AzTrials
AzTrials

Head and Neck Squamous Cell CarcinomaPhase 1NCT04762225

RPTR-168 in Patients With Human Papillomavirus Strain 16 (HPV-16) E6/E7 Positive Tumors and Melanoma

A Phase 1 study testing RPTR-168 in people with Head and Neck Squamous Cell Carcinoma and Melanoma, run by Repertoire Immune Medicines at 4 sites in United States.

Terminated

Stopped early. The study ended before it was planned to and will not resume.

Official record
Search all trials

Trial summary

The purpose of this study is to assess the safety and tolerability of escalating doses of RPTR-168 as a monotherapy in patients with HPV-16 E6/E7 positive tumors (HNSCC, cervical) and melanoma. Read more about this study

Who is it for?
Ages 18 years and older
What is being tested?
RPTR-168
Could I receive a placebo?
No, everyone receives an active treatment
How many people
7 participants
Where
4 sitesUnited States
Study dates
10 May 2021to 11 Oct 2022
Phase
Phase 1
Are there results?
None posted in the registry

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

  • Ages 18 years and older
  • All sexes
  • No healthy volunteers
  • Adult, Older adult

Who may be able to join

  • Patients eligible for inclusion in this study must meet all of the following criteria:
  • Be willing and able to provide written informed consent for the trial.
  • Written informed consent must be obtained prior to any study procedures.
  • Age ≥18 years.
  • Patients must have one of the following histologically- or cytologically-confirmed, relapsed/refractory, and metastatic or locally advanced solid tumor types and their disease must have has progressed despite all appropriate curative or life-prolonging treatments, unless they are intolerant to these therapies or have refused standard treatment.
  • Malignant melanoma for RPTR-168:1 therapy. Patients with non-cutaneous melanoma must have PRAME positive tumor, as determined by a qualified laboratory. For patients with PRAME negative tumors, the Investigator must consult with the Sponsor medical monitor about the suitability of an individual patient for enrollment.
Show all 36Show fewer
  • HPV-16 E6/E7 positive tumors for RPTR-168:2 therapy.
  • Failure to respond to standard therapy, or for whom no appropriate therapies are available (based on the judgment of the Investigator).
  • For melanoma patients, the definition of failure to respond an approved therapy for recurrent or metastatic disease is the following:
  • Tumor refractory to or progressing following prior PD-1/PD-L1 therapy alone or in combination with an anti-CTLA-4 agent unless the patient was deemed ineligible for such treatment.
  • If a subject is BRAF V600E/K positive, they must have received an approved BRAF- targeted regimen prior to entering the study, unless the patient was deemed ineligible for such treatment.
  • Prior adjuvant therapy cannot be used to define prior treatment failure.
  • For head and neck cancer patients, the definition of failure to respond to standard therapy is tumor refractory to or progressing following approved first- and second-line therapy for metastatic or recurrent disease consisting of one or more of the following:
  • PD-1/PD-L1 therapy alone or in combination unless the patient was deemed ineligible for such treatment.
  • Cetuximab therapy alone or in combination unless the patient was deemed ineligible for such treatment.
  • Prior adjuvant or neo-adjuvant therapy cannot be used to define prior treatment failure.
  • For cervical cancer patients, the definition of failure to respond to an approved therapy for recurrent or metastatic disease is the following:
  • For all patients: Tumor refractory to or progressing following prior treatment with a platinum-based chemotherapy.
  • For PD1 expressing tumors: Tumor refractory to or progressing following prior PD-1/PD-L1 therapy alone or in combination.
  • For anal and penile cancer patients the definition of failure to respond to an approved therapy for recurrent or metastatic disease is the following:
  • Tumor refractory to or progressing following prior treatment with a platinum-based chemotherapy.
  • For vulvar cancer patients a patient must no longer be a candidate for local/regional therapy
  • Able to provide a buccal swab to undergo HLA typing, or submit documented HLA typing from a previously performed test, to be reviewed and approved by the Sponsor.
  • For patients undergoing screening to receive RPTR-168:2 therapy, patients must have archival tumor tissue or be able to undergo a fresh tumor biopsy to submit tissue for HPV testing, as well as profiling of DNA, RNA and proteins. HPV-16 E6/E7 positivity in the patient's tumor tissue must be established using a validated clinical trial assay performed in a CLIA/CAP accredited reference laboratory. If documented results of HPV-16 E6/E7 are available from a previous test, the patient can be enrolled using these results after review and approval by the Sponsor.
  • Patients must have measurable disease per mRECIST 1.1 as determined by radiologic evaluations or tumor assessments obtained within 2 months prior to study entry.
  • If there are no pre-existing radiologic assessments within 2 months prior to study entry available, other evidence of measurable disease may be considered sufficient to fulfill this criterion following documented discussion and approval from the Sponsor.
  • Please note, patients must have a radiological/tumor assessment per mRECIST v1.1 within 28 days prior to receiving study therapy to serve as the patient's baseline tumor assessment.
  • Eastern Cooperative Oncology Group (ECOG) Performance Status ≤1.
  • Patient must be willing and able to provide a tumor tissue sample prior to the start of study therapy and once during study therapy.
  • For the pre-dose tumor sample, a fresh tumor biopsy obtained prior to the start of study therapy is preferred, but an archival sample (collected within ≤ 2 months prior to the start of study therapy) may be submitted.
  • For the on-treatment tumor sample, the patient must be willing and able to have a fresh tumor biopsy to collect tissue for submission.
  • A female participant is eligible to participate if she is not pregnant, not breastfeeding, and at least one of the following conditions applies:
  • Not a woman of childbearing potential (WOCBP), defined as all women physiologically capable of becoming pregnant.
  • A WOCBP who agrees to follow contraceptive guidance during the treatment period and for at least 120 days after the last dose of study treatment.
  • A serum pregnancy test must be performed during screening to confirm the patient is not pregnant.
  • A male participant must agree to use contraception during the treatment period and for at least 120 days after the last dose of study treatment.

