Nutritional Intervention Using Protein Rich Whole Food SourcesFFTNCT04794153
Investigating the Consumption of Different Protein Rich Whole Food Sources on Muscle Growth in Trained Males and Females
A study testing whole food sources in people with Nutritional Intervention Using Protein Rich Whole Food Sources, run by University of Exeter at 1 site in United Kingdom.
Trial summary
Background To date, most of the literature investigating the role of dietary protein in muscle growth has focused on isolated protein sources. However, dietary protein is most commonly consumed within a whole food source. Consuming dietary protein within a whole food matrix may additionally stimulate muscle growth. Read more about this study
- Who is it for?
- Ages 18 to 40 yearsHealthy volunteers can take part
- Conditions the study is for
- Nutritional Intervention Using Protein Rich Whole Food Sources
- What is being tested?
- whole food sources
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 66 participants
- Where
- 1 siteUnited Kingdom
- Study dates
- 1 May 2021to 1 May 2024
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 40 years
- All sexes
- Healthy volunteers accepted
- Adult
Who may be able to join
- Males and Females
- BMI 18.5 - 30 kg/m2
- Aged 18 - 40 years
- Structured Resistance training consistently for > 6 months
- A 5-7 day "washout" period from any supplementation
Who cannot join
- Age >40 years
- Body mass index (BMI) <18.5 or >30 kg/m2
- Any metabolic impairments
- Any cardiovascular impairments
- High blood pressure (≥140/90 mmHg)
- Any gastrointestinal disorders
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- Any medications known to affect protein and/or amino acid metabolism
- A personal or family history of epilepsy, seizures or schizophrenia, motor disorder
- Chronic over the counter use of pharmaceuticals (> 1 month)
- Allergic to any of the whole foods included in the study
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Assessing the Muscle Protein Synthetic Response Following the Ingestion of a Variety of Protein Rich Whole Foods Compared to an Isolated Protein Source.
Background To date, most of the literature investigating the role of dietary protein in muscle growth has focused on isolated protein sources. However, dietary protein is most commonly consumed within a whole food source. Consuming dietary protein within a whole food matrix may additionally stimulate muscle growth. The idea being, there may be other components within food, capable of producing a greater response.
Objectives: To assess the effect of consuming a variety of whole food sources, on the stimulation of muscle growth compared to an isolated protein source following a single bout of lower body resistance exercise.
Read more
Methods Young healthy resistance-trained volunteers will consume a protein rich whole food source, following a bout of lower body resistance exercise. Stable isotope IV infusions and repeated blood and muscle samples will be taken to assess protein digestion and absorption, as well as muscle protein synthesis rates.
Value of Research:
To determine whether whole food sources potentiate muscle protein synthesis rates (and to what extent across whole food sources) compared to an isolated protein source. In doing so, we can further investigate the nutrients involved that may be contributing to this effect.
- Being tested
- whole food sources
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
whole food sourcesDietary supplement
Foods selected are naturally high in protein and consumed by the general population as part of a meal.
| Study group | Role | What they receive |
|---|---|---|
| Pork | Experimental | Locally sourced Receives: Dietary Supplement: whole food sources |
| Salmon | Experimental | Locally sourced Receives: Dietary Supplement: whole food sources |
| Mycoprotein | Experimental | Provided by Marlow Foods Receives: Dietary Supplement: whole food sources |
| Lentils | Experimental | Red Receives: Dietary Supplement: whole food sources |
| Egg | Experimental | Local supplier Receives: Dietary Supplement: whole food sources |
| Egg whites | Active comparator | Local Supplier Receives: Dietary Supplement: whole food sources |
What is being measured
The primary outcome is the main question the study is designed to answer.
Postprandial Muscle protein Synthetic Response following the ingestion of a protein rich whole food source.
84 participants will undergo a single bout of lower body exercise followed by the ingestion of one of the six protein rich whole food sources. Using stable isotope tracer methodology and muscle biopsy samples, the postprandial muscle protein synthetic response will be able to be calculated.
Measured: 2 years
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted11 Mar 2021
- Study start1 May 2021
- Primary completion1 Apr 2024
- Study completion1 May 2024
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for Nutritional Intervention Using Protein Rich Whole Food SourcesStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Other
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Enrolment
- 66 participants (actual)
Sponsor and investigators
- Lead sponsor
- University of Exeter
- Sponsor type
- University, hospital or other
- Collaborators
- Marlow Foods Ltd
- Responsible party
- Sponsor
- Investigators
- Professor Wall, Principal investigator, University of Exeter
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT04794153
- Sponsor's protocol ID
- FFT
- Acronym
- FFT
- Status last verified
- May 2024
- First submitted
- 4 Mar 2021
- Last updated
- 9 May 2024
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Publications
Haigh FA, Monteyne AJ, Abdelrahman DR, Murton AJ, Finnigan TJ, Theobald HE, Stephens FB, Wall BT. Ingestion of diverse protein-rich whole-foods result in similar post exercise whole body and myofibrillar protein synthesis rates compared with a more isolated protein source in young adults. Am J Clin Nutr. 2026 Apr;123(4):101231. doi: 10.1016/j.ajcnut.2026.101231. Epub 2026 Feb 3.
