An Outpatient Clinical Trial Using Ivermectin and Doxycycline in COVID-19 Positive Patients at High Risk to Prevent COVID-19 Related Hospitalization

The investigators will be assessing for a decrease in total duration of symptoms secondary to respiratory illness related to COVID-19. This will be assessed over the duration of 5 weeks.

The investigators will assess the patient's White Blood Cell Count (WBC) at the onset of trial enrollment and at day 7 and day 14. The investigator's will monitor the patients White Blood Cell count in cells/Liter. The investigators will monitor for increases or decreases in the WBC count value throughout the first 2 weeks of trial enrollment. Participants will have their blood work sent to a designated laboratory.

The investigators will assess the patient's Hemoglobin (Hgb) level at the onset of trial enrollment and at day 7 and day 14. The investigator's will monitor the patients Hemoglobin count in grams/deciliter (g/dl). The investigators will monitor for increases or decreases in the Hgb value throughout the first 2 weeks of trial enrollment. Participants will have their blood work sent to a designated laboratory.

The investigators will assess the patient's Hematocrit (Hct) level at the onset of trial enrollment and at day 7 and day 14. The investigator's will monitor the patients Hematocrit in units of percentage (%). The investigators will monitor for increases or decreases in the Hct value throughout the first 2 weeks of trial enrollment. Participants will have their blood work sent to a designated laboratory.

The investigators will assess the patient's Platelet Count level at the onset of trial enrollment and at day 7 and day 14. The investigator's will monitor the patients Platelet Count in units of platelets per microliter. The investigators will monitor for increases or decreases in the Platelet count throughout the first 2 weeks of trial enrollment. Participants will have their blood work sent to a designated laboratory.

The investigators will assess the patient's Sodium (Na) at the onset of trial enrollment and at day 7 and day 14. The investigator's will monitor the patients Sodium level in units of milliequivalents per liter (mEq/L). The investigators will monitor for increases or decreases in the Sodium level throughout the first 2 weeks of trial enrollment. Participants will have their blood work sent to a designated laboratory.

The investigators will assess the patient's Potassium (K) at the onset of trial enrollment and at day 7 and day 14. The investigator's will monitor the patients Potassium level in units of milliequivalents per liter (mEq/L). The investigators will monitor for increases or decreases in the Potassium level throughout the first 2 weeks of trial enrollment. Participants will have their blood work sent to a designated laboratory.

The investigators will assess the patient's Chloride (Cl) at the onset of trial enrollment and at day 7 and day 14. The investigator's will monitor the patients Chloride level in units of millimoles per liter (mmol/L). The investigators will monitor for increases or decreases in the Chloride level throughout the first 2 weeks of trial enrollment. Participants will have their blood work sent to a designated laboratory.

The investigators will assess the patient's Carbon Dioxide (C02) level at the onset of trial enrollment and at day 7 and day 14. The investigator's will monitor the patients Carbon Dioxide level in units of millimoles per liter (mmol/L). The investigators will monitor for increases or decreases in the Carbon Dioxide level throughout the first 2 weeks of trial enrollment. Participants will have their blood work sent to a designated laboratory.

The investigators will assess the patient's Blood Urea Nitrogen (BUN) level at the onset of trial enrollment and at day 7 and day 14. The investigator's will monitor the patients Blood Urea Nitrogen level in units of milligrams per deciliter (mg/dL). The investigators will monitor for increases or decreases in the Blood Urea Nitrogen level throughout the first 2 weeks of trial enrollment. Participants will have their blood work sent to a designated laboratory.

The investigators will assess the patient's Creatinine (Crt) level at the onset of trial enrollment and at day 7 and day 14. The investigator's will monitor the patients Creatinine level in units of milligrams per deciliter (mg/dL). The investigators will monitor for increases or decreases in the Creatinine level throughout the first 2 weeks of trial enrollment. Participants will have their blood work sent to a designated laboratory.

The investigators will assess the patient's Calcium (Ca) level at the onset of trial enrollment and at day 7 and day 14. The investigator's will monitor the patients Calcium level in units of milligrams per deciliter (mg/dL). The investigators will monitor for increases or decreases in the Calcium level throughout the first 2 weeks of trial enrollment. Participants will have their blood work sent to a designated laboratory.