Who cannot join

  • Patients eligible for this study must not meet any of the following criteria:
  • Previously identified hypersensitivity to components of the study treatment or excipients.
  • Presence of active CNS disease and/or carcinomatous meningitis. Participants with previously treated brain metastases may participate provided they are radiologically stable, i.e., without evidence of progression for at least 4 weeks by repeat imaging (note that the repeat imaging should be performed during study screening), clinically stable, and without requirement of steroid treatment for at least 14 days prior to study entry.
  • Has received prior radiotherapy within 2 weeks prior to study entry. Participants must have recovered from all radiation-related toxicities, not require corticosteroids, and not have had radiation pneumonitis. A 1-week washout is permitted for palliative radiation (≤2 weeks of radiotherapy) to non-CNS disease. The target lesions must not be irradiated.
  • Patient having out of range laboratory values defined as:
  • Creatinine clearance (calculated using Cockcroft-Gault formula, or measured) <40 mL/min
Show all 49Show fewer
  • Total bilirubin >1.5 x upper limit of normal (ULN), except for patients with Gilbert's syndrome who are excluded if total bilirubin >3.0 x ULN or direct bilirubin >1.5 x ULN
  • Alanine aminotransferase (ALT) and Aspartate aminotransferase (AST) >2 x ULN, except for patients that have tumor involvement of the liver, who are excluded if ALT and AST >3 x ULN. ALT and AST up to 5x ULN may be considered with documented discussion and approval from sponsor.
  • Absolute neutrophil count (ANC) ≤1.0 x 109/L
  • Absolute lymphocyte count ≤0.5 x 109/L. Patients with ALC counts ≤0.5 x 109/L may be considered for inclusion after discussion and approval by the sponsor medical monitor.
  • Platelet count ≤75 x 109/L absent platelet transfusion for 2 weeks
  • Hemoglobin (Hgb) ≤9 g/dL absent RBC transfusion for 2 weeks
  • Coagulation (prothrombin time [PT] or international normalized ratio [INR] and partial thromboplastin time [PTT] or activated partial thromboplastin time [aPTT])
  • >1.5 × ULN unless participant is receiving anticoagulant therapy as long as PT/INR and PTT/aPTT is within therapeutic range of intended use of anticoagulants
  • Potassium, magnesium, calcium or phosphate abnormality > Grade 1 (CTCAE v5.0) despite appropriate oral replacement therapy:
  • Serum triglycerides >500 mg/dL due to potential interference with cell separation methods
  • Clinically significant and/or uncontrolled heart disease such as congestive heart failure requiring treatment (New York Heart Association [NYHA] Grade ≥2), uncontrolled hypertension, or clinically significant arrhythmia.
  • Acute myocardial infarction or unstable angina pectoris <6 months prior to study entry.
  • Patients with active, known or suspected autoimmune disease that has required systemic treatment in the past 2 years (i.e., with use of disease modifying agents, corticosteroids, or immunosuppressive drugs).
  • Replacement therapy (e.g., thyroxine, insulin, or physiologic corticosteroid replacement therapy for adrenal or pituitary insufficiency) is not considered a form of systemic treatment and is allowed.
  • Patients with vitiligo, type 1 diabetes mellitus, residual hypothyroidism due to autoimmune condition only requiring hormone replacement, psoriasis not requiring systemic treatment, or conditions not expected to recur in the absence of an external trigger are permitted to enroll.
  • Has a history of (non-infectious) pneumonitis that required steroids or has current pneumonitis.
  • Has a diagnosis of immunodeficiency or is receiving chronic systemic steroid therapy (in dosing exceeding 10 mg daily of prednisone equivalent) or any other form of immunosuppressive therapy within 7 days prior to study entry.
  • Has a known additional malignancy that is progressing or has required active treatment within the past 3 years.
  • Note: Participants with basal cell carcinoma of the skin, squamous cell carcinoma of the skin, or carcinoma in situ (e.g., breast carcinoma, cervical cancer in situ) that have undergone potentially curative therapy are not excluded.
