Fetal Growth RestrictionPhase 3NCT04557475
Transplacental Aspirin Therapy for Early Onset Fetal Growth Restriction
A Phase 3 study testing Aspirin in people with Fetal Growth Restriction and Fetal Growth Retardation, run by Johns Hopkins University.
Trial summary
The purpose of this investigation is to evaluate the ability of maternal aspirin (ASA) therapy to prevent preterm birth for fetal indications prior to 32 weeks gestation in women with early onset Fetal Growth Restriction (FGR). Aspirin is a commonly used medication that blocks blood platelets from clumping. Read more about this study
- Who is it for?
- Ages 18 years and older, women only
- Conditions the study is for
- Fetal Growth Restriction, Fetal Growth Retardation, Intrauterine Growth Restriction
- What is being tested?
- Aspirin
- Type of treatment
- Pill or oral medicine
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 0 participants
- Where
- No sites listed yet
- Study dates
- 11 Jun 2022to 11 Jun 2023
- Phase
- Phase 3
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- Women only
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Pregnant women at least 18 years old
- Gestational age between 220/7 to 300/7 weeks
- Fetal abdominal circumference < 10th percentile
- Umbilical artery Doppler index elevation > 95th percentile
- Forward umbilical artery end-diastolic flow
- Able to understand purpose, risks/benefits, and voluntary nature of study participant
Who cannot join
- Multiple pregnancy
- Currently taking 81 mg aspirin
- Maternal contraindication to aspirin treatment including allergy
- Active vaginal bleeding
- Presence of any physical fetal anomaly
- Fetal viral infection if diagnosed by the appropriate diagnostic test
- Fetal chromosomal abnormalities if diagnosed by invasive fetal testing
- Need for imminent delivery
About this study
Official title: A Randomized Trial of Transplacental Aspirin Therapy for Early Onset Fetal Growth
The purpose of this investigation is to evaluate the ability of maternal aspirin (ASA) therapy to prevent preterm birth for fetal indications prior to 32 weeks gestation in women with early onset Fetal Growth Restriction (FGR). Aspirin is a commonly used medication that blocks blood platelets from clumping. Aspirin crosses the placenta in a dose dependent mode. There is preliminary evidence in smaller studies that aspirin can block fetal platelet clumping and, therefore, slow down the progression of placental disease under specific circumstances. The optimal time for aspirin to work is when the fetus' placental dysfunction is still mild. The goal of this research study is to show if fetuses that receive aspirin through maternal intake at a dose shown to affect fetal platelet aggregation will be less likely to deliver before 32 weeks for fetal deterioration. The outcomes of patients that receive aspirin will be compared to women that receive standard FGR management but do not take any aspirin. The decision if a study participant receives aspirin or not will be randomly picked. Such a research study is called a randomized controlled trial.
Read the detailed description
Early onset FGR requiring preterm delivery by 32 weeks gestation complicates 1-5% of pregnancies and is an important health problem. Over 60% of children have long-term health consequences after being delivered for early onset FGR. There is no prenatal treatment for fetal growth restriction. The current management of FGR consists of fetal surveillance to detect a decline in the baby's health and deliver when this can be safely done. In a large number of early onset FGR, premature delivery is required to prevent the fetus from becoming more compromised or even dying in the womb.
Placental dysfunction leading to early onset FGR is characterized by changes to the blood vessels of the placenta, leading to a decline in the amount of blood flow to the placenta. The arteries that run in the umbilical cord of the fetus (umbilical arteries) are important for nutrient exchange between the fetal and placental circulation. Many fetuses with early onset FGR have elevated resistance in the blood vessels entering the placenta. This results in decreased blood flow in the umbilical artery (UA). The blood flow in the umbilical artery is evaluated by a specialized ultrasound technique called Doppler ultrasound. Doppler ultrasound of the umbilical arteries examines the blood flow to see if there is evidence of abnormal blood flow into the placenta. When the amount of blood flow at the end of every pulse decreases, it is classified as elevated UA blood flow resistance. When the blood flow briefly pauses at the end of each pulse, this is called absent end-diastolic velocity (AEDV) or UA AEDV. When the blood flow reverses at the end of each pulse, this is called reversed end-diastolic velocity (UA REDV). In fetuses with elevated UA blood flow, the placenta can usually supply enough nutrients and oxygen for at least 9 weeks. After that time, delivery is typically required. The worsening of blood flow to UA AEDV, or even UA REDV, increases the risk for fetal deterioration and preterm birth within the next 2-6 weeks. Approximately, 80% of early onset FGR fetuses progress to UA AEDV, or even UA REDV, and then require delivery by 32 weeks. There is no treatment that can stop this progression which is of critical importance in determining how much time is left for the fetus before delivery will be necessary.
