AzTrials
AzTrials

Polyradiculoneuropathy, Chronic Inflammatory DemyelinatingEarly Phase 1LYMPHOARESISNCT04742374

Effects of Single Plasma Exchange and Double Filtration Plasmapheresis (DFPP) on Peripheral Lymphocyte Phenotypes in Patients With Chronic Inflammatory Demyelinating Polyradiculoneuropathy

A Early Phase 1 study testing Blood sampling in people with Polyradiculoneuropathy, Chronic Inflammatory Demyelinating, run by Centre Hospitalier Universitaire de Nīmes at 1 site in France.

Completed

Finished. The study has ended and is not enrolling. Results may be posted on the official record.

Official record
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Trial summary

CIDP, a rare disorder affecting young adults, causes gradual weakness of the limbs, areflexia and impaired sensory function. New CIDP phenotypes without antibodies but with modified cell profiles have been described. Read more about this study

Who is it for?
Ages 18 years and older
What is being tested?
Blood sampling
Could I receive a placebo?
No, everyone receives an active treatment
How many people
8 participants
Where
1 siteFrance
Study dates
12 Mar 2021to 18 Dec 2023
Phase
Early Phase 1
Are there results?
None posted in the registry

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

  • Ages 18 years and older
  • All sexes
  • No healthy volunteers
  • Adult, Older adult

Who may be able to join

  • Patients with confirmed Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) without pathogenic antibodies and stable under therapeutic plasmapheresis with one session every 2-3 weeks for at least two months.
  • Patients who have given free written informed consent.
  • Patients who have signed the consent form.
  • Patients affiliated to or beneficiaries of a health insurance scheme.
  • Adult patients (≥18 ans).
  • Healthy subjects of the same age and sex

Who cannot join

  • Patients Under the age of 18.
  • Patients under immunosuppressive treatment for less than 3 months.
  • Patients participating in Category 1 research involving human subjects.
  • Patients in an exclusion period determined by another study.
  • Patients under legal protection, guardianship or curatorship.
  • Patients unable to express consent.
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  • Patients for whom it is impossible to give informed information.
  • Pregnant, parturient or breastfeeding patients.
  • Healthy subject with chronic pathology or drug treatment

Trial locations and contacts

1 site in 1 country.

France1 site

  • Olivier MORANNE

    Nîmes

Other trials in France

About this study

Official title: Comparison of the Effects of 2 Therapeutic Plasmapheresis Techniques: Single Plasma Exchange and Double Filtration Plasmapheresis (DFPP) on Peripheral Lymphocyte Phenotypes in Patients With Chronic Inflammatory Demyelinating Polyradiculoneuropathy (CIDP). A Monocentric Prospective Study With a Single-Case Experimental Design

CIDP, a rare disorder affecting young adults, causes gradual weakness of the limbs, areflexia and impaired sensory function. New CIDP phenotypes without antibodies but with modified cell profiles have been described. Treatments include corticotherapy, IVIg and plasmapheresis but the latter's action mechanisms remain unclear. Plasmapheresis supposedly removes toxic agents like antibodies from plasma but it is uncertain whether it has an immune-modulating effect. Also, the refining mechanisms of the two main plasmapheresis techniques - single plasma exchange and double filtration plasmapheresis (DFPP) - are different and unclear. This study aims to compare the evolution of peripheral lymphocyte profiles in patients with CIDP according to their treatment (single centrifugation plasmapheresis or DFPP) to better grasp the action mechanisms of both techniques.

Being tested
Blood sampling
Keywords
Plasma exchange, Double filtration plasmapheresis
Medical subject headings
Polyradiculoneuropathy, Chronic Inflammatory Demyelinating

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

  • Blood samplingBiological

    Blood sampling before and after each type of cycle, Single Plasma Exchange or Double Filtration Plasmapheresis

Study groups in NCT04742374
Study groupRoleWhat they receive
Group AExperimentalPatients alternating single plasma exchange followed by double filtration plasmapheresis etc.
Receives: Biological: Blood sampling
Group BExperimentalPatients alternating double filtration plasmapheresis followed by single plasma exchange etc.
Receives: Biological: Blood sampling

What is being measured

The primary outcome is the main question the study is designed to answer.

  1. Cycle 1, Group A : TH1 cells BEFORE single plasma exchange

    5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and the number of TH1 peripheral lymphocyte cells will be measured in %.

    Measured: Day 0, Time 0

  2. Cycle 1, Group A : TH1 cells AFTER single plasma exchange

    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and the number of TH1 peripheral lymphocyte cells will be measured in %.

    Measured: Day 0, Hour 3

  3. Cycle 1, Group A : TH1 cells 7-10 days AFTER single plasma exchange

    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and the number of TH1 peripheral lymphocyte cells will be measured in %.

    Measured: Day 7 -10

  4. Cycle 1, Group A : TH17 cells BEFORE first single plasma exchange

    5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and the number of TH17 peripheral lymphocyte cells will be measured in %.

    Measured: Day 0, Time 0

  5. Cycle 1, Group A : TH17 cells AFTER single plasma exchange

    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and the number of TH17 peripheral lymphocyte cells will be measured in %.

    Measured: Day 0, Hour 3

  6. Cycle 1, Group A : TH17 cells 7 - 10 days AFTER single plasma exchange

    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and the number of TH17 peripheral lymphocyte cells will be measured in %.

    Measured: Day 7 - 10

  7. Cycle 1, Group A : T-reg cells BEFORE first single plasma exchange

    5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and the number of T-reg cells will be measured in %.

    Measured: Day 0, Hour 0

  8. Cycle 1, Group A : T-reg cells AFTER single plasma exchange

    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and the number of T-reg cells will be measured in %.

    Measured: Day 0, Hour 3

  9. Cycle 1, Group A : T-reg cells 7 - 10 days AFTER single plasma exchange

    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and the number of T-reg cells will be measured in %.

    Measured: Day 7 - 10

  10. Cycle 1, Group B : TH1 cells BEFORE first double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and the number of TH1 peripheral lymphocyte cells will be measured in %.

    Measured: Day 0, Hour 0

  11. Cycle 1, Group B : TH1 cells AFTER the first double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and the number of TH1 peripheral lymphocyte cells will be measured in %.

    Measured: Day 0, Hour 3

  12. Cycle 1, Group B : TH1 cells 7-10 days AFTER the first double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and the number of TH1 peripheral lymphocyte cells will be measured in %.

    Measured: Day 7 - 10

  13. Cycle 1, Group B : TH17 cells BEFORE the first double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and the number of TH17 cells will be measured in %.

    Measured: Day0, Hour 0

  14. Cycle 1, Group B : TH17 cells AFTER the first double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and the number of TH17 cells will be measured in %.

    Measured: Day 0, Hour 3

  15. Cycle 1, Group B : T17 cells 7-10 days AFTER double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and the number of TH17 cells will be measured in %.

    Measured: Day 7-10

  16. Cycle 1, Group B : T-reg cells BEFORE double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and the number of T-reg cells will be measured in %.

    Measured: Day 0, Hour 0

  17. Cycle 1, Group B : T-reg cells AFTER double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and the number of T-reg cells will be measured in %.

    Measured: Day 0, Hour 3

  18. Cycle 1, Group B : T-reg cells 7-10 days AFTER double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and the number of T-reg cells will be measured in %.

    Measured: Day 7 - 10

  19. Cycle 2, Group A: TH1 cells BEFORE double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and the number of TH1 cells will be measured in %.

    Measured: Day 0, Hour 0

  20. Cycle 2, Group A: TH1 cells AFTER double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and the number of TH1 cells will be measured in %.

    Measured: Day 0, Hour 3

  21. Cycle 2, Group A: TH1 cells 7-10 days AFTER double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and the number of TH1 cells will be measured in %.

    Measured: Day 7 - 10

  22. Cycle 2, Group A: TH17 cells BEFORE double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and the number of TH17 cells will be measured in %.

