MemoryMOTORMEMONCT04598945
Acquisition and Retention of Motor Memories in Adults and Typically Developing Children
A study testing Functionel MRI in people with Memory, run by University Hospital, Grenoble at 1 site in France.
Trial summary
Our motor skills require motor memories without which our behavior is only reflexes and stereotypies. The way which these memories form in the human brain constitute therefore a major challenge for neuroscience research. Read more about this study
- Who is it for?
- Ages 8 to 40 yearsHealthy volunteers can take part
- Conditions the study is for
- Memory
- What is being tested?
- Functionel MRI
- Type of treatment
- Injection or infusion
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 60 participants
- Where
- 1 siteFrance
- Study dates
- 20 Oct 2020to 1 Nov 2022
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 8 to 40 years
- All sexes
- Healthy volunteers accepted
- Child, Adult
Who may be able to join
- right-handed
- affiliated to a social security scheme
- who gave their consent to participate in the study
Who cannot join
- Contraindication to MRI
- visual impairment;
- suffering from one of the following pathologies:
- dysphasia,
- ADHD,
- dyspraxia,
Show all 14Show fewer
- dyslexia,
- dysorthography,
- dyscalculia;
- history of epilepsy
- subject in period of exclusion from another study,
- subject under administrative or judicial supervision
- pregnant or breastfeeding women
- Persons referred to in articles l1121-8
Trial locations and contacts
1 site in 1 country.
France1 site, 1 recruiting
- Recruiting
CHU Grenoble-Alpes
Grenoble, 38043
Fabien cignetti, fabien.cignetti@univ-grenoble-alpes.fr
Aurélien COURVOISIER
About this study
Official title: Acquisition and Retention of Motor Memories in Adults and Typically Developing Children. IRM f Study
Our motor skills require motor memories without which our behavior is only reflexes and stereotypies. The way which these memories form in the human brain constitute therefore a major challenge for neuroscience research. Some a lot of evidence suggests that any new motor skills is acquired in the cerebellum and then persisted in the cortex. This vision seems however caricature, the formation of memories motor probably requiring complex remodeling of cortico-cerebellar networks. The MotorMemo project aspires to better understand this remodeling, by testing more specifically the hypothesis of cerebellar weakening and strengthening cortical as a substrate for the formation of motor memories. A longitudinal study using a sensorimotor adaptation protocol, fMRI as well as a developmental perspective is proposed to verify this hypothesis.
Read the detailed description
A fundamental human faculty is that of adapting our motor behavior to changing environmental conditions. This faculty is comparable to an apprenticeship adaptive during which the individual updates, on a trial and error basis, the correspondence between sensory inputs and the resulting motor commands. Once updated, these correspondences or internal models allow the individual to produce a behavior precise and reproducible motor. The issue of model acquisition and retention internal movement is therefore central to our understanding of motor control. Relatedly, this question constitutes a gateway to a more comprehensive understanding of the mechanisms of learning and procedural memory.
The MotorMemo project therefore aims to study the formation of internal models of movement in the human brain, with the particularity of being interested in the correlates cerebral processes of acquiring and retaining an internal model of visuomotor transformation in healthy children (8-12 years) and adults.
- Conditions
- Memory
- Being tested
- Functionel MRI
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Functionel MRIOther
During the activation fMRI sequences, the subject will perform target pointing tasks, that is to say that he will have to reach, by controlling a cursor using a non-magnetic joystick, targets projected onto a display screen. In each of the pointing tasks he will have to reach the target as quickly and as precisely as possible, and stay in the center of it for a long time times reached.
| Study group | Role | What they receive |
|---|---|---|
| Adults | Experimental | The subject will be subjected to 2 functional MRI sessions spaced 3 days apart Each session will be composed of the same MRI sequences without injection, namely an anatomical exploration sequence followed by sequences of functional exploration of rest and activation (while the subject performs the task motor). The resting functional exploration sequences will frame (1 before, 1 after) the functional activation sequence. Receives: Other: Functionel MRI |
| Children | Experimental | The subject will be subjected to 2 functional MRI sessions spaced 3 days apart Each session will be composed of the same MRI sequences without injection, namely an anatomical exploration sequence followed by sequences of functional exploration of rest and activation (while the subject performs the task motor). The resting functional exploration sequences will frame (1 before, 1 after) the functional activation sequence. Receives: Other: Functionel MRI |
What is being measured
The primary outcome is the main question the study is designed to answer.
Evaluate, in adults and children, whether the acquisition and retention of a new internal movement pattern are linked to the activation of a large cortico-cerebellar network ladder.
Change in cerebellar activation and cortical induced by the visuomotor adaptation task compared to a task motor control not requiring adaptation
Measured: 3 days
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted22 Oct 2020
- Study start20 Oct 2020
- Primary completion1 Oct 2022 (estimated)
- Study completion1 Nov 2022 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for MemoryStudies of the same condition, open and under way.
