Stigma, SocialNCT04760223
Reducing Stigma Towards Depression Among Adolescents
A study testing Video intervention in people with Stigma, Social, run by Research Foundation for Mental Hygiene, Inc. at 2 sites in United States.
Trial summary
The investigators conducted a randomized controlled study to test the utility of a brief video-based intervention to: 1) reduce stigma towards depression, and 2) increase treatment-seeking intentions among adolescents. Read more about this study
- Who is it for?
- Ages 14 to 18 yearsHealthy volunteers can take part
- Conditions the study is for
- Stigma, Social
- What is being tested?
- Video intervention
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- Yes, some participants may receive a placebo
- How many people
- 1,183 participants
- Where
- 2 sitesUnited States
- Study dates
- 1 Jan 2021to 1 Feb 2021
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 14 to 18 years
- All sexes
- Healthy volunteers accepted
- Child, Adult
Who may be able to join
- 14-18-year-old
- US residents
- English speaker
Who cannot join
- None
Trial locations and contacts
2 sites in 1 country.
United States2 sites
Yale University
New Haven, Connecticut, 06520
New York State Psychiatric Institute
New York, New York, 10032
About this study
Official title: Reducing Depression-related Stigma and Increasing Treatment-seeking Among Adolescents: Randomized Controlled Trial of a Brief Video Intervention
The investigators conducted a randomized controlled study to test the utility of a brief video-based intervention to: 1) reduce stigma towards depression, and 2) increase treatment-seeking intentions among adolescents.
Read the detailed description
Young people present with the higher prevalence of mental health disorders compared to individuals at any other age, with up to 20% of adolescents likely to experience mental health disorders. Around 50% of mental health conditions start before the age of 14 and the onset of 75% of cases is before the age of 18. Depression is the most common diagnosis and epidemiological studies suggest that at any one time 8% to 10% of adolescents have severe depression. This means that the major burden of assessing and managing adolescent depression falls on primary care practitioners. Depression is a principal cause of illness and disability in teenagers, and suicide is the third most common cause of death among older adolescents. Mental health problems can significantly affect the development of children and young people having an enduring impact on their health and social functioning in adulthood. However, 75% of adolescents with mental health problems are not in contact with mental health services,8 and the primary reason for the reluctance to seek help is stigma.
Stigma refers to negative beliefs and stereotypes held toward a specific group of people and adversely affects people with mental illness. Public stigma refers to negative attitudes and beliefs that motivate individuals to fear, reject, avoid, and discriminate against people with mental illness. Individuals with mental illness expect to face prejudice and discrimination (anticipated stigma) and internalize public stereotypes of people with mental illness (self-stigma). Adolescents are particularly aware of how others perceive them and care greatly about what their peers think of them. Public stigma toward youngsters with mental illness has been identified as a barrier to seeking help; therefore, reducing public stigma among young people at risk for or even experiencing depression could enhance their receptivity to seeking help or treatment.
Applying strategies to reduce stigma towards mental health care among adolescents with high levels of depression may prevent worsening of symptoms, ameliorate impaired functioning, and reduce risks for long-term psychiatric illness. Among possible strategies, studies19 have shown that social contact is the most effective type of intervention to reduce stigmatizing attitudes. Social contact involves interpersonal contact with members of the stigmatized group: members of the general public who meet and interact with individuals who suffer from depression are likely to lessen their stigma. Corrigan identified the most important ingredients of contact-based programs: an empowered presenter with lived experience who attains his/her goals (e.g., "I was able to fight the depression and go back to school"). Although direct, in-person social contact, as well as indirect, video-based social contact have effectively improved attitudes toward mental issues and care, the latter can be implemented on a larger scale, use minimal resources and be easily disseminated.
The purpose of this study is to: (1) examine adolescents' stigma-related attitudes towards depression; and (2) test the utility of a brief video-based intervention in reducing stigma towards depression and increasing help-seeking intentions.