    Measured: Day 0, Hour 0

  23. Cycle 2, Group A: TH17 cells AFTER double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and the number of TH17 cells will be measured in %.

    Measured: Day 0, Hour 3

  24. Cycle 2, Group A: TH17 cells 7-10 days AFTER double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and the number of TH17 cells will be measured in %.

    Measured: Day 7-10

  25. Cycle 2, Group A: T-reg cells BEFORE double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and the number of T-reg cells will be measured in %.

    Measured: Day 0, Hour 0

  26. Cycle 2, Group A: T-reg cells AFTER double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and the number of T-reg cells will be measured in %.

    Measured: Day 0, Hour 3

  27. Cycle 2, Group A: T-reg cells 7-10 days AFTER double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and the number of T-reg cells will be measured in %.

    Measured: Day 7-10

  28. Cycle 2, Group B: TH1 cells BEFORE single plasma exchange

    5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and the number of TH1 cells will be measured in %.

    Measured: Day 0, Hour 0

  29. Cycle 2, Group B: TH1 cells AFTER single plasma exchange

    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and the number of TH1 cells will be measured in %.

    Measured: Day 0, Hour 3

  30. Cycle 2, Group B: TH1 cells 7-10 days AFTER single plasma exchange

    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and the number of TH1 cells will be measured in %.

    Measured: Day 7-10

  31. Cycle 2, Group B: T17 cells BEFORE single plasma exchange

    5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and the number of T17 cells will be measured in %.

    Measured: Day 0, Hour 0

  32. Cycle 2, Group B: TH17 cells AFTER single plasma exchange

    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and the number of T17 cells will be measured in %.

    Measured: Day 0, Hour 3

  33. Cycle 2, Group B: TH17 cells 7-10 days AFTER single plasma exchange

    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and the number of TH17 cells will be measured in %.

    Measured: Day 7-10

  34. Cycle 2, Group B: T-reg cells BEFORE single plasma exchange

    5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and the number of T-reg cells will be measured in %.

    Measured: Day 0, Hour 0

  35. Cycle 2, Group B: T-reg cells AFTER single plasma exchange

    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and the number of T-reg cells will be measured in %.

    Measured: Day 0, Hour 3

  36. Cycle 2, Group B: T-reg cells 7-10 days AFTER single plasma exchange

    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and the number of T-reg cells will be measured in %.

    Measured: Day 7-10

  37. Cycle 3, Group A: TH1 cells BEFORE single plasma exchange

    5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and the number of TH1 peripheral lymphocyte cells will be measured in %.

    Measured: Day 1, Hour 1

  38. Cycle 3, Group A: TH1 cells AFTER single plasma exchange

    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and the number of TH1 peripheral lymphocyte cells will be measured in %.

    Measured: Day 1, Hour 3

  39. Cycle 3, Group A: T1 cells 7-10 days AFTER single plasma exchange

    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and the number of TH1 peripheral lymphocyte cells will be measured in %.

    Measured: Day 7 - 10

  40. Cycle 3, Group A: TH17 cells BEFORE single plasma exchange

    5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and the number of TH17 cells will be measured in %.

    Measured: Day 1, Hour 1

  41. Cycle 3, Group A: TH17 cells AFTER single plasma exchange

    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and the number of TH17 cells will be measured in %.

    Measured: Day 1, Hour 3

  42. Cycle 3, Group A: TH17 cells 7-10 days AFTER single plasma exchange

    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and the number of TH17 cells will be measured in %.

    Measured: Day 7 - 10

  43. Cycle 3, Group A: T-reg cells BEFORE single plasma exchange

    5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and the number of T-reg cells will be measured in %.

    Measured: Day 0, Hour 0

  44. Cycle 3, Group A: T-reg cells AFTER single plasma exchange

    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and the number of T-reg cells will be measured in %.

    Measured: Day 0, Hour 3

  45. Cycle 3, Group A: T-reg cells 7-10 days AFTER single plasma exchange

    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and the number of T-reg cells will be measured in %.

    Measured: Day 7-10

  46. Cycle 3, Group B: TH1 cells BEFORE double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and the number of TH1 peripheral lymphocyte cells will be measured in %.

    Measured: Day 0, Hour 0

  47. Cycle 3, Group B: TH1 cells AFTER double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and the number of TH1 peripheral lymphocyte cells will be measured in %.

    Measured: Day 0, Hour 3

  48. Cycle 3, Group B: TH1 cells 7-10 days AFTER double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and the number of TH1 peripheral lymphocyte cells will be measured in %.

    Measured: Day 7-10

  49. Cycle 3, Group B: TH17 cells BEFORE double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and the number of TH17 cells will be measured in %.

    Measured: Day 0, Hour 0

  50. Cycle 3, Group B: TH17 cells AFTER double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and the number of TH17 cells will be measured in %.

    Measured: Day 0, Hour 3

  51. Cycle 3, Group B: TH17 cells 7-10 days AFTER double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and the number of TH17 cells will be measured in %.

    Measured: Day 7-10

  52. Cycle 3, Group B: T-reg cells BEFORE double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and the number of T-reg cells will be measured in %.

    Measured: Day 0, Hour 0

  53. Cycle 3, Group B: T-reg cells AFTER double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and the number of T-reg cells will be measured in %.

    Measured: Day 0, Hour 3

  54. Cycle 3, Group B: T-reg cells 7-10 days AFTER double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and the number of T-reg cells will be measured in %.

    Measured: Day 7-10

  55. Cycle 4, Group A: T1 cells BEFORE double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and the number of T1 peripheral lymphocyte cells will be measured in %.

    Measured: Day 0, Hour 0

  56. Cycle 4, Group A: T1 cells AFTER double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and the number of T1 peripheral lymphocyte cells will be measured in %.

    Measured: Day 0, Hour 3

  57. Cycle 4, Group A: TH1 cells 7-10 days AFTER double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and the number of TH1 peripheral lymphocyte cells will be measured in %.

    Measured: Day 7 - 10

  58. Cycle 4, Group A: TH17 cells BEFORE double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and the number of TH17 cells will be measured in %.

    Measured: Day 0, Hour 0

  59. Cycle 4, Group A: TH17 cells AFTER double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and the number of TH17 cells will be measured in %.

    Measured: Day 0, Hour 3

  60. Cycle 4, Group A: TH17 cells 7-10 days AFTER double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and the number of TH17 peripheral lymphocyte cells will be measured in %.

    Measured: Day 7 - 10

  61. Cycle 4, Group A: T-reg cells BEFORE double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and the number of T-reg cells will be measured in %.

    Measured: Day 0, Hour 0

  62. Cycle 4, Group A: T-reg cells AFTER double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and the number of T-reg cells will be measured in %.

    Measured: Day 0, Hour 3

  63. Cycle 4, Group A: T-reg cells 7-10 days AFTER double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and the number of T-reg peripheral lymphocyte cells will be measured in %.

    Measured: Day 7 - 10

  64. Cycle 4, Group B : TH1 cells BEFORE single plasma exchange

    5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and the number of TH1 peripheral lymphocyte cells will be measured in %.

    Measured: Day 0, Hour 0

  65. Cycle 4, Group B : TH1 cells AFTER single plasma exchange

    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and the number of TH1 peripheral lymphocyte cells will be measured in %.

    Measured: Day 0, Hour 3

  66. Cycle 4, Group B : TH1 cells 7-10 days AFTER single plasma exchange

    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and the number of TH1 peripheral lymphocyte cells will be measured in %.

    Measured: Day 7 -10

  67. Cycle 4, Group B : TH17 cells BEFORE single plasma exchange

    5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and the number of TH17 cells will be measured in %.

    Measured: Day 0, Hour 0

  68. Cycle 4, Group B : TH17 cells AFTER single plasma exchange

    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and the number of TH17 cells will be measured in %.

    Measured: Day 0, Hour 3

  69. Cycle 4, Group B : T17 cells 7-10 days AFTER single plasma exchange

    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and the number of T1 peripheral lymphocyte cells will be measured in %.

