Palmoplantar PsoriasisPhase 4NCT04622033
Brodalumab in Palmoplantar Psoriasis
A Phase 4 study testing Brodalumab in people with Palmoplantar Psoriasis, run by First OC Dermatology.
Trial summary
This is a Phase 4 single center, single-arm, open-label study that will evaluate the efficacy and safety of brodalumab in psoriasis patients as well as the impact on quality of life in addition to clinical photography. Efficacy will be evaluated by a study treatment assessor. Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Palmoplantar Psoriasis
- What is being tested?
- Brodalumab
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 10 participants
- Where
- No sites listed yet
- Study dates
- 1 Dec 2020to 31 May 2022
- Phase
- Phase 4
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Consent
- Subjects or their legally authorized representative must voluntarily sign and date an informed consent, approved by an independent ethics committee (IEC)/institutional review board (IRB), prior to the initiation of any screening or study-specific procedures.
- Demographic and Laboratory Assessments
- Adult male or female, at least 18 years old.
- Laboratory values meeting the following criteria prior to the first dose of study drug: Serum aspartate transaminase < 3 × upper limit of normal (ULN); Serum alanine transaminase 3 2 × ULN; Serum direct bilirubin ≤ 2.0 mg/dL; except for subjects with isolated elevation of indirect bilirubin relating to a confirmed diagnosis of Gilbert syndrome; Total white blood cell count > 3,000/µL; Absolute neutrophil count > 1,500/µL; Platelet count > 100,000/µL; Hemoglobin > 8 g/dL. (Note: If an exclusionary laboratory result is obtained during the Screening period, one re-test of that particular test is allowed without repeating all other laboratory tests within the 30 day screening window. If the patient has recent laboratory examinations within 3 months, these results can be taken in lieu of screening labs. Subjects who initially do not meet all eligibility criteria for the study may be permitted to repeat the Screening Visit one time following re-consent. )
- Are willing or able to comply with procedures required in this protocol including self-administration of study drug.
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- Disease Activity
- Diagnosis of chronic palmoplantar psoriasis by a board certified dermatologist prior to the baseline visit.
- Subject meets the following disease activity criteria: stable palmoplantar psoriasis who are candidates for systemic or phototherapy.
- Contraception
- For all females of child-bearing potential; a negative urine pregnancy test at the Screening Visit and a negative urine pregnancy test at baseline and following visits (as outlined in the Study Activity Table of this protocol) prior to the first dose of study drug.
- Female subjects must be postmenopausal OR permanently surgically sterile OR for a woman of child bearing potential be practicing at least one protocol-specified method of birth control that is effective from the baseline visit through at least 70 days (10 weeks) after the last dose of study drug
- Female who is not pregnant, breastfeeding, or considering becoming pregnant during the study or for approximately 70 days (10 weeks) after the last dose of study drug.
- Contraception Recommendations:
- Contraception Requirements for Females Subjects must follow the following contraceptive guidelines as specified: Females, Non-Childbearing Potential Females do not need to use birth control during or following study drug treatment if considered of non-childbearing potential due to meeting any of the following criteria:
- Postmenopausal, age > 55 years with no menses for 12 or more months without an alternative medical cause
- Postmenopausal, age ≤ 55 years with no menses for 12 or more months without an alternative medical cause AND a follicule-stimulating hormone (FSH) level > 40 IU/L
- Permanently surgically sterile (bilateral oophorectomy, bilateral salpingectomy, or hysterectomy)
- Females who have not experienced menarche (at least one menstrual period)
- Females of Childbearing Potential
- Females of childbearing potential must avoid pregnancy while taking study drug(s) and for at least 70 days after the last dose of study drug. Females must commit to one of the following methods of birth control:
- Combined (estrogen and progestogen containing) hormonal birth control (oral, intravaginal, transdermal, injectable) associated with inhibition of ovulation initiated at least 1 month prior to study Baseline (Study Day 1)
- Progestogen-only hormonal birth control (oral, injectable, implantable) associated with inhibition of ovulation initiated at least 1 month prior to study Baseline (Study Day 1)
- Bilateral tubal occlusion/ligation (can be via hysteroscopy, provided a hysterosalpingogram confirms success of the procedure)
- Intrauterine device (IUD)
- Intrauterine hormone-releasing system (IUS)
- Vasectomized sexual partner(s) (the vasectomized partner[s] has received medical assessment of the surgical success and is the sole sexual partner of the study subject).
- True abstinence: Refraining from heterosexual intercourse when this is in line with the preferred and usual lifestyle of the subject.
- Periodic abstinence [e.g., calendar, ovulation, symptothermal, post-ovulation methods] and withdrawal are not acceptable.