The investigators will assess the patient's Glucose level at the onset of trial enrollment and at day 7 and day 14. The investigator's will monitor the patients Glucose level in units of milligrams per deciliter (mg/dL). The investigators will monitor for increases or decreases in the Glucose level throughout the first 2 weeks of trial enrollment. Participants will have their blood work sent to a designated laboratory.

The investigators will assess the patient's Total Bilirubin (T bili) level at the onset of trial enrollment and at day 7 and day 14. The investigator's will monitor the patients Total Bilirubin level in units of milligrams per deciliter (mg/dL). The investigators will monitor for increases or decreases in the Total Bilirubin level throughout the first 2 weeks of trial enrollment. Participants will have their blood work sent to a designated laboratory.

The investigators will assess the patient's Total Protein level at the onset of trial enrollment and at day 7 and day 14. The investigator's will monitor the patients Total Protein level in units of grams per deciliter (g/dL). The investigators will monitor for increases or decreases in the Total Protein level throughout the first 2 weeks of trial enrollment. Participants will have their blood work sent to a designated laboratory.

The investigators will assess the patient's Albumin level at the onset of trial enrollment and at day 7 and day 14. The investigator's will monitor the patients Albumin level in units of grams per deciliter (g/dL). The investigators will monitor for increases or decreases in the Albumin level throughout the first 2 weeks of trial enrollment. Participants will have their blood work sent to a designated laboratory.

The investigators will assess the patient's Aspartate Aminotransferase (AST) level at the onset of trial enrollment and at day 7 and day 14. The investigator's will monitor the patients Aspartate Aminotransferase level in units of International Units per liter (IU/L). The investigators will monitor for increases or decreases in the Aspartate Aminotransferase level throughout the first 2 weeks of trial enrollment. Participants will have their blood work sent to a designated laboratory.

The investigators will assess the patient's Alanine Aminotransferase (ALT) level at the onset of trial enrollment and at day 7 and day 14. The investigator's will monitor the patients Alanine Aminotransferase level in units of International Units per liter (IU/L). The investigators will monitor for increases or decreases in the Alanine Aminotransferase level throughout the first 2 weeks of trial enrollment. Participants will have their blood work sent to a designated laboratory.

The investigators will assess the patient's Alkaline Phosphatase (ALP) level at the onset of trial enrollment and at day 7 and day 14. The investigator's will monitor the patients Alkaline Phosphatase level in units of International Units per liter (IU/L). The investigators will monitor for increases or decreases in the Alkaline Phosphatase level throughout the first 2 weeks of trial enrollment. Participants will have their blood work sent to a designated laboratory.

The investigators will assess the patient's Ferritin level at the onset of trial enrollment and at day 7 and day 14. The investigator's will monitor the patients Ferritin level measured in micrograms per liter (mg/L). The investigators will monitor for increases or decreases in the Ferritin level throughout the first 2 weeks of trial enrollment. Participants will have their blood work sent to a designated laboratory.

The investigators will assess the patient's D-dimer level at the onset of trial enrollment and at day 7 and day 14. The investigator's will monitor the patients D-dimer level measured in micrograms per milliliter fibrinogen equivalent units (mcg/mL FEU). The investigators will monitor for increases or decreases in the D-dimer level throughout the first 2 weeks of trial enrollment. Participants will have their blood work sent to a designated laboratory.

The investigators will assess the patient's Creatine Phosphokinase level at the onset of trial enrollment and at day 7 and day 14. The investigator's will monitor the patients Creatine Phosphokinase level measured in units per liter (U/L). The investigators will monitor for increases or decreases in the Creatine Phosphokinase level throughout the first 2 weeks of trial enrollment. Participants will have their blood work sent to a designated laboratory.

The investigators will assess the patient's C-Reactive Protein level at the onset of trial enrollment and at day 7 and day 14. The investigator's will monitor the patients C-Reactive Protein level measured in milligrams per liter (mg/L). The investigators will monitor for increases or decreases in the C-Reactive Protein level throughout the first 2 weeks of trial enrollment. Participants will have their blood work sent to a designated laboratory.

The investigators will assess the patient's Prothrombin Time and International Normalized Ratio (INR) at the onset of trial enrollment and at day 7 and day 14. The investigator's will monitor the patients Prothrombin Time measured in seconds and International Normalized Ratio measured in it's own units. The investigators will monitor for increases or decreases in the Prothrombin Time and International Normalized Ratio throughout the first 2 weeks of trial enrollment. Participants will have their blood work sent to a designated laboratory.