  • Has a known history of human immunodeficiency virus (HIV) infection. No HIV testing is required unless mandated by local health authority.
  • Documented history of Hepatitis B (defined as Hepatitis B surface antigen [HBsAg] reactive) or known active Hepatitis C virus (defined as HCV RNA [qualitative] is detected) infection.
  • Note: No testing for Hepatitis B and Hepatitis C is required unless mandated by local health authority.
  • Malignant disease, other than that being treated in this study expected to interfere with the assessment of efficacy in the opinion of the investigator.
  • Active infection requiring systemic therapy.
  • Patients requiring chronic treatment with systemic steroid therapy, other than replacement dose steroids in the setting of adrenal insufficiency. Topical, inhaled, nasal, or ophthalmic steroids are allowed.
  • Patients receiving systemic treatment with any other immunosuppressive medication.
  • Use of any live vaccines against infectious diseases within 30 days of study entry. Examples of live vaccines include, but are not limited to, the following: measles, mumps, rubella, varicella/zoster (chicken pox), yellow fever, rabies, Bacillus Calmette-Guérin (BCG), and typhoid vaccine. Seasonal influenza vaccines for injection are generally killed virus vaccines and are allowed; however, intranasal influenza vaccines (e.g., FluMist®) are live attenuated vaccines and are not allowed.
  • Major surgery within 4 weeks of study entry (mediastinoscopy, insertion of a central venous access device, and insertion of a feeding tube are not considered major surgery).
  • Note: If participant received major surgery, they must have recovered adequately from the toxicity and/or complications from the intervention.
  • Is currently participating in or has participated in a study of an investigational agent or has used an investigational agent or device within 4 weeks prior to the first dose of study drug.
  • Note: Patients participating in another investigational study, or receiving standard of care treatment, may consent to having archival tumor tissue sent for testing (eg, to assess HPV-16 E6/E7 status).
  • Presence of ≥ Grade 2 (CTCAE v5.0) toxicity from prior therapy (except alopecia, peripheral neuropathy, and ototoxicity, which are excluded if ≥ Grade 3 [CTCAE v5.0]) due to prior cancer treatment.
  • Patients who were required to discontinue PD-1/PD-L1, CTLA-4, or other immunomodulatory antibodies due to ≥Grade 3 irAE may be included following discussion with the Sponsor.
  • Patients who received prior T-cell anti-cancer vaccines and T-cell therapies are excluded.
  • Has undergone prior allogeneic HSCT
  • Patients with rapidly progressing disease that would preclude waiting 4-6 weeks after apheresis to receive study therapy.
  • Prior therapy with PD-1/PDL-1, CTLA-4 or other immunomodulatory antibodies inhibitors ≤2 weeks prior to the apheresis procedure.
  • Systemic anti-cancer therapy within 5 half-lives or 2 weeks; whichever occurs first, prior to the apheresis procedure.
  • Systemic cytotoxic agents that have major delayed toxicity, e.g. mitomycin C and nitrosoureas, ≤6 weeks prior to study entry.
  • Participants must have recovered from all AEs due to previous therapies to ≤Grade 1 or baseline. Participants with ≤Grade 2 neuropathy may be eligible.
  • Has a history or current evidence of any condition, therapy, or laboratory abnormality that might confound the results of the study, interfere with the participant's participation for the full duration of the study, or is not in the best interest of the participant to participate, in the opinion of the treating investigator.
  • Has known psychiatric or substance abuse disorders that would interfere with cooperating with the requirements of the study.
  • Is pregnant or breastfeeding or expecting to conceive or father children within the projected duration of the study, starting with the screening visit through 120 days after the last dose of study treatment.

