Aircraft AccidentNCT04728373
An Analysis of Air-Crash Injury Patterns Presenting at a Level 1 Trauma Unit in Johannesburg, a Retrospective Cohort Study.
An observational study of Aircraft Accident, run by Sefako Makgatho Health Sciences University.
Trial summary
Aviation related deaths are often fatal, with most patients dying at the scene; however, with increased safety and improvement in medical management, patients are surviving aviation accidents. Read more about this study
- Who is it for?
- Any age
- Conditions the study is for
- Aircraft Accident
- What is being tested?
- surgery
- Type of treatment
- Surgery or procedure
- How many people
- 56 participants
- Where
- No sites listed yet
- Study dates
- Jan 2011to Dec 2019
- Phase
- Observational
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages Any age
- All sexes
- No healthy volunteers
- Child, Adult, Older adult
Study population: all aircraft accidents victims
Who may be able to join
- all patients involved in aircraft accidents presenting to the hospital
Who cannot join
- patients who died on scene
About this study
Aviation related deaths are often fatal, with most patients dying at the scene; however, with increased safety and improvement in medical management, patients are surviving aviation accidents. Among the aviation-related deaths reported between 1980 and 1990, polytrauma was listed as the immediate cause of death in 42% of fatalities, followed by head injuries (22%), internal organ injuries of the thorax, abdomen, pelvis (12%), burns (4%), and drowning (3%) .
Analysis and interpretation of aviation-pattern injuries may provide healthcare facilities with planning information on the spectrum of possible injuries that may be expected, and, furthermore, tools for a protocol and guidelines on the comprehensive and complete management of such patients.
The aim of the study was to describe the injury patterns, and mortality rate resulting from air crashes presenting at a level 1 trauma centre in Johannesburg, South Africa
Read the detailed description
In the twenty-first century, transportation disasters and subsequent injuries are on the rise, in particular air travel, and, thus, contributing significantly to the morbidity and mortality of this millennium. However, information regarding injuries sustained by air crash survivors is lacking. As the number of commercial and non-commercial flights are increasing, health care facilities are faced with a rise in the number of patients with air crash injuries. Consequently, management guidelines must be formulated for the treatment of patients with these air crash injuries.
According to the South African Civil Aviation authority, 565 aviation accidents and incidents were reported from 2011 to 2019. The injuries and outcomes of patients involved in these accidents are unknown. There is little data to describe injury patterns and outcomes of patients in aviation accidents within our setting. Consequently, to find data on the frequency distribution of aviation injury patterns in hospitalized patients, one must use other data sources Injury patterns from several aircraft disasters have been previously described. Some authors have described injury patterns and fatalities from aviation accidents based on their patients and aircraft data. Friedman et al. described that when a plane impacts with the ground, the landing gear of an aircraft may be retracted, resulting in energy being directly transmitted from the aircraft to the passengers, through the body of the aircraft from the bottom going upwards along the axial skeleton causing vertebral column injuries that are coming with air crash patients. Therefore, it is of utmost importance that such survivors of crashes be transferred to an adequately equipped trauma center.
In 2009, Baker et al. aimed to explore the configurations of aviation-related injuries in hospitals in the United States of America (USA) whilst comparing them to the aviation deaths over the same time frame (2000 - 2005). This revealed just over 4500 aviation-related (87% non-commercial aircraft, and 7% commercial aircraft) deaths occurred in the USA - an average of 753 per year, with one death for every 1.3 hospitalizations. This represents the largest number of patients reported to date. Lower limb fractures/injuries were the most common sustained injuries, followed by head injuries, various open soft tissue wounds, upper extremity fractures/injuries, and lastly internal organ injuries. Head injuries were the cause of most fatalities. This study's case-fatality showed that 39% were due to vascular injuries, 13% due to burns, followed by 8% from head injuries.
Rautji et al. discussed the injury pattern examined in the post-mortem findings in eight occupants of a light executive jet aircraft crash. One body was severely burnt, but the other seven were intact. On serum blood toxicology, it was established that there was no carboxyhemoglobin present. Therefore, all burns were sustained post-mortem; concluding that the cause of death in all these cases was polytrauma. This evaluation found that the most commonly occurring fractures were ribs (72.3%), skull (55.1%), facial bones (49.4%), tibia (37.9%), and pelvis (36%) [9]. The common organ injuries were liver (48.1%), lung (37.6%), heart (35.6%), spleen (30.1%), and hemorrhagic cerebral and pulmonary injuries being 33.3% and 32.9%, respectively. Once again, injuries of sudden deceleration transmitted in a vertical fashion were also described, resulting in vertebral column injuries and extensive visceral damage.
A report discussed by Afshar et al. illustrated that up to 85% of injuries of survivors of a Boeing 727 flight were extremity injuries (particularly lower limb injuries), followed by vertebral column injuries at various levels, and a minority sustained internal organ injuries . Similarly, Rowles et al. (1990) concluded that most M1 Kegworth air crash injuries were orthopedic in nature, approximately 85%, and 3.8% were general surgical procedures (laparotomies, thoracotomies, vascular repair, and a tracheostomy).