The investigators will assess the patient's activated Partial Thromboplastin Time at the onset of trial enrollment and at day 7 and day 14. The investigator's will monitor the patients activated Partial Thromboplastin Time in seconds. The investigators will monitor for increases or decreases in the activated Partial Thromboplastin Time throughout the first 2 weeks of trial enrollment. Participants will have their blood work sent to a designated laboratory.

The investigators will assess the patient's Fibrinogen Activity at the onset of trial enrollment and at day 7 and day 14. The investigator's will monitor the patients Fibrinogen Activity in milligrams per deciliter (mg/dl). The investigators will monitor for increases or decreases in Fibrinogen Activity throughout the first 2 weeks of trial enrollment. Participants will have their blood work sent to a designated laboratory.

The investigators will assess the patient's Interleukin 6 level at the onset of trial enrollment and at day 7 and day 14. The investigator's will monitor the patients Interleukin 6 level in units of picograms per milliliter (pg/mL). The investigators will monitor for increases or decreases in the Total Interleukin 6 level throughout the first 2 weeks of trial enrollment. Participants will have their blood work sent to a designated laboratory.

The investigators will assess the patient's Interleukin 6 receptor level at the onset of trial enrollment and at day 7 and day 14. The investigator's will monitor the patients Interleukin 6 receptor level in units of picograms per milliliter (pg/mL). The investigators will monitor for increases or decreases in the Total Interleukin 6 level throughout the first 2 weeks of trial enrollment. Participants will have their blood work sent to a designated laboratory.

The investigators will assess the patient's Tumor Necrosis Factor Alpha level at the onset of trial enrollment and at day 7 and day 14. The investigator's will monitor the patients Tumor Necrosis Factor Alpha level in units of picograms per milliliter (pg/mL). The investigators will monitor for increases or decreases in the Tumor Necrosis Factor Alpha level throughout the first 2 weeks of trial enrollment. Participants will have their blood work sent to a designated laboratory.

The investigators will assess the patient's Tumor Necrosis Factor Alpha Receptor level at the onset of trial enrollment and at day 7 and day 14. The investigator's will monitor the patients Tumor Necrosis Factor Alpha Receptor level in units of picograms per milliliter (pg/mL). The investigators will monitor for increases or decreases in the Tumor Necrosis Factor Alpha Receptor level throughout the first 2 weeks of trial enrollment. Participants will have their blood work sent to a designated laboratory.

The investigators will assess for any reductions or increase in mortality during the duration of the study.

The investigators will assess for new onset of medication side effects on a twice a week basis for the duration of 5 weeks using a standardized form. The investigators will ask about rash/itching/hives, bleeding/easy bruising of skin, palpitations or irregular heart beats, vision disturbances or blurry vision, light flashes or light streak in vision, fainting spells, seizure, headaches, nausea or vomiting, ringing in the ears, loss of appetite, loss of taste sensation, oral ulcers, abdominal pain, diarrhea or loss stools, yellow discoloration of eyes or skin, upper extremity or lower extremity muscle weakness, mood changes, teeth discoloration, photosensitivity or sunburn reactions after sun exposure, or any other effects. This may occur via Tele-Health visits or via in person visits.

The investigators will assess for new onset Shortness of Breath or changes in the severity of Shortness of Breath on a twice a week basis for the duration of 5 weeks. The investigators will be using a standardized form which will record if Shortness of Breath is present and grade the severity of Shortness of Breath if present (mild, moderate, severe). Moderate to Severe Shortness of Breath will be immediately reported to the Principal Investigator. This may occur via Tele-Health visits or via in person visits.

The investigators will assess Pulse Oximetry readings on room air on a twice a week basis for the duration of 5 weeks. The investigators will be using a standardized form which will record Pulse Oximetry readings on room air. If the Pulse Oximetry readings on room air are less then 93% on room air or drop by 4% from baseline established at the onset of the study, the Prinicipal Investigator will be notified. This may occur via Tele-Health visits or via in person visits.

The investigators will assess for new onset of Red Eyes or changes in the severity of Red Eyes on a twice a week basis for the duration of 5 weeks. The investigators will be using a standardized form which will record if Red Eyes are present and grade the severity of Red Eyes if present (mild, moderate, severe). This may occur via Tele-Health visits or via in person visits.

The investigators will assess for new onset of Chills or changes in the severity of Chills on a twice a week basis for the duration of 5 weeks. The investigators will be using a standardized form which will record if Chills are present and grade the severity of Chills if present (mild, moderate, severe). This may occur via Tele-Health visits or via in person visits.