- More trials run by University Hospital, GrenobleThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Basic science
- Allocation
- Non-randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Enrolment
- 60 participants (estimated)
Sponsor and investigators
- Lead sponsor
- University Hospital, Grenoble
- Sponsor type
- University, hospital or other
- Collaborators
- TIMC-IMAG
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT04598945
- Sponsor's protocol ID
- 38RC20.005
- Acronym
- MOTORMEMO
- Status last verified
- Nov 2020
- First submitted
- 16 Oct 2020
- Last updated
- 17 Nov 2020
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 17 Nov 2020. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Acquisition and Retention of Motor Memories in Adults and Typically Developing Children. IRM f Study
- ClinicalTrials.gov ID
- NCT04598945
- Acronym / sponsor ID
- MOTORMEMO / 38RC20.005
- Conditions
- Memory
- Study type
- Interventional
- Recruitment status
- Unknown status
- Enrolment
- 60 participants (estimated)
- Lead sponsor
- University Hospital, GrenobleUniversity, hospital or other
- Collaborators
- TIMC-IMAG
- Study start
- 20 Oct 2020 (actual)
- Primary completion
- 1 Oct 2022 (estimated)
- Study completion
- 1 Nov 2022 (estimated)
- First posted
- 22 Oct 2020 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Our motor skills require motor memories without which our behavior is only reflexes and stereotypies. The way which these memories form in the human brain constitute therefore a major challenge for neuroscience research. Some a lot of evidence suggests that any new motor skills is acquired in the cerebellum and then persisted in the cortex. This vision seems however caricature, the formation of memories motor probably requiring complex remodeling of cortico-cerebellar networks. The MotorMemo project aspires to better understand this remodeling, by testing more specifically the hypothesis of cerebellar weakening and strengthening cortical as a substrate for the formation of motor memories. A longitudinal study using a sensorimotor adaptation protocol, fMRI as well as a developmental perspective is proposed to verify this hypothesis.
Detailed description
A fundamental human faculty is that of adapting our motor behavior to changing environmental conditions. This faculty is comparable to an apprenticeship adaptive during which the individual updates, on a trial and error basis, the correspondence between sensory inputs and the resulting motor commands. Once updated, these correspondences or internal models allow the individual to produce a behavior precise and reproducible motor. The issue of model acquisition and retention internal movement is therefore central to our understanding of motor control. Relatedly, this question constitutes a gateway to a more comprehensive understanding of the mechanisms of learning and procedural memory.
The MotorMemo project therefore aims to study the formation of internal models of movement in the human brain, with the particularity of being interested in the correlates cerebral processes of acquiring and retaining an internal model of visuomotor transformation in healthy children (8-12 years) and adults.
Study design
- Primary purpose
- Basic science
- Allocation
- Non-randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Adults | Experimental | Other: Functionel MRIThe subject will be subjected to 2 functional MRI sessions spaced 3 days apart Each session will be composed of the same MRI sequences without injection, namely an anatomical exploration sequence followed by sequences of functional exploration of rest and activation (while the subject performs the task motor). The resting functional exploration sequences will frame (1 before, 1 after) the functional activation sequence. |
| Children | Experimental | Other: Functionel MRIThe subject will be subjected to 2 functional MRI sessions spaced 3 days apart Each session will be composed of the same MRI sequences without injection, namely an anatomical exploration sequence followed by sequences of functional exploration of rest and activation (while the subject performs the task motor). The resting functional exploration sequences will frame (1 before, 1 after) the functional activation sequence. |
Who may qualify
- Ages
- 8 to 40 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Child, Adult
Key inclusion criteria (3 listed)
- right-handed
- affiliated to a social security scheme
- who gave their consent to participate in the study
Key exclusion criteria (14 listed)
- Contraindication to MRI
- visual impairment;
- suffering from one of the following pathologies:
- subject in period of exclusion from another study,
- subject under administrative or judicial supervision
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Functionel MRIDuring the activation fMRI sequences, the subject will perform target pointing tasks, that is to say that he will have to reach, by controlling a cursor using a non-magnetic joystick, targets projected onto a display screen. In each of the pointing tasks he will have to reach the target as quickly and as precisely as possible, and stay in the center of it for a long time times reached. | Other | Adults, Children |
Primary outcome
Evaluate, in adults and children, whether the acquisition and retention of a new internal movement pattern are linked to the activation of a large cortico-cerebellar network ladder.
Time frame: 3 days
Change in cerebellar activation and cortical induced by the visuomotor adaptation task compared to a task motor control not requiring adaptation
Results and safety
Results are not available in the source record.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 17 Nov 2020.
Related trials for Memory
Not yet recruitingPhase 3
Women Who Are Victims of Violence: Treatment of PTSD Through Reactivation of Traumatic Memories Using Propranolol
Post-Traumatic Stress Disorder, PTSD
RecruitingPhase 1
Lm-LLO-TT and Gemcitabine in Unresectable Pancreatic Ductal Adenocarcinoma
Pancreas Cancer, Duct Cell Adenocarcinoma, Pancreatic Cancer
RecruitingObservational study
Studies of Blood Flow to the Brain During Thought
Healthy Volunteer
Not yet recruitingObservational study
Prospective Research on Identification of Dementia in Early Stages (P.R.I.D.E)
Mild Cognitive Impairment, Memory Disorders
Active, not recruitingObservational study
A Study of Attention and Memory Processes in Breast Cancer Survivors
Breast Cancer Survivors
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Functionel MRI in people with Memory, run by University Hospital, Grenoble at 1 site in France.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 14 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: status not confirmed, as of the sponsor's last update on 17 Nov 2020. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in France. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
Results are not available in the source record.
How can a doctor refer a patient or contact the research team?
Contact Fabien CIGNETTI, phD (04 76 63 71 10 ext. 0033, fabien.cignetti@univ-grenoble-alpes.fr), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Evaluate, in adults and children, whether the acquisition and retention of a new internal movement pattern are linked to the activation of a large cortico-cerebellar network ladder. (time frame: 3 days). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 17 Nov 2020.