Cardiovascular FitnessNCT04656509
Effects of Short Duration High-intensity Interval Training on Peak Oxygen Consumption
A study testing 4-s sprint inertial load training in people with Cardiovascular Fitness, run by University of Texas at Austin at 1 site in United States.
Trial summary
High-intensity interval training (HIIT) is an effective tool to improve cardiovascular fitness and maximal anaerobic power. Different methods of HIIT have been studied but the effect of a maximal effort cycling and very short exercise time (i.e., 4-s) with short recovery time (15-30 s) and a high number of repetitions… Read more about this study
- Who is it for?
- Ages 18 to 49 yearsHealthy volunteers can take part
- Conditions the study is for
- Cardiovascular Fitness
- What is being tested?
- 4-s sprint inertial load training
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 11 participants
- Where
- 1 siteUnited States
- Study dates
- 1 Apr 2019to 24 Apr 2020
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 49 years
- All sexes
- Healthy volunteers accepted
- Adult
Who may be able to join
- Young (18-30), Healthy, Recreationally active, but untrained (not meeting ACSM's recommendations of 150 min/week of moderate-vigorous aerobic exercise) -
Who cannot join
- Cardiovascular disease Smoking Subjects who were exercising regularly (>75 min/week) were excluded.
- -
Trial locations and contacts
1 site in 1 country.
United States1 site
Human Performance Laboratory, Department of Kinesiology and Health Education, the University of Texas at Austin
Austin, Texas, 78712
About this study
High-intensity interval training (HIIT) is an effective tool to improve cardiovascular fitness and maximal anaerobic power. Different methods of HIIT have been studied but the effect of a maximal effort cycling and very short exercise time (i.e., 4-s) with short recovery time (15-30 s) and a high number of repetitions (i.e., 30 bouts) is unknown.
Read the detailed description
The investigators examined the effects of training at maximal anaerobic power during cycling (PC) on maximal anaerobic power, peak oxygen consumption (VO2peak), and total blood volume in 11 young healthy individuals (age: 21.3±0.5 y) (6 men, 5 women). Methods: Participants trained three times a week for eight weeks performing a PC program consisting of 30 bouts of 4-s at an all-out intensity (i.e., 2 minutes of exercise per session). The cardiovascular stress progressively increased over the weeks by decreasing the recovery time between sprints (30 to 24 to 15-s) and thus session time decreased from 17 to < 10 min.
- Conditions
- Cardiovascular Fitness
- Being tested
- 4-s sprint inertial load training
- Keywords
- exercise, cardiovascular fitness, sprinting, performance
- Medical subject headings
- Motor Activity
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
4-s sprint inertial load trainingOther
A program employing 30 bouts of 4s inertial load sprint training with progressively reduced recovery time (30 to 15 s) between sprints is effective for improving blood volume, VO2peak and maximal power.
| Study group | Role | What they receive |
|---|---|---|
| 4-s sprint inertial load training | Experimental | Participants trained three times a week for eight weeks following the training program consisting of 30 bouts of 4s all-out cycling on an inertial-load ergometer with progressively decreasing recovery time (30 to 24 to 15s). Receives: Other: 4-s sprint inertial load training |
What is being measured
The primary outcome is the main question the study is designed to answer.
Cardiovascular changes
Maximal oxygen consumption (VO2max) is an indicator of health and fitness. The investigators measured VO2max with a graded exercise using electronically braked cycling ergometer.
Measured: Pre and post training (8 weeks)
Blood volume changes
Hematological variables can effect the performance of the people. The investigators measured total blood volume, red blood cell volume, and plasma volume before and after training.
Measured: Pre and post training (8 weeks)
Secondary outcomes (1)
Performance changes
Study participants trained at maximal anaerobic power for 4-s. Therefore, the investigators measured maximal anaerobic power with different testing methods.
Measured: Pre and post training (8 weeks)
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted7 Dec 2020
- Study start1 Apr 2019
- Primary completion31 Mar 2020
- Study completion24 Apr 2020
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for Cardiovascular FitnessStudies of the same condition, open and under way.