The investigators will assess for new onset of Runny Nose or changes in the severity of Runny Nose on a twice a week basis for the duration of 5 weeks. The investigators will be using a standardized form which will record if Runny Nose is present and grade the severity of Runny Nose if present (mild, moderate, severe). This may occur via Tele-Health visits or via in person visits.

The investigators will assess for new onset of Sore Throat or changes in the severity of Sore Throat on a twice a week basis for the duration of 5 weeks. The investigators will be using a standardized form which will record if Sore Throat is present and grade the severity of Sore Throat if present (mild, moderate, severe). This may occur via Tele-Health visits or via in person visits.

The investigators will assess for new onset of Loss of Smell or changes in the severity of Loss of Smell on a twice a week basis for the duration of 5 weeks. The investigators will be using a standardized form which will record if Loss of Smell is present and grade the severity of Loss of Smell if present (mild, moderate, severe). This may occur via Tele-Health visits or via in person visits.

The investigators will assess for new onset of Loss of Taste or changes in the severity of Loss of Taste on a twice a week basis for the duration of 5 weeks. The investigators will be using a standardized form which will record if Loss of Taste is present and grade the severity of Loss of Taste if present (mild, moderate, severe). This may occur via Tele-Health visits or via in person visits.

The investigators will assess for new onset of Body Aches or Body Pains or changes in the severity of Body Aches or Body Pains on a twice a week basis for the duration of 5 weeks. The investigators will be using a standardized form which will record if Body Aches or Body Pains are present and grade the severity of Body Aches or Body Pains if present (mild, moderate, severe). This may occur via Tele-Health visits or via in person visits.

The investigators will assess for new onset of Diarrhea or changes in the severity of Diarrhea on a twice a week basis for the duration of 5 weeks. The investigators will be using a standardized form which will record if Diarrhea is present and grade the severity of Diarrhea if present (mild, moderate, severe). This may occur via Tele-Health visits or via in person visits.

The investigators will assess for new onset of Headaches or changes in the severity of Headaches on a twice a week basis for the duration of 5 weeks. The investigators will be using a standardized form which will record if Headaches are present and grade the severity of Headaches if present (mild, moderate, severe). This may occur via Tele-Health visits or via in person visits.

The investigators will assess for new onset of Anxiety or changes in the severity of Anxiety on a twice a week basis for the duration of 5 weeks. The investigators will be using a standardized form which will record if Anxiety is present and grade the severity of Anxiety if present (mild, moderate, severe). This may occur via Tele-Health visits or via in person visits.

The investigators will assess for new onset of fatigue or changes in the severity of fatigue on a twice a week basis for the duration of 5 weeks. The investigators will be using a standardized form which will record if fatigue is present and grade the severity of fatigue if present (mild, moderate, severe). This may occur via Tele-Health visits or via in person visits.

The investigators will assess for new onset of Trouble Concentrating or changes in the severity of Trouble Concentrating on a twice a week basis for the duration of 5 weeks. The investigators will be using a standardized form which will record if Trouble Concentrating is present and grade the severity of Trouble Concentrating if present (mild, moderate, severe). This may occur via Tele-Health visits or via in person visits.

The investigators will assess for new onset of cough or changes in the severity of cough on a twice a week basis for the duration of 5 weeks. The investigators will be using a standardized form which will record if cough is present and grade the severity of cough if present (mild, moderate, severe). This may occur via Tele-Health visits or via in person visits.

The investigators will assess for new onset of vomiting or changes in the severity of vomiting on a twice a week basis for the duration of 5 weeks. The investigators will be using a standardized form which will record if vomiting is present and grade the severity of vomiting if present (mild, moderate, severe). This may occur via Tele-Health visits or via in person visits.

The investigators will assess for new onset of nausea or changes in the severity of nausea on a twice a week basis for the duration of 5 weeks. The investigators will be using a standardized form which will record if nausea is present and grade the severity of nausea if present (mild, moderate, severe). This may occur via Tele-Health visits or via in person visits.

The investigators will assess for new onset of feelings of hopelessness or changes in the severity of feelings of hopelessness on a twice a week basis for the duration of 5 weeks. The investigators will be using a standardized form which will record if feelings of hopelessness are present and grade the severity of hopelessness if present (mild, moderate, severe). If more then mild, the investigators will utilize the Hamilton Depression Scale. This may occur via Tele-Health visits or via in person visits.