- If required per local guidelines, male or female condom with or without spermicides OR cap, diaphragm or sponge with spermicides should be used in addition to one of the birth control methods listed above (excluding true abstinence). Contraception recommendations related to use of concomitant therapies prescribed per standard of care should be based on the local label.
Who cannot join
- Subject History
- No history of: Erythrodermic psoriasis, generalized or localized pustular psoriasis, medication-induced or medication-exacerbated psoriasis, or new onset guttate psoriasis; Active skin disease other than psoriasis that could interfere with the assessment of psoriasis; Chronic infections including human immunodeficiency virus, viral hepatitis (hepatitis B, hepatitis C), and/ or active TB. Subjects with a positive QuantiFERON®-TB /purified protein derivative (tuberculin) test result may participate in the study if further work up (according to local practice/guidelines) establishes conclusively that the subject has no evidence of active TB. If presence of latent TB is established, subjects are not required to be treated with prophylactic anti-TB therapy prior to or during the study, if the subject is considered low risk for reactivation per investigator judgment. Active systemic infection during the last 2 weeks prior to baseline visit (exception: common cold), as assessed by the investigator.
- No history of any documented active or suspected malignancy or history of any malignancy within the last 5 years except for successfully treated non-melanoma skin cancer or localized carcinoma in situ of the cervix.
- No history of clinically significant (per investigator's judgment) drug or alcohol abuse within the last 6 months.
- No history of underlying medical diseases or problems including but not limited to the following: Subject has been a previous recipient of a solid organ transplant; Evidence of a current or previous disease, medical condition (including chronic alcohol or drug abuse) other than psoriasis, surgical procedure (i.e., organ transplant), medical examination finding (including vital signs and electrocardiogram), or laboratory value at the screening visit outside the given range that, in the opinion of the investigator, is clinically significant and would make the study participant unreliable to adhere to the protocol or to complete the trial, compromise the safety of the patient, or compromise the quality of the data
- No history of an allergic reaction or significant sensitivity to constituents of the study drug (and its excipients) and/or other products in the same class.
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- No major surgery performed within 8 weeks prior to randomization or planned to be performed during the conduct of the trial (e.g., hip replacement, aneurysm removal, stomach ligation) as assessed by the Investigator.
- Concomitant Medications
- No previous exposure to brodalumab.
- No use of any restricted medication as specified in the prohibited medications/therapy section or any drug considered likely to interfere with the safe conduct of the study.
- Subject must not have been treated with any investigational drug within 30 days or 5 half-lives of the drug (whichever is longer) prior to the first dose of study drug or is currently enrolled in another clinical study.
- Prohibited Medications and Therapy
- Prohibited medications and therapy are defined as using the following prohibited concomitant psoriasis treatments within the specified timeframe prior to Baseline Visit and throughout the study.
- Any systemic biologic to treat psoriasis: Adalimumab, infliximab or biosimilar versions within 12weeks; Etanercept or biosimilar versions within 6 weeks; Ixekizumab, secukinumab, or other IL-17 inhibitors within 16 weeks; Ustekinumab, efalizumab, guselkumab, tildrakizumab, mirikizumab, risankizumab or other IL-23 inhibitors within 24 weeks.
- Systemic non-biologic therapy for psoriasis, including but not limited to cyclosporine, corticosteroids, methotrexate, oral retinoids, apremilast, and fumaric acid derivatives within 4 weeks.
- Phototherapy treatment, laser therapy, tanning booth, or extended sun exposure that could affect disease severity or interfere with disease assessments within 4 weeks.
- Topical psoriasis treatments, including but not limited to corticosteroids, anthralin, calcipotriene, topical vitamin D derivatives, retinoids, urea, alpha-or beta-hydroxyl acids, and medicated shampoos (for example those that contain > 3% salicylic acid, corticosteroids, coal tar or vitamin D3 analogues) within 2 weeks. Exception: Subjects are allowed to use bland (containing no psoriasis treatment) emollients and shampoos and/or low potency topical corticosteroids (US Class 6 -7) on the palms, soles, face, infra-mammary area, and groin only.
- Treatment with an experimental non-biologic for psoriasis within 4 weeks or five half-lives of the drug (whichever is longer).
- Treatment with an experimental biologic for psoriasis within 12 weeks or five half-lives of the drug (whichever is longer).
- Receipt of any live vaccine within 6 weeks or is expected to need live vaccination during study participation, including at least 20 weeks after the last dose of study drug.
- Live or attenuated vaccines are NOT allowed during the study and for 70 days after the last dose of study drug. Examples of such vaccines include but are not limited to the following: Live attenuated influenza, Herpes zoster (i.e., Zostavax®), Rotavirus, Varicella (chicken pox), Measles-mumps-rubella (MMR) or measles mumps rubella varicella (MMRV), Oral polio vaccine (OPV), Smallpox, Yellow fever, Bacille Calmette-Guérin (BCG), Oral typhoid.