The investigators propose to randomly assign 1,000 individuals aged 14-18 in to either: (a) brief video-based intervention 1 ('Video 1'); (b) brief video-based intervention 2 ('Video 2'); or (c) no intervention video control arm ('Control'). The intervention videos will focus on empowered presenters with depression. The presenters will be 16-year-old adolescent professional actors, one of them is a boy (Video 1), one is a girl (Video 2). They each will share his/her personal story regarding depression and describe how social support from family, friends, and professionals have helped them overcome their symptoms and recover. The third group will watch a same length video with unrelated contents. Assessments will occur at baseline and at post-intervention and will tap into demographic identifiers and attitudes around stigma and help-seeking questionnaires.
Actors will be hired through the Child Study Center, and / or through the Standardized Patient Program of Teaching and Learning Center, Yale School of Medicine. Actors will be compensated and follow standardized patient best practices, including those specifically pertaining to under-age actors.
- Conditions
- Stigma, Social
- Being tested
- Video intervention
- Medical subject headings
- Social Stigma
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Video interventionBehavioural
a 100-second video, presenting a personal story of a boy/girl dealing with depression
| Study group | Role | What they receive |
|---|---|---|
| Video intervention 1 | Experimental | We presented a 100-second video to study participants to reduce stigma towards depression (a boy presenter). The protagonist discussed his own depression and how getting help assist him. Receives: Behavioral: Video intervention |
| Video intervention 2 | Experimental | We presented a 100-second video to study participants to reduce stigma towards depression (a girl presenter). The protagonist discussed his own depression and how getting help assist her. Receives: Behavioral: Video intervention |
| control video 1 | Placebo comparator | A 100-second video presenting a boy without depression Receives: Behavioral: Video intervention |
| control video 2 | Placebo comparator | A 100-second video presenting a girl without depression Receives: Behavioral: Video intervention |
What is being measured
The primary outcome is the main question the study is designed to answer.
Stigma levels
Level of stigma towards depression measured by the 9-item Depression Stigma Scale (DSS). This is a 9-item self report questionnaire to measure the personal stigma towards depression. It has 5-point Likert scale tanging from strongly disagree (1) and strongly agree (5). It had test-retest reliability of 0.71 and internal consistency of 0.76 (Griffiths KM et al. 2004)
Measured: Through the study completion (pre and post-intervention), an average of one month
help-seeking intentions
The General Help-Seeking Questionnaire (GHSQ) has been developed to measure help-seeking intentions from different sources (friend, parent, mental health professional, and others) and is divided into personal-emotional problems and suicidal thoughts. The instrument consists of 10 items repeated twice for each part, measured with a 7-point Likert scale ranging from 1 (extremely unlikely) to 7 (extremely likely). One question is stated as "I would not seek help from anyone" and is reverse scored. Higher scores on this scale indicate more help-seeking. The GHSQ has shown good psychometric properties: Cronbach's alpha = 0.70, and test-retest of 0.86 for personal-emotional problems, and Cronbach's alpha = 0.83, and test-retest of 0.88 for suicidal thoughts (Wilson CJ et al. 2008)
Measured: Through the study completion (pre and post-intervention), an average of one month
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted18 Feb 2021
- Study start1 Jan 2021
- Primary completion12 Jan 2021
- Study completion1 Feb 2021
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for Stigma, SocialStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Health services research
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Model description
- Randomized controlled trial
- Masking
- Single blind
- Who is masked
- Participant
- Enrolment
- 1,183 participants (actual)
Sponsor and investigators
- Lead sponsor
- Research Foundation for Mental Hygiene, Inc.
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Yuval Y Neria, Research Foundation for Mental Hygiene, Inc.