The investigators will assess for new onset of feelings of depression or changes in the severity of feelings of depression on a twice a week basis for the duration of 5 weeks. The investigators will be using a standardized form which will record if feelings of depression are present and grade the severity of feelings of depression if present (mild, moderate, severe). If more then mild, the investigators will utilize the Hamilton Depression Scale. This may occur via Tele-Health visits or via in person visits.

The investigators will assess for new onset of a fever or changes in the severity of fever on a twice a week basis for the duration of 5 weeks. The investigators will be monitoring for fever in Fahrenheit (F). The investigators will be using a standardized form which will record if fever is present and grade the severity of fever if present (mild fever at 100.4 degrees F to 101 degrees F, moderate fever at 101.1 to 101.9 degrees, severe fever at greater then 102 degrees). We will also record the temperatures in the standardized form. This may occur via Tele-Health visits or via in person visits.

The investigators will assess for new onset of moving slowly or changes in severity of moving slowly on a twice a week basis for the duration of 5 weeks. The investigators will be using a standardized form which will record if moving slowly is present and grade the severity of moving slowly if present (mild, moderate, severe). This may occur via Tele-Health visits or via in person visits.

The investigators will assess for new onset of speaking slowly or changes in severity of speaking slowly on a twice a week basis for the duration of 5 weeks. The investigators will be using a standardized form which will record if speaking slowly is present and grade the severity of speaking slowly if present (mild, moderate, severe). This may occur via Tele-Health visits or via in person visits.

The investigators will assess for new onset feelings of restlessness or changes in severity of feelings of restlessness on a twice a week basis for the duration of 5 weeks. The investigators will be using a standardized form which will record if feelings of restlessness are present and grade the severity of these feelings of restlessness if present (mild, moderate, severe). This may occur via Tele-Health visits or via in person visits.

The investigators will assess for new onset thoughts of better off being dead or changes in severity of thoughts of better off being dead on a twice a week basis for the duration of 5 weeks. The investigators will be using a standardized form which will record if thoughts of better off being dead are present and grade the severity of these thoughts of better off being dead if present (mild, moderate, severe). This may occur via Tele-Health visits or via in person visits.

The investigators will assess for new onset thoughts of hurting yourself or changes in severity of thoughts of hurting yourself on a twice a week basis for the duration of 5 weeks. The investigators will be using a standardized form which will record if thoughts of hurting yourself are present and grade the severity of these thoughts of hurting yourself if present (mild, moderate, severe). This may occur via Tele-Health visits or via in person visits.

The investigators will assess for new onset loss of interest in doing things or changes in the severity of loss of interest in doing things on a twice a week basis for the duration of 5 weeks. The investigators will be using a standardized form which will record if loss of interest in doing things are present and grade the severity of the loss of interest in doing things if present (mild, moderate, severe). This may occur via Tele-Health visits or via in person visits.

The investigators will assess for new onset loss of pleasure in doing things or changes in the severity of loss of pleasure in doing things on a twice a week basis for the duration of 5 weeks. The investigators will be using a standardized form which will record if loss of pleasure in doing things are present and grade the severity of the loss of pleasure in doing things if present (mild, moderate, severe). This may occur via Tele-Health visits or via in person visits.

The investigators will assess for new onset trouble falling asleep or changes in the severity of trouble falling asleep on a twice a week basis for the duration of 5 weeks. The investigators will be using a standardized form which will record if trouble falling asleep are present and grade the severity of the trouble falling asleep if present (mild, moderate, severe). This may occur via Tele-Health visits or via in person visits.

The investigators will assess for new onset trouble staying asleep or changes in the severity of trouble staying asleep on a twice a week basis for the duration of 5 weeks. The investigators will be using a standardized form which will record if trouble staying asleep is present and grade the severity of trouble staying asleep if present (mild, moderate, severe). This may occur via Tele-Health visits or via in person visits.

The investigators will assess for new onset unmentioned negative impacts of COVID 19 infection or changes in the severity of these unmentioned negative impacts of COVID 19 infection on a twice a week basis for the duration of 5 weeks. The investigators will be using a standardized form which will record if unmentioned negative impacts of COVID 19 infection are present and grade the severity of these unmentioned negative impacts of COVID 19 infection if present (mild, moderate, severe). This may occur via Tele-Health visits or via in person visits.