Suicide, AttemptedTAPASNCT04638205
The Life Paths That Lead Teenagers to Attempted Suicide:Trajectories of Proximal Adversity
An observational study of Suicide, Attempted, run by University Hospital, Lille at 1 site in France.
Trial summary
Suicidal behaviors seriously alter the vital and functional prognosis of adolescents. Although the literature has lighted out a considerable number of risk factors for suicide attempts in youth, theoretical models - among which bio-psycho-social models - still lack empirical evidence. Read more about this study
- Who is it for?
- Ages 15 to 24 years
- Conditions the study is for
- Suicide, Attempted
- How many people
- 39 participants
- Where
- 1 siteFrance
- Study dates
- 1 Nov 2019to 31 Dec 2022
- Phase
- Observational
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 15 to 24 years
- All sexes
- No healthy volunteers
- Child, Adult
Study population: Patient recruitment will be supported by the VigilanS program. VigilanS is a suicide recurrence prevention device implemented in all establishments in the Hauts-de-France region that receive patients who have attempted suicide (www.dispositifvigilans.org).
Who may be able to join
- Youth aged 15-24 inclusive
- Who stayed at the hospital or in the emergency room for less than 15 days after a first suicide attempt
- Who were discharged less than 15 days ago
- Who gave their informed consent for majors, or whose parents gave their informed consent for minors Inclusion criteria for controls
- Youth aged 15-24 inclusive
- Who have never experienced any suicidal ideation or suicide attempt
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- Who gave their informed consent for majors, or whose parents gave their informed consent for minors Inclusion criteria for informants
- Close relatives of the participant
- Who are major
- Who lived in the same household as the participant or have interacted with him/her for more than half the weeks of the year preceding the index suicide attempt
Who cannot join
- No consent or consent withdrawal for majors and/or their parents for minors
- Neurological or psychiatric condition altering the capacity to understand
Trial locations and contacts
1 site in 1 country.
About this study
Official title: The Life Paths That Lead Teenagers to Attempted Suicide: Trajectories of Proximal Adversity
Suicidal behaviors seriously alter the vital and functional prognosis of adolescents. Although the literature has lighted out a considerable number of risk factors for suicide attempts in youth, theoretical models - among which bio-psycho-social models - still lack empirical evidence. More specifically, the way adverse life events dynamically interact together and with the individual's diathesis to precipitate suicidal attempts remains unclear. Studies of life trajectories have opened an alternative approach to traditional linear epidemiological analysis to capture such a complex process. To date, adverse trajectories approaches never have been applied to the period immediately preceding the occurrence of the suicidal gesture (proximal adverse trajectories).
- Conditions
- Suicide, Attempted
- Keywords
- Suicide attempt, adolescence, adverse life event, developmental model, trajectories
- Medical subject headings
- Suicide, Attempted
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
| Study group | Role | What they receive |
|---|---|---|
| Suicide attempt cases | Adolescents and young adults who attempted suicide between 7 and 30 days prior the inclusion | |
| Non-suicidal controls | Adolescents and young adults without history of suicide attempt or ideation |
What is being measured
The primary outcome is the main question the study is designed to answer.
Growth parameters of the patterns of proximal adverse trajectories in adolescents who attempted suicide, as compared to non-suicidal adolescents
We will build growth mixture models to account for the 1-year longitudinal evolution of the Burden of Adversity values. Each group will be characterized by the parameters (intercepts and slopes) of the best-fitting model.
We will the compare the parameters of the 2 groups to search for statistical differences
Measured: 1 year
Secondary outcomes (3)
Statistical tests comparing the sociodemographic, vulnerabily and psychopathological indicators between the sub-group of adolescents identified from the mixture model.
Growth mixture models will allow for identifying sub-groups of individuals who are similar as regards to their burden of adversity trajectories. We will compare the characteristics of theses subgroups
Measured: 1 year
Growth parameters of the patterns of evolution of psychological pain
Parallel to the burden of adversity growth models, we will build, for each group, growth models to predict the longitudinal evolution of psychological pain.
We will then test whether the growth parameters of the ideation/pain trajectories correlate with those of the adversity trajectories
Measured: 1 year
Growth parameters of the patterns of evolution of suicidal ideation intensity
Parallel to the burden of adversity growth models, we will build, for each group, growth models to predict the longitudinal evolution of the severity of the suicidal ideations.