    Measured: Day 7 -10

  70. Cycle 4, Group B : T-reg cells BEFORE single plasma exchange

    5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and the number of T-reg cells will be measured in %.

    Measured: Day 0, Hour 0

  71. Cycle 4, Group B : T-reg cells AFTER single plasma exchange

    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and the number of T-reg cells will be measured in %.

    Measured: Day 0, Hour 3

  72. Cycle 4, Group B : T-reg cells 7-10 days AFTER single plasma exchange

    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and the number of T-reg cells will be measured in %.

    Measured: Day 7 - 10

  73. Cycle 5, Group A : TH1 cells BEFORE single plasma exchange

    5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and the number of TH1 peripheral lymphocyte cells will be measured in %.

    Measured: Day 0, Hour 0

  74. Cycle 5, Group A : TH1 cells AFTER single plasma exchange

    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and the number of TH1 peripheral lymphocyte cells will be measured in %.

    Measured: Day 0, Hour 3

  75. Cycle 5, Group A : TH1 cells 7-10 days AFTER single plasma exchange

    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and the number of TH1 cells will be measured in %.

    Measured: Day 7 - 10

  76. Cycle 5, Group A : TH17 cells BEFORE single plasma exchange

    5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and the number of TH17 cells will be measured in %.

    Measured: Day 0, Hour 0

  77. Cycle 5, Group A : TH17 cells AFTER single plasma exchange

    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and the number of TH17 cells will be measured in %.

    Measured: Day 0, Hour 3

  78. Cycle 5, Group A : TH17 cells 7-10 days AFTER single plasma exchange

    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and the number of TH17 cells will be measured in %.

    Measured: Day 7 - 10

  79. Cycle 5, Group A : T-reg cells BEFORE single plasma exchange

    5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and the number of T-reg cells will be measured in %.

    Measured: Day 0, Hour 0

  80. Cycle 5, Group A : T-reg cells AFTER single plasma exchange

    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and the number of T-reg cells will be measured in %.

    Measured: Day 0, Hour 3

  81. Cycle 5, Group A : T-reg cells 7-10 days AFTER single plasma exchange

    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and the number of T-reg cells will be measured in %.

    Measured: Day 7 - 10

  82. Cycle 5, Group B : TH1 cells BEFORE double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and the number of TH1 peripheral lymphocyte cells will be measured in %.

    Measured: Day 0, Hour 0

  83. Cycle 5, Group B : TH1 cells AFTER double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and the number of TH1 peripheral lymphocyte cells will be measured in %.

    Measured: Day 0, Hour 3

  84. Cycle 5, Group B : TH1 cells 7-10 days AFTER double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and the number of TH1 peripheral lymphocyte cells will be measured in %.

    Measured: Day 7-10

  85. Cycle 5, Group B : TH17 cells BEFORE double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and the number of TH17 cells will be measured in %.

    Measured: Day 0, Hour 0

  86. Cycle 5, Group B : TH17 cells AFTER double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and the number of TH17 cells will be measured in %.

    Measured: Day 0, Hour 3

  87. Cycle 5, Group B : TH17 cells 7-10 days AFTER double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and the number of TH17 cells will be measured in %.

    Measured: Day 7-10

  88. Cycle 5, Group B : T-reg cells BEFORE double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and the number of T-reg cells will be measured in %.

    Measured: Day 0, Hour 0

  89. Cycle 5, Group B : T-reg cells AFTER double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and the number of T-reg cells will be measured in %.

    Measured: Day 0, Hour 3

  90. Cycle 5, Group B : T-reg cells 7-10 days AFTER double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and the number of T-reg cells will be measured in %.

    Measured: Day 7-10

  91. Cycle 6, Group A : TH1 cells BEFORE double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and the number of TH1 peripheral lymphocyte cells will be measured in %.

    Measured: Day 0 Hour 0

  92. Cycle 6, Group A : TH1 cells AFTER double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and the number of TH1 peripheral lymphocyte cells will be measured in %.

    Measured: Day 0 Hour 3

  93. Cycle 6, Group A : TH1 cells 7-10 days AFTER double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube 7-10 days AFTER double filtration plasmapheresis and the number of TH1 peripheral lymphocyte cells will be measured in %.

    Measured: Day 7-10

  94. Cycle 6, Group A : TH17 cells BEFORE double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and the number of TH17 cells will be measured in %.

    Measured: Day 0 Hour 0

  95. Cycle 6, Group A : TH17 cells AFTER double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and the number of TH17 cells will be measured in %.

    Measured: Day 0 Hour 3

  96. Cycle 6, Group A : TH17 cells 7-10 days AFTER double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube 7-10 days AFTER double filtration plasmapheresis and the number of TH17 cells will be measured in %.

    Measured: Day 7-10

  97. Cycle 6, Group A : T-reg cells BEFORE double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and the number of T-reg cells will be measured in %.

    Measured: Day 0 Hour 0

  98. Cycle 6, Group A : T-reg cells AFTER double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and the number of T-reg cells will be measured in %.

    Measured: Day 0 Hour 3

  99. Cycle 6, Group A : T-reg cells 7-10 days AFTER double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube 7-10 days AFTER double filtration plasmapheresis and the number of T-reg cells will be measured in %.

    Measured: Day 7-10

  100. Cycle 6, Group B : TH1 cells BEFORE single plasma exchange

    5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and the number of TH1 peripheral lymphocyte cells will be measured in %.

    Measured: Day 0 Hour 0

  101. Cycle 6, Group B : TH1 cells AFTER single plasma exchange

    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and the number of TH1 peripheral lymphocyte cells will be measured in %.

    Measured: Day 0 Hour 3

  102. Cycle 6, Group B : TH1 cells 7-10 days AFTER single plasma exchange

    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and the number of TH1 peripheral lymphocyte cells will be measured in %.

    Measured: Day 7-10

  103. Cycle 6, Group B : TH17 cells BEFORE single plasma exchange

    5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and the number of TH17 cells will be measured in %.

    Measured: Day 0 Hour 0

  104. Cycle 6, Group B : TH17 cells AFTER single plasma exchange

    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and the number of TH17 cells will be measured in %.

    Measured: Day 0 Hour 3

  105. Cycle 6, Group B : TH17 cells 7-10 days AFTER single plasma exchange

    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and the number of TH17 cells will be measured in %.

    Measured: Day 7-10

  106. Cycle 6, Group B : T-reg cells BEFORE single plasma exchange

    5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and the number of T-reg cells will be measured in %.

    Measured: Day 0 Hour 0

  107. Cycle 6, Group B : T-reg cells AFTER single plasma exchange

    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and the number of T-reg cells will be measured in %.

    Measured: Day 0 Hour 3

  108. Cycle 6, Group B : T-reg cells 7-10 days AFTER single plasma exchange

    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and the number of T-reg cells will be measured in %.