Trial locations and contacts

4 sites in 1 country.

United States4 sites

  • University of Michigan Comprehensive Cancer Center

    Ann Arbor, Michigan, 48109

  • Carolina BioOncology Institute

    Huntersville, North Carolina, 28078

  • USC Norris Comprehensive Cancer Center

    Los Angeles, California, 90033

  • HonorHealth Research Institute

    Scottsdale, Arizona, 85258

Other trials in United States

About this study

Official title: A Phase 1/2 Open-Label Multi-Center Study to Characterize the Safety and Tolerability of RPTR-168 in Patients With Relapsed/Refractory HPV-16 E6/E7 Positive Tumors and Melanoma

The purpose of this study is to assess the safety and tolerability of escalating doses of RPTR-168 as a monotherapy in patients with HPV-16 E6/E7 positive tumors (HNSCC, cervical) and melanoma.

Read the detailed description

This is a phase 1/2, open-label, first-in-human, multi-center study to characterize the safety and tolerability of RPTR-168 administered i.v. as a monotherapy in patients with relapsed/refractory metastatic or locally-advanced HPV-16 E6/E7 positive tumors and melanoma.

The study will include 2 dosing periods: A Dose Escalation (Phase 1) followed by an Expansion (Phase 2).

Being tested
RPTR-168
Keywords
Adoptive cellular therapy, Cell therapy, Cytokine, Interleukin 12 (IL-12)
Medical subject headings
Squamous Cell Carcinoma of Head and Neck, Melanoma, Uterine Cervical Neoplasms

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

  • RPTR-168Biological

    Escalating doses of RPTR-168 as a monotherapy

Study groups in NCT04762225
Study groupRoleWhat they receive
RPTR-168ExperimentalEscalating doses of RPTR-168 as a monotherapy in HPV-16 E6/E7 positive tumors and melanoma.
Receives: Biological: RPTR-168

What is being measured

The primary outcome is the main question the study is designed to answer.