- Conditions
- Fetal Growth Restriction, Fetal Growth Retardation, Intrauterine Growth Restriction, Intrauterine Growth Retardation
- Being tested
- Aspirin
- Keywords
- Maternal Aspirin Therapy
- Medical subject headings
- Fetal Growth Retardation
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
AspirinDrug
Also called acetylsalicylic acid (ASA)
Two tablets daily with dinner
| Study group | Role | What they receive |
|---|---|---|
| ASA Group | Experimental | Receives standard of care and intervention. Receives: Drug: Aspirin |
| SOC Group | No intervention | Receives standard of care (SOC), only |
What is being measured
The primary outcome is the main question the study is designed to answer.
Number of fetuses delivered for non-reassuring fetal status prior to 32+0 week's gestation
To determine the frequency of delivery prior to 32+0 weeks' gestation for abnormal fetal surveillance parameters.
Measured: From randomization until birth, up to 38 weeks gestation
Secondary outcomes (7)
Change in UA Doppler index
UA Doppler index is assessed at enrollment (baseline) and weekly. Qualitative changes in UA Doppler index are measured as presence, absence or reversal of end-diastolic velocity.
Measured: Baseline and weekly, up to 38 weeks gestation
Change in amniotic fluid index (AFI)
Amniotic fluid index, measured with amniotic fluid volume [in centimeters (cm)] will be assessed at enrollment (baseline) and weekly. Oligohydramnios is an AFI ≤ 5 cm or a maximum vertical pocket (MVP) pocket ≤ 2 cm.
Measured: Baseline and weekly, up to 38 weeks gestation
Change in fetal heart rate decelerations
Fetal heart rate decelerations [in milliseconds (ms)] is assessed at enrollment (baseline) and weekly to bi-weekly. Heart rate variability increases with gestational age. After 29 weeks gestation, 4.0 ms and 3.0 ms meet criteria for reduced or very low short-term variation (STV) respectively. Before 29 weeks gestation, an STV <3.5 ms is considered reduced and <2.6 ms as very low.
Measured: Baseline and weekly to bi-weekly, up to 38 weeks gestation
Change in biophysical profile score
Biophysical profile score is assessed at enrollment (baseline) and weekly to bi-weekly. The biophysical profile (BPP) combines a nonstress test (NST) with an ultrasound to evaluate a baby's heart rate, breathing, movements, muscle tone and amniotic fluid level. Each gives a score between 0 and 2 and are added up for a total maximum score of 10. A score of 8 or 10 is considered normal, while a score below 8 usually requires further evaluation or delivery of the baby.
Measured: Baseline and weekly to bi-weekly, up to 38 weeks gestation
Gestational age at delivery
Gestational age at delivery measured in weeks.
Measured: At time of birth, up to 38 weeks gestation
Birthweight percentile at delivery
Birthweight percentile will be assessed at the time of delivery.
Measured: At time of birth, up to 38 weeks gestation
Placental size at delivery
Placental size measured in grams at delivery.
Measured: At time of birth, up to 38 weeks gestation
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted21 Sep 2020
- Study start11 Jun 2022 (estimated)
- Primary completion11 Jun 2023 (estimated)
- Study completion11 Jun 2023 (estimated)
Why it stopped: We are modifying this trial's protocol and will resubmit a new application at a later date.
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (32)Papers the sponsor has linked to this study.
- Other trials for Fetal Growth RestrictionStudies of the same condition, open and under way.