Aviation related deaths are often fatal, with most patients dying at the scene; however, with increased safety and improvement in medical management, patients are surviving aviation accidents. Among the aviation-related deaths reported between 1980 and 1990, polytrauma was listed as the immediate cause of death in 42% of fatalities, followed by head injuries (22%), internal organ injuries of the thorax, abdomen, pelvis (12%), burns (4%), and drowning (3%) .
Analysis and interpretation of aviation-pattern injuries may provide healthcare facilities with planning information on the spectrum of possible injuries that may be expected, and, furthermore, tools for a protocol and guidelines on the comprehensive and complete management of such patients.
Aim of the study was to describe the injury patterns, and mortality rate resulting from air crashes presenting at a level 1 trauma centre in Johannesburg, South Africa
- Conditions
- Aircraft Accident
- Being tested
- surgery
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
surgeryProcedure or surgery
the need for surgery after aircraft accidents
What is being measured
The primary outcome is the main question the study is designed to answer.
An Analysis of Air-Crash Injury Patterns Presenting at a Level 1 Trauma Unit
An Analysis of Air-Crash Injury Patterns Presenting at a Level 1 Trauma Unit in Johannesburg, a retrospective cohort study
Measured: 8 years
Secondary outcomes (1)
An Analysis of Air-Crash Injury Patterns Presenting at a Level 1 Trauma Unit in Johannesburg, a retrospective cohort study
28 day in-hospital mortality post aircraft accidents
Measured: 8 years
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted28 Jan 2021
- Study startJan 2011
- Primary completionDec 2019
- Study completionDec 2019
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (2)Papers the sponsor has linked to this study.
- Other trials for Aircraft AccidentStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Retrospective
- Enrolment
- 56 participants (actual)
Sponsor and investigators
- Lead sponsor
- Sefako Makgatho Health Sciences University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, shumani Makhadi, Sefako Makgatho Health Sciences University
- Investigators
- Shumani Makhadi, Mmed, Principal investigator, Sefako Makgatho Health Sciences University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT04728373
- Sponsor's protocol ID
- M180463
- Status last verified
- Jan 2021
- First submitted
- 23 Jan 2021
- Last updated
- 2 Feb 2021
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Undecided: protocol, study report, and statistical analysis
Publications
Friedman A, Floman Y, Sabatto S, Safran O, Mosheiff R. Light aircraft crash--a case analysis of injuries. Isr Med Assoc J. 2002 May;4(5):337-9.
PubMed 12040820Lundin T. Transportation disasters--a review. J Trauma Stress. 1995 Jul;8(3):381-9. doi: 10.1002/jts.2490080302. No abstract available.
PubMed 7582604
Study at a glance
From the registry record, last updated by the sponsor on 2 Feb 2021. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- An Analysis of Air-Crash Injury Patterns Presenting at a Level 1 Trauma Unit in Johannesburg, a Retrospective Cohort Study.
- ClinicalTrials.gov ID
- NCT04728373
- Acronym / sponsor ID
- M180463
- Conditions
- Aircraft Accident
- Study type
- Observational
- Recruitment status
- Completed
- Enrolment
- 56 participants (actual)
- Lead sponsor
- Sefako Makgatho Health Sciences UniversityUniversity, hospital or other
- Study start
- Jan 2011 (actual)
- Primary completion
- Dec 2019 (actual)
- Study completion
- Dec 2019 (actual)
- First posted
- 28 Jan 2021 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Aviation related deaths are often fatal, with most patients dying at the scene; however, with increased safety and improvement in medical management, patients are surviving aviation accidents. Among the aviation-related deaths reported between 1980 and 1990, polytrauma was listed as the immediate cause of death in 42% of fatalities, followed by head injuries (22%), internal organ injuries of the thorax, abdomen, pelvis (12%), burns (4%), and drowning (3%) .
Analysis and interpretation of aviation-pattern injuries may provide healthcare facilities with planning information on the spectrum of possible injuries that may be expected, and, furthermore, tools for a protocol and guidelines on the comprehensive and complete management of such patients.
The aim of the study was to describe the injury patterns, and mortality rate resulting from air crashes presenting at a level 1 trauma centre in Johannesburg, South Africa
Detailed description
In the twenty-first century, transportation disasters and subsequent injuries are on the rise, in particular air travel, and, thus, contributing significantly to the morbidity and mortality of this millennium. However, information regarding injuries sustained by air crash survivors is lacking. As the number of commercial and non-commercial flights are increasing, health care facilities are faced with a rise in the number of patients with air crash injuries. Consequently, management guidelines must be formulated for the treatment of patients with these air crash injuries.
According to the South African Civil Aviation authority, 565 aviation accidents and incidents were reported from 2011 to 2019. The injuries and outcomes of patients involved in these accidents are unknown. There is little data to describe injury patterns and outcomes of patients in aviation accidents within our setting. Consequently, to find data on the frequency distribution of aviation injury patterns in hospitalized patients, one must use other data sources Injury patterns from several aircraft disasters have been previously described. Some authors have described injury patterns and fatalities from aviation accidents based on their patients and aircraft data. Friedman et al. described that when a plane impacts with the ground, the landing gear of an aircraft may be retracted, resulting in energy being directly transmitted from the aircraft to the passengers, through the body of the aircraft from the bottom going upwards along the axial skeleton causing vertebral column injuries that are coming with air crash patients. Therefore, it is of utmost importance that such survivors of crashes be transferred to an adequately equipped trauma center.