    Measured: Day 7-10

Secondary outcomes (324)

  1. Cycle 1, Group A : T4 lymphocytes BEFORE single plasma exchange

    5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0 Hour 0

  2. Cycle 1, Group A : T4-DR+ lymphocytes BEFORE single plasma exchange

    5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0 Hour 0

  3. Cycle 1, Group A : T8 lymphocytes BEFORE single plasma exchange

    5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0 Hour 0

  4. Cycle 1, Group A : T8 DR+ lymphocytes BEFORE single plasma exchange

    5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0 Hour 0

  5. Cycle 1, Group A : B lymphocytes BEFORE single plasma exchange

    5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0 Hour 0

  6. Cycle 1, Group A : CD45RA+CCR7+ cells BEFORE single plasma exchange

    5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0 Hour 0

  7. Cycle 1, Group A : CD45RA-CCR7+ cells BEFORE single plasma exchange

    5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0 Hour 0

  8. Cycle 1, Group A : CD45RA-CCR7- cells BEFORE single plasma exchange

    5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0 Hour 0

  9. Cycle 1, Group A : CCR6-CXCR3- cells BEFORE single plasma exchange

    5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0 Hour 0

  10. Cycle 1, Group A : T4 lymphocytes AFTER single plasma exchange

    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0 Hour 3

  11. Cycle 1, Group A : T4-DR+ lymphocytes AFTER single plasma exchange

    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0 Hour 3

  12. Cycle 1, Group A : T8 lymphocytes AFTER single plasma exchange

    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0 Hour 3

  13. Cycle 1, Group A : T8 DR+ lymphocytes AFTER single plasma exchange

    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0 Hour 3

  14. Cycle 1, Group A : B lymphocytes AFTER single plasma exchange

    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0 Hour 3

  15. Cycle 1, Group A : CD45RA+CCR7+ cells AFTER single plasma exchange

    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0 Hour 3

  16. Cycle 1, Group A : CD45RA-CCR7+ cells AFTER single plasma exchange

    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0 Hour 3

  17. Cycle 1, Group A : CD45RA-CCR7- cells AFTER single plasma exchange

    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0 Hour 3

  18. Cycle 1, Group A : CR6-CXCR3- cells AFTER single plasma exchange

    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0 Hour 3

  19. Cycle 1, Group A : T4 lymphocytes 7-10 days AFTER single plasma exchange

    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 7-10

  20. Cycle 1, Group A : T4-DR+ lymphocytes 7-10 days AFTER single plasma exchange

    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 7-10

  21. Cycle 1, Group A : T8 lymphocytes 7-10 days AFTER single plasma exchange

    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 7-10

  22. Cycle 1, Group A : T8 DR+ lymphocytes 7-10 days AFTER single plasma exchange

    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 7-10

  23. Cycle 1, Group A : B lymphocytes 7-10 days AFTER single plasma exchange

    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 7-10

  24. Cycle 1, Group A : CD45RA+CCR7+ cells 7-10 days AFTER single plasma exchange

    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 7-10

  25. Cycle 1, Group A : CD45RA-CCR7+ cells 7-10 days AFTER single plasma exchange

    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 7-10

  26. Cycle 1, Group A : CD45RA-CCR7- cells 7-10 days AFTER single plasma exchange

    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 7-10

  27. Cycle 1, Group A : CCR6-CXCR3- cells 7-10 days AFTER single plasma exchange

    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 7-10

  28. Cycle 1, Group B: T4 lymphocytes BEFORE double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0 Hour 0

  29. Cycle 1, Group B: T4 DR+ lymphocytes BEFORE double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0 Hour 0

  30. Cycle 1, Group B: T8 lymphocytes BEFORE double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0 Hour 0

  31. Cycle 1, Group B: T8 DR+ lymphocytes BEFORE double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0 Hour 0

  32. Cycle 1, Group B: B lymphocytes BEFORE double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0 Hour 0

  33. Cycle 1, Group B: CD45RA+CCR7+ cells BEFORE double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0 Hour 0

  34. Cycle 1, Group B: CD45RA-CCR7+ cells BEFORE double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0 Hour 0

  35. Cycle 1, Group B: CD45RA-CCR7- cells BEFORE double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0 Hour 0

  36. Cycle 1, Group B: CCR6-CXCR3- cells BEFORE double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0 Hour 0

  37. Cycle 1, Group B:T4 lymphocytes AFTER double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0 Hour 3

  38. Cycle 1, Group B:T4 DR+ lymphocytes AFTER double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0 Hour 3

  39. Cycle 1, Group B:T8 lymphocytes AFTER double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0 Hour 3

  40. Cycle 1, Group B:T8 DR+ lymphocytes AFTER double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0 Hour 3

  41. Cycle 1, Group B: B lymphocytes AFTER double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0 Hour 3

  42. Cycle 1, Group B: CD45RA+CCR7+ cells AFTER double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0 Hour 3

  43. Cycle 1, Group B: CD45RA-CCR7+ cells AFTER double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0 Hour 3

  44. Cycle 1, Group B: CD45RA-CCR7- cells AFTER double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0 Hour 3

  45. Cycle 1, Group B: CCR6-CXCR3- cells AFTER double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0 Hour 3

  46. Cycle 1, Group B: T4 lymphocytes 7-10 days AFTER double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube 7-10 days AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 7-10

  47. Cycle 1, Group B: T4 DR+ lymphocytes 7-10 days AFTER double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube 7-10 days AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 7-10

  48. Cycle 1, Group B: T8 lymphocytes 7-10 days AFTER double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube 7-10 days AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 7-10

  49. Cycle 1, Group B: T8 DR+ lymphocytes 7-10 days AFTER double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube 7-10 days AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 7-10

  50. Cycle 1, Group B: B lymphocytes 7-10 days AFTER double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube 7-10 days AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 7-10

  51. Cycle 1, Group B: CD45RA+CCR7+ cells 7-10 days AFTER double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube 7-10 days AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 7-10

  52. Cycle 1, Group B: CD45RA-CCR7+ cells 7-10 days AFTER double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube 7-10 days AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 7-10

  53. Cycle 1, Group B: CD45RA-CCR7- cells 7-10 days AFTER double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube 7-10 days AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 7-10

  54. Cycle 1, Group B: CCR6-CXCR3- cells 7-10 days AFTER double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube 7-10 days AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 7-10

  55. Cycle 2, Group A : T4 lymphocytes BEFORE double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0 Hour 0

  56. Cycle 2, Group A : T4 DR+ lymphocytes BEFORE double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0 Hour 0

  57. Cycle 2, Group A : T8 lymphocytes BEFORE double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0 Hour 0

  58. Cycle 2, Group A : T8 DR+ lymphocytes BEFORE double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0 Hour 0

  59. Cycle 2, Group A : B lymphocytes BEFORE double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) a,d measured as a percentage.

    Measured: Day 0 Hour 0

  60. Cycle 2, Group A : CD45RA+CCR7+ cells BEFORE double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) a,d measured as a percentage.

    Measured: Day 0 Hour 0

  61. Cycle 2, Group A : CD45RA-CCR7+ cells BEFORE double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) a,d measured as a percentage.

    Measured: Day 0 Hour 0

  62. Cycle 2, Group A : CD45RA-CCR7- cells BEFORE double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) a,d measured as a percentage.

    Measured: Day 0 Hour 0

  63. Cycle 2, Group A : CCR6-CXCR3- cells BEFORE double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) a,d measured as a percentage.

    Measured: Day 0 Hour 0

  64. Cycle 2, Group A : T4 lymphocytes AFTER double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) a,d measured as a percentage.

    Measured: Day 0 Hour 3

  65. Cycle 2, Group A : T4 DR+ lymphocytes AFTER double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0 Hour 3

  66. Cycle 2, Group A : T8 lymphocytes AFTER double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0 Hour 3

  67. Cycle 2, Group A : T8 DR+ lymphocytes AFTER double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0 Hour 3

  68. Cycle 2, Group A : B lymphocytes AFTER double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0 Hour 3

  69. Cycle 2, Group A : CD45RA+CCR7+ cells AFTER double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0 Hour 3

  70. Cycle 2, Group A : CD45RA-CCR7+ cells AFTER double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0 Hour 3

  71. Cycle 2, Group A : CD45RA-CCR7- cells AFTER double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0 Hour 3

  72. Cycle 2, Group A : CCR6-CXCR3- cells AFTER double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0 Hour 3

  73. Cycle 2, Group A : T4 lymphocytes 7-10 days AFTER double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 7 - 10

  74. Cycle 2, Group A : T4 DR+ lymphocytes 7-10 days AFTER double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 7 - 10

  75. Cycle 2, Group A : T8 lymphocytes 7-10 days AFTER double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 7 - 10

  76. Cycle 2, Group A : T8 DR+ lymphocytes 7-10 days AFTER double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 7 - 10

  77. Cycle 2, Group A : B lymphocytes 7-10 days AFTER double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 7 - 10

  78. Cycle 2, Group A : CD45RA+CCR7+ cells 7-10 days AFTER double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 7 - 10

