ventricular contractions.
Who may be able to join
- All patients undergoing catheter ablation for ventricular tachycardia (VT) or premature ventricular contractions (PVCs).
Who cannot join
None listed.
Trial locations and contacts
41 sites in 7 countries. Contact the study team or a site near you to ask about taking part.
41 sites in 7 countries
United States34 sites
University of Michigan Frankel Cardiovascular Center
Ann Arbor, Michigan, 48109
University of Colorado Hospital
Aurora, Colorado, 80045
Texas Cardiac Arrhythmia Institute at St. David's Medical Center
Austin, Texas, 78705
University of Maryland Medical Center
Baltimore, Maryland, 21201
Johns Hopkins Heart and Vascular Institute
Baltimore, Maryland, 21287
Boston Children's Hospital
Boston, Massachusetts, 02115
Brigham and Women's Hospital
Boston, Massachusetts, 02115
Beth Israel Deaconess Medical Center
Boston, Massachusetts, 02215
Medical University of South Carolina
Charleston, South Carolina, 29425
University of Virginia Health System
Charlottesville, Virginia, 22903
Cleveland Clinic Foundation
Cleveland, Ohio, 44195
University of Florida Health
Gainesville, Florida, 32610
Hartford HealthCare
Hartford, Connecticut, 06103
Houston Methodist Hospital
Houston, Texas, 77030
The Kansas City Heart Rhythm Institute
Kansas City, Kansas, 66211
Cedars-Sinai Medical Center
Los Angeles, California, 90048
University of California, Los Angeles
Los Angeles, California, 90095
University of Minnesota VA Medical Center
Minneapolis, Minnesota, 55417
Vanderbilt Heart and Vascular Institute
Nashville, Tennessee, 37232
The Mount Sinai Hospital
New York, New York, 10029
Columbia University Irving Medical Center
New York, New York, 10032
Children's Hospital of Pennsylvania
Philadelphia, Pennsylvania, 19104
University of Pennsylvania Health System
Philadelphia, Pennsylvania, 19104
Banner Health, University of Arizona Medical Center
Phoenix, Arizona, 85719
Oregon Health & Science University
Portland, Oregon, 97239
Mayo Clinic
Rochester, Minnesota, 55902
University of California, Davis
Sacramento, California, 95817
University of Utah Health
Salt Lake City, Utah, 84132
University of California San Francisco
San Francisco, California, 94143
University of Washington Medical Center
Seattle, Washington, 98195
Washington University in St. Louis
St Louis, Missouri, 63130
Montefiore Medical Center
The Bronx, New York, 10461
UMass Memorial Health Care
Worcester, Massachusetts, 01655
Wellspan Health
York, Pennsylvania, 17403
Netherlands2 sites
Leiden University
Leiden
Erasmus Medical Center
Rotterdam
About this study
Official title: An International VT Ablation Center Collaborative Group (IVTCC): A Multicenter Ventricular Tachycardia Catheter Ablation Registry
This is a prospective multi-center international registry. The objective of this registry is to collect prospective data on patients undergoing catheter ablation for Ventricular Tachycardia (VT) and Premature Ventricular Contractions (PVC). The registry will be used for clinical monitoring, research, and quality improvement purposes.
Read the detailed description
Sudden cardiac death (SCD), predominantly due to ventricular tachyarrhythmias, is a leading cause of mortality in the United States and around the world. Catheter ablation of ventricular arrhythmias has proven efficacious in reducing the burden of arrhythmias and reducing implantable cardiac defibrillator (ICD) shocks.
The aim of this study is to create a prospective international database registry that will allow for better assessment of the outcomes of catheter ablation of ventricular arrhythmias. The registry, with approximately 30 participating centers, will help to identify the overall success rates and associated benefits of the procedure and provide more comprehensive data on understudied populations and treatment.
- Conditions
- Ventricular Arrhythmia, Ventricular Tachycardia, Premature Ventricular Contraction (PVC), Cardiomyopathy
- Keywords
- Arrhythmia, Cardiac Conduction System Disease, Sudden Cardiac Death, Implantable Cardiac Defibrillator (ICD)
- Medical subject headings
- Tachycardia, Ventricular, Ventricular Premature Complexes, Cardiomyopathies, Arrhythmias, Cardiac, Cardiac Conduction System Disease, Death, Sudden, Cardiac
What is being measured
The primary outcome is the main question the study is designed to answer.
Ventricular tachycardia (VT) recurrence
Freedom from ventricular tachycardia episodes requiring ICD Intervention (shock or Anti-Tachycardia Pacing) or repeat procedure.
Measured: From date of procedure assessed by shock, Anti-Tachycardia Pacing, or repeat procedure, up to 10 years.
Secondary outcomes (2)
Rate of complications
Cardiovascular-related and procedure-related major complications and/or adverse events.
Measured: From date of procedure assessed up to 12 months.
Time to transplant or death
Measured: From date of procedure assessed by date of transplant and/or death, up to 10 years.
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted20 Aug 2020
- Study start1 Dec 2018
- Primary completionDec 2026 (estimated)
- Study completionNov 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Ventricular ArrhythmiaStudies of the same condition, open and under way.
