Focus of the Study is MRI Sequence DevelopmentMINIONNCT04749134
MRI Development for Radiotherapy Planning and Delivery in Non-Patient Volunteers
An observational study of Focus of the Study is MRI Sequence Development, run by The Christie NHS Foundation Trust at 1 site in United Kingdom.
Trial summary
Non-patient volunteers will be scanned on the MR-Linac and MRSIM to facilitate the development, optimisation and validation of MRI protocols at The Christie NHS Foundation Trust. Read more about this study
- Who is it for?
- Ages 16 years and olderHealthy volunteers can take part
- Conditions the study is for
- Focus of the Study is MRI Sequence Development
- How many people
- 500 participants
- Where
- 1 siteUnited Kingdom
- Study dates
- 1 Aug 2021to 31 Aug 2028
- Phase
- Observational
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 16 years and older
- All sexes
- Healthy volunteers accepted
- Child, Adult, Older adult
Study population: Personnel at The Christie NHS Foundation Trust
Who may be able to join
- Willing and able to provide written consent
- Volunteers must undergo and satisfy MRI safety screening
- Volunteers must be ≥ 16 years of age
- Participants must agree to registration as a non-patient in CWP (the Trust's Electronic Health Record - EHR- system) and have their MRIs read and reported for incidental findings by a clinical radiologist
Who cannot join
- Any contraindications to MRI identified after MRI safety screening including completion of an MRI Safety Screening Form
- Unable to tolerate MRI scan
- Known Pregnancy
- Known or suspected pathology in body region to be scanned
- Member of study team
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
United Kingdom1 site, 1 recruiting
- Recruiting
The Christie NHS FT
Manchester
Cynthia Eccles, DPhil, 16187999, cynhia.eccles1@nhs.net
About this study
Non-patient volunteers will be scanned on the MR-Linac and MRSIM to facilitate the development, optimisation and validation of MRI protocols at The Christie NHS Foundation Trust.
What is being measured
The primary outcome is the main question the study is designed to answer.
Developed and optimised of MRI scanning sequences for use in clinical radiotherapy practice in MR guided radiotherapy
on-going development of MRI protocols to be released for clinical use
Measured: Through study completion - up to 5 years
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted11 Feb 2021
- Study start1 Aug 2021
- Primary completion31 Aug 2028 (estimated)
- Study completion31 Aug 2028 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Focus of the Study is MRI Sequence DevelopmentStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Other
- Time perspective
- Other
- Enrolment
- 500 participants (estimated)
Sponsor and investigators
- Lead sponsor
- The Christie NHS Foundation Trust
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Cynthia Eccles, The Christie NHS Foundation Trust
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT04749134
- Sponsor's protocol ID
- CFTSp170
- Acronym
- MINION
- Status last verified
- Aug 2025
- First submitted
- 27 Jan 2021
- Last updated
- 24 Aug 2025
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 24 Aug 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- MRI Development for Radiotherapy Planning and Delivery in Non-Patient Volunteers
- ClinicalTrials.gov ID
- NCT04749134
- Acronym / sponsor ID
- MINION / CFTSp170
- Study type
- Observational
- Recruitment status
- Recruiting
- Enrolment
- 500 participants (estimated)
- Lead sponsor
- The Christie NHS Foundation TrustUniversity, hospital or other
- Study start
- 1 Aug 2021 (actual)
- Primary completion
- 31 Aug 2028 (estimated)
- Study completion
- 31 Aug 2028 (estimated)
- First posted
- 11 Feb 2021 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Non-patient volunteers will be scanned on the MR-Linac and MRSIM to facilitate the development, optimisation and validation of MRI protocols at The Christie NHS Foundation Trust.
Study design
- Observational model
- Other
- Time perspective
- Other
Who may qualify
- Ages
- 16 years and older
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Child, Adult, Older adult
- Study population
- Personnel at The Christie NHS Foundation Trust
Key inclusion criteria (4 listed)
- Willing and able to provide written consent
- Volunteers must undergo and satisfy MRI safety screening
- Volunteers must be ≥ 16 years of age
- Participants must agree to registration as a non-patient in CWP (the Trust's Electronic Health Record - EHR- system) and have their MRIs read and reported for incidental findings by a clinical radiologist
Key exclusion criteria (5 listed)
- Any contraindications to MRI identified after MRI safety screening including completion of an MRI Safety Screening Form
- Unable to tolerate MRI scan
- Known Pregnancy
- Known or suspected pathology in body region to be scanned
- Member of study team
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Primary outcome
Developed and optimised of MRI scanning sequences for use in clinical radiotherapy practice in MR guided radiotherapy
Time frame: Through study completion - up to 5 years
on-going development of MRI protocols to be released for clinical use
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 24 Aug 2025.
- Individual participant dataSharing planned: No
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Focus of the Study is MRI Sequence Development, run by The Christie NHS Foundation Trust at 1 site in United Kingdom.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 5 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 24 Aug 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United Kingdom. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Each site lists its own contact: choose the nearest one under Trial locations. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Developed and optimised of MRI scanning sequences for use in clinical radiotherapy practice in MR guided radiotherapy (time frame: Through study completion - up to 5 years). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 24 Aug 2025.