We will then test whether the growth parameters of the ideation/pain trajectories correlate with those of the adversity trajectories
Measured: 1 year
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted20 Nov 2020
- Study start1 Nov 2019
- Primary completion31 Dec 2022
- Study completion31 Dec 2022
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Suicide, AttemptedStudies of the same condition, open and under way.
- More trials run by University Hospital, LilleThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Case-control
- Time perspective
- Retrospective
- Enrolment
- 39 participants (actual)
Sponsor and investigators
- Lead sponsor
- University Hospital, Lille
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
- Investigators
- Charles-Edouard Notredame, MD, Principal investigator, University Hospital, Lille
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT04638205
- Sponsor's protocol ID
- 2018_20
- Other IDs
- 2018-A03065-50
- Acronym
- TAPAS
- Status last verified
- Dec 2025
- First submitted
- 9 Jul 2020
- Last updated
- 26 Dec 2025
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 26 Dec 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- The Life Paths That Lead Teenagers to Attempted Suicide: Trajectories of Proximal Adversity
- ClinicalTrials.gov ID
- NCT04638205
- Acronym / sponsor ID
- TAPAS / 2018_20
- Conditions
- Suicide, Attempted
- Keywords
- Suicide attempt, adolescence, adverse life event, developmental model, trajectories
- Study type
- Observational
- Recruitment status
- Completed
- Enrolment
- 39 participants (actual)
- Lead sponsor
- University Hospital, LilleUniversity, hospital or other
- Study start
- 1 Nov 2019 (actual)
- Primary completion
- 31 Dec 2022 (actual)
- Study completion
- 31 Dec 2022 (actual)
- First posted
- 20 Nov 2020 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Suicidal behaviors seriously alter the vital and functional prognosis of adolescents. Although the literature has lighted out a considerable number of risk factors for suicide attempts in youth, theoretical models - among which bio-psycho-social models - still lack empirical evidence. More specifically, the way adverse life events dynamically interact together and with the individual's diathesis to precipitate suicidal attempts remains unclear. Studies of life trajectories have opened an alternative approach to traditional linear epidemiological analysis to capture such a complex process. To date, adverse trajectories approaches never have been applied to the period immediately preceding the occurrence of the suicidal gesture (proximal adverse trajectories).
Study design
- Observational model
- Case-control
- Time perspective
- Retrospective
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Suicide attempt cases | – | –Adolescents and young adults who attempted suicide between 7 and 30 days prior the inclusion |
| Non-suicidal controls | – | –Adolescents and young adults without history of suicide attempt or ideation |
Who may qualify
- Ages
- 15 to 24 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Child, Adult
- Study population
- Patient recruitment will be supported by the VigilanS program. VigilanS is a suicide recurrence prevention device implemented in all establishments in the Hauts-de-France region that receive patients who have attempted suicide (www.dispositifvigilans.org).
Key inclusion criteria (10 listed)
- Youth aged 15-24 inclusive
- Who stayed at the hospital or in the emergency room for less than 15 days after a first suicide attempt
- Who were discharged less than 15 days ago
- Who gave their informed consent for majors, or whose parents gave their informed consent for minors Inclusion criteria for controls
- Youth aged 15-24 inclusive
Key exclusion criteria (2 listed)
- No consent or consent withdrawal for majors and/or their parents for minors
- Neurological or psychiatric condition altering the capacity to understand
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Primary outcome
Growth parameters of the patterns of proximal adverse trajectories in adolescents who attempted suicide, as compared to non-suicidal adolescents
Time frame: 1 year
We will build growth mixture models to account for the 1-year longitudinal evolution of the Burden of Adversity values. Each group will be characterized by the parameters (intercepts and slopes) of the best-fitting model. We will the compare the parameters of the 2 groups to search for statistical differences
3 secondary outcomes
Statistical tests comparing the sociodemographic, vulnerabily and psychopathological indicators between the sub-group of adolescents identified from the mixture model.
Time frame: 1 year
Growth parameters of the patterns of evolution of psychological pain
Time frame: 1 year
Growth parameters of the patterns of evolution of suicidal ideation intensity
Time frame: 1 year
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 26 Dec 2025.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Charles-Edouard Notredame, MD principal investigator
University Hospital, Lille
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Suicide, Attempted, run by University Hospital, Lille at 1 site in France.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 10 inclusion and 2 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 26 Dec 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in France. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Growth parameters of the patterns of proximal adverse trajectories in adolescents who attempted suicide, as compared to non-suicidal adolescents (time frame: 1 year). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 26 Dec 2025.