PubMed 41643855
Study at a glance
From the registry record, last updated by the sponsor on 9 May 2024. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Assessing the Muscle Protein Synthetic Response Following the Ingestion of a Variety of Protein Rich Whole Foods Compared to an Isolated Protein Source.
- ClinicalTrials.gov ID
- NCT04794153
- Acronym / sponsor ID
- FFT / FFT
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 66 participants (actual)
- Lead sponsor
- University of ExeterUniversity, hospital or other
- Collaborators
- Marlow Foods Ltd
- Study start
- 1 May 2021 (actual)
- Primary completion
- 1 Apr 2024 (actual)
- Study completion
- 1 May 2024 (actual)
- First posted
- 11 Mar 2021 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Background To date, most of the literature investigating the role of dietary protein in muscle growth has focused on isolated protein sources. However, dietary protein is most commonly consumed within a whole food source. Consuming dietary protein within a whole food matrix may additionally stimulate muscle growth. The idea being, there may be other components within food, capable of producing a greater response.
Objectives: To assess the effect of consuming a variety of whole food sources, on the stimulation of muscle growth compared to an isolated protein source following a single bout of lower body resistance exercise.
Methods Young healthy resistance-trained volunteers will consume a protein rich whole food source, following a bout of lower body resistance exercise. Stable isotope IV infusions and repeated blood and muscle samples will be taken to assess protein digestion and absorption, as well as muscle protein synthesis rates.
Value of Research:
To determine whether whole food sources potentiate muscle protein synthesis rates (and to what extent across whole food sources) compared to an isolated protein source. In doing so, we can further investigate the nutrients involved that may be contributing to this effect.
Study design
- Primary purpose
- Other
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 6
| Arm | Type | Receives |
|---|---|---|
| Pork | Experimental | Dietary Supplement: whole food sourcesLocally sourced |
| Salmon | Experimental | Dietary Supplement: whole food sourcesLocally sourced |
| Mycoprotein | Experimental | Dietary Supplement: whole food sourcesProvided by Marlow Foods |
| Lentils | Experimental | Dietary Supplement: whole food sourcesRed |
| Egg | Experimental | Dietary Supplement: whole food sourcesLocal supplier |
| Egg whites | Active comparator | Dietary Supplement: whole food sourcesLocal Supplier |
Who may qualify
- Ages
- 18 to 40 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (5 listed)
- Males and Females
- BMI 18.5 - 30 kg/m2
- Aged 18 - 40 years
- Structured Resistance training consistently for > 6 months
- A 5-7 day "washout" period from any supplementation
Key exclusion criteria (10 listed)
- Age >40 years
- Body mass index (BMI) <18.5 or >30 kg/m2
- Any metabolic impairments
- Any cardiovascular impairments
- High blood pressure (≥140/90 mmHg)
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| whole food sourcesFoods selected are naturally high in protein and consumed by the general population as part of a meal. | Dietary supplement | Egg, Egg whites, Lentils, Mycoprotein, Pork, Salmon |
Primary outcome
Postprandial Muscle protein Synthetic Response following the ingestion of a protein rich whole food source.
Time frame: 2 years
84 participants will undergo a single bout of lower body exercise followed by the ingestion of one of the six protein rich whole food sources. Using stable isotope tracer methodology and muscle biopsy samples, the postprandial muscle protein synthetic response will be able to be calculated.
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 9 May 2024.
- Derived from this study: PubMed 41643855Haigh FA, Monteyne AJ, Abdelrahman DR, Murton AJ, Finnigan TJ, Theobald HE, Stephens FB, Wall BT. Ingestion of diverse protein-rich whole-foods result in similar post exercise whole body and myofibrillar protein synthesis rates compared with a more isolated protein source in young adults. Am J Clin Nutr. 2026 Apr;123(4):101231. doi: 10.1016/j.ajcnut.2026.101231. Epub 2026 Feb 3.
- Individual participant dataSharing planned: No
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Professor Wall principal investigator
University of Exeter
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing whole food sources in people with Nutritional Intervention Using Protein Rich Whole Food Sources, run by University of Exeter at 1 site in United Kingdom.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 5 inclusion and 10 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 9 May 2024. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United Kingdom. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Postprandial Muscle protein Synthetic Response following the ingestion of a protein rich whole food source. (time frame: 2 years). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT04794153, which also lists 1 linked publication.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 9 May 2024.