Acute Physical ExerciseSPEMONCT04680494
Effect of Acute Physical Exercise on Memory
A study testing moderate intensity physical exercise, high intensity physical exercise and rest in people with Acute Physical Exercise, run by University of Geneva, Switzerland.
Trial summary
An increasing amount of studies show the beneficial effect of regular exercise on cognitive and brain functions and especially in the memory domain. Yet little is known of what happens within an acute bout of exercise and whether it would also yield cognitive effects. Read more about this study
- Who is it for?
- Ages 18 to 38 years, men onlyHealthy volunteers can take part
- Conditions the study is for
- Acute Physical Exercise
- What is being tested?
- moderate intensity physical exercise, high intensity physical exercise and rest
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 25 participants
- Where
- No sites listed yet
- Study dates
- 9 Oct 2015to 27 Jul 2016
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 38 years
- Men only
- Healthy volunteers accepted
- Adult
Who may be able to join
- Male
- Right-handed,
- Exercising regularly (at least twice per week).
- VO2max comprised between 40ml/kg/min and 65ml/kg/min.
Who cannot join
- Psychiatric and neurological history
About this study
An increasing amount of studies show the beneficial effect of regular exercise on cognitive and brain functions and especially in the memory domain. Yet little is known of what happens within an acute bout of exercise and whether it would also yield cognitive effects. The literature clearly shows that molecules such as brain derived neurotrophic factor (BDNF) and endocannabinoids (mainly anandamide, AEA) are heavily involved in neural plasticity mechanisms and increase when we exercise hinting at possible mechanisms underlying memory improvement after exercise.
This protocol assesses the effects of acute exercise on associative and motor sequence memory, their underlying neural activations (measured using fMRI) and blood biomarkers (BDNF and AEA). A related aim is to assess the effect of exercise intensity, therefore three exercising conditions (rest, moderate intensity and high intensity) were included. Finally, a 3-month delayed retest visit is also realized to assess effects of acute exercise on long-term memory consolidation.
- Conditions
- Acute Physical Exercise
- Being tested
- moderate intensity physical exercise, high intensity physical exercise, rest
- Keywords
- fMRI, BDNF, endocannabinoid, physical exercise
- Medical subject headings
- Motor Activity
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
moderate intensity physical exerciseOther
high intensity physical exerciseOther
restOther
| Study group | Role | What they receive |
|---|---|---|
| Rest | Experimental | Participants rest quietly for 30 minutes, sitting on a chair. They may read magazines not involving motion-related elements Receives: Other: rest |
| Moderate intensity exercise | Experimental | Participants cycle on a cycle ergometer during 30 minutes at 65% of their maximal cardiac frequency Receives: Other: moderate intensity physical exercise |
| High intensity exercise | Experimental | Participants cycle on a cycle ergometer during 15 minutes at 75% of their maximal cardiac frequency. This session also includes 3 minutes of warm-up and three minutes of cool down at 50% of their maximal cardiac frequency Receives: Other: high intensity physical exercise |
What is being measured
The primary outcome is the main question the study is designed to answer.
cognitive measures - performance
we measure performance during cognitive tasks. Performance is measured as percentage of correct trials, with higher percentages corresponding to better performance - measured in percentages.
Measured: Till the end of the study for each participant, i.e.3 months (long time retest)
cognitive measures - reaction times
we measure reaction times during cognitive tasks. For reaction times, lower measures correspond to faster response times and therefore to better outcome - measured in milliseconds.
Measured: Till the end of the study for each participant, i.e.3 months (long time retest)
BDNF levels
we measure BDNF levels before and after physical exercise and rest, measured in ng/mL of serum.
Measured: up to 1 hour
endocannabinoid levels
we measure endocannabinoid levels before and after physical exercise and rest, measured in ng/mL of plasma.
Measured: up to 1 hour
brain activations
we measure brain activations using fMRI during cognitive tasks
Measured: up to 1 hour
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted23 Dec 2020
- Study start9 Oct 2015
- Primary completion27 Jul 2016
- Study completion27 Jul 2016
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for Acute Physical ExerciseStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Other
- Allocation
- Randomised
- Intervention model
- Crossover
- Model description
- This is a within-subject study, all participants perform all conditions in cross-over randomized order.
- Masking
- None (open label)
- Enrolment
- 25 participants (actual)
Sponsor and investigators
- Lead sponsor
- University of Geneva, Switzerland
- Sponsor type
- University, hospital or other
- Collaborators
- University Hospital, Geneva
- Responsible party
- Principal investigator, Igloi Kinga, University of Geneva, Switzerland
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT04680494
- Sponsor's protocol ID
- PB_2017-00360
- Acronym
- SPEMO
- Status last verified
- Dec 2020
- First submitted
- 11 Dec 2020
- Last updated
- 23 Dec 2020
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Publications
Marin Bosch B, Bringard A, Logrieco MG, Lauer E, Imobersteg N, Thomas A, Ferretti G, Schwartz S, Igloi K. Effect of acute physical exercise on motor sequence memory. Sci Rep. 2020 Sep 18;10(1):15322. doi: 10.1038/s41598-020-72108-1.