- Vaccines that are inactivated, toxoid, or biosynthetic may be administered at any time without restrictions. Examples of common vaccines that meet these criteria include but are not limited to: injectable influenza vaccine, pneumococcal, pertussis (Tdap), and Shingrix®.
Trial locations and contacts
No sites are listed yet.
About this study
Official title: Palmoplantar Psoriasis: Evaluating Efficacy and Clinical Photography With Brodalumab in Palmoplantar Psoriasis
This is a Phase 4 single center, single-arm, open-label study that will evaluate the efficacy and safety of brodalumab in psoriasis patients as well as the impact on quality of life in addition to clinical photography. Efficacy will be evaluated by a study treatment assessor. The study includes a 30-day screening period with study visits at Week 0, 2, 4, 8, 12, 16, and 24. Study drug dosing will consist of patients self-injecting according to on-label FDA approved dosing of brodalumab 210mg at week 0, 1, 2 and then every 2 weeks thereafter for moderate to severe psoriasis patients after adequate injection training is given at study center site. Subjects will be instructed at Week 0 (pre-injection) by the site staff on how to self-inject via the dosing syringe. Study drug will be dispensed through the delineated REMS approved pharmacy. Baseline assessment will be performed at week 0 and efficacy assessments will be performed at week 4, 8, 12, 16 and 24, then every 2 weeks thereafter for palmoplantar psoriasis using approved dosing schedule for moderate to severe psoriasis. Patients will self inject after adequate injection training is given at the study center site.
- Conditions
- Palmoplantar Psoriasis
- Being tested
- Brodalumab
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
BrodalumabBiological
brodalumab 210mg at week 0, 1, 2 and then every 2 weeks up to 24 weeks.
| Study group | Role | What they receive |
|---|---|---|
| Brodalumab 210mg | Experimental | Not described Receives: Biological: Brodalumab |
What is being measured
The primary outcome is the main question the study is designed to answer.
Mean change in PASI from baseline to week 24 and the endpoint of subjects achieving palmoplantarIGA of clear (0) or almost clear (1). Lower scores are better.
Mean change in PASI from baseline to week 24 and the endpoint of subjects achieving palmoplantarIGA of clear (0) or almost clear (1). Lower scores are better.
Measured: 24 weeks
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted9 Nov 2020
- Study start1 Dec 2020 (estimated)
- Primary completion30 Nov 2021 (estimated)
- Study completion31 May 2022 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Palmoplantar PsoriasisStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase 4
- Primary purpose
- Treatment
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Enrolment
- 10 participants (estimated)
Sponsor and investigators
- Lead sponsor
- First OC Dermatology
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT04622033
- Sponsor's protocol ID
- SILIQIISOD1
- Status last verified
- Nov 2020
- First submitted
- 4 Nov 2020
- Last updated
- 16 Nov 2020
- Results posted
- No
- FDA-regulated drug
- Yes
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 16 Nov 2020. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Palmoplantar Psoriasis: Evaluating Efficacy and Clinical Photography With Brodalumab in Palmoplantar Psoriasis
- ClinicalTrials.gov ID
- NCT04622033
- Acronym / sponsor ID
- SILIQIISOD1
- Conditions
- Palmoplantar Psoriasis
- Phase
- Phase 4
- Study type
- Interventional
- Recruitment status
- Unknown status
- Enrolment
- 10 participants (estimated)
- Lead sponsor
- First OC DermatologyUniversity, hospital or other
- Study start
- 1 Dec 2020 (estimated)
- Primary completion
- 30 Nov 2021 (estimated)
- Study completion
- 31 May 2022 (estimated)
- First posted
- 9 Nov 2020 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This is a Phase 4 single center, single-arm, open-label study that will evaluate the efficacy and safety of brodalumab in psoriasis patients as well as the impact on quality of life in addition to clinical photography. Efficacy will be evaluated by a study treatment assessor. The study includes a 30-day screening period with study visits at Week 0, 2, 4, 8, 12, 16, and 24. Study drug dosing will consist of patients self-injecting according to on-label FDA approved dosing of brodalumab 210mg at week 0, 1, 2 and then every 2 weeks thereafter for moderate to severe psoriasis patients after adequate injection training is given at study center site. Subjects will be instructed at Week 0 (pre-injection) by the site staff on how to self-inject via the dosing syringe. Study drug will be dispensed through the delineated REMS approved pharmacy. Baseline assessment will be performed at week 0 and efficacy assessments will be performed at week 4, 8, 12, 16 and 24, then every 2 weeks thereafter for palmoplantar psoriasis using approved dosing schedule for moderate to severe psoriasis. Patients will self inject after adequate injection training is given at the study center site.
