HealthyNCT04573101
EEG Responses to Arabic Music Scales
A study testing Music listening / EEG recording in people with Healthy, run by Weill Cornell Medical College in Qatar at 1 site in Qatar.
Trial summary
Recent studies showed that various factors can contribute to the efficiency of a music therapy such as the type of music used, the type of instrument, the ethnicity, musical preference of the subjects and many others. Read more about this study
- Who is it for?
- Ages 18 years and olderHealthy volunteers can take part
- Conditions the study is for
- Healthy
- What is being tested?
- Music listening / EEG recording
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 42 participants
- Where
- 1 siteQatar
- Study dates
- 11 Feb 2019to 20 Sep 2022
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Who may be able to join
- Age: 18 years old to or above (might include pregnant women)
- Living in Qatar
- Understand either English or arabic
Who cannot join
- Individuals not meeting the inclusion criteria
- Individuals with auditory impairments
- Individuals with any known neurological condition (including epilepsy, Alzheimer, Parkinson, Autism etc)
- Individuals not able to come to the site (WCMQ).
- Adults not able to consent
Trial locations and contacts
1 site in 1 country.
About this study
Official title: An EEG-based Exploration of the Variables Affecting Cortical Responses to Arabic Music Scales for a Personalised and Effective Music Therapy in the Middle East: a Clinical Study
Recent studies showed that various factors can contribute to the efficiency of a music therapy such as the type of music used, the type of instrument, the ethnicity, musical preference of the subjects and many others. Investigators noticed that most of studies and clinical trials, while acknowledging the importance of ethnicity and musical preferences, use the Western Music type in their investigations and practice. While in the Middle East, Music Therapy played a tremendous role in the 10th century since the "scales theory" of the famous Scientists El Farabi and Avicenna, very little countries of the Middle East are investing in scientific studies using Arabic Music as a therapeutic tool. This study will be an electroencephalogram (EEG)-based investigation on correlations of multiple factors that can influence the cortical responses of the subject to the music and self-reported state of emotion and anxiety.
Read the detailed description
This is the first clinical study involving Music in Qatar and the Gulf region, and the first study to explore Arab Music Scales using a combination of EEG and self-reported assessements.
Using EEG, investigators will analyze the full brain activity of brainwaves produced by up to 100 subjects in response to the audio musical stimuli. 24 different audio recordings have been designed to investigate on different acoustic cues:
- with versus without quartertones
- known music versus improvisation
- Maqam Saba (sad) versus maqam Kurd (happy)
- 3 different Middle Eastern instruments: Ney, Oud and Qanun
- Two pitches: from Re or from Sol
The presentation of the audio stimuli clips will be randomized by the SuperLab5 software and EEG brainwaves will be recorded using the Power Lab (AD instrument). Between every audio clip, recording will be paused to ask the subjects to self-report on their emotional and anxiety states using a self-evaluation questionnaire. Subjects will be randomly assigned to morning of afternoon sessions of recording.
Using bioinformatic tools, investigators will perform a correlation study between EEG results, emotional self-report from the PANAS-X questionnaire, as well as answers to another questionnaire asking for their age, gender, ethnicity, right or left handedness, musical preferences, and if the subject plays an instrument.
The outcomes will have direct applications on the development of personalized Music Therapy in the region for treatment and management of mental health conditions, neurodegenerative diseases and other conditions that are of high prevalence in the region.