- More trials run by Johns Hopkins UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase 3
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Model description
- Two Group Assignment
- Masking
- None (open label)
- Enrolment
- 0 participants (actual)
Sponsor and investigators
- Lead sponsor
- Johns Hopkins University
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
- Investigators
- Ahmet A Baschat, Principal investigator, Johns Hopkins UniversityAshi R Daftary, MD, Principal investigator, Allegheny Health Network
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT04557475
- Sponsor's protocol ID
- IRB00259253
- Status last verified
- Jun 2021
- First submitted
- 15 Sep 2020
- Last updated
- 16 Jun 2021
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Publications
Khong TY, Mooney EE, Ariel I, Balmus NC, Boyd TK, Brundler MA, Derricott H, Evans MJ, Faye-Petersen OM, Gillan JE, Heazell AE, Heller DS, Jacques SM, Keating S, Kelehan P, Maes A, McKay EM, Morgan TK, Nikkels PG, Parks WT, Redline RW, Scheimberg I, Schoots MH, Sebire NJ, Timmer A, Turowski G, van der Voorn JP, van Lijnschoten I, Gordijn SJ. Sampling and Definitions of Placental Lesions: Amsterdam Placental Workshop Group Consensus Statement. Arch Pathol Lab Med. 2016 Jul;140(7):698-713. doi: 10.5858/arpa.2015-0225-CC. Epub 2016 May 25.
PubMed 27223167Kingdom JC, Burrell SJ, Kaufmann P. Pathology and clinical implications of abnormal umbilical artery Doppler waveforms. Ultrasound Obstet Gynecol. 1997 Apr;9(4):271-86. doi: 10.1046/j.1469-0705.1997.09040271.x. No abstract available.
PubMed 9168580Morrow RJ, Adamson SL, Bull SB, Ritchie JW. Effect of placental embolization on the umbilical arterial velocity waveform in fetal sheep. Am J Obstet Gynecol. 1989 Oct;161(4):1055-60. doi: 10.1016/0002-9378(89)90783-7.
PubMed 2679101Giles WB, Trudinger BJ, Baird PJ. Fetal umbilical artery flow velocity waveforms and placental resistance: pathological correlation. Br J Obstet Gynaecol. 1985 Jan;92(1):31-8. doi: 10.1111/j.1471-0528.1985.tb01045.x.
PubMed 3966988Jackson MR, Walsh AJ, Morrow RJ, Mullen JB, Lye SJ, Ritchie JW. Reduced placental villous tree elaboration in small-for-gestational-age pregnancies: relationship with umbilical artery Doppler waveforms. Am J Obstet Gynecol. 1995 Feb;172(2 Pt 1):518-25. doi: 10.1016/0002-9378(95)90566-9.
PubMed 7856679Redline RW, Ravishankar S. Fetal vascular malperfusion, an update. APMIS. 2018 Jul;126(7):561-569. doi: 10.1111/apm.12849.
PubMed 30129125Wilcox GR, Trudinger BJ. Fetal platelet consumption: a feature of placental insufficiency. Obstet Gynecol. 1991 Apr;77(4):616-21.
PubMed 2002988Trudinger B, Song JZ, Wu ZH, Wang J. Placental insufficiency is characterized by platelet activation in the fetus. Obstet Gynecol. 2003 May;101(5 Pt 1):975-81. doi: 10.1016/s0029-7844(03)00173-x.
PubMed 12738160Ohshige A, Yoshimura T, Maeda T, Ito M, Okamura H. Increased platelet-activating factor-acetylhydrolase activity in the umbilical venous plasma of growth-restricted fetuses. Obstet Gynecol. 1999 Feb;93(2):180-3. doi: 10.1016/s0029-7844(98)00407-4.
PubMed 9932551Sciscione AC, Bessos H, Callan N, Blakemore K, Kickler T. Indicators of platelet turnover in thrombocytopenic infants. Br J Obstet Gynaecol. 1997 Jun;104(6):743-5. doi: 10.1111/j.1471-0528.1997.tb11990.x.
PubMed 9197883Baschat AA, Gembruch U, Reiss I, Gortner L, Weiner CP, Harman CR. Absent umbilical artery end-diastolic velocity in growth-restricted fetuses: a risk factor for neonatal thrombocytopenia. Obstet Gynecol. 2000 Aug;96(2):162-6. doi: 10.1016/s0029-7844(00)00904-2.