  79. Cycle 2, Group A : CD45RA-CCR7+ cells 7-10 days AFTER double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 7 - 10

  80. Cycle 2, Group A : CD45RA-CCR7- cells 7-10 days AFTER double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 7 - 10

  81. Cycle 2, Group A : CCR6-CXCR3- cells 7-10 days AFTER double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 7 - 10

  82. Cycle 2, Group B : T4 lymphocytes BEFORE single plasma exchange

    5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0 Hour 0

  83. Cycle 2, Group B : T4 DR+ lymphocytes BEFORE single plasma exchange

    5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0 Hour 0

  84. Cycle 2, Group B : T8 lymphocytes BEFORE single plasma exchange

    5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0 Hour 0

  85. Cycle 2, Group B : T8 DR+ lymphocytes BEFORE single plasma exchange

    5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0 Hour 0

  86. Cycle 2, Group B : B lymphocytes BEFORE single plasma exchange

    5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0 Hour 0

  87. Cycle 2, Group B : CD45RA+CCR7+ cells BEFORE single plasma exchange

    5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0 Hour 0

  88. Cycle 2, Group B : CD45RA-CCR7+ cells BEFORE single plasma exchange

    5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0 Hour 0

  89. Cycle 2, Group B : CD45RA-CCR7- cells BEFORE single plasma exchange

    5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0 Hour 0

  90. Cycle 2, Group B : CCR6-CXCR3- cells BEFORE single plasma exchange

    5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0 Hour 0

  91. Cycle 2, Group B : T4 lymphocytes AFTER single plasma exchange

    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0 Hour 3

  92. Cycle 2, Group B : T4 DR+ lymphocytes AFTER single plasma exchange

    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0 Hour 3

  93. Cycle 2, Group B : T8 lymphocytes AFTER single plasma exchange

    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0 Hour 3

  94. Cycle 2, Group B : T8 DR+ lymphocytes AFTER single plasma exchange

    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0 Hour 3

  95. Cycle 2, Group B : B lymphocytes AFTER single plasma exchange

    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0 Hour 3

  96. Cycle 2, Group B : CD45RA+CCR7+ cells AFTER single plasma exchange

    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0 Hour 3

  97. Cycle 2, Group B : CD45RA-CCR7+ cells AFTER single plasma exchange

    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0 Hour 3

  98. Cycle 2, Group B : CD45RA-CCR7- cells AFTER single plasma exchange

    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0 Hour 3

  99. Cycle 2, Group B : CCR6-CXCR3- cells AFTER single plasma exchange

    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0 Hour 3

  100. Cycle 2, Group B : T4 lymphocytes 7-10 days AFTER single plasma exchange

    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 7-10

  101. Cycle 2, Group B : T4 DR+ lymphocytes 7-10 days AFTER single plasma exchange

    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 7-10

  102. Cycle 2, Group B : T8 lymphocytes 7-10 days AFTER single plasma exchange

    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 7-10

  103. Cycle 2, Group B : T8 DR+ lymphocytes 7-10 days AFTER single plasma exchange

    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 7-10

  104. Cycle 2, Group B : B lymphocytes 7-10 days AFTER single plasma exchange

    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 7-10

  105. Cycle 2, Group B : CD45RA+CCR7+ cells 7-10 days AFTER single plasma exchange

    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 7-10

  106. Cycle 2, Group B : CD45RA-CCR7+ cells 7-10 days AFTER single plasma exchange

    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 7-10

  107. Cycle 2, Group B : CD45RA-CCR7- cells 7-10 days AFTER single plasma exchange

    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured a percentage.

    Measured: Day 7-10

  108. Cycle 2, Group B : CCR6-CXCR3- cells 7-10 days AFTER single plasma exchange

    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 7-10

  109. Cycle 3, Group A : T4 lymphocytes BEFORE single plasma exchange

    5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0 Hour 0

  110. Cycle 3, Group A : T4 DR+ lymphocytes BEFORE single plasma exchange

    5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0 Hour 0

  111. Cycle 3, Group A : T8 lymphocytes BEFORE single plasma exchange

    5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0 Hour 0

  112. Cycle 3, Group A : T8 DR+ lymphocytes BEFORE single plasma exchange

    5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0 Hour 0

  113. Cycle 3, Group A : B lymphocytes BEFORE single plasma exchange

    5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0 Hour 0

  114. Cycle 3, Group A : CC45RA+CCR7+ cells BEFORE single plasma exchange

    5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0 Hour 0

  115. Cycle 3, Group A : CC45RA-CCR7+ cells BEFORE single plasma exchange

    5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0 Hour 0

  116. Cycle 3, Group A : CC45RA-CCR7- cells BEFORE single plasma exchange

    5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0 Hour 0

  117. Cycle 3, Group A : CCR6-CXCR3- cells BEFORE single plasma exchange

    5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0 Hour 0

  118. Cycle 3, Group A : T4 lymphocytes AFTER single plasma exchange

    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0 Hour 3

  119. Cycle 3, Group A : T4 DR+ lymphocytes AFTER single plasma exchange

    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0 Hour 3

  120. Cycle 3, Group A : T8 lymphocytes AFTER single plasma exchange

    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0 Hour 3

  121. Cycle 3, Group A : T8 DR+ lymphocytes AFTER single plasma exchange

    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0 Hour 3

  122. Cycle 3, Group A : B lymphocytes AFTER single plasma exchange

    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0 Hour 3

  123. Cycle 3, Group A : CD45RA+CCR7+ cells AFTER single plasma exchange

    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0 Hour 3

  124. Cycle 3, Group A : CD45RA-CCR7+ cells AFTER single plasma exchange

    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0 Hour 3

  125. Cycle 3, Group A : CD45RA-CCR7- cells AFTER single plasma exchange

    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0 Hour 3

  126. Cycle 3, Group A : CCR6-CXCR3- cells AFTER single plasma exchange

    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0 Hour 3

  127. Cycle 3, Group A : T4 DR+ lymphocytes 7-10 days AFTER single plasma exchange

    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 7-10

  128. Cycle 3, Group A : T4 lymphocytes 7 -10 days AFTER single plasma exchange

    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 7-10

  129. Cycle 3, Group A : T8 lymphocytes 7-10 days AFTER single plasma exchange

    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 7-10

  130. Cycle 3, Group A : T8 DR+ lymphocytes 7-10 days AFTER single plasma exchange

    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 7-10

  131. Cycle 3, Group A : B lymphocytes 7-10 days AFTER single plasma exchange

    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 7-10

  132. Cycle 3, Group A : CD45RA+CCR7+ cells 7-10 days AFTER single plasma exchange

    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 7-10

  133. Cycle 3, Group A : CD45RA-CCR7+ cells 7-10 days AFTER single plasma exchange

    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 7-10

  134. Cycle 3, Group A : CD45RA-CCR7- cells 7-10 days AFTER single plasma exchange

    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 7-10

  135. Cycle 3, Group A : CCR6-CXCR3- cells 7-10 days AFTER single plasma exchange

    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 7-10

  136. Cycle 3, Group B : T4 lymphocytes BEFORE double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube BEFORE double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0 Hour 0

  137. Cycle 3, Group B : T4 DR+ lymphocytes BEFORE double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube BEFORE double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0 Hour 0

  138. Cycle 3, Group B : T8 lymphocytes BEFORE double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube BEFORE double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0 Hour 0

  139. Cycle 3, Group B : T8 DR+ lymphocytes BEFORE double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube BEFORE double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0 Hour 0

  140. Cycle 3, Group B : B lymphocytes BEFORE double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube BEFORE double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0 Hour 0

  141. Cycle 3, Group B : CD45RA+CCR7+ cells BEFORE double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube BEFORE double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0 Hour 0

  142. Cycle 3, Group B : CD45RA-CCR7+ cells BEFORE double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube BEFORE double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0 Hour 0

  143. Cycle 3, Group B : CD45RA-CCR7- cells BEFORE double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube BEFORE double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0 Hour 0

