Ischemic StrokeNCT04637074
A Cohort Study on Thrombectomy for Stroke
An observational study of Ischemic Stroke, run by Ning Wang, MD., PhD. at 1 site in China.
Trial summary
The cerebral collateral circulation refers to the subsidiary network of vascular channels that stabilize cerebral blood flow when principal conduits fail. Collateral status differs among patients with acute ischemic stroke. Read more about this study
- Who is it for?
- Ages 18 to 85 years
- Conditions the study is for
- Ischemic Stroke
- How many people
- 300 participants
- Where
- 1 siteChina
- Study dates
- 15 Nov 2020to 30 Dec 2025
- Phase
- Observational
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 85 years
- All sexes
- No healthy volunteers
- Adult, Older adult
Study population: Patients experiencing brain infarction complicating the large-vessel occlusion
Who may be able to join
- Age ≥ 18 years.
- Mechanical thrombectomy initiated within 24 hours after onset
- CT perfusion can be performed before the initiation of thrombectomy and 24h after thrombectomy
Who cannot join
- Contraindication to imaging with contrast agents
- Delay between imaging and beginning of thrombectomy > 90 minutes
Trial locations and contacts
1 site in 1 country.
China1 site, 1 recruiting
- Recruiting
Department of Neurology, First Affiliated Hospital of Fujian Medical University
Fuzhou, 350000
Ying M Fu, MD, +8613920263688, fuying@fjmu.eu.cn
About this study
Official title: Registrated Cohort Study on Thrombectomy for Stroke
The cerebral collateral circulation refers to the subsidiary network of vascular channels that stabilize cerebral blood flow when principal conduits fail. Collateral status differs among patients with acute ischemic stroke. Relatively sparse attention has been devoted to the role of baseline collateral circulation in patients with acute ischemic stroke who are candidates for revascularization. This study aim to investigate the correlation between baseline collateral circulation and the likelihood of opening of an arterial occlusion, the extent of reperfusion, tissue injury and clinical impairment.
- Conditions
- Ischemic Stroke
- Medical subject headings
- Ischemic Stroke
What is being measured
The primary outcome is the main question the study is designed to answer.
Modified Rankin Scale
Good functional outcome will be defined by a Modified Rankin Scale of 0-2, 3 months after stroke onset
Measured: 3 month
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted19 Nov 2020
- Study start15 Nov 2020
- Primary completion30 Dec 2025 (estimated)
- Study completion30 Dec 2025 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for Ischemic StrokeStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Prospective
- Enrolment
- 300 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Ning Wang, MD., PhD.
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor-investigator, Ning Wang, MD., PhD., First Affiliated Hospital of Fujian Medical University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT04637074
- Sponsor's protocol ID
- MRCTA, ECFAH of FMU [2020]389
- Status last verified
- Nov 2021
- First submitted
- 15 Nov 2020
- Last updated
- 29 Dec 2021
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Publications
Du X, Yu X, Wang M, Fu Y, Lin K, Wu J, Lin Q, Zhao W, Lin Y. Intracranial Mitochondrial Microparticles Promote Cerebral Edema via Endothelial Injury in Stroke. Transl Stroke Res. 2026 Jul 21;17(4):83. doi: 10.1007/s12975-026-01480-3.
PubMed 42479125
Study at a glance
From the registry record, last updated by the sponsor on 29 Dec 2021. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Registrated Cohort Study on Thrombectomy for Stroke
- ClinicalTrials.gov ID
- NCT04637074
- Acronym / sponsor ID
- MRCTA, ECFAH of FMU [2020]389
- Conditions
- Ischemic Stroke
- Study type
- Observational
- Recruitment status
- Unknown status
- Enrolment
- 300 participants (estimated)
- Lead sponsor
- Ning Wang, MD., PhD.University, hospital or other
- Study start
- 15 Nov 2020 (actual)
- Primary completion
- 30 Dec 2025 (estimated)
- Study completion
- 30 Dec 2025 (estimated)
- First posted
- 19 Nov 2020 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The cerebral collateral circulation refers to the subsidiary network of vascular channels that stabilize cerebral blood flow when principal conduits fail. Collateral status differs among patients with acute ischemic stroke. Relatively sparse attention has been devoted to the role of baseline collateral circulation in patients with acute ischemic stroke who are candidates for revascularization. This study aim to investigate the correlation between baseline collateral circulation and the likelihood of opening of an arterial occlusion, the extent of reperfusion, tissue injury and clinical impairment.
Study design
- Observational model
- Cohort
- Time perspective
- Prospective
Who may qualify
- Ages
- 18 to 85 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
- Study population
- Patients experiencing brain infarction complicating the large-vessel occlusion
Key inclusion criteria (3 listed)
- Age ≥ 18 years.
- Mechanical thrombectomy initiated within 24 hours after onset
- CT perfusion can be performed before the initiation of thrombectomy and 24h after thrombectomy
Key exclusion criteria (2 listed)
- Contraindication to imaging with contrast agents
- Delay between imaging and beginning of thrombectomy > 90 minutes
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Primary outcome
Modified Rankin Scale
Time frame: 3 month
Good functional outcome will be defined by a Modified Rankin Scale of 0-2, 3 months after stroke onset
Results and safety
Results are not available in the source record.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 29 Dec 2021.
- Derived from this study: PubMed 42479125Du X, Yu X, Wang M, Fu Y, Lin K, Wu J, Lin Q, Zhao W, Lin Y. Intracranial Mitochondrial Microparticles Promote Cerebral Edema via Endothelial Injury in Stroke. Transl Stroke Res. 2026 Jul 21;17(4):83. doi: 10.1007/s12975-026-01480-3.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Ischemic Stroke, run by Ning Wang, MD., PhD. at 1 site in China.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 2 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: status not confirmed, as of the sponsor's last update on 29 Dec 2021. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in China. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
Results are not available in the source record.
How can a doctor refer a patient or contact the research team?
Contact Ying M Fu, MD (+8613920263688, fuying@fjmu.eu.cn), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Modified Rankin Scale (time frame: 3 month). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT04637074, which also lists 1 linked publication.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 29 Dec 2021.