Study design
- Primary purpose
- Treatment
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| Brodalumab 210mg | Experimental | Biological: Brodalumab |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (30 listed)
- Consent
- Subjects or their legally authorized representative must voluntarily sign and date an informed consent, approved by an independent ethics committee (IEC)/institutional review board (IRB), prior to the initiation of any screening or study-specific procedures.
- Demographic and Laboratory Assessments
- Adult male or female, at least 18 years old.
- Laboratory values meeting the following criteria prior to the first dose of study drug: Serum aspartate transaminase < 3 × upper limit of normal (ULN); Serum alanine transaminase 3 2 × ULN; Serum direct bilirubin ≤ 2.0 mg/dL; except for subjects with isolated elevation of indirect bilirubin relating to a confirmed diagnosis of Gilbert syndrome; Total white blood cell count > 3,000/µL; Absolute neutrophil count > 1,500/µL; Platelet count > 100,000/µL; Hemoglobin > 8 g/dL. (Note: If an exclusionary laboratory result is obtained during the Screening period, one re-test of that particular test is allowed without repeating all other laboratory tests within the 30 day screening window. If the patient has recent laboratory examinations within 3 months, these results can be taken in lieu of screening labs. Subjects who initially do not meet all eligibility criteria for the study may be permitted to repeat the Screening Visit one time following re-consent. )
Key exclusion criteria (22 listed)
- Subject History
- No history of: Erythrodermic psoriasis, generalized or localized pustular psoriasis, medication-induced or medication-exacerbated psoriasis, or new onset guttate psoriasis; Active skin disease other than psoriasis that could interfere with the assessment of psoriasis; Chronic infections including human immunodeficiency virus, viral hepatitis (hepatitis B, hepatitis C), and/ or active TB. Subjects with a positive QuantiFERON®-TB /purified protein derivative (tuberculin) test result may participate in the study if further work up (according to local practice/guidelines) establishes conclusively that the subject has no evidence of active TB. If presence of latent TB is established, subjects are not required to be treated with prophylactic anti-TB therapy prior to or during the study, if the subject is considered low risk for reactivation per investigator judgment. Active systemic infection during the last 2 weeks prior to baseline visit (exception: common cold), as assessed by the investigator.
- No history of any documented active or suspected malignancy or history of any malignancy within the last 5 years except for successfully treated non-melanoma skin cancer or localized carcinoma in situ of the cervix.
- No history of clinically significant (per investigator's judgment) drug or alcohol abuse within the last 6 months.
- No history of underlying medical diseases or problems including but not limited to the following: Subject has been a previous recipient of a solid organ transplant; Evidence of a current or previous disease, medical condition (including chronic alcohol or drug abuse) other than psoriasis, surgical procedure (i.e., organ transplant), medical examination finding (including vital signs and electrocardiogram), or laboratory value at the screening visit outside the given range that, in the opinion of the investigator, is clinically significant and would make the study participant unreliable to adhere to the protocol or to complete the trial, compromise the safety of the patient, or compromise the quality of the data
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Brodalumabbrodalumab 210mg at week 0, 1, 2 and then every 2 weeks up to 24 weeks. | Biological | Brodalumab 210mg |
Primary outcome
Mean change in PASI from baseline to week 24 and the endpoint of subjects achieving palmoplantarIGA of clear (0) or almost clear (1). Lower scores are better.
Time frame: 24 weeks
Mean change in PASI from baseline to week 24 and the endpoint of subjects achieving palmoplantarIGA of clear (0) or almost clear (1). Lower scores are better.
Results and safety
Results are not available in the source record.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 16 Nov 2020.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Questions about this trial
What is this clinical trial studying?
A Phase 4 study testing Brodalumab in people with Palmoplantar Psoriasis, run by First OC Dermatology.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 30 inclusion and 22 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: status not confirmed, as of the sponsor's last update on 16 Nov 2020. Status can change between updates, so confirm with the study contact before making plans.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
What does this phase mean?
Phase 4 studies take place after a treatment is approved, to learn more about its long-term benefits and risks in everyday use.
Not every study follows the same path, and some studies (observational studies, device studies) have no phase.
Are results available for this study?
Results are not available in the source record.
How can a doctor refer a patient or contact the research team?
Contact Bao Bui, MD (7145312966, baobui.derm@gmail.com), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Mean change in PASI from baseline to week 24 and the endpoint of subjects achieving palmoplantarIGA of clear (0) or almost clear (1). Lower scores are better. (time frame: 24 weeks). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 16 Nov 2020.