- Conditions
- Healthy
- Being tested
- Music listening / EEG recording
- Keywords
- Music, Emotions, Ethnicity, Culture, Music Preference
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Music listening / EEG recordingOther
Participants listen to 24 different audio clips of 1 min long each, and select emotion in between. EEG is recorded while participants are listening. Participants select the emotion that best describes their feeling from Table 1 of the PANAS-X. https://www2.psychology.uiowa.edu/faculty/clark/panas-x.pdf
| Study group | Role | What they receive |
|---|---|---|
| Before intervention | No intervention | Participants answer questionnaire before any stimulus is given. |
| After intervention | No intervention | Participants answer questionnaire after the series of stimulus is given. |
| N1 (Ney - Improvisation- Saba Re) | Experimental | Improvisation with Ney, on Saba maqam on Re. Receives: Other: Music listening / EEG recording |
| O1 (Oud - Improvisation- Saba Re) | Experimental | Improvisation with Oud, on Saba maqam on Re. Receives: Other: Music listening / EEG recording |
| Q1(Qanun - Improvisation- Saba Re) | Experimental | Improvisation with Qanun, on Saba maqam on Re. Receives: Other: Music listening / EEG recording |
| N2 (Ney - Improvisation- Saba Sol) | Experimental | Improvisation with Ney, on Saba maqam on Sol. Receives: Other: Music listening / EEG recording |
| O2 (Oud - Improvisation- Saba Sol) | Experimental | Improvisation with Oud, on Saba maqam on Sol. Receives: Other: Music listening / EEG recording |
| Q2 (Qanun - Improvisation- Saba Sol) | Experimental | Improvisation with Qanun, on Saba maqam on Sol. Receives: Other: Music listening / EEG recording |
| N3 (Ney - Improvisation- Kurd Re) | Experimental | Improvisation with Ney, on Kurd maqam on Re. Receives: Other: Music listening / EEG recording |
| O3 (Oud - Improvisation- Kurd Re) | Experimental | Improvisation with Oud, on Kurd maqam on Re. Receives: Other: Music listening / EEG recording |
| Q3 (Qanun - Improvisation- Kurd Re) | Experimental | Improvisation with Qanun, on Kurd maqam on Re. Receives: Other: Music listening / EEG recording |
| N4 (Ney - Improvisation- Kurd Sol) | Experimental | Improvisation with Ney, on Kurd maqam on Sol. Receives: Other: Music listening / EEG recording |
| O4 (Oud - Improvisation- Kurd Sol) | Experimental | Improvisation with Oud, on Kurd maqam on Sol. Receives: Other: Music listening / EEG recording |
| Q4 (Qanun - Improvisation- Kurd Sol) | Experimental | Improvisation with Qanun, on Kurd maqam on Sol. Receives: Other: Music listening / EEG recording |
| N5 (Ney - Known music- Kurd Re) | Experimental | Known music with Ney, on Kurd maqam on Re. (El Rabii) Receives: Other: Music listening / EEG recording |
| O5 (Oud - Known music- Kurd Re) | Experimental | Known music with Oud, on Kurd maqam on Re. (El Rabii) Receives: Other: Music listening / EEG recording |
| Q5 (Qanun - Known music- Kurd Re) | Experimental | Known music with Qanun, on Kurd maqam on Re. (El Rabii) Receives: Other: Music listening / EEG recording |
| N6 (Ney - Known music- Kurd Sol) | Experimental | Known music with Ney, on Kurd maqam on Sol. (El Rabii) Receives: Other: Music listening / EEG recording |
| O6 (Oud - Known music- Kurd Sol) | Experimental | Known music with Oud, on Kurd maqam on Sol. (El Rabii) Receives: Other: Music listening / EEG recording |
| Q6 (Qanun - Known music- Kurd Sol) | Experimental | Known music with Qanun, on Kurd maqam on Sol. (El Rabii) Receives: Other: Music listening / EEG recording |
| N7 (Ney - Known music- Saba Re) | Experimental | Known music with Ney, on Saba maqam on Re. (Howa Sahih) Receives: Other: Music listening / EEG recording |
| O7 (Oud - Known music- Saba Re) | Experimental | Known music with Oud, on Saba maqam on Re. (Howa Sahih) Receives: Other: Music listening / EEG recording |
| Q7 (Qanun - Known music- Saba Re) | Experimental | Known music with Qanun, on Saba maqam on Re. (Howa Sahih) Receives: Other: Music listening / EEG recording |
| N8 (Ney - Known music- Saba Sol) | Experimental | Known music with Ney, on Saba maqam on Sol. (Howa Sahih) Receives: Other: Music listening / EEG recording |
| O8 (Oud - Known music- Saba Sol) | Experimental | Known music with Oud, on Saba maqam on Sol. (Howa Sahih) Receives: Other: Music listening / EEG recording |
| Q8 (Qanun - Known music- Saba Sol) | Experimental | Known music with Qanun, on Saba maqam on Sol. (Howa Sahih) Receives: Other: Music listening / EEG recording |
What is being measured
The primary outcome is the main question the study is designed to answer.
Quantification of brain waves
Relative power of each of the brainwaves (alpha, beta, gamma, theta, delta).