  1. Number of subjects with dose limiting toxicities (DLT)

    Safety of RPTR-168:1 as a monotherapy in patients with melanoma

    Measured: At the end of the DLT period (28 days)

  2. Number of subjects with dose limiting toxicities (DLT)

    Safety of RPTR-168:2 as a monotherapy in patients with HPV-16 E6/E7 positive tumors

    Measured: At the end of the DLT period (28 days)

  3. Frequency of dose interruptions

    Tolerability of RPTR-168:1 as a monotherapy in patients with melanoma

    Measured: At the end of the DLT period (28 days)

  4. Frequency of dose interruptions

    Tolerability of RPTR-168:2 as a monotherapy in patients with HPV-16 E6/E7 positive tumors

    Measured: At the end of the DLT period (28 days)

Secondary outcomes (5)

  1. Best overall response

    Per modified RECIST v1.1 (solid tumor)

    Measured: Baseline through approximately 6 months after RPTR-168 last dose as monotherapy

  2. Progression free survival

    Per modified RECIST v1.1 (solid tumor)

    Measured: Baseline through approximately 6 months after RPTR-168 last dose as monotherapy

  3. Maximum observed serum concentration of RPTR-168 as monotherapy

    Maximum observed serum concentration

    Measured: Baseline through approximately 1 year

  4. Area under the serum concentration-time curve

    Area under the serum concentration-time curve

    Measured: Baseline through approximately 1 year

  5. Immunogenicity of RPTR-168 as monotherapy

    Number of subject with anti-RPTR-168 antibodies

    Measured: Pre-dose through approximately 1 year after RPTR-168 last dose

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

  1. First posted21 Feb 2021
  2. Study start10 May 2021
  3. Primary completion14 Sep 2022
  4. Study completion11 Oct 2022

Why it stopped: Development program terminated

Resources

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design
Study type
Interventional
Phase
Phase 1
Primary purpose
Treatment
Allocation
Not applicable
Intervention model
Single group
Masking
None (open label)
Enrolment
7 participants (actual)
IDs, dates and publications
ClinicalTrials.gov ID
NCT04762225
Sponsor's protocol ID
PRIME-102
Status last verified
Dec 2022
First submitted
16 Feb 2021
Last updated
6 Dec 2022
Results posted
No
Data monitoring committee
No
FDA-regulated drug
Yes
FDA-regulated device
No
Individual data sharing
No

Questions about this trial

What is this clinical trial studying?

A Phase 1 study testing RPTR-168 in people with Head and Neck Squamous Cell Carcinoma and Melanoma, run by Repertoire Immune Medicines at 4 sites in United States.

The full registered description is in the About this study section and the official record.

Who may be eligible to take part?

The sponsor lists 36 inclusion and 49 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.

Is this clinical trial currently recruiting?

The record says: stopped early, as of the sponsor's last update on 6 Dec 2022. Status can change between updates, so confirm with the study contact before making plans.

Where is the study taking place?

The record lists 4 sites in United States. Whether a site is taking part right now should be confirmed with that site. See every site.

What are the possible benefits and risks?

They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.

What does this phase mean?

Phase 1 studies test a treatment in a small group of people for the first time or in a new way, mainly to check safety and find the right dose.

Not every study follows the same path, and some studies (observational studies, device studies) have no phase.

Are results available for this study?

The study was stopped early (reason given: Development program terminated). Results are not available in the source record.

How can a doctor refer a patient or contact the research team?

The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.

What does the primary outcome measure?

Number of subjects with dose limiting toxicities (DLT) (time frame: At the end of the DLT period (28 days)). The study lists 4 primary outcomes in all. It is what the study was designed to measure, not a finding.

Where can I read the original study information?

On the ClinicalTrials.gov record for NCT04762225.

Does a listing mean the treatment is approved or proven to work?

No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.

How often is this information updated?

AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 6 Dec 2022.

AzTrials uses cookies for analytics and advertising. You can accept or reject them; the site works either way. Privacy Policy.

Free account

Log in to keep searching

You’ve used your 3 free searches. AzTrials is free: log in or create a free account to keep searching clinical trials and save the ones you want to follow.

Create a free accountLog in