- Investigators
- Doron Amsalem, MD, Study director, Columbia University and NYSPI
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT04760223
- Sponsor's protocol ID
- ResearchFMH
- Status last verified
- Feb 2021
- First submitted
- 11 Feb 2021
- Last updated
- 18 Feb 2021
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Publications
Amsalem D, Martin A. Reducing depression-related stigma and increasing treatment seeking among adolescents: randomized controlled trial of a brief video intervention. J Child Psychol Psychiatry. 2022 Feb;63(2):210-217. doi: 10.1111/jcpp.13427. Epub 2021 Apr 6.
PubMed 33821507
Study at a glance
From the registry record, last updated by the sponsor on 18 Feb 2021. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Reducing Depression-related Stigma and Increasing Treatment-seeking Among Adolescents: Randomized Controlled Trial of a Brief Video Intervention
- ClinicalTrials.gov ID
- NCT04760223
- Acronym / sponsor ID
- ResearchFMH
- Conditions
- Stigma, Social
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 1,183 participants (actual)
- Lead sponsor
- Research Foundation for Mental Hygiene, Inc.University, hospital or other
- Study start
- 1 Jan 2021 (actual)
- Primary completion
- 12 Jan 2021 (actual)
- Study completion
- 1 Feb 2021 (actual)
- First posted
- 18 Feb 2021 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The investigators conducted a randomized controlled study to test the utility of a brief video-based intervention to: 1) reduce stigma towards depression, and 2) increase treatment-seeking intentions among adolescents.
Detailed description
Young people present with the higher prevalence of mental health disorders compared to individuals at any other age, with up to 20% of adolescents likely to experience mental health disorders. Around 50% of mental health conditions start before the age of 14 and the onset of 75% of cases is before the age of 18. Depression is the most common diagnosis and epidemiological studies suggest that at any one time 8% to 10% of adolescents have severe depression. This means that the major burden of assessing and managing adolescent depression falls on primary care practitioners. Depression is a principal cause of illness and disability in teenagers, and suicide is the third most common cause of death among older adolescents. Mental health problems can significantly affect the development of children and young people having an enduring impact on their health and social functioning in adulthood. However, 75% of adolescents with mental health problems are not in contact with mental health services,8 and the primary reason for the reluctance to seek help is stigma.
Stigma refers to negative beliefs and stereotypes held toward a specific group of people and adversely affects people with mental illness. Public stigma refers to negative attitudes and beliefs that motivate individuals to fear, reject, avoid, and discriminate against people with mental illness. Individuals with mental illness expect to face prejudice and discrimination (anticipated stigma) and internalize public stereotypes of people with mental illness (self-stigma). Adolescents are particularly aware of how others perceive them and care greatly about what their peers think of them. Public stigma toward youngsters with mental illness has been identified as a barrier to seeking help; therefore, reducing public stigma among young people at risk for or even experiencing depression could enhance their receptivity to seeking help or treatment.
Applying strategies to reduce stigma towards mental health care among adolescents with high levels of depression may prevent worsening of symptoms, ameliorate impaired functioning, and reduce risks for long-term psychiatric illness. Among possible strategies, studies19 have shown that social contact is the most effective type of intervention to reduce stigmatizing attitudes. Social contact involves interpersonal contact with members of the stigmatized group: members of the general public who meet and interact with individuals who suffer from depression are likely to lessen their stigma. Corrigan identified the most important ingredients of contact-based programs: an empowered presenter with lived experience who attains his/her goals (e.g., "I was able to fight the depression and go back to school"). Although direct, in-person social contact, as well as indirect, video-based social contact have effectively improved attitudes toward mental issues and care, the latter can be implemented on a larger scale, use minimal resources and be easily disseminated.
The purpose of this study is to: (1) examine adolescents' stigma-related attitudes towards depression; and (2) test the utility of a brief video-based intervention in reducing stigma towards depression and increasing help-seeking intentions.