Measured: During the intervention (an average of 30 minutes)
Quantification of selected emotions
Count of every emotion (selected by participant from the provided Table).
Measured: immediately before each intervention
Quantification of selected emotions
Count of every emotion (selected by participant from the provided Table)
Measured: immediately after each intervention
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted5 Oct 2020
- Study start11 Feb 2019
- Primary completion20 Sep 2022
- Study completion20 Sep 2022
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for HealthyStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Basic science
- Allocation
- Randomised
- Intervention model
- Crossover
- Model description
- Each participants is exposed to 24 different audio recordings and asked to select emotion that best describes feeling after each auditory stimulus. The 24 audio stimuli are distributed in a random manner by computer. In addition, emotional assessment is performed before and after the session. This is a total of 26 arms.
- Masking
- None (open label)
- Enrolment
- 42 participants (actual)
Sponsor and investigators
- Lead sponsor
- Weill Cornell Medical College in Qatar
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
- Investigators
- GHIZLANE BENDRISS, PhD, Principal investigator, Weill Cornell Medicine Qatar
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT04573101
- Sponsor's protocol ID
- 19-00013
- Status last verified
- Oct 2022
- First submitted
- 23 Sep 2020
- Last updated
- 4 Oct 2022
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Yes: Individual participants data that underlie the results reported will be available after deidentification beginning 3 months after publication and ending 3 years after publication. The study protocol and statistical analysis plan will also be available beginning 3 months after publication and ending 3 years after publication. Anyone who wishes to access the individual data, to achieve aims in the approved proposal, will be eligible to gain access to data by submitting a proposal to ghb2002@qatar-med.cornell.edu and data will be available at this link: https://drive.google.com/drive/folders/1OVjWK7RNTs18c4OIDQErzGjbhmUC98qi?usp=sharing
Study at a glance
From the registry record, last updated by the sponsor on 4 Oct 2022. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- An EEG-based Exploration of the Variables Affecting Cortical Responses to Arabic Music Scales for a Personalised and Effective Music Therapy in the Middle East: a Clinical Study
- ClinicalTrials.gov ID
- NCT04573101
- Acronym / sponsor ID
- 19-00013
- Conditions
- Healthy
- Keywords
- Music, Emotions, Ethnicity, Culture, Music Preference
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 42 participants (actual)
- Lead sponsor
- Weill Cornell Medical College in QatarUniversity, hospital or other
- Study start
- 11 Feb 2019 (actual)
- Primary completion
- 20 Sep 2022 (actual)
- Study completion
- 20 Sep 2022 (actual)
- First posted
- 5 Oct 2020 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Recent studies showed that various factors can contribute to the efficiency of a music therapy such as the type of music used, the type of instrument, the ethnicity, musical preference of the subjects and many others. Investigators noticed that most of studies and clinical trials, while acknowledging the importance of ethnicity and musical preferences, use the Western Music type in their investigations and practice. While in the Middle East, Music Therapy played a tremendous role in the 10th century since the "scales theory" of the famous Scientists El Farabi and Avicenna, very little countries of the Middle East are investing in scientific studies using Arabic Music as a therapeutic tool. This study will be an electroencephalogram (EEG)-based investigation on correlations of multiple factors that can influence the cortical responses of the subject to the music and self-reported state of emotion and anxiety.
Detailed description
This is the first clinical study involving Music in Qatar and the Gulf region, and the first study to explore Arab Music Scales using a combination of EEG and self-reported assessements.
Using EEG, investigators will analyze the full brain activity of brainwaves produced by up to 100 subjects in response to the audio musical stimuli. 24 different audio recordings have been designed to investigate on different acoustic cues:
- with versus without quartertones
- known music versus improvisation
- Maqam Saba (sad) versus maqam Kurd (happy)
- 3 different Middle Eastern instruments: Ney, Oud and Qanun
- Two pitches: from Re or from Sol
The presentation of the audio stimuli clips will be randomized by the SuperLab5 software and EEG brainwaves will be recorded using the Power Lab (AD instrument). Between every audio clip, recording will be paused to ask the subjects to self-report on their emotional and anxiety states using a self-evaluation questionnaire. Subjects will be randomly assigned to morning of afternoon sessions of recording.