In 2009, Baker et al. aimed to explore the configurations of aviation-related injuries in hospitals in the United States of America (USA) whilst comparing them to the aviation deaths over the same time frame (2000 - 2005). This revealed just over 4500 aviation-related (87% non-commercial aircraft, and 7% commercial aircraft) deaths occurred in the USA - an average of 753 per year, with one death for every 1.3 hospitalizations. This represents the largest number of patients reported to date. Lower limb fractures/injuries were the most common sustained injuries, followed by head injuries, various open soft tissue wounds, upper extremity fractures/injuries, and lastly internal organ injuries. Head injuries were the cause of most fatalities. This study's case-fatality showed that 39% were due to vascular injuries, 13% due to burns, followed by 8% from head injuries.
Rautji et al. discussed the injury pattern examined in the post-mortem findings in eight occupants of a light executive jet aircraft crash. One body was severely burnt, but the other seven were intact. On serum blood toxicology, it was established that there was no carboxyhemoglobin present. Therefore, all burns were sustained post-mortem; concluding that the cause of death in all these cases was polytrauma. This evaluation found that the most commonly occurring fractures were ribs (72.3%), skull (55.1%), facial bones (49.4%), tibia (37.9%), and pelvis (36%) [9]. The common organ injuries were liver (48.1%), lung (37.6%), heart (35.6%), spleen (30.1%), and hemorrhagic cerebral and pulmonary injuries being 33.3% and 32.9%, respectively. Once again, injuries of sudden deceleration transmitted in a vertical fashion were also described, resulting in vertebral column injuries and extensive visceral damage.
A report discussed by Afshar et al. illustrated that up to 85% of injuries of survivors of a Boeing 727 flight were extremity injuries (particularly lower limb injuries), followed by vertebral column injuries at various levels, and a minority sustained internal organ injuries . Similarly, Rowles et al. (1990) concluded that most M1 Kegworth air crash injuries were orthopedic in nature, approximately 85%, and 3.8% were general surgical procedures (laparotomies, thoracotomies, vascular repair, and a tracheostomy).
Aviation related deaths are often fatal, with most patients dying at the scene; however, with increased safety and improvement in medical management, patients are surviving aviation accidents. Among the aviation-related deaths reported between 1980 and 1990, polytrauma was listed as the immediate cause of death in 42% of fatalities, followed by head injuries (22%), internal organ injuries of the thorax, abdomen, pelvis (12%), burns (4%), and drowning (3%) .
Analysis and interpretation of aviation-pattern injuries may provide healthcare facilities with planning information on the spectrum of possible injuries that may be expected, and, furthermore, tools for a protocol and guidelines on the comprehensive and complete management of such patients.
Aim of the study was to describe the injury patterns, and mortality rate resulting from air crashes presenting at a level 1 trauma centre in Johannesburg, South Africa
Study design
- Observational model
- Cohort
- Time perspective
- Retrospective
Who may qualify
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Child, Adult, Older adult
- Study population
- all aircraft accidents victims
Key inclusion criteria (1 listed)
- all patients involved in aircraft accidents presenting to the hospital
Key exclusion criteria (1 listed)
- patients who died on scene
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| surgerythe need for surgery after aircraft accidents | Procedure or surgery | – |
Primary outcome
An Analysis of Air-Crash Injury Patterns Presenting at a Level 1 Trauma Unit
Time frame: 8 years
An Analysis of Air-Crash Injury Patterns Presenting at a Level 1 Trauma Unit in Johannesburg, a retrospective cohort study
1 secondary outcome
An Analysis of Air-Crash Injury Patterns Presenting at a Level 1 Trauma Unit in Johannesburg, a retrospective cohort study
Time frame: 8 years
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 2 Feb 2021.
- Background: PubMed 12040820Friedman A, Floman Y, Sabatto S, Safran O, Mosheiff R. Light aircraft crash--a case analysis of injuries. Isr Med Assoc J. 2002 May;4(5):337-9.
- Background: PubMed 7582604Lundin T. Transportation disasters--a review. J Trauma Stress. 1995 Jul;8(3):381-9. doi: 10.1002/jts.2490080302. No abstract available.
- Individual participant dataSharing planned: Undecided. protocol, study report, and statistical analysis
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Shumani Makhadi, Mmed principal investigator
Sefako Makgatho Health Sciences University
Questions about this trial
What is this clinical trial studying?
An observational study of Aircraft Accident, run by Sefako Makgatho Health Sciences University.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 1 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 2 Feb 2021. Status can change between updates, so confirm with the study contact before making plans.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
An Analysis of Air-Crash Injury Patterns Presenting at a Level 1 Trauma Unit (time frame: 8 years). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT04728373, which also lists 2 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 2 Feb 2021.