PubMed 10908756Turan OM, Turan S, Gungor S, Berg C, Moyano D, Gembruch U, Nicolaides KH, Harman CR, Baschat AA. Progression of Doppler abnormalities in intrauterine growth restriction. Ultrasound Obstet Gynecol. 2008 Aug;32(2):160-7. doi: 10.1002/uog.5386.
PubMed 18634130Crimmins S, Desai A, Block-Abraham D, Berg C, Gembruch U, Baschat AA. A comparison of Doppler and biophysical findings between liveborn and stillborn growth-restricted fetuses. Am J Obstet Gynecol. 2014 Dec;211(6):669.e1-10. doi: 10.1016/j.ajog.2014.06.022. Epub 2014 Jun 12.
PubMed 24931475Caradeux J, Martinez-Portilla RJ, Basuki TR, Kiserud T, Figueras F. Risk of fetal death in growth-restricted fetuses with umbilical and/or ductus venosus absent or reversed end-diastolic velocities before 34 weeks of gestation: a systematic review and meta-analysis. Am J Obstet Gynecol. 2018 Feb;218(2S):S774-S782.e21. doi: 10.1016/j.ajog.2017.11.566. Epub 2017 Dec 9.
PubMed 29233550Ferrazzi E, Bozzo M, Rigano S, Bellotti M, Morabito A, Pardi G, Battaglia FC, Galan HL. Temporal sequence of abnormal Doppler changes in the peripheral and central circulatory systems of the severely growth-restricted fetus. Ultrasound Obstet Gynecol. 2002 Feb;19(2):140-6. doi: 10.1046/j.0960-7692.2002.00627.x.
PubMed 11876805
Study at a glance
From the registry record, last updated by the sponsor on 16 Jun 2021. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- A Randomized Trial of Transplacental Aspirin Therapy for Early Onset Fetal Growth
- ClinicalTrials.gov ID
- NCT04557475
- Acronym / sponsor ID
- IRB00259253
- Conditions
- Fetal Growth Restriction, Fetal Growth Retardation, Intrauterine Growth Restriction, Intrauterine Growth Retardation
- Keywords
- Maternal Aspirin Therapy
- Phase
- Phase 3
- Study type
- Interventional
- Recruitment status
- WithdrawnReason stopped: We are modifying this trial's protocol and will resubmit a new application at a later date.
- Enrolment
- 0 participants (actual)
- Lead sponsor
- Johns Hopkins UniversityUniversity, hospital or other
- Study start
- 11 Jun 2022 (estimated)
- Primary completion
- 11 Jun 2023 (estimated)
- Study completion
- 11 Jun 2023 (estimated)
- First posted
- 21 Sep 2020 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The purpose of this investigation is to evaluate the ability of maternal aspirin (ASA) therapy to prevent preterm birth for fetal indications prior to 32 weeks gestation in women with early onset Fetal Growth Restriction (FGR). Aspirin is a commonly used medication that blocks blood platelets from clumping. Aspirin crosses the placenta in a dose dependent mode. There is preliminary evidence in smaller studies that aspirin can block fetal platelet clumping and, therefore, slow down the progression of placental disease under specific circumstances. The optimal time for aspirin to work is when the fetus' placental dysfunction is still mild. The goal of this research study is to show if fetuses that receive aspirin through maternal intake at a dose shown to affect fetal platelet aggregation will be less likely to deliver before 32 weeks for fetal deterioration. The outcomes of patients that receive aspirin will be compared to women that receive standard FGR management but do not take any aspirin. The decision if a study participant receives aspirin or not will be randomly picked. Such a research study is called a randomized controlled trial.
Detailed description
Early onset FGR requiring preterm delivery by 32 weeks gestation complicates 1-5% of pregnancies and is an important health problem. Over 60% of children have long-term health consequences after being delivered for early onset FGR. There is no prenatal treatment for fetal growth restriction. The current management of FGR consists of fetal surveillance to detect a decline in the baby's health and deliver when this can be safely done. In a large number of early onset FGR, premature delivery is required to prevent the fetus from becoming more compromised or even dying in the womb.
