Anesthesia, GeneralNCT04532502
Impact of Anesthetic Environment the Sex Ratio of the Children of Female Assistants
An observational study of Anesthesia, General and Anesthetics Adverse Reaction, run by University of Liege at 1 site in Belgium.
Trial summary
The aims of this multi center retrospective study was to determine: whether the sex ratio of the offspring of female assistants in anesthesia-resuscitation differs from that of the population at large whether the assistants' work environment at the time of their offspring's conception influences the sex of their… Read more about this study
- Who is it for?
- Ages 18 years and older, women only
- Conditions the study is for
- Anesthesia, General, Anesthetics Adverse Reaction
- What is being tested?
- Anesthetics, Inhalation
- How many people
- 143 participants
- Where
- 1 siteBelgium
- Study dates
- 2 Oct 2021to 2 Dec 2021
- Phase
- Observational
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- Women only
- Adult, Older adult
Study population: The anesthesia department of the three French-speaking universities in Belgium wimp e-mail a questionnaire to all female assistants in anesthesia-resuscitation via a system similar to Survey Monkey. The data will be completely anonymized through those of such a system. Reminder will be e-mailed 1 and 3 months after the questionnaire is sent out. Filling the questionnaire will be equated with consent
Who may be able to join
- Female assistants in anesthesia-resuscitation in the Wallonia-Brussels Federation (Belgium) who conceived one or more children in the course of their training between 2009 and 2019 and who delivered before the end of 2019 (cut-off: midnight on 31 December 2019)
Who cannot join
- Male assistants in anesthesia-resuscitation
- Female assistants in anesthesia-resuscitation who trained before 2009 or after 2019.
- Female assistants in anesthesia-resuscitation who relied on medically assisted reproduction.
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Work Environment's Impact on the Sex Ratio of the Children of Resuscitation Anesthesia Assistants
The aims of this multi center retrospective study was to determine:
- whether the sex ratio of the offspring of female assistants in anesthesia-resuscitation differs from that of the population at large
- whether the assistants' work environment at the time of their offspring's conception influences the sex of their offspring
- Conditions
- Anesthesia, General, Anesthetics Adverse Reaction
- Being tested
- Anesthetics, Inhalation
- Keywords
- Anesthesia care providers, offspring sex ratio, Inhalation induction of anesthesia
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Anesthetics, InhalationDrug
Work environmental exposure
| Study group | Role | What they receive |
|---|---|---|
| Study group | All female assistants in anesthesia Receives: Drug: Anesthetics, Inhalation |
What is being measured
The primary outcome is the main question the study is designed to answer.
Offspring sex ratio
Offspring sex ratio of female anesthesia assistants will be recorded
Measured: 5 years (duration of anesthesia training)
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted31 Aug 2020
- Study start2 Oct 2021
- Primary completion2 Dec 2021
- Study completion2 Dec 2021
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (2)Papers the sponsor has linked to this study.
- Other trials for Anesthesia, GeneralStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Retrospective
- Enrolment
- 143 participants (actual)
Sponsor and investigators
- Lead sponsor
- University of Liege
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Jean François Brichant, University of Liege
- Investigators
- Philippe J Van der Linden, MD, Study director, CHU Brugmann, Free University of Brussels, Belgium
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT04532502
- Sponsor's protocol ID
- GENREANES
- Status last verified
- Dec 2021
- First submitted
- 25 Aug 2020
- Last updated
- 3 Dec 2021
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Publications
Gupta D, Kaminski E, McKelvey G, Wang H. Firstborn offspring sex ratio is skewed towards female offspring in anesthesia care providers: A questionnaire-based nationwide study from United States. J Anaesthesiol Clin Pharmacol. 2013 Apr;29(2):221-7. doi: 10.4103/0970-9185.111728.
PubMed 23878446Leroy C, Daelemans C, Debauche C, Van Leeuw V. Santé périnatale en Wallonie - année 2017, Centre d'Epidémiologie Périnatale 2019.
Study at a glance
From the registry record, last updated by the sponsor on 3 Dec 2021. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Work Environment's Impact on the Sex Ratio of the Children of Resuscitation Anesthesia Assistants
- ClinicalTrials.gov ID
- NCT04532502
- Acronym / sponsor ID
- GENREANES
- Conditions
- Anesthesia, General, Anesthetics Adverse Reaction
- Keywords
- Anesthesia care providers, offspring sex ratio, Inhalation induction of anesthesia
- Study type
- Observational
- Recruitment status
- Completed
- Enrolment
- 143 participants (actual)
- Lead sponsor
- University of LiegeUniversity, hospital or other
- Study start
- 2 Oct 2021 (actual)
- Primary completion
- 2 Dec 2021 (actual)
- Study completion
- 2 Dec 2021 (actual)
- First posted
- 31 Aug 2020 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The aims of this multi center retrospective study was to determine:
- whether the sex ratio of the offspring of female assistants in anesthesia-resuscitation differs from that of the population at large
- whether the assistants' work environment at the time of their offspring's conception influences the sex of their offspring
Study design
- Observational model
- Cohort
- Time perspective
- Retrospective
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| Study group | – | Drug: Anesthetics, InhalationAll female assistants in anesthesia |
Who may qualify
- Ages
- 18 years and older
- Sex
- Female only
- Age groups
- Adult, Older adult
- Study population
- The anesthesia department of the three French-speaking universities in Belgium wimp e-mail a questionnaire to all female assistants in anesthesia-resuscitation via a system similar to Survey Monkey. The data will be completely anonymized through those of such a system. Reminder will be e-mailed 1 and 3 months after the questionnaire is sent out. Filling the questionnaire will be equated with consent
Key inclusion criteria (1 listed)
- Female assistants in anesthesia-resuscitation in the Wallonia-Brussels Federation (Belgium) who conceived one or more children in the course of their training between 2009 and 2019 and who delivered before the end of 2019 (cut-off: midnight on 31 December 2019)
Key exclusion criteria (3 listed)
- Male assistants in anesthesia-resuscitation
- Female assistants in anesthesia-resuscitation who trained before 2009 or after 2019.
- Female assistants in anesthesia-resuscitation who relied on medically assisted reproduction.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Anesthetics, InhalationWork environmental exposure | Drug | Study group |
Primary outcome
Offspring sex ratio
Time frame: 5 years (duration of anesthesia training)
Offspring sex ratio of female anesthesia assistants will be recorded
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 3 Dec 2021.
- Background: PubMed 23878446Gupta D, Kaminski E, McKelvey G, Wang H. Firstborn offspring sex ratio is skewed towards female offspring in anesthesia care providers: A questionnaire-based nationwide study from United States. J Anaesthesiol Clin Pharmacol. 2013 Apr;29(2):221-7. doi: 10.4103/0970-9185.111728.
- BackgroundLeroy C, Daelemans C, Debauche C, Van Leeuw V. Santé périnatale en Wallonie - année 2017, Centre d'Epidémiologie Périnatale 2019.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Philippe J Van der Linden, MD study director
CHU Brugmann, Free University of Brussels, Belgium
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Anesthesia, General and Anesthetics Adverse Reaction, run by University of Liege at 1 site in Belgium.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 1 inclusion and 3 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 3 Dec 2021. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Belgium. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Offspring sex ratio (time frame: 5 years (duration of anesthesia training)). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT04532502, which also lists 2 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 3 Dec 2021.