  144. Cycle 3, Group B : CCR6-CXCR3- cells BEFORE double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube BEFORE double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0 Hour 0

  145. Cycle 3, Group B : T4 lymphocytes AFTER double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube AFTER double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0 Hour 3

  146. Cycle 3, Group B : T4 DR+ lymphocytes AFTER double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube AFTER double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0 Hour 3

  147. Cycle 3, Group B : T8 lymphocytes AFTER double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube AFTER double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0 Hour 3

  148. Cycle 3, Group B : T8 DR+ lymphocytes AFTER double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube AFTER double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0 Hour 3

  149. Cycle 3, Group B : B lymphocytes AFTER double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube AFTER double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0 Hour 3

  150. Cycle 3, Group B : CD45RA+CCR7+ cells AFTER double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube AFTER double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0 Hour 3

  151. Cycle 3, Group B : CD45RA-CCR7+ cells AFTER double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube AFTER double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0 Hour 3

  152. Cycle 3, Group B : CD45RA-CCR7- cells AFTER double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube AFTER double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0 Hour 3

  153. Cycle 3, Group B : CCR6-CXCR3- cells AFTER double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube AFTER double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0 Hour 3

  154. Cycle 3, Group B : T4 lymphocytes 7-10 days AFTER double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube AFTER double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 7-10

  155. Cycle 3, Group B : T4 DR+ lymphocytes 7-10 days AFTER double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube AFTER double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 7-10

  156. Cycle 3, Group B : T8 lymphocytes 7-10 days AFTER double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube AFTER double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 7-10

  157. Cycle 3, Group B : T8 DR+ lymphocytes 7-10 days AFTER double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube AFTER double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 7-10

  158. Cycle 3, Group B : B lymphocytes 7-10 days AFTER double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube AFTER double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 7-10

  159. Cycle 3, Group B : CD45RA+CCR7+ cells 7-10 days AFTER double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube AFTER double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 7-10

  160. Cycle 3, Group B : CD45RA-CCR7+ cells 7-10 days AFTER double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube AFTER double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 7-10

  161. Cycle 3, Group B : CD45RA-CCR7- cells 7-10 days AFTER double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube AFTER double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 7-10

  162. Cycle 3, Group B : CCR6-CXCR3- cells 7-10 days AFTER double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube AFTER double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 7-10

  163. Cycle 4, Group A : T4 lymphocytes BEFORE double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube BEFORE double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0 Hour 0

  164. Cycle 4, Group A : T4 DR+ lymphocytes BEFORE double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube BEFORE double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0 Hour 0

  165. Cycle 4, Group A : T8 lymphocytes BEFORE double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube BEFORE double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0 Hour 0

  166. Cycle 4, Group A : T8 DR+ lymphocytes BEFORE double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube BEFORE double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0 Hour 0

  167. Cycle 4, Group A : B lymphocytes BEFORE double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube BEFORE double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0 Hour 0

  168. Cycle 4, Group A : CD45RA+CCR7+ cells BEFORE double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube BEFORE double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0 Hour 0

  169. Cycle 4, Group A : CD45RA-CCR7+ cells BEFORE double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube BEFORE double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0 Hour 0

  170. Cycle 4, Group A : CD45RA-CCR7- cells BEFORE double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube BEFORE double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0 Hour 0

  171. Cycle 4, Group A : CCR6-CXCR3- cells BEFORE double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube BEFORE double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0 Hour 0

  172. Cycle 4, Group A : T4 lymphocytes AFTER double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube AFTER double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0 Hour 3

  173. Cycle 4, Group A : T4 DR+ lymphocytes AFTER double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube AFTER double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0 Hour 3

  174. Cycle 4, Group A : T8 lymphocytes AFTER double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube AFTER double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0 Hour 3

  175. Cycle 4, Group A : T8 DR+ lymphocytes AFTER double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube AFTER double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0 Hour 3

  176. Cycle 4, Group A : B lymphocytes AFTER double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube AFTER double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0 Hour 3

  177. Cycle 4, Group A : CD45RA+CCR7+ cells AFTER double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube AFTER double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0 Hour 3

  178. Cycle 4, Group A : CD45RA-CCR7+ cells AFTER double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube AFTER double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0 Hour 3

  179. Cycle 4, Group A : CD45RA-CCR7- cells AFTER double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube AFTER double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0 Hour 3

  180. Cycle 4, Group A : CCR6-CXCR3- cells AFTER double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube AFTER double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0 Hour 3

  181. Cycle 4, Group A : T4 lymphocytes 7-10 days AFTER double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube AFTER double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 7-10

  182. Cycle 4, Group A : T4 DR+ lymphocytes 7-10 days AFTER double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube AFTER double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 7-10

  183. Cycle 4, Group A : T8 lymphocytes 7-10 days AFTER double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube AFTER double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 7-10

  184. Cycle 4, Group A : T8 DR+ lymphocytes 7-10 days AFTER double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube AFTER double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 7-10

  185. Cycle 4, Group A : B lymphocytes 7-10 days AFTER double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube AFTER double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 7-10

  186. Cycle 4, Group A : CD45RA+CCR7+ cells 7-10 days AFTER double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube AFTER double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 7-10

  187. Cycle 4, Group A : CD45RA-CCR7+ cells 7-10 days AFTER double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube AFTER double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 7-10

  188. Cycle 4, Group A : CD45RA-CCR7- cells 7-10 days AFTER double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube AFTER double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 7-10

  189. Cycle 4, Group A : CCR6-CXCR3- cells 7-10 days AFTER double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube AFTER double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 7-10