Placental dysfunction leading to early onset FGR is characterized by changes to the blood vessels of the placenta, leading to a decline in the amount of blood flow to the placenta. The arteries that run in the umbilical cord of the fetus (umbilical arteries) are important for nutrient exchange between the fetal and placental circulation. Many fetuses with early onset FGR have elevated resistance in the blood vessels entering the placenta. This results in decreased blood flow in the umbilical artery (UA). The blood flow in the umbilical artery is evaluated by a specialized ultrasound technique called Doppler ultrasound. Doppler ultrasound of the umbilical arteries examines the blood flow to see if there is evidence of abnormal blood flow into the placenta. When the amount of blood flow at the end of every pulse decreases, it is classified as elevated UA blood flow resistance. When the blood flow briefly pauses at the end of each pulse, this is called absent end-diastolic velocity (AEDV) or UA AEDV. When the blood flow reverses at the end of each pulse, this is called reversed end-diastolic velocity (UA REDV). In fetuses with elevated UA blood flow, the placenta can usually supply enough nutrients and oxygen for at least 9 weeks. After that time, delivery is typically required. The worsening of blood flow to UA AEDV, or even UA REDV, increases the risk for fetal deterioration and preterm birth within the next 2-6 weeks. Approximately, 80% of early onset FGR fetuses progress to UA AEDV, or even UA REDV, and then require delivery by 32 weeks. There is no treatment that can stop this progression which is of critical importance in determining how much time is left for the fetus before delivery will be necessary.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 2
- Model description
- Two Group Assignment
| Arm | Type | Receives |
|---|---|---|
| ASA Group | Experimental | Drug: AspirinReceives standard of care and intervention. |
| SOC Group | No intervention | –Receives standard of care (SOC), only |
Who may qualify
- Ages
- 18 years and older
- Sex
- Female only
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (6 listed)
- Pregnant women at least 18 years old
- Gestational age between 220/7 to 300/7 weeks
- Fetal abdominal circumference < 10th percentile
- Umbilical artery Doppler index elevation > 95th percentile
- Forward umbilical artery end-diastolic flow
Key exclusion criteria (8 listed)
- Multiple pregnancy
- Currently taking 81 mg aspirin
- Maternal contraindication to aspirin treatment including allergy
- Active vaginal bleeding
- Presence of any physical fetal anomaly
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| AspirinAlso: acetylsalicylic acid (ASA)Two tablets daily with dinner | Drug | ASA Group |
Primary outcome
Number of fetuses delivered for non-reassuring fetal status prior to 32+0 week's gestation
Time frame: From randomization until birth, up to 38 weeks gestation
To determine the frequency of delivery prior to 32+0 weeks' gestation for abnormal fetal surveillance parameters.
7 secondary outcomes
Change in UA Doppler index
Time frame: Baseline and weekly, up to 38 weeks gestation
Change in amniotic fluid index (AFI)
Time frame: Baseline and weekly, up to 38 weeks gestation
Change in fetal heart rate decelerations
Time frame: Baseline and weekly to bi-weekly, up to 38 weeks gestation
Change in biophysical profile score
Time frame: Baseline and weekly to bi-weekly, up to 38 weeks gestation
Gestational age at delivery
Time frame: At time of birth, up to 38 weeks gestation
Birthweight percentile at delivery
Time frame: At time of birth, up to 38 weeks gestation
Placental size at delivery
Time frame: At time of birth, up to 38 weeks gestation
Results and safety
The study was withdrawn before enrolling participants, so there are no results.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 16 Jun 2021.
- Background: PubMed 27223167Khong TY, Mooney EE, Ariel I, Balmus NC, Boyd TK, Brundler MA, Derricott H, Evans MJ, Faye-Petersen OM, Gillan JE, Heazell AE, Heller DS, Jacques SM, Keating S, Kelehan P, Maes A, McKay EM, Morgan TK, Nikkels PG, Parks WT, Redline RW, Scheimberg I, Schoots MH, Sebire NJ, Timmer A, Turowski G, van der Voorn JP, van Lijnschoten I, Gordijn SJ. Sampling and Definitions of Placental Lesions: Amsterdam Placental Workshop Group Consensus Statement. Arch Pathol Lab Med. 2016 Jul;140(7):698-713. doi: 10.5858/arpa.2015-0225-CC. Epub 2016 May 25.
- Background: PubMed 9168580Kingdom JC, Burrell SJ, Kaufmann P. Pathology and clinical implications of abnormal umbilical artery Doppler waveforms. Ultrasound Obstet Gynecol. 1997 Apr;9(4):271-86. doi: 10.1046/j.1469-0705.1997.09040271.x. No abstract available.