Using bioinformatic tools, investigators will perform a correlation study between EEG results, emotional self-report from the PANAS-X questionnaire, as well as answers to another questionnaire asking for their age, gender, ethnicity, right or left handedness, musical preferences, and if the subject plays an instrument.
The outcomes will have direct applications on the development of personalized Music Therapy in the region for treatment and management of mental health conditions, neurodegenerative diseases and other conditions that are of high prevalence in the region.
Study design
- Primary purpose
- Basic science
- Allocation
- Randomised
- Intervention model
- Crossover
- Masking
- None (open label)
- Number of arms
- 26
- Model description
- Each participants is exposed to 24 different audio recordings and asked to select emotion that best describes feeling after each auditory stimulus. The 24 audio stimuli are distributed in a random manner by computer. In addition, emotional assessment is performed before and after the session. This is a total of 26 arms.
| Arm | Type | Receives |
|---|---|---|
| Before intervention | No intervention | –Participants answer questionnaire before any stimulus is given. |
| After intervention | No intervention | –Participants answer questionnaire after the series of stimulus is given. |
| N1 (Ney - Improvisation- Saba Re) | Experimental | Other: Music listening / EEG recordingImprovisation with Ney, on Saba maqam on Re. |
| O1 (Oud - Improvisation- Saba Re) | Experimental | Other: Music listening / EEG recordingImprovisation with Oud, on Saba maqam on Re. |
| Q1(Qanun - Improvisation- Saba Re) | Experimental | Other: Music listening / EEG recordingImprovisation with Qanun, on Saba maqam on Re. |
| N2 (Ney - Improvisation- Saba Sol) | Experimental | Other: Music listening / EEG recordingImprovisation with Ney, on Saba maqam on Sol. |
| O2 (Oud - Improvisation- Saba Sol) | Experimental | Other: Music listening / EEG recordingImprovisation with Oud, on Saba maqam on Sol. |
| Q2 (Qanun - Improvisation- Saba Sol) | Experimental | Other: Music listening / EEG recordingImprovisation with Qanun, on Saba maqam on Sol. |
| N3 (Ney - Improvisation- Kurd Re) | Experimental | Other: Music listening / EEG recordingImprovisation with Ney, on Kurd maqam on Re. |
| O3 (Oud - Improvisation- Kurd Re) | Experimental | Other: Music listening / EEG recordingImprovisation with Oud, on Kurd maqam on Re. |
| Q3 (Qanun - Improvisation- Kurd Re) | Experimental | Other: Music listening / EEG recordingImprovisation with Qanun, on Kurd maqam on Re. |
| N4 (Ney - Improvisation- Kurd Sol) | Experimental | Other: Music listening / EEG recordingImprovisation with Ney, on Kurd maqam on Sol. |
| O4 (Oud - Improvisation- Kurd Sol) | Experimental | Other: Music listening / EEG recordingImprovisation with Oud, on Kurd maqam on Sol. |
| Q4 (Qanun - Improvisation- Kurd Sol) | Experimental | Other: Music listening / EEG recordingImprovisation with Qanun, on Kurd maqam on Sol. |
| N5 (Ney - Known music- Kurd Re) | Experimental | Other: Music listening / EEG recordingKnown music with Ney, on Kurd maqam on Re. (El Rabii) |
| O5 (Oud - Known music- Kurd Re) | Experimental | Other: Music listening / EEG recordingKnown music with Oud, on Kurd maqam on Re. (El Rabii) |
| Q5 (Qanun - Known music- Kurd Re) | Experimental | Other: Music listening / EEG recordingKnown music with Qanun, on Kurd maqam on Re. (El Rabii) |
| N6 (Ney - Known music- Kurd Sol) | Experimental | Other: Music listening / EEG recordingKnown music with Ney, on Kurd maqam on Sol. (El Rabii) |
| O6 (Oud - Known music- Kurd Sol) | Experimental | Other: Music listening / EEG recordingKnown music with Oud, on Kurd maqam on Sol. (El Rabii) |
| Q6 (Qanun - Known music- Kurd Sol) | Experimental | Other: Music listening / EEG recordingKnown music with Qanun, on Kurd maqam on Sol. (El Rabii) |
| N7 (Ney - Known music- Saba Re) | Experimental | Other: Music listening / EEG recordingKnown music with Ney, on Saba maqam on Re. (Howa Sahih) |
| O7 (Oud - Known music- Saba Re) | Experimental | Other: Music listening / EEG recordingKnown music with Oud, on Saba maqam on Re. (Howa Sahih) |
| Q7 (Qanun - Known music- Saba Re) | Experimental | Other: Music listening / EEG recordingKnown music with Qanun, on Saba maqam on Re. (Howa Sahih) |
| N8 (Ney - Known music- Saba Sol) | Experimental | Other: Music listening / EEG recordingKnown music with Ney, on Saba maqam on Sol. (Howa Sahih) |
| O8 (Oud - Known music- Saba Sol) | Experimental | Other: Music listening / EEG recordingKnown music with Oud, on Saba maqam on Sol. (Howa Sahih) |
| Q8 (Qanun - Known music- Saba Sol) | Experimental | Other: Music listening / EEG recordingKnown music with Qanun, on Saba maqam on Sol. (Howa Sahih) |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (3 listed)
- Age: 18 years old to or above (might include pregnant women)
- Living in Qatar
- Understand either English or arabic
Key exclusion criteria (5 listed)
- Individuals not meeting the inclusion criteria
- Individuals with auditory impairments
- Individuals with any known neurological condition (including epilepsy, Alzheimer, Parkinson, Autism etc)
- Individuals not able to come to the site (WCMQ).