  190. Cycle 4, Group B : T4 lymphocytes BEFORE plasma exchange

    5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0 Hour 0

  191. Cycle 4, Group B : T4 DR+ lymphocytes BEFORE plasma exchange

    5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0 Hour 0

  192. Cycle 4, Group B : T8 lymphocytes BEFORE plasma exchange

    5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0 Hour 0

  193. Cycle 4, Group B : T8 DR+ lymphocytes BEFORE single plasma exchange

    5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0 Hour 0

  194. Cycle 4, Group B : B lymphocytes BEFORE single plasma exchange

    5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0 Hour 0

  195. Cycle 4, Group B : CD45RA+CCR7+ cells BEFORE single plasma exchange

    5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0 Hour 0

  196. Cycle 4, Group B : CD45RA-CCR7+ cells BEFORE single plasma exchange

    5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0 Hour 0

  197. Cycle 4, Group B : CD45RA-CCR7- cells BEFORE single plasma exchange

    5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0 Hour 0

  198. Cycle 4, Group B : CCR6-CXCR3- cells BEFORE single plasma exchange

    5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0 Hour 0

  199. Cycle 4, Group B : T4 lymphocytes AFTER single plasma exchange

    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0 Hour 3

  200. Cycle 4, Group B : T4 DR+ lymphocytes AFTER single plasma exchange

    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0 Hour 3

  201. Cycle 4, Group B : T8 lymphocytes AFTER single plasma exchange

    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0 Hour 3

  202. Cycle 4, Group B : T8 DR+ lymphocytes AFTER single plasma exchange

    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0 Hour 3

  203. Cycle 4, Group B : B lymphocytes AFTER single plasma exchange

    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0 Hour 3

  204. Cycle 4, Group B : CD45RA+CCR7+ cells AFTER single plasma exchange

    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0 Hour 3

  205. Cycle 4, Group B : CD45RA-CCR7+ cells AFTER single plasma exchange

    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0 Hour 3

  206. Cycle 4, Group B : CD45RA-CCR7- cells AFTER single plasma exchange

    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0 Hour 3

  207. Cycle 4, Group B : CCR6-CXCR3- cells AFTER single plasma exchange

    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0 Hour 3

  208. Cycle 4, Group B : T4 lymphocytes 7-10 days AFTER single plasma exchange

    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 7-10

  209. Cycle 4, Group B : T4 DR+ lymphocytes 7-10 days AFTER single plasma exchange

    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 7-10

  210. Cycle 4, Group B : T8 lymphocytes 7-10 days AFTER single plasma exchange

    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 7-10

  211. Cycle 4, Group B : T8 DR+ lymphocytes 7-10 days AFTER single plasma exchange

    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 7-10

  212. Cycle 4, Group B : B lymphocytes 7-10 days AFTER single plasma exchange

    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 7-10

  213. Cycle 4, Group B : CD45RA+CCR7+ cells 7-10 days AFTER single plasma exchange

    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 7-10

  214. Cycle 4, Group B : CD45RA-CCR7+ cells 7-10 days AFTER single plasma exchange

    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 7-10

  215. Cycle 4, Group B : CD45RA-CCR7- cells 7-10 days AFTER single plasma exchange

    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 7-10

  216. Cycle 4, Group B : CCR6-CXCR3- cells 7-10 days AFTER single plasma exchange

    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 7-10

  217. Cycle 5, Group A : T4 lymphocytes BEFORE single plasma exchange

    5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0, Hour 0

  218. Cycle 5, Group A : T4 DR+ lymphocytes BEFORE single plasma exchange

    5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0, Hour 0

  219. Cycle 5, Group A : T8 lymphocytes BEFORE single plasma exchange

    5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0, Hour 0

  220. Cycle 5, Group A : T8 DR+ lymphocytes BEFORE single plasma exchange

    5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0, Hour 0

  221. Cycle 5, Group A : B lymphocytes BEFORE single plasma exchange

    5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0, Hour 0

  222. Cycle 5, Group A : CD45RA+CCR7+ cells BEFORE single plasma exchange

    5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0, Hour 0

  223. Cycle 5, Group A : CD45RA-CCR7+ cells BEFORE single plasma exchange

    5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0, Hour 0

  224. Cycle 5, Group A : CD45RA-CCR7- cells BEFORE single plasma exchange

    5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0, Hour 0

  225. Cycle 5, Group A : CCR6-CXCR3- cells BEFORE single plasma exchange

    5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0, Hour 0

  226. Cycle 5, Group A : T4 lymphocytes AFTER single plasma exchange

    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0, Hour 3

  227. Cycle 5, Group A : T4 DR+ lymphocytes AFTER single plasma exchange

    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0, Hour 3

  228. Cycle 5, Group A : T8 lymphocytes AFTER single plasma exchange

    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0, Hour 3

  229. Cycle 5, Group A : T8 DR+ lymphocytes AFTER single plasma exchange

    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0, Hour 3

  230. Cycle 5, Group A : B lymphocytes AFTER single plasma exchange

    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0, Hour 3

  231. Cycle 5, Group A : CD45RA+CCR7+ cells AFTER single plasma exchange

    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0, Hour 3

  232. Cycle 5, Group A : CD45RA-CCR7+ cells AFTER single plasma exchange

    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0, Hour 3

  233. Cycle 5, Group A : CD45RA-CCR7- cells AFTER single plasma exchange

    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0, Hour 3

  234. Cycle 5, Group A : CCR6-CXCR3- cells AFTER single plasma exchange

    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0, Hour 3

  235. Cycle 5, Group A : T4 lymphocytes 7-10 days AFTER single plasma exchange

    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 7-10

  236. Cycle 5, Group A : T4 DR+ lymphocytes 7-10 days AFTER single plasma exchange

    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 7-10

  237. Cycle 5, Group A : T8 lymphocytes 7-10 days AFTER single plasma exchange

    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 7-10

  238. Cycle 5, Group A : T8 DR+ lymphocytes 7-10 days AFTER single plasma exchange

    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 7-10

  239. Cycle 5, Group A : B lymphocytes 7-10 days AFTER single plasma exchange

    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 7-10

  240. Cycle 5, Group A : CD45RA+CCR7+ cells 7-10 days AFTER single plasma exchange

    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 7-10

  241. Cycle 5, Group A : CD45RA-CCR7+ cells 7-10 days AFTER single plasma exchange

    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 7-10

  242. Cycle 5, Group A : CD45RA-CCR7- cells 7-10 days AFTER single plasma exchange

    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 7-10

  243. Cycle 5, Group A : CCR6-CXCR3- cells 7-10 days AFTER single plasma exchange

    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 7-10

  244. Cycle 5, Group B : T4 lymphocytes BEFORE double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0, Hour 0

  245. Cycle 5, Group B : T4 DR+ lymphocytes BEFORE double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0, Hour 0

  246. Cycle 5, Group B : T8 lymphocytes BEFORE double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0, Hour 0

  247. Cycle 5, Group B : T8 DR+ lymphocytes BEFORE double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0, Hour 0

  248. Cycle 5, Group B : B lymphocytes BEFORE double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0, Hour 0

  249. Cycle 5, Group B : CD45RA+CCR7+ cells BEFORE double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0, Hour 0

  250. Cycle 5, Group B : CD45RA-CCR7+ cells BEFORE double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0, Hour 0

  251. Cycle 5, Group B : CD45RA-CCR7- cells BEFORE double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0, Hour 0

  252. Cycle 5, Group B : CCR6-CXCR3- cells BEFORE double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0, Hour 0

  253. Cycle 5, Group B : T4 lymphocytes AFTER double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0, Hour 3

  254. Cycle 5, Group B : T4 DR+ lymphocytes AFTER double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0, Hour 3

  255. Cycle 5, Group B : T8 lymphocytes AFTER double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0, Hour 3

  256. Cycle 5, Group B : T8 DR+ lymphocytes AFTER double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0, Hour 3

  257. Cycle 5, Group B : B lymphocytes AFTER double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0, Hour 3

  258. Cycle 5, Group B : CD45RA+CCR7+ cells AFTER double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0, Hour 3

  259. Cycle 5, Group B : CD45RA-CCR7+ cells AFTER double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0, Hour 3

  260. Cycle 5, Group B : CD45RA-CCR7- cells AFTER double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0, Hour 3

  261. Cycle 5, Group B : CCR6-CXCR3- cells AFTER double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0, Hour 3

  262. Cycle 5, Group B : T4 lymphocytes 7-10 days AFTER double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 7-10

  263. Cycle 5, Group B : T4 DR+ lymphocytes 7-10 days AFTER double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 7-10

  264. Cycle 5, Group B : T8 lymphocytes 7-10 days AFTER double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 7-10

  265. Cycle 5, Group B : T8 DR+ lymphocytes 7-10 days AFTER double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 7-10

  266. Cycle 5, Group B : B lymphocytes 7-10 days AFTER double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 7-10

  267. Cycle 5, Group B : CD45RA+CCR7+ cells 7-10 days AFTER double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 7-10

  268. Cycle 5, Group B : CD45RA-CCR7+ cells 7-10 days AFTER double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 7-10

  269. Cycle 5, Group B : CD45RA-CCR7- cells 7-10 days AFTER double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 7-10

  270. Cycle 5, Group B : CCR6-CXCR3- cells 7-10 days AFTER double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 7-10