- More trials run by University of California, Los AngelesThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Prospective
- Enrolment
- 10,000 participants (estimated)
- Target duration
- 10 Years
Sponsor and investigators
- Lead sponsor
- University of California, Los Angeles
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Jason Bradfield, MD, University of California, Los Angeles
- Investigators
- Jason Bradfield, MD, Principal investigator, University of California, Los AngelesKalyanam Shivkumar, MD, PhD, Study chair, University of California, Los AngelesPaolo Della Bella, MD, Study chair, San Raffaele Hospital, ItalyFrancis Marchlinski, MD, FACC, FAHA, FHRS, Study chair, University of Pennsylvania Health SystemAndrea Natale, MD, FACC, FHRS, FESC, Study chair, Texas Cardiac Arrhythmia Institute at St. David's Medical CenterWilliam G Stevenson, MD, Study chair, Vanderbilt Heart and Vascular Institute
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT04520347
- Sponsor's protocol ID
- 17-001725
- Acronym
- IVTCC
- Status last verified
- Dec 2025
- First submitted
- 10 Jul 2020
- Last updated
- 15 Dec 2025
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 15 Dec 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- An International VT Ablation Center Collaborative Group (IVTCC): A Multicenter Ventricular Tachycardia Catheter Ablation Registry
- ClinicalTrials.gov ID
- NCT04520347
- Acronym / sponsor ID
- IVTCC / 17-001725
- Conditions
- Ventricular Arrhythmia, Ventricular Tachycardia, Premature Ventricular Contraction (PVC), Cardiomyopathy
- Keywords
- Arrhythmia, Cardiac Conduction System Disease, Sudden Cardiac Death, Implantable Cardiac Defibrillator (ICD)
- Study type
- Observational
- Recruitment status
- Enrolling by invitation
- Enrolment
- 10,000 participants (estimated)
- Lead sponsor
- University of California, Los AngelesUniversity, hospital or other
- Study start
- 1 Dec 2018 (actual)
- Primary completion
- Dec 2026 (estimated)
- Study completion
- Nov 2027 (estimated)
- First posted
- 20 Aug 2020 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This is a prospective multi-center international registry. The objective of this registry is to collect prospective data on patients undergoing catheter ablation for Ventricular Tachycardia (VT) and Premature Ventricular Contractions (PVC). The registry will be used for clinical monitoring, research, and quality improvement purposes.
Detailed description
Sudden cardiac death (SCD), predominantly due to ventricular tachyarrhythmias, is a leading cause of mortality in the United States and around the world. Catheter ablation of ventricular arrhythmias has proven efficacious in reducing the burden of arrhythmias and reducing implantable cardiac defibrillator (ICD) shocks.
The aim of this study is to create a prospective international database registry that will allow for better assessment of the outcomes of catheter ablation of ventricular arrhythmias. The registry, with approximately 30 participating centers, will help to identify the overall success rates and associated benefits of the procedure and provide more comprehensive data on understudied populations and treatment.
Study design
- Observational model
- Cohort
- Time perspective
- Prospective
- Target follow-up
- 10 Years
Who may qualify
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Child, Adult, Older adult
- Study population
- Patients with ventricular arrhythmias that undergo catheter ablation for ventricular tachycardia or premature ventricular contractions.
Key inclusion criteria (1 listed)
- All patients undergoing catheter ablation for ventricular tachycardia (VT) or premature ventricular contractions (PVCs).
Key exclusion criteria (0 listed)
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Primary outcome
Ventricular tachycardia (VT) recurrence
Time frame: From date of procedure assessed by shock, Anti-Tachycardia Pacing, or repeat procedure, up to 10 years.
Freedom from ventricular tachycardia episodes requiring ICD Intervention (shock or Anti-Tachycardia Pacing) or repeat procedure.
2 secondary outcomes
Rate of complications
Time frame: From date of procedure assessed up to 12 months.
Time to transplant or death
Time frame: From date of procedure assessed by date of transplant and/or death, up to 10 years.
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 15 Dec 2025.
Related trials for Ventricular Arrhythmia
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VINTAGE (Ventricular Intramyocardial Navigation for Tachycardia Ablation Guided by Electrograms) Using Commercial Off-The-Shelf (COTS) Catheters
Ventricular Arrhythmia
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EDEN Intracardiac Electrogram Recording and Classifying System
Ventricular Arrhythmia
Active, not recruiting
Assessment of Combined CCM and ICD Device in HFrEF
Heart Failure, Heart Failure With Reduced Ejection Fraction
RecruitingObservational study
Physical Impairments in Premature Ventricular Complex
Premature Ventricular Complexes
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A Study of Dual Energy THERMOCOOL SMARTTOUCH™ SF Catheter With the TRUPULSE™ Generator for Treatment of Ventricular Arrhythmias
Arrhythmias, Cardiac
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Jason Bradfield, MD principal investigator
University of California, Los Angeles
Kalyanam Shivkumar, MD, PhD study chair
University of California, Los Angeles
Paolo Della Bella, MD study chair
San Raffaele Hospital, Italy
41 sites in 7 countries: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Ventricular Arrhythmia and Ventricular Tachycardia, run by University of California, Los Angeles at 41 sites in 7 countries.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 1 inclusion and 0 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: enrolling by invitation, as of the sponsor's last update on 15 Dec 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 41 sites in United States, Netherlands, Canada, Israel, Japan and 2 more countries. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Ventricular tachycardia (VT) recurrence (time frame: From date of procedure assessed by shock, Anti-Tachycardia Pacing, or repeat procedure, up to 10 years.). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 15 Dec 2025.