Aphasia, AcquiredNCT04623125
Spaced Retrieval as Treatment for Aphasia
A study testing Spaced Retrieval Practice in people with Aphasia, Acquired and Aphasia Primary Progressive, run by Rotman Research Institute at Baycrest at 1 site in Canada.
Trial summary
Spaced Repetition training has been found to be more effective than massed repetition for individuals with aphasia. This study seeks to examine the relative efficiency of three kinds of spacing for picture-naming training: traditional random presentation, non-adaptive spaced repetition, and adaptive spaced repetition. Read more about this study
- Who is it for?
- Any age
- Conditions the study is for
- Aphasia, Acquired, Aphasia Primary Progressive
- What is being tested?
- Spaced Retrieval Practice
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 21 participants
- Where
- 1 siteCanada
- Study dates
- 1 Oct 2020to 1 Jan 2022
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages Any age
- All sexes
- No healthy volunteers
- Child, Adult, Older adult
Who may be able to join
- presence of a post-stroke word finding deficit (i.e. aphasia), or primary progressive aphasia.
- ability to evaluate the correctness of one's own responses when subsequently provided the with the correct answer
Who cannot join
- diagnosis of a neurological disorder other than post-stroke or primary progressive aphasia
- inability to evaluate the correctness of ones responses when subsequently provided with the correct answer
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Spaced Retrieval as Treatment for Aphasia: Does Adaptive Spacing Enhance Picture Naming Performance?
Spaced Repetition training has been found to be more effective than massed repetition for individuals with aphasia. This study seeks to examine the relative efficiency of three kinds of spacing for picture-naming training: traditional random presentation, non-adaptive spaced repetition, and adaptive spaced repetition.
Read the detailed description
Participants undergo a screening evaluation including the Quick Aphasia Battery (administered via teleconferencing software), and a preliminary picture naming test of approximately 300 pictures, used to select individual items for treatment. Participants then undertake online picture naming training for 30 minutes a day, over two weeks. Pictures are repeated according to three different schedules to be compared: random presentation, non-adaptive spaced repetition, and adaptive spaced repetition. We compare the number of pictures successfully learned and the verbal reaction time for the pictures assigned to the three conditions.
- Conditions
- Aphasia, Acquired, Aphasia Primary Progressive
- Being tested
- Spaced Retrieval Practice
- Keywords
- Adaptive Spaced-Retrieval, Aphasia, Anomia, Anki
- Medical subject headings
- Aphasia, Pick Disease of the Brain, Anomia
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Spaced Retrieval PracticeBehavioural
Online picture-naming training with 60 words which the participant experiences word-retrieval difficulties. Cards are shuffled arranged by the computerized training program.
| Study group | Role | What they receive |
|---|---|---|
| Spaced Repetition | Experimental | Two weeks (10 sessions) of online picture-naming training with 60 words. Receives: Behavioral: Spaced Retrieval Practice |
What is being measured
The primary outcome is the main question the study is designed to answer.
Change in Picture Naming performance across conditions
Word retention assessed after treatment
Measured: Change from baseline to post-intervention immediately after two weeks of daily sessions, and one month followup.
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted10 Nov 2020
- Study start1 Oct 2020
- Primary completion1 Jan 2022
- Study completion1 Jan 2022
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Aphasia, AcquiredStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Enrolment
- 21 participants (actual)
Sponsor and investigators
- Lead sponsor
- Rotman Research Institute at Baycrest
- Sponsor type
- University, hospital or other
- Collaborators
- Heart and Stroke Foundation of Canada
- Responsible party
- Principal investigator, Jed A. Meltzer, Ph.D, Rotman Research Institute at Baycrest
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT04623125
- Sponsor's protocol ID
- 16-43s
- Status last verified
- Mar 2023
- First submitted
- 29 Oct 2020
- Last updated
- 29 Mar 2023
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 29 Mar 2023. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Spaced Retrieval as Treatment for Aphasia: Does Adaptive Spacing Enhance Picture Naming Performance?
- ClinicalTrials.gov ID
- NCT04623125
- Acronym / sponsor ID
- 16-43s
- Conditions
- Aphasia, Acquired, Aphasia Primary Progressive
- Keywords
- Adaptive Spaced-Retrieval, Aphasia, Anomia, Anki
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 21 participants (actual)
- Lead sponsor
- Rotman Research Institute at BaycrestUniversity, hospital or other
- Collaborators
- Heart and Stroke Foundation of Canada
- Study start
- 1 Oct 2020 (actual)
- Primary completion
- 1 Jan 2022 (actual)
- Study completion
- 1 Jan 2022 (actual)
- First posted
- 10 Nov 2020 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Spaced Repetition training has been found to be more effective than massed repetition for individuals with aphasia. This study seeks to examine the relative efficiency of three kinds of spacing for picture-naming training: traditional random presentation, non-adaptive spaced repetition, and adaptive spaced repetition.
Detailed description
Participants undergo a screening evaluation including the Quick Aphasia Battery (administered via teleconferencing software), and a preliminary picture naming test of approximately 300 pictures, used to select individual items for treatment. Participants then undertake online picture naming training for 30 minutes a day, over two weeks. Pictures are repeated according to three different schedules to be compared: random presentation, non-adaptive spaced repetition, and adaptive spaced repetition. We compare the number of pictures successfully learned and the verbal reaction time for the pictures assigned to the three conditions.
Study design
- Primary purpose
- Treatment
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| Spaced Repetition | Experimental | Behavioral: Spaced Retrieval PracticeTwo weeks (10 sessions) of online picture-naming training with 60 words. |
Who may qualify
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Child, Adult, Older adult
Key inclusion criteria (2 listed)
- presence of a post-stroke word finding deficit (i.e. aphasia), or primary progressive aphasia.
- ability to evaluate the correctness of one's own responses when subsequently provided the with the correct answer
Key exclusion criteria (2 listed)
- diagnosis of a neurological disorder other than post-stroke or primary progressive aphasia
- inability to evaluate the correctness of ones responses when subsequently provided with the correct answer
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Spaced Retrieval PracticeOnline picture-naming training with 60 words which the participant experiences word-retrieval difficulties. Cards are shuffled arranged by the computerized training program. | Behavioural | Spaced Repetition |
Primary outcome
Change in Picture Naming performance across conditions
Time frame: Change from baseline to post-intervention immediately after two weeks of daily sessions, and one month followup.
Word retention assessed after treatment
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 29 Mar 2023.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Spaced Retrieval Practice in people with Aphasia, Acquired and Aphasia Primary Progressive, run by Rotman Research Institute at Baycrest at 1 site in Canada.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 2 inclusion and 2 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 29 Mar 2023. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Canada. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Change in Picture Naming performance across conditions (time frame: Change from baseline to post-intervention immediately after two weeks of daily sessions, and one month followup.). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 29 Mar 2023.