- Background: PubMed 2679101Morrow RJ, Adamson SL, Bull SB, Ritchie JW. Effect of placental embolization on the umbilical arterial velocity waveform in fetal sheep. Am J Obstet Gynecol. 1989 Oct;161(4):1055-60. doi: 10.1016/0002-9378(89)90783-7.
- Background: PubMed 3966988Giles WB, Trudinger BJ, Baird PJ. Fetal umbilical artery flow velocity waveforms and placental resistance: pathological correlation. Br J Obstet Gynaecol. 1985 Jan;92(1):31-8. doi: 10.1111/j.1471-0528.1985.tb01045.x.
- Background: PubMed 7856679Jackson MR, Walsh AJ, Morrow RJ, Mullen JB, Lye SJ, Ritchie JW. Reduced placental villous tree elaboration in small-for-gestational-age pregnancies: relationship with umbilical artery Doppler waveforms. Am J Obstet Gynecol. 1995 Feb;172(2 Pt 1):518-25. doi: 10.1016/0002-9378(95)90566-9.
- Background: PubMed 30129125Redline RW, Ravishankar S. Fetal vascular malperfusion, an update. APMIS. 2018 Jul;126(7):561-569. doi: 10.1111/apm.12849.
- Background: PubMed 2002988Wilcox GR, Trudinger BJ. Fetal platelet consumption: a feature of placental insufficiency. Obstet Gynecol. 1991 Apr;77(4):616-21.
- Background: PubMed 12738160Trudinger B, Song JZ, Wu ZH, Wang J. Placental insufficiency is characterized by platelet activation in the fetus. Obstet Gynecol. 2003 May;101(5 Pt 1):975-81. doi: 10.1016/s0029-7844(03)00173-x.
- Background: PubMed 9932551Ohshige A, Yoshimura T, Maeda T, Ito M, Okamura H. Increased platelet-activating factor-acetylhydrolase activity in the umbilical venous plasma of growth-restricted fetuses. Obstet Gynecol. 1999 Feb;93(2):180-3. doi: 10.1016/s0029-7844(98)00407-4.
- Background: PubMed 9197883Sciscione AC, Bessos H, Callan N, Blakemore K, Kickler T. Indicators of platelet turnover in thrombocytopenic infants. Br J Obstet Gynaecol. 1997 Jun;104(6):743-5. doi: 10.1111/j.1471-0528.1997.tb11990.x.
- Background: PubMed 10908756Baschat AA, Gembruch U, Reiss I, Gortner L, Weiner CP, Harman CR. Absent umbilical artery end-diastolic velocity in growth-restricted fetuses: a risk factor for neonatal thrombocytopenia. Obstet Gynecol. 2000 Aug;96(2):162-6. doi: 10.1016/s0029-7844(00)00904-2.
- Background: PubMed 18634130Turan OM, Turan S, Gungor S, Berg C, Moyano D, Gembruch U, Nicolaides KH, Harman CR, Baschat AA. Progression of Doppler abnormalities in intrauterine growth restriction. Ultrasound Obstet Gynecol. 2008 Aug;32(2):160-7. doi: 10.1002/uog.5386.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Ahmet A Baschat principal investigator
Johns Hopkins University
Ashi R Daftary, MD principal investigator
Allegheny Health Network
Questions about this trial
What is this clinical trial studying?
A Phase 3 study testing Aspirin in people with Fetal Growth Restriction and Fetal Growth Retardation, run by Johns Hopkins University.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 6 inclusion and 8 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: withdrawn, as of the sponsor's last update on 16 Jun 2021. Status can change between updates, so confirm with the study contact before making plans.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
What does this phase mean?
Phase 3 studies compare the treatment with the current standard treatment or a placebo in a large group, to confirm how well it works and watch for side effects.
Not every study follows the same path, and some studies (observational studies, device studies) have no phase.
Are results available for this study?
The study was withdrawn before enrolling participants, so there are no results.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Number of fetuses delivered for non-reassuring fetal status prior to 32+0 week's gestation (time frame: From randomization until birth, up to 38 weeks gestation). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT04557475, which also lists 32 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 16 Jun 2021.