- More trials run by University of Texas at AustinThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Enrolment
- 11 participants (actual)
Sponsor and investigators
- Lead sponsor
- University of Texas at Austin
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
- Investigators
- Edward F Coyle, Ph.D., Study director, University of Texas at Austin
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT04656509
- Sponsor's protocol ID
- 2019-01-0132
- Status last verified
- Dec 2020
- First submitted
- 12 Oct 2020
- Last updated
- 9 Dec 2020
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Publications
Satiroglu R, Lalande S, Hong S, Nagel MJ, Coyle EF. Four-Second Power Cycling Training Increases Maximal Anaerobic Power, Peak Oxygen Consumption, and Total Blood Volume. Med Sci Sports Exerc. 2021 Dec 1;53(12):2536-2542. doi: 10.1249/MSS.0000000000002748.
PubMed 34310498
Study at a glance
From the registry record, last updated by the sponsor on 9 Dec 2020. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Effects of Short Duration High-intensity Interval Training on Peak Oxygen Consumption
- ClinicalTrials.gov ID
- NCT04656509
- Acronym / sponsor ID
- 2019-01-0132
- Conditions
- Cardiovascular Fitness
- Keywords
- exercise, cardiovascular fitness, sprinting, performance
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 11 participants (actual)
- Lead sponsor
- University of Texas at AustinUniversity, hospital or other
- Study start
- 1 Apr 2019 (actual)
- Primary completion
- 31 Mar 2020 (actual)
- Study completion
- 24 Apr 2020 (actual)
- First posted
- 7 Dec 2020 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
High-intensity interval training (HIIT) is an effective tool to improve cardiovascular fitness and maximal anaerobic power. Different methods of HIIT have been studied but the effect of a maximal effort cycling and very short exercise time (i.e., 4-s) with short recovery time (15-30 s) and a high number of repetitions (i.e., 30 bouts) is unknown.
Detailed description
The investigators examined the effects of training at maximal anaerobic power during cycling (PC) on maximal anaerobic power, peak oxygen consumption (VO2peak), and total blood volume in 11 young healthy individuals (age: 21.3±0.5 y) (6 men, 5 women). Methods: Participants trained three times a week for eight weeks performing a PC program consisting of 30 bouts of 4-s at an all-out intensity (i.e., 2 minutes of exercise per session). The cardiovascular stress progressively increased over the weeks by decreasing the recovery time between sprints (30 to 24 to 15-s) and thus session time decreased from 17 to < 10 min.
Study design
- Primary purpose
- Treatment
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| 4-s sprint inertial load training | Experimental | Other: 4-s sprint inertial load trainingParticipants trained three times a week for eight weeks following the training program consisting of 30 bouts of 4s all-out cycling on an inertial-load ergometer with progressively decreasing recovery time (30 to 24 to 15s). |
Who may qualify
- Ages
- 18 to 49 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (1 listed)
- Young (18-30), Healthy, Recreationally active, but untrained (not meeting ACSM's recommendations of 150 min/week of moderate-vigorous aerobic exercise) -
Key exclusion criteria (2 listed)
- Cardiovascular disease Smoking Subjects who were exercising regularly (>75 min/week) were excluded.
- -
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| 4-s sprint inertial load trainingA program employing 30 bouts of 4s inertial load sprint training with progressively reduced recovery time (30 to 15 s) between sprints is effective for improving blood volume, VO2peak and maximal power. | Other | 4-s sprint inertial load training |
Primary outcome
Cardiovascular changes
Time frame: Pre and post training (8 weeks)
Maximal oxygen consumption (VO2max) is an indicator of health and fitness. The investigators measured VO2max with a graded exercise using electronically braked cycling ergometer.
Blood volume changes
Time frame: Pre and post training (8 weeks)
Hematological variables can effect the performance of the people. The investigators measured total blood volume, red blood cell volume, and plasma volume before and after training.
1 secondary outcome
Performance changes
Time frame: Pre and post training (8 weeks)
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 9 Dec 2020.
- Derived from this study: PubMed 34310498Satiroglu R, Lalande S, Hong S, Nagel MJ, Coyle EF. Four-Second Power Cycling Training Increases Maximal Anaerobic Power, Peak Oxygen Consumption, and Total Blood Volume. Med Sci Sports Exerc. 2021 Dec 1;53(12):2536-2542. doi: 10.1249/MSS.0000000000002748.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Edward F Coyle, Ph.D. study director
University of Texas at Austin
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing 4-s sprint inertial load training in people with Cardiovascular Fitness, run by University of Texas at Austin at 1 site in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 1 inclusion and 2 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 9 Dec 2020. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Cardiovascular changes (time frame: Pre and post training (8 weeks)). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT04656509, which also lists 1 linked publication.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 9 Dec 2020.