  271. Cycle 6, Group A : T4 lymphocytes BEFORE double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0, Hour 0

  272. Cycle 6, Group A : T4 DR+ lymphocytes BEFORE double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0, Hour 0

  273. Cycle 6, Group A : T8 lymphocytes BEFORE double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0, Hour 0

  274. Cycle 6, Group A : T8 DR+ lymphocytes BEFORE double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0, Hour 0

  275. Cycle 6, Group A : B lymphocytes BEFORE double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0, Hour 0

  276. Cycle 6, Group A : CD45RA+CCR7+ cells BEFORE double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0, Hour 0

  277. Cycle 6, Group A : CD45RA-CCR7+ cells BEFORE double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0, Hour 0

  278. Cycle 6, Group A : CD45RA-CCR7- cells BEFORE double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0, Hour 0

  279. Cycle 6, Group A : CCR6-CXCR3- cells BEFORE double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0, Hour 0

  280. Cycle 6, Group A : T4 lymphocytes AFTER double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0, Hour 3

  281. Cycle 6, Group A : T4 DR+ lymphocytes AFTER double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0, Hour 3

  282. Cycle 6, Group A : T8 lymphocytes AFTER double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0, Hour 3

  283. Cycle 6, Group A : T8 DR+ lymphocytes AFTER double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0, Hour 3

  284. Cycle 6, Group A : B lymphocytes AFTER double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0, Hour 3

  285. Cycle 6, Group A : CD45RA+CCR7+ cells AFTER double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0, Hour 3

  286. Cycle 6, Group A : CD45RA-CCR7+ cells AFTER double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0, Hour 3

  287. Cycle 6, Group A : CD45RA-CCR7- cells AFTER double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0, Hour 3

  288. Cycle 6, Group A : CCR6-CXCR3- cells AFTER double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0, Hour 3

  289. Cycle 6, Group A : T4 lymphocytes 7-10 days AFTER double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 7-10

  290. Cycle 6, Group A : T4 DR+ lymphocytes 7-10 days AFTER double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 7-10

  291. Cycle 6, Group A : T8 lymphocytes 7-10 days AFTER double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 7-10

  292. Cycle 6, Group A : T8 DR+ lymphocytes 7-10 days AFTER double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 7-10

  293. Cycle 6, Group A : B lymphocytes 7-10 days AFTER double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 7-10

  294. Cycle 6, Group A : CD45RA+CCR7+ cells 7-10 days AFTER double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 7-10

  295. Cycle 6, Group A : CD45RA-CCR7+ cells 7-10 days AFTER double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 7-10

  296. Cycle 6, Group A : CD45RA-CCR7- cells 7-10 days AFTER double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 7-10

  297. Cycle 6, Group A : CCR6-CXCR3- cells 7-10 days AFTER double filtration plasmapheresis

    5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 7-10

  298. Cycle 6, Group B : T4 lymphocytes BEFORE single plasma exchange

    5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0, H0

  299. Cycle 6, Group B : T4 DR+ lymphocytes BEFORE single plasma exchange

    5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0, H0

  300. Cycle 6, Group B : T8 lymphocytes BEFORE single plasma exchange

    5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0, H0

  301. Cycle 6, Group B : T8 DR+ lymphocytes BEFORE single plasma exchange

    5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0, H0

  302. Cycle 6, Group B : B lymphocytes BEFORE single plasma exchange

    5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0, H0

  303. Cycle 6, Group B : CD45RA+CCR7+ cells BEFORE single plasma exchange

    5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0, H0

  304. Cycle 6, Group B : CD45RA-CCR7+ cells BEFORE single plasma exchange

    5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0, H0

  305. Cycle 6, Group B : CD45RA-CCR7- cells BEFORE single plasma exchange

    5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0, H0

  306. Cycle 6, Group B : CCR6-CXCR3- cells BEFORE single plasma exchange

    5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0, H0

  307. Cycle 6, Group B : T4 lymphocytes AFTER single plasma exchange

    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0, H3

  308. Cycle 6, Group B : T4 DR+ lymphocytes AFTER single plasma exchange

    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0, H3

  309. Cycle 6, Group B : T8 lymphocytes AFTER single plasma exchange

    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0, H3

  310. Cycle 6, Group B : T8 DR+ lymphocytes AFTER single plasma exchange

    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0, H3

  311. Cycle 6, Group B : B lymphocytes AFTER single plasma exchange

    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0, H3

  312. Cycle 6, Group B : CD45RA+CCR7+ cells AFTER single plasma exchange

    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0, H3

  313. Cycle 6, Group B : CD45RA-CCR7+ cells AFTER single plasma exchange

    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0, H3

  314. Cycle 6, Group B : CD45RA-CCR7- cells AFTER single plasma exchange

    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0, H3

  315. Cycle 6, Group B : CCR6-CXCR3- cells AFTER single plasma exchange

    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 0, H3

  316. Cycle 6, Group B : T4 lymphocytes 7-10 days AFTER single plasma exchange

    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 7-10

  317. Cycle 6, Group B : T4 DR+ lymphocytes 7-10 days AFTER single plasma exchange

    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 7-10

  318. Cycle 6, Group B : T8 lymphocytes 7-10 days AFTER single plasma exchange

    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 7-10

  319. Cycle 6, Group B : T8 DR+ lymphocytes 7-10 days AFTER single plasma exchange

    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 7-10

  320. Cycle 6, Group B : B lymphocytes 7-10 days AFTER single plasma exchange

    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 7-10

  321. Cycle 6, Group B : CD45RA+CCR7+ cells 7-10 days AFTER single plasma exchange

    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 7-10

  322. Cycle 6, Group B : CD45RA-CCR7+ cells 7-10 days AFTER single plasma exchange

    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 7-10

  323. Cycle 6, Group B : CD45RA-CCR7- cells 7-10 days AFTER single plasma exchange

    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 7-10

  324. Cycle 6, Group B : CCR6-CXCR3- cells 7-10 days AFTER single plasma exchange

    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

    Measured: Day 7-10

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

  1. First posted8 Feb 2021
  2. Study start12 Mar 2021
  3. Primary completion18 Dec 2023
  4. Study completion18 Dec 2023

Resources

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design
Study type
Interventional
Phase
Early Phase 1
Primary purpose
Treatment
Allocation
Randomised
Intervention model
Crossover
Model description
Proof-of-concept, monocentric, prospective, Single-Case Experimental Design
Masking
Single blind
Who is masked
Participant
Enrolment
8 participants (actual)
IDs, dates and publications
ClinicalTrials.gov ID
NCT04742374
Sponsor's protocol ID
NIMAO/2020-01/OM001
Other IDs
2020-A02879-30
Acronym
LYMPHOARESIS
Status last verified
Dec 2025
First submitted
26 Jan 2021
Last updated
10 Dec 2025
Results posted
No
Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No

Publications

  • Moranne O, Ion IM, Cezar R, Messikh Z, Prelipcean C, Chkair S, Thouvenot E, Tran TA, Corbeau P, Chevallier T. Protocol of comparison of the effects of single plasma exchange and double filtration plasmapheresis on peripheral lymphocyte phenotypes in patients with Chronic Inflammatory Demyelinating Polyradiculoneuropathy: a monocentric prospective study with single-case experimental design. BMC Neurol. 2022 Aug 5;22(1):293. doi: 10.1186/s12883-022-02816-w.

    PubMed 35931957

Questions about this trial

What is this clinical trial studying?

A Early Phase 1 study testing Blood sampling in people with Polyradiculoneuropathy, Chronic Inflammatory Demyelinating, run by Centre Hospitalier Universitaire de Nīmes at 1 site in France.

The full registered description is in the About this study section and the official record.

Who may be eligible to take part?

The sponsor lists 6 inclusion and 9 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.

Is this clinical trial currently recruiting?

The record says: finished, as of the sponsor's last update on 10 Dec 2025. Status can change between updates, so confirm with the study contact before making plans.

Where is the study taking place?

The record lists 1 site in France. Whether a site is taking part right now should be confirmed with that site. See every site.

What are the possible benefits and risks?

They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.

What does this phase mean?

Early Phase 1 (sometimes called Phase 0) studies give a very small amount of a treatment to a few people, mainly to see how the body handles it.

Not every study follows the same path, and some studies (observational studies, device studies) have no phase.

Are results available for this study?

The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.

How can a doctor refer a patient or contact the research team?

The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.

What does the primary outcome measure?

Cycle 1, Group A : TH1 cells BEFORE single plasma exchange (time frame: Day 0, Time 0). The study lists 108 primary outcomes in all. It is what the study was designed to measure, not a finding.

Where can I read the original study information?

On the ClinicalTrials.gov record for NCT04742374, which also lists 1 linked publication.

Does a listing mean the treatment is approved or proven to work?

No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.

How often is this information updated?

AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 10 Dec 2025.

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