PubMed 32948800
Study at a glance
From the registry record, last updated by the sponsor on 23 Dec 2020. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Effect of Acute Physical Exercise on Memory
- ClinicalTrials.gov ID
- NCT04680494
- Acronym / sponsor ID
- SPEMO / PB_2017-00360
- Conditions
- Acute Physical Exercise
- Keywords
- fMRI, BDNF, endocannabinoid, physical exercise
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 25 participants (actual)
- Lead sponsor
- University of Geneva, SwitzerlandUniversity, hospital or other
- Collaborators
- University Hospital, Geneva
- Study start
- 9 Oct 2015 (actual)
- Primary completion
- 27 Jul 2016 (actual)
- Study completion
- 27 Jul 2016 (actual)
- First posted
- 23 Dec 2020 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
An increasing amount of studies show the beneficial effect of regular exercise on cognitive and brain functions and especially in the memory domain. Yet little is known of what happens within an acute bout of exercise and whether it would also yield cognitive effects. The literature clearly shows that molecules such as brain derived neurotrophic factor (BDNF) and endocannabinoids (mainly anandamide, AEA) are heavily involved in neural plasticity mechanisms and increase when we exercise hinting at possible mechanisms underlying memory improvement after exercise.
This protocol assesses the effects of acute exercise on associative and motor sequence memory, their underlying neural activations (measured using fMRI) and blood biomarkers (BDNF and AEA). A related aim is to assess the effect of exercise intensity, therefore three exercising conditions (rest, moderate intensity and high intensity) were included. Finally, a 3-month delayed retest visit is also realized to assess effects of acute exercise on long-term memory consolidation.
Study design
- Primary purpose
- Other
- Allocation
- Randomised
- Intervention model
- Crossover
- Masking
- None (open label)
- Number of arms
- 3
- Model description
- This is a within-subject study, all participants perform all conditions in cross-over randomized order.
| Arm | Type | Receives |
|---|---|---|
| Rest | Experimental | Other: restParticipants rest quietly for 30 minutes, sitting on a chair. They may read magazines not involving motion-related elements |
| Moderate intensity exercise | Experimental | Other: moderate intensity physical exerciseParticipants cycle on a cycle ergometer during 30 minutes at 65% of their maximal cardiac frequency |
| High intensity exercise | Experimental | Other: high intensity physical exerciseParticipants cycle on a cycle ergometer during 15 minutes at 75% of their maximal cardiac frequency. This session also includes 3 minutes of warm-up and three minutes of cool down at 50% of their maximal cardiac frequency |
Who may qualify
- Ages
- 18 to 38 years
- Sex
- Male only
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (4 listed)
- Male
- Right-handed,
- Exercising regularly (at least twice per week).
- VO2max comprised between 40ml/kg/min and 65ml/kg/min.
Key exclusion criteria (1 listed)
- Psychiatric and neurological history
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| moderate intensity physical exercise | Other | Moderate intensity exercise |
| high intensity physical exercise | Other | High intensity exercise |
| rest | Other | Rest |
Primary outcome
cognitive measures - performance
Time frame: Till the end of the study for each participant, i.e.3 months (long time retest)
we measure performance during cognitive tasks. Performance is measured as percentage of correct trials, with higher percentages corresponding to better performance - measured in percentages.
cognitive measures - reaction times
Time frame: Till the end of the study for each participant, i.e.3 months (long time retest)
we measure reaction times during cognitive tasks. For reaction times, lower measures correspond to faster response times and therefore to better outcome - measured in milliseconds.
BDNF levels
Time frame: up to 1 hour
we measure BDNF levels before and after physical exercise and rest, measured in ng/mL of serum.
endocannabinoid levels
Time frame: up to 1 hour
we measure endocannabinoid levels before and after physical exercise and rest, measured in ng/mL of plasma.
brain activations
Time frame: up to 1 hour
we measure brain activations using fMRI during cognitive tasks
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 23 Dec 2020.
- Results publication: PubMed 32948800Marin Bosch B, Bringard A, Logrieco MG, Lauer E, Imobersteg N, Thomas A, Ferretti G, Schwartz S, Igloi K. Effect of acute physical exercise on motor sequence memory. Sci Rep. 2020 Sep 18;10(1):15322. doi: 10.1038/s41598-020-72108-1.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
Questions about this trial
What is this clinical trial studying?
A study testing moderate intensity physical exercise, high intensity physical exercise and rest in people with Acute Physical Exercise, run by University of Geneva, Switzerland.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 23 Dec 2020. Status can change between updates, so confirm with the study contact before making plans.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
cognitive measures - performance (time frame: Till the end of the study for each participant, i.e.3 months (long time retest)). The study lists 5 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT04680494, which also lists 1 linked publication.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 23 Dec 2020.