- Adults not able to consent
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Music listening / EEG recordingParticipants listen to 24 different audio clips of 1 min long each, and select emotion in between. EEG is recorded while participants are listening. Participants select the emotion that best describes their feeling from Table 1 of the PANAS-X. https://www2.psychology.uiowa.edu/faculty/clark/panas-x.pdf | Other | N1 (Ney - Improvisation- Saba Re), N2 (Ney - Improvisation- Saba Sol), N3 (Ney - Improvisation- Kurd Re), N4 (Ney - Improvisation- Kurd Sol), N5 (Ney - Known music- Kurd Re), N6 (Ney - Known music- Kurd Sol), N7 (Ney - Known music- Saba Re), N8 (Ney - Known music- Saba Sol), O1 (Oud - Improvisation- Saba Re), O2 (Oud - Improvisation- Saba Sol), O3 (Oud - Improvisation- Kurd Re), O4 (Oud - Improvisation- Kurd Sol), O5 (Oud - Known music- Kurd Re), O6 (Oud - Known music- Kurd Sol), O7 (Oud - Known music- Saba Re), O8 (Oud - Known music- Saba Sol), Q1(Qanun - Improvisation- Saba Re), Q2 (Qanun - Improvisation- Saba Sol), Q3 (Qanun - Improvisation- Kurd Re), Q4 (Qanun - Improvisation- Kurd Sol), Q5 (Qanun - Known music- Kurd Re), Q6 (Qanun - Known music- Kurd Sol), Q7 (Qanun - Known music- Saba Re), Q8 (Qanun - Known music- Saba Sol) |
Primary outcome
Quantification of brain waves
Time frame: During the intervention (an average of 30 minutes)
Relative power of each of the brainwaves (alpha, beta, gamma, theta, delta).
Quantification of selected emotions
Time frame: immediately before each intervention
Count of every emotion (selected by participant from the provided Table).
Quantification of selected emotions
Time frame: immediately after each intervention
Count of every emotion (selected by participant from the provided Table)
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 4 Oct 2022.
- Individual participant dataSharing planned: Yes. Individual participants data that underlie the results reported will be available after deidentification beginning 3 months after publication and ending 3 years after publication. The study protocol and statistical analysis plan will also be available beginning 3 months after publication and ending 3 years after publication. Anyone who wishes to access the individual data, to achieve aims in the approved proposal, will be eligible to gain access to data by submitting a proposal to ghb2002@qatar-med.cornell.edu and data will be available at this link: https://drive.google.com/drive/folders/1OVjWK7RNTs18c4OIDQErzGjbhmUC98qi?usp=sharing
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
GHIZLANE BENDRISS, PhD principal investigator
Weill Cornell Medicine Qatar
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Music listening / EEG recording in people with Healthy, run by Weill Cornell Medical College in Qatar at 1 site in Qatar.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 5 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 4 Oct 2022. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Qatar. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Quantification of brain waves (time frame: During the intervention (an average of 30 minutes)). The study lists 3 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 4 Oct 2022.