The investigators propose to randomly assign 1,000 individuals aged 14-18 in to either: (a) brief video-based intervention 1 ('Video 1'); (b) brief video-based intervention 2 ('Video 2'); or (c) no intervention video control arm ('Control'). The intervention videos will focus on empowered presenters with depression. The presenters will be 16-year-old adolescent professional actors, one of them is a boy (Video 1), one is a girl (Video 2). They each will share his/her personal story regarding depression and describe how social support from family, friends, and professionals have helped them overcome their symptoms and recover. The third group will watch a same length video with unrelated contents. Assessments will occur at baseline and at post-intervention and will tap into demographic identifiers and attitudes around stigma and help-seeking questionnaires.
Actors will be hired through the Child Study Center, and / or through the Standardized Patient Program of Teaching and Learning Center, Yale School of Medicine. Actors will be compensated and follow standardized patient best practices, including those specifically pertaining to under-age actors.
Study design
- Primary purpose
- Health services research
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (participant)
- Number of arms
- 4
- Model description
- Randomized controlled trial
| Arm | Type | Receives |
|---|---|---|
| Video intervention 1 | Experimental | Behavioral: Video interventionWe presented a 100-second video to study participants to reduce stigma towards depression (a boy presenter). The protagonist discussed his own depression and how getting help assist him. |
| Video intervention 2 | Experimental | Behavioral: Video interventionWe presented a 100-second video to study participants to reduce stigma towards depression (a girl presenter). The protagonist discussed his own depression and how getting help assist her. |
| control video 1 | Placebo comparator | Behavioral: Video interventionA 100-second video presenting a boy without depression |
| control video 2 | Placebo comparator | Behavioral: Video interventionA 100-second video presenting a girl without depression |
Who may qualify
- Ages
- 14 to 18 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Child, Adult
Key inclusion criteria (3 listed)
- 14-18-year-old
- US residents
- English speaker
Key exclusion criteria (1 listed)
- None
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Video interventiona 100-second video, presenting a personal story of a boy/girl dealing with depression | Behavioural | Video intervention 1, Video intervention 2, control video 1, control video 2 |
Primary outcome
Stigma levels
Time frame: Through the study completion (pre and post-intervention), an average of one month
Level of stigma towards depression measured by the 9-item Depression Stigma Scale (DSS). This is a 9-item self report questionnaire to measure the personal stigma towards depression. It has 5-point Likert scale tanging from strongly disagree (1) and strongly agree (5). It had test-retest reliability of 0.71 and internal consistency of 0.76 (Griffiths KM et al. 2004)
help-seeking intentions
Time frame: Through the study completion (pre and post-intervention), an average of one month
The General Help-Seeking Questionnaire (GHSQ) has been developed to measure help-seeking intentions from different sources (friend, parent, mental health professional, and others) and is divided into personal-emotional problems and suicidal thoughts. The instrument consists of 10 items repeated twice for each part, measured with a 7-point Likert scale ranging from 1 (extremely unlikely) to 7 (extremely likely). One question is stated as "I would not seek help from anyone" and is reverse scored. Higher scores on this scale indicate more help-seeking. The GHSQ has shown good psychometric properties: Cronbach's alpha = 0.70, and test-retest of 0.86 for personal-emotional problems, and Cronbach's alpha = 0.83, and test-retest of 0.88 for suicidal thoughts (Wilson CJ et al. 2008)
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 18 Feb 2021.
- Derived from this study: PubMed 33821507Amsalem D, Martin A. Reducing depression-related stigma and increasing treatment seeking among adolescents: randomized controlled trial of a brief video intervention. J Child Psychol Psychiatry. 2022 Feb;63(2):210-217. doi: 10.1111/jcpp.13427. Epub 2021 Apr 6.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Doron Amsalem, MD study director
Columbia University and NYSPI
2 sites in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Video intervention in people with Stigma, Social, run by Research Foundation for Mental Hygiene, Inc. at 2 sites in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 18 Feb 2021. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 2 sites in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. Some participants in this study may receive a placebo. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Stigma levels (time frame: Through the study completion (pre and post-intervention), an average of one month). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT04760223, which also lists 1 linked publication.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 18 Feb 2021; AzTrials last refreshed its